ES8603574A1 - "procedimiento de tecnologia genetica para preparar secuen- cias parciales del gamma-interferon de humano". - Google Patents

"procedimiento de tecnologia genetica para preparar secuen- cias parciales del gamma-interferon de humano".

Info

Publication number
ES8603574A1
ES8603574A1 ES542337A ES542337A ES8603574A1 ES 8603574 A1 ES8603574 A1 ES 8603574A1 ES 542337 A ES542337 A ES 542337A ES 542337 A ES542337 A ES 542337A ES 8603574 A1 ES8603574 A1 ES 8603574A1
Authority
ES
Spain
Prior art keywords
human gamma
ifn
polypeptides
production
interferon activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES542337A
Other languages
English (en)
Other versions
ES542337A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8603574A1 publication Critical patent/ES8603574A1/es
Publication of ES542337A0 publication Critical patent/ES542337A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/811—Interferon
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/142—Interferon

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO DE TECNOLOGIA GENETICA PARA PREPARAR SECUENCIAS DEL GAMMA-INTERFERON DE HUMANO. CONSISTE EN HACERSE EXPRESAR EN UN ORGANISMO HOSPEDANTE UN GEN SINTETICO CON UN ADN DE FORMULA (PR)X-XY-R-YZ-Z DONDE X, Y Y Z, INDEPENDIENTEMENTE ENTRE SI, SIGNIFICAN 0 O 1, PERO Y Y Z NO SIGNIFICAN AMBOS 1 SI X REPRESENTA MET-CYS-TYR-CYS-CLN, Y PR, X, R E Y REPRESENTAN SECUENCIAS DE NUCLEOTIDOS QUE CODIFICAN LOS SIGUIENTES AMINOACIDOS O LAS SIGUIENTES SECUENCIAS DE NUCLEOTIDOS QUE CODIFICAN LOS SIGUIENTES AMINOACIDOS O LAS SIGUIENTES SECUENCIAS DE AMINOACIDOS: PR, UN PREPEPTIDO QUE ES SEPARADO EN EL ORGANISMO HOSPEDANTE O <IN VITRO>; X CODIFICA MET, MET-CYS-TYR-CYS-GLN O H-CYS-TYR-CYS-GLN; R, CODIFICA LOS AMINOACIDOS 5 A 127 O MODIFICACIONES DE ESTA SECUENCIA DE AMINOACIDOS; Y CODIFICA LOS AMINOACIDOS 128 A 146 O MODIFICACIONES DE ESTA SECUENCIA DE AMINOACIDOS Y Z SIGNIFICA UNO O DOS CODON(ES) DE DETENCION. TIENEN APLICACIONES FARMACEUTICAS PARA PREPARADOS ANTIVIRICOS Y OTROS.
ES542337A 1984-04-19 1985-04-17 "procedimiento de tecnologia genetica para preparar secuen- cias parciales del gamma-interferon de humano". Granted ES542337A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843414831 DE3414831A1 (de) 1984-04-19 1984-04-19 Herstellung von polypeptiden mit human-gammainterferon-aktivitaet

Publications (2)

Publication Number Publication Date
ES8603574A1 true ES8603574A1 (es) 1985-12-16
ES542337A0 ES542337A0 (es) 1985-12-16

Family

ID=6234006

Family Applications (1)

Application Number Title Priority Date Filing Date
ES542337A Granted ES542337A0 (es) 1984-04-19 1985-04-17 "procedimiento de tecnologia genetica para preparar secuen- cias parciales del gamma-interferon de humano".

Country Status (20)

Country Link
US (1) US4832959A (es)
EP (1) EP0161504B1 (es)
JP (2) JPH0745516B2 (es)
KR (1) KR920009505B1 (es)
AT (1) ATE69241T1 (es)
CA (1) CA1339892C (es)
DE (2) DE3414831A1 (es)
DK (1) DK164940C (es)
ES (1) ES542337A0 (es)
FI (1) FI90436C (es)
GR (1) GR850941B (es)
HU (1) HU210111B (es)
IE (1) IE59460B1 (es)
IL (1) IL74947A (es)
MA (1) MA20411A1 (es)
NO (1) NO171983C (es)
NZ (1) NZ211827A (es)
PH (1) PH25251A (es)
PT (1) PT80300B (es)
ZA (1) ZA852900B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3409966A1 (de) * 1984-03-19 1985-09-26 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von human-gammainterferon und mittel zur durchfuehrung dieses verfahrens
DE3536939A1 (de) * 1985-10-17 1987-04-23 Hoechst Ag Biologisch aktive derivate des human-(gamma)-interferons, ihre herstellung und arzneimittel, die solche derivate enthalten
GB8619725D0 (en) * 1986-08-13 1986-09-24 Hoffmann La Roche Homogenous interferon fragments
DE3642096A1 (de) * 1986-12-10 1988-06-16 Boehringer Ingelheim Int Pferde-(gamma)-interferon
US5157004A (en) * 1986-12-27 1992-10-20 Takeda Chemical Industries, Ltd. Polypeptides and production thereof
JP2653061B2 (ja) * 1986-12-27 1997-09-10 武田薬品工業株式会社 新規ポリペプチドおよびその製造法
CA2390292A1 (en) 1999-11-12 2001-05-25 Maxygen Holdings Ltd. Interferon gamma conjugates
CN1309423C (zh) 1999-11-12 2007-04-11 马克西根控股公司 干扰素γ偶联物
US6958388B2 (en) 2001-04-06 2005-10-25 Maxygen, Aps Interferon gamma polypeptide variants
US7038015B2 (en) * 2001-04-06 2006-05-02 Maxygen Holdings, Ltd. Interferon gamma polypeptide variants
AU2003239774A1 (en) * 2002-07-03 2004-01-23 Maxygen Holdings Ltd. Full-length interferon gamma polypeptide variants
US20050003533A1 (en) 2003-05-08 2005-01-06 Pawel Kalinski Mature type-1 polarized dendritic cells with enhanced IL-12 production and methods of serum-free production and use
BG66458B1 (bg) 2005-03-21 2014-10-31 Иван Иванов Средство за конкурентно инхибиране на ендогенен гама интерферон
CA2607806A1 (en) * 2005-05-04 2006-11-16 Nautilus Biotech, S.A. Modified interferon-gamma polypeptides and methods for using modified interferon-gamma polypeptides
WO2008121461A2 (en) * 2007-02-26 2008-10-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Vaccine for activating helper function of cd8+ tcells
US9359421B2 (en) 2008-04-08 2016-06-07 Tigo Gmbh Suppressor of the endogenous interferon-gamma
BG66517B1 (bg) * 2008-04-08 2016-02-29 Tigo Gmbh Супресор на ендогенния човешки гама - интерферон
JP4821891B2 (ja) * 2009-07-01 2011-11-24 トヨタ自動車株式会社 電池制御システム及び車両
BG67190B1 (bg) 2017-03-29 2020-11-16 Tigo Gmbh Анти-гама мутантен протеин срещу ендогенния човешки гама интерферон
WO2020076970A1 (en) 2018-10-11 2020-04-16 Inhibrx, Inc. B7h3 single domain antibodies and therapeutic compositions thereof
US20210380679A1 (en) 2018-10-11 2021-12-09 Inhibrx, Inc. Dll3 single domain antibodies and therapeutic compositions thereof
WO2020077257A1 (en) 2018-10-11 2020-04-16 Inhibrx, Inc. Pd-1 single domain antibodies and therapeutic compositions thereof
US20210340273A1 (en) 2018-10-11 2021-11-04 Inhlbrx, inc. 5t4 single domain antibodies and therapeutic compositions thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU561343B2 (en) * 1981-10-19 1987-05-07 Genentech Inc. Human immune interferon by recombinant dna
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
ZA831094B (en) * 1982-02-22 1983-11-30 Biogen Nv Dna sequences,recombinant dna molecules and processes for producing human immune interferon-like polypeptides
IL68100A0 (en) * 1982-03-24 1983-06-15 Takeda Chemical Industries Ltd Novel dna and use thereof
US6936694B1 (en) * 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
JPH0787797B2 (ja) * 1982-05-20 1995-09-27 サントリー株式会社 ヒト・ガンマ・インタ−フエロン様ポリペプチドの製造法
US4681848A (en) * 1982-09-22 1987-07-21 Takeda Chemical Industries, Ltd. Novel peptide and use thereof
US4604284A (en) * 1983-09-20 1986-08-05 Hoffmann-La Roche Inc. Homogeneous immune interferon fragment
US4855238A (en) * 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor

Also Published As

Publication number Publication date
IE850995L (en) 1985-10-19
DK176285D0 (da) 1985-04-18
PT80300B (pt) 1987-09-30
IL74947A (en) 2000-06-01
FI851529L (fi) 1985-10-20
NO851564L (no) 1985-10-21
FI90436B (fi) 1993-10-29
EP0161504B1 (de) 1991-11-06
PH25251A (en) 1991-03-27
IL74947A0 (en) 1985-08-30
HU210111B (en) 1995-02-28
ZA852900B (en) 1985-11-27
ATE69241T1 (de) 1991-11-15
JPH07100037B2 (ja) 1995-11-01
CA1339892C (en) 1998-06-02
DK164940C (da) 1993-02-01
JPH06153957A (ja) 1994-06-03
NO171983B (no) 1993-02-15
JPH0745516B2 (ja) 1995-05-17
PT80300A (de) 1985-05-01
DK176285A (da) 1985-10-20
NZ211827A (en) 1988-07-28
KR850007274A (ko) 1985-12-02
GR850941B (es) 1985-11-25
KR920009505B1 (ko) 1992-10-17
DE3584579D1 (de) 1991-12-12
MA20411A1 (fr) 1985-12-31
FI851529A0 (fi) 1985-04-17
FI90436C (fi) 1994-02-10
ES542337A0 (es) 1985-12-16
EP0161504A1 (de) 1985-11-21
IE59460B1 (en) 1994-02-23
DK164940B (da) 1992-09-14
JPS60233100A (ja) 1985-11-19
NO171983C (no) 1993-05-26
HUT37815A (en) 1986-02-28
DE3414831A1 (de) 1985-10-31
US4832959A (en) 1989-05-23

Similar Documents

Publication Publication Date Title
ES8603574A1 (es) &#34;procedimiento de tecnologia genetica para preparar secuen- cias parciales del gamma-interferon de humano&#34;.
ES8207514A1 (es) Un procedimiento para la preparacion de interferon
AU561343B2 (en) Human immune interferon by recombinant dna
AU568067B2 (en) Oligonucleotide therapeutic agent and methods of making same
EP0048970A3 (en) Polypeptides, process for their microbial production, intermediates therefor and compositions containing them
IL77369A (en) Alpha, beta or omega horse interferon, their preparation and pharmaceutical compositions containing them, recombinant dna coding therefor and transformed host organisms containing such dna
ES8802235A1 (es) Procedimiento para preparar un polipeptido
AU6733487A (en) Mammalian interleukin-4
ES2000278A6 (es) Procedimiento para preparar una proteina de fusion y para preparar una proteina eucariotica.
IT8119760A0 (it) Polipeptide prodotto microbiologicamente con la sequenza di aminoacidi dell&#39;interferone umano, dna e plasmidi che codificano per questa sequenza, microorganismi che contengono queste informazioni genetiche e processo per la loro preparazione.
EP0182372A3 (en) New factor viii coagulant polypeptides
AU5233686A (en) Dna sequence encoding a hirudin-like protein and process for preparing such protein
EP0200280A3 (en) Oxidation resistant il-2 muteins and their production, formulations containing such muteins, and dna sequences and expression vectors coding for such muteins and corresponding transformed host cells
EP0146413A3 (en) Interferons with novel cysteine pattern
EP0229161A4 (en) COMPOSITE PLASMIDS AND SYNTHESIS OF AMINO ACIDS.
IL75963A0 (en) Interferon derivatives,their preparation and pharmaceutical compositions containing them
EP0835661A3 (en) Human interferon-Beta2A for use as a medicament
IL80562A0 (en) Recombinant human lysozyme,its preparation by recombinant dna technology and pharmaceutical compositions containing it
IE801912L (en) Gaming machine
DE3574145D1 (en) Novel, distinct family of human leukocyte interferons, compositions containing them, methods for their production, and dna and transfected hosts therefor
EP0072541A3 (en) Human leukocyte interferons, process for their microbial production, intermediates therefor and compositions containing them
IT8119759A0 (it) Umano, dna e plasmidi che polipeptide prodotto codificano per questa sequenza, microbiologicamente con la sequenza microorganismi che contengono di aminoacidi dell&#39;interferone queste informazioni genetiche e processo per la loro preparazione.
ES2039390T3 (es) Un procedimiento para producir un factor de diferenciacion de celulas b humanas.
DE69306273T2 (de) Mitogen für die glatte Muskulatur und dessen kodierende DNS
WO1985004186A3 (en) A modified gamma interferon, dna sequences encoding it and processes for producing it