ES8207514A1 - Un procedimiento para la preparacion de interferon - Google Patents

Un procedimiento para la preparacion de interferon

Info

Publication number
ES8207514A1
ES8207514A1 ES503528A ES503528A ES8207514A1 ES 8207514 A1 ES8207514 A1 ES 8207514A1 ES 503528 A ES503528 A ES 503528A ES 503528 A ES503528 A ES 503528A ES 8207514 A1 ES8207514 A1 ES 8207514A1
Authority
ES
Spain
Prior art keywords
mature human
human leukocyte
leukocyte interferon
compositions containing
microbial preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503528A
Other languages
English (en)
Other versions
ES503528A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Hoffmann La Roche Inc
Original Assignee
F Hoffmann La Roche AG
Hoffmann La Roche Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8207514(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/256,204 external-priority patent/US6610830B1/en
Application filed by F Hoffmann La Roche AG, Hoffmann La Roche Inc filed Critical F Hoffmann La Roche AG
Publication of ES8207514A1 publication Critical patent/ES8207514A1/es
Publication of ES503528A0 publication Critical patent/ES503528A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE INTERFERON. CONSISTE EN CONSTRUIR UNA PRIMERA SECUENCIA DNA QUE CODIFICA UN POLIPEPTIDO QUE COMPRENDE LA SECUENCIA AMINOACIDO DE UN INTERFERON LEUCOCITARIO HUMANO MADURO NO ACOMPAÑADA DE NINGUNA PRESENCIA; ESTA PRIMERA SECUENCIA SE ENLAZA CON UNA SEGUNDA DNA CAPAZ DE EFECTUAR EXPRESION MICROBIANA DEL POLIPEPTIDO, TRANSFORMAR UN MICROORGANISMO CON UN VEHICULO DE EXPRESION MICROBIANA REPLICABLE QUE CONTENGA DICHA SECUENCUA DNA ENLAZADA,DESARROLLAR EL MICROORGANISMO TRANSFMORMADOS, HACER QUE EL MICROORGANISMO EXPRESE EL POLIPEPTIDO Y RECUPERAR EL POLIPEPTIDO. LA SECUENCIA DE AMINOACIDO DEL INTERFERON INCLUYE LA SECUENCIA PARCIAL CYS-ALA--TRP-CLU-VAL-ARG-ALA-GLU--ILE-MET-ARG-SER.
ES503528A 1980-07-01 1981-06-30 Un procedimiento para la preparacion de interferon Granted ES503528A0 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16498680A 1980-07-01 1980-07-01
US18490980A 1980-09-08 1980-09-08
US20557880A 1980-11-10 1980-11-10
US06/256,204 US6610830B1 (en) 1980-07-01 1981-04-21 Microbial production of mature human leukocyte interferons

Publications (2)

Publication Number Publication Date
ES8207514A1 true ES8207514A1 (es) 1982-10-01
ES503528A0 ES503528A0 (es) 1982-10-01

Family

ID=27496622

Family Applications (1)

Application Number Title Priority Date Filing Date
ES503528A Granted ES503528A0 (es) 1980-07-01 1981-06-30 Un procedimiento para la preparacion de interferon

Country Status (36)

Country Link
EP (2) EP0043980B1 (es)
AR (1) AR242833A1 (es)
AT (3) ATE79901T1 (es)
AU (1) AU552004B2 (es)
BG (1) BG42189A3 (es)
BR (1) BR8104189A (es)
CH (2) CH657141A5 (es)
CS (1) CS273152B2 (es)
DD (3) DD210305A5 (es)
DE (3) DE3176448D1 (es)
DK (1) DK173543B1 (es)
DZ (1) DZ312A1 (es)
ES (1) ES503528A0 (es)
FI (1) FI82712C (es)
FR (1) FR2486098B1 (es)
GB (1) GB2079291B (es)
GE (1) GEP19960519B (es)
GR (1) GR75714B (es)
HK (1) HK49285A (es)
HU (1) HU196457B (es)
IE (1) IE49255B1 (es)
IT (1) IT1137272B (es)
KE (1) KE3534A (es)
LU (1) LU83461A1 (es)
MC (1) MC1396A1 (es)
MY (1) MY8700711A (es)
NL (1) NL8103151A (es)
NO (1) NO159392C (es)
NZ (1) NZ197572A (es)
PH (1) PH18036A (es)
PL (3) PL148261B1 (es)
PT (1) PT73289B (es)
RO (1) RO87590A (es)
SE (2) SE465223C5 (es)
SU (1) SU1414319A3 (es)
YU (1) YU47700B (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
IE57069B1 (en) 1980-04-03 1992-04-22 Biogen Inc Dna sequences,recombinant dna molecules and processes for producing human fibroblast interferon
EP0042246B1 (en) * 1980-06-12 1987-03-18 The Cancer Institute Of Japanese Foundation For Cancer Research Plasmid
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
WO1983000693A1 (en) * 1981-08-14 1983-03-03 Berg, Kurt, Frimann SUBJECTS RELATING TO HUMAN INTEFERON-'alpha' SUBTYPE PROTEINS AND CORRESPONDING ANTIBODIES
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
US4975276A (en) * 1982-01-15 1990-12-04 Cetus Corporation Interferon-alpha 54
US4973479A (en) * 1982-01-15 1990-11-27 Cetus Corporation Interferon-α61
US5098703A (en) * 1982-01-15 1992-03-24 Cetus Corporation Interferon-alpha 76
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
DE3382317D1 (de) * 1982-03-15 1991-07-25 Schering Corp Hybride dns, damit hergestellte bindungszusammensetzung und verfahren dafuer.
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
US4748233A (en) * 1982-03-23 1988-05-31 Bristol-Myers Company Alpha-interferon Gx-1
US4695543A (en) * 1982-03-23 1987-09-22 Bristol-Myers Company Alpha Interferon GX-1
US6936694B1 (en) * 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
DE3490055T1 (de) * 1983-02-24 1985-05-02 Institut bioorganičeskoj chimii imeni M.M. Šemjakina Akademii nauk SSSR, Moskau/Moskva Menschliches Leukozyteninterferon N und Verfahren zu dessen Herstellung in Bakterienzellen
EP0165942A1 (en) * 1983-12-23 1986-01-02 Monash University PRODUCTION OF HUMAN INTERFERON-$g(a)
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
WO1986002068A1 (en) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Mutual separation of proteins
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
DE3515336C2 (de) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Verfahren zur Herstellung und Reinigung von â-Interferon
JP2514950B2 (ja) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
CA1309044C (en) * 1987-11-09 1992-10-20 Toshiya Takano Method of producing foreign gene products
GB8813032D0 (en) * 1988-06-02 1988-07-06 Boehringer Ingelheim Int Antiviral pharmaceutical composition
WO1991003251A1 (en) * 1989-09-08 1991-03-21 California Institute Of Biological Research Cr2 ligand compositions and methods for modulating immune cell functions
DE3932311A1 (de) * 1989-09-28 1991-04-11 Boehringer Ingelheim Int Verfahren zur reinigung von beta-interferon
EP0741577B1 (en) * 1994-03-07 2002-11-06 IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE The use of interferon subtype alpha 8 in the preparation of medicaments to treat viral infections of the liver
DK0679718T3 (da) * 1994-04-09 2001-10-22 Hoffmann La Roche Fremgangsmåde til fremstilling af alfa-interferon
GB9609932D0 (en) * 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
IL136326A0 (en) 1997-12-08 2001-05-20 Genentech Inc Human interferon-epsilon: a type i interferon
ES2404074T3 (es) 1998-08-06 2013-05-23 Mountain View Pharmaceuticals, Inc. Conjugados de peg-oxidasa de urato y su uso
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
EP2292652A2 (en) * 2000-11-03 2011-03-09 Pestka Biomedical Laboratories, Inc. Interferons uses and compositions related thereto
FR2822845B1 (fr) 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr) 2001-06-11 2004-09-24 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
PL3321359T3 (pl) 2005-04-11 2021-06-28 Horizon Pharma Rheumatology Llc Wariantowe postacie oksydazy moczanowej i ich zastosowanie
KR20100103595A (ko) * 2008-01-18 2010-09-27 에프. 호프만-라 로슈 아게 비-글라이코실화된 단백질의 정제
EP3482768A1 (en) 2009-06-25 2019-05-15 Horizon Pharma Rheumatology LLC Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
WO2018087345A1 (en) 2016-11-14 2018-05-17 F. Hoffmann-La Roche Ag COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (es) * 1978-11-24 1982-12-04 Hoffmann La Roche
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
NO164037C (no) * 1980-01-08 1990-08-22 Biogen Inc Fremgangsmaate ved fremstilling av et polypeptid av interferon alfa (ifnalfa)-type.
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
EP0042246B1 (en) * 1980-06-12 1987-03-18 The Cancer Institute Of Japanese Foundation For Cancer Research Plasmid
ES506955A0 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
FI64813C (fi) * 1980-12-31 1984-01-10 Ilkka Antero Palva Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
EP0062971B1 (en) * 1981-03-27 1990-03-07 Imperial Chemical Industries Plc Genetically modified microorganisms

Also Published As

Publication number Publication date
NL8103151A (nl) 1982-02-01
YU162281A (en) 1984-02-29
CS503781A2 (en) 1990-07-12
HK49285A (en) 1985-07-05
FR2486098A1 (fr) 1982-01-08
LU83461A1 (de) 1983-04-06
SE8104093L (sv) 1982-01-02
IE811463L (en) 1982-01-01
IE49255B1 (en) 1985-09-04
BG42189A3 (en) 1987-10-15
BR8104189A (pt) 1982-03-16
SE465223C5 (sv) 1998-02-10
FI82712B (fi) 1990-12-31
EP0211148B1 (en) 1992-08-26
SE465223B (sv) 1991-08-12
NZ197572A (en) 1985-07-31
HU196457B (en) 1988-11-28
CH651308A5 (de) 1985-09-13
AR242833A1 (es) 1993-05-31
PL148260B1 (en) 1989-09-30
EP0043980B1 (en) 1987-09-16
DD202307A5 (de) 1983-09-07
PL231940A1 (en) 1983-07-18
AU7246281A (en) 1982-01-07
ES503528A0 (es) 1982-10-01
DD210304A5 (de) 1984-06-06
DD210305A5 (de) 1984-06-06
DE3177288T2 (de) 1992-12-10
RO87590A (ro) 1986-07-30
ATA290981A (de) 1985-09-15
PT73289A (en) 1981-07-01
EP0043980A2 (en) 1982-01-20
AT380272B (de) 1986-05-12
EP0211148B2 (en) 1999-11-24
GB2079291A (en) 1982-01-20
SU1414319A3 (ru) 1988-07-30
GR75714B (es) 1984-08-02
MY8700711A (en) 1987-12-31
FI812067L (fi) 1982-01-02
NO159392C (no) 1988-12-21
KE3534A (en) 1985-06-07
PL148276B1 (en) 1989-09-30
DK173543B1 (da) 2001-02-05
AU552004B2 (en) 1986-05-22
PH18036A (en) 1985-03-06
EP0043980A3 (en) 1982-09-15
GEP19960519B (en) 1996-07-02
YU47700B (sh) 1996-01-08
ATE29727T1 (de) 1987-10-15
DE3176448D1 (en) 1987-10-22
DE3177288T3 (de) 2000-03-16
CS273152B2 (en) 1991-03-12
FR2486098B1 (fr) 1985-12-27
DZ312A1 (fr) 2004-09-13
DE3125706A1 (de) 1982-04-15
IT1137272B (it) 1986-09-03
GB2079291B (en) 1984-06-13
FI82712C (fi) 1991-04-10
IT8122682A0 (it) 1981-07-01
ATE79901T1 (de) 1992-09-15
NO812247L (no) 1982-01-04
DE3125706C2 (de) 1995-05-24
EP0211148A1 (en) 1987-02-25
PT73289B (en) 1983-05-11
NO159392B (no) 1988-09-12
PL148261B1 (en) 1989-09-30
DK291081A (da) 1982-01-02
MC1396A1 (fr) 1982-04-27
DE3177288D1 (de) 1992-10-01
CH657141A5 (de) 1986-08-15

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