ATE79901T1 - Reife menschliche leukozyten-interferone, verfahren zu ihrer bacteriellen herstellung, zwischenprodukte hierfuer und zusammensetzungen diese enthaltend. - Google Patents

Reife menschliche leukozyten-interferone, verfahren zu ihrer bacteriellen herstellung, zwischenprodukte hierfuer und zusammensetzungen diese enthaltend.

Info

Publication number
ATE79901T1
ATE79901T1 AT86105365T AT86105365T ATE79901T1 AT E79901 T1 ATE79901 T1 AT E79901T1 AT 86105365 T AT86105365 T AT 86105365T AT 86105365 T AT86105365 T AT 86105365T AT E79901 T1 ATE79901 T1 AT E79901T1
Authority
AT
Austria
Prior art keywords
processes
compositions containing
intermediate products
mature human
human leukocyte
Prior art date
Application number
AT86105365T
Other languages
English (en)
Inventor
David Van Norman Goeddel
Sidney Pestka
Original Assignee
Hoffmann La Roche
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE79901(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/256,204 external-priority patent/US6610830B1/en
Application filed by Hoffmann La Roche, Genentech Inc filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE79901T1 publication Critical patent/ATE79901T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT86105365T 1980-07-01 1981-06-30 Reife menschliche leukozyten-interferone, verfahren zu ihrer bacteriellen herstellung, zwischenprodukte hierfuer und zusammensetzungen diese enthaltend. ATE79901T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16498680A 1980-07-01 1980-07-01
US18490980A 1980-09-08 1980-09-08
US20557880A 1980-11-10 1980-11-10
US06/256,204 US6610830B1 (en) 1980-07-01 1981-04-21 Microbial production of mature human leukocyte interferons
EP86105365A EP0211148B2 (de) 1980-07-01 1981-06-30 Reife menschliche Leukozyten-Interferone, Verfahren zu ihrer bacteriellen Herstellung, Zwischenprodukte hierfür und Zusammensetzungen diese enthaltend

Publications (1)

Publication Number Publication Date
ATE79901T1 true ATE79901T1 (de) 1992-09-15

Family

ID=27496622

Family Applications (3)

Application Number Title Priority Date Filing Date
AT86105365T ATE79901T1 (de) 1980-07-01 1981-06-30 Reife menschliche leukozyten-interferone, verfahren zu ihrer bacteriellen herstellung, zwischenprodukte hierfuer und zusammensetzungen diese enthaltend.
AT0290981A AT380272B (de) 1980-07-01 1981-06-30 Verfahren zur herstellung von mikroorganismen
AT81105067T ATE29727T1 (de) 1980-07-01 1981-06-30 Reifes menschliches leukozyteninterferon a, verfahren zu seiner mikrobiellen produktion, zwischenprodukte dazu und es enthaltende zusammensetzungen.

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT0290981A AT380272B (de) 1980-07-01 1981-06-30 Verfahren zur herstellung von mikroorganismen
AT81105067T ATE29727T1 (de) 1980-07-01 1981-06-30 Reifes menschliches leukozyteninterferon a, verfahren zu seiner mikrobiellen produktion, zwischenprodukte dazu und es enthaltende zusammensetzungen.

Country Status (36)

Country Link
EP (2) EP0211148B2 (de)
AR (1) AR242833A1 (de)
AT (3) ATE79901T1 (de)
AU (1) AU552004B2 (de)
BG (1) BG42189A3 (de)
BR (1) BR8104189A (de)
CH (2) CH651308A5 (de)
CS (1) CS273152B2 (de)
DD (3) DD210304A5 (de)
DE (3) DE3177288T3 (de)
DK (1) DK173543B1 (de)
DZ (1) DZ312A1 (de)
ES (1) ES8207514A1 (de)
FI (1) FI82712C (de)
FR (1) FR2486098B1 (de)
GB (1) GB2079291B (de)
GE (1) GEP19960519B (de)
GR (1) GR75714B (de)
HK (1) HK49285A (de)
HU (1) HU196457B (de)
IE (1) IE49255B1 (de)
IT (1) IT1137272B (de)
KE (1) KE3534A (de)
LU (1) LU83461A1 (de)
MC (1) MC1396A1 (de)
MY (1) MY8700711A (de)
NL (1) NL8103151A (de)
NO (1) NO159392C (de)
NZ (1) NZ197572A (de)
PH (1) PH18036A (de)
PL (3) PL148261B1 (de)
PT (1) PT73289B (de)
RO (1) RO87590A (de)
SE (2) SE465223C5 (de)
SU (1) SU1414319A3 (de)
YU (1) YU47700B (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
NO811118L (no) 1980-04-03 1981-10-05 Biogen Nv Dna-sekvenser, rekombinante dna-molekyler og fremgangsmaate ved fremstilling av polypeptider
ATE25985T1 (de) * 1980-06-12 1987-04-15 Japan Found Cancer Plasmid.
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
JPS58501543A (ja) * 1981-08-14 1983-09-16 エイ／エス　アルフレツド　ベンツオン ヒトインタ−フエロン蛋白とヒトインタ−フエロン蛋白に対する抗体に関する改良
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
US4975276A (en) * 1982-01-15 1990-12-04 Cetus Corporation Interferon-alpha 54
US5098703A (en) * 1982-01-15 1992-03-24 Cetus Corporation Interferon-alpha 76
US4973479A (en) * 1982-01-15 1990-11-27 Cetus Corporation Interferon-α61
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
ATE64618T1 (de) * 1982-03-15 1991-07-15 Schering Corp Hybride dns, damit hergestellte bindungszusammensetzung und verfahren dafuer.
US4748233A (en) * 1982-03-23 1988-05-31 Bristol-Myers Company Alpha-interferon Gx-1
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
US4695543A (en) * 1982-03-23 1987-09-22 Bristol-Myers Company Alpha Interferon GX-1
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
DE3490055T1 (de) * 1983-02-24 1985-05-02 Institut bioorganičeskoj chimii imeni M.M. Šemjakina Akademii nauk SSSR, Moskau/Moskva Menschliches Leukozyteninterferon N und Verfahren zu dessen Herstellung in Bakterienzellen
WO1985002862A1 (en) * 1983-12-23 1985-07-04 Monash University PRODUCTION OF HUMAN INTERFERON-alpha
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
WO1986002068A1 (fr) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Separation mutuelle de proteines
DE3515336C2 (de) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Verfahren zur Herstellung und Reinigung von â-Interferon
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
JP2514950B2 (ja) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
CA1309044C (en) * 1987-11-09 1992-10-20 Toshiya Takano Method of producing foreign gene products
GB8813032D0 (en) * 1988-06-02 1988-07-06 Boehringer Ingelheim Int Antiviral pharmaceutical composition
WO1991003251A1 (en) * 1989-09-08 1991-03-21 California Institute Of Biological Research Cr2 ligand compositions and methods for modulating immune cell functions
DE3932311A1 (de) * 1989-09-28 1991-04-11 Boehringer Ingelheim Int Verfahren zur reinigung von beta-interferon
PT741577E (pt) * 1994-03-07 2003-03-31 Imperial College Utilizacao do subtipo de interferao alfa 8 na preparacao de medicamentos para tratar infeccoes virais do figado
DE69522492T2 (de) * 1994-04-09 2002-05-23 F. Hoffmann-La Roche Ag, Basel Verfahren zur Herstellung von Alpha-Interferon
GB9609932D0 (en) * 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
AU761577C (en) 1997-12-08 2004-02-05 Genentech Inc. Human interferon-epsilon: a type I interferon
PT2316475T (pt) 1998-08-06 2017-12-21 Univ Duke Uricase tetramérica isolada
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
EP1355939A2 (de) * 2000-11-03 2003-10-29 Pestka Biomedical Laboratories, Inc. Interferone, deren verwendungen und zusammensetzungen
FR2822845B1 (fr) 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr) 2001-06-11 2004-09-24 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
EP1871874B1 (de) 2005-04-11 2015-04-08 Crealta Pharmaceuticals LLC Varianten der uricase und deren verwendung
CA2711375C (en) * 2008-01-18 2019-04-16 F. Hoffmann-La Roche Ag Purification of not-glycosylated polypeptides
RU2535038C2 (ru) 2009-06-25 2014-12-10 Криэлта Фармасьютикалз ЭлЭлСи Способы и наборы для прогнозирования риска инфузионных реакций и опосредованной антителами потери ответа при терапии пэгилированной уриказой с помощью мониторинга содержания мочевой кислоты в сыворотке крови
CN110234340A (zh) 2016-11-11 2019-09-13 好利恩风湿病制药有限责任公司 泼尼松和尿酸酶分子的组合疗法及其用途
WO2018087345A1 (en) 2016-11-14 2018-05-17 F. Hoffmann-La Roche Ag COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON
WO2020160325A1 (en) 2019-01-30 2020-08-06 Horizon Pharma Rheumatology Llc Reducing immunogenicity to pegloticase
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (de) * 1978-11-24 1982-12-04 Hoffmann La Roche
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
PH21848A (en) * 1980-01-08 1988-03-17 Biogen Nv Dna sequences and recombinant dna molecules
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
ATE25985T1 (de) * 1980-06-12 1987-04-15 Japan Found Cancer Plasmid.
ES506955A0 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
FI64813C (fi) * 1980-12-31 1984-01-10 Ilkka Antero Palva Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
EP0062971B1 (de) * 1981-03-27 1990-03-07 Imperial Chemical Industries Plc Genetisch modifizierte Mikroorganismen

Also Published As

Publication number Publication date
EP0043980A2 (de) 1982-01-20
DD210305A5 (de) 1984-06-06
CH651308A5 (de) 1985-09-13
NO159392B (no) 1988-09-12
AR242833A1 (es) 1993-05-31
IE49255B1 (en) 1985-09-04
EP0043980A3 (en) 1982-09-15
CS273152B2 (en) 1991-03-12
EP0211148A1 (de) 1987-02-25
LU83461A1 (de) 1983-04-06
MC1396A1 (fr) 1982-04-27
GR75714B (de) 1984-08-02
YU162281A (en) 1984-02-29
FR2486098B1 (fr) 1985-12-27
FI82712B (fi) 1990-12-31
DE3177288T3 (de) 2000-03-16
IE811463L (en) 1982-01-01
DK173543B1 (da) 2001-02-05
YU47700B (sh) 1996-01-08
FI82712C (fi) 1991-04-10
BG42189A3 (en) 1987-10-15
ES503528A0 (es) 1982-10-01
ES8207514A1 (es) 1982-10-01
DE3177288D1 (de) 1992-10-01
PT73289B (en) 1983-05-11
CH657141A5 (de) 1986-08-15
PL148261B1 (en) 1989-09-30
HK49285A (en) 1985-07-05
FR2486098A1 (fr) 1982-01-08
PT73289A (en) 1981-07-01
GB2079291A (en) 1982-01-20
DE3176448D1 (en) 1987-10-22
GEP19960519B (en) 1996-07-02
DD210304A5 (de) 1984-06-06
NO812247L (no) 1982-01-04
EP0043980B1 (de) 1987-09-16
CS503781A2 (en) 1990-07-12
EP0211148B2 (de) 1999-11-24
RO87590A (ro) 1986-07-30
DZ312A1 (fr) 2004-09-13
BR8104189A (pt) 1982-03-16
AT380272B (de) 1986-05-12
AU7246281A (en) 1982-01-07
NL8103151A (nl) 1982-02-01
NZ197572A (en) 1985-07-31
ATE29727T1 (de) 1987-10-15
SE465223B (sv) 1991-08-12
HU196457B (en) 1988-11-28
AU552004B2 (en) 1986-05-22
PH18036A (en) 1985-03-06
DE3177288T2 (de) 1992-12-10
DD202307A5 (de) 1983-09-07
SU1414319A3 (ru) 1988-07-30
SE465223C5 (sv) 1998-02-10
PL148260B1 (en) 1989-09-30
FI812067L (fi) 1982-01-02
IT1137272B (it) 1986-09-03
DE3125706A1 (de) 1982-04-15
DK291081A (da) 1982-01-02
PL148276B1 (en) 1989-09-30
SE8104093L (sv) 1982-01-02
ATA290981A (de) 1985-09-15
IT8122682A0 (it) 1981-07-01
PL231940A1 (en) 1983-07-18
MY8700711A (en) 1987-12-31
DE3125706C2 (de) 1995-05-24
NO159392C (no) 1988-12-21
KE3534A (en) 1985-06-07
GB2079291B (en) 1984-06-13
EP0211148B1 (de) 1992-08-26

Similar Documents

Publication Publication Date Title
ATE79901T1 (de) Reife menschliche leukozyten-interferone, verfahren zu ihrer bacteriellen herstellung, zwischenprodukte hierfuer und zusammensetzungen diese enthaltend.
ATE7910T1 (de) Substituierte iminodisaeuren, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
DE3177311D1 (de) Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung.
ATE10938T1 (de) Cyclohexandionderivate, verfahren zu ihrer herstellung und diese enthaltende herbizide.
DE3575724D1 (de) Quinolizinon-verbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ATE8892T1 (de) Substituierte azabicyclooctancarboxylsaeure, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE3483957D1 (de) Komplexe, verfahren zu ihrer herstellung und dieselben enthaltende formulierungen.
ATE1249T1 (de) Gereinigte bakterielle proteoglycane, verfahren zu ihrer herstellung und sie enthaltender impfstoff.
ATE23152T1 (de) Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel.
ATE60767T1 (de) Aminoacyllabdane, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel.
DE3576686D1 (de) Chinolinone, verfahren zu ihrer herstellung und die sie enthaltenden pharmazeutischen praeparate.
ATE5257T1 (de) Tricyclische aether, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DE3483308D1 (de) Semicarbazid-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ATE10634T1 (de) Pyrazoloindazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitung.
DE58907211D1 (de) Bithienylderivate, Verfahren zu ihrer Herstellung und sie enthaltende Mittel.
ATE6250T1 (de) Substituierte phenoxy-aminopropanol-derivate, zwischenprodukte und verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel.
DE3483628D1 (de) 1,n-diaryl-4,5-dihydro-1h-pyrazol-3-amine, diese enthaltende zusammensetzungen und verfahren zu ihrer herstellung.
ATE8392T1 (de) Carbamoyloxyamino-1,4-benzodiazepine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ATE11044T1 (de) Substituierte trifluormet hylphenyltetrahydropyridine mit appetitzueglerwirksamkeit, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
PT74077B (de) N-pyrimidinyl-carbaminsaureester verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3773240D1 (de) Hydrochinolinverbindungen, diese enthaltende zusammensetzungen und verfahren zu ihrer herstellung.
DE3684803D1 (de) Dihydropyridin-alkanolamine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ATE8886T1 (de) 3h-2-benzazepine, zwischenprodukte und verfahren zu ihrer herstellung, sowie diese enthaltende praeparate.
ATE23343T1 (de) N-methyl-11-aza-10-deoxy-10-dihydro-erythromyci - a, zwischenprodukte und verfahren zu ihrer herstellung.
ATE7388T1 (de) Srs-a entgegenwirkende carboxamid-verbindungen, heilmittel, die sie enthalten, verfahren zu ihrer herstellung und zwischenprodukte.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time