GR75714B - - Google Patents

Info

Publication number
GR75714B
GR75714B GR65379A GR810165379A GR75714B GR 75714 B GR75714 B GR 75714B GR 65379 A GR65379 A GR 65379A GR 810165379 A GR810165379 A GR 810165379A GR 75714 B GR75714 B GR 75714B
Authority
GR
Greece
Application number
GR65379A
Inventor
David Van Norman Goeddel
Sidney Pestka
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR75714(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/256,204 external-priority patent/US6610830B1/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of GR75714B publication Critical patent/GR75714B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
GR65379A 1980-07-01 1981-06-30 GR75714B (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16498680A 1980-07-01 1980-07-01
US18490980A 1980-09-08 1980-09-08
US20557880A 1980-11-10 1980-11-10
US06/256,204 US6610830B1 (en) 1980-07-01 1981-04-21 Microbial production of mature human leukocyte interferons

Publications (1)

Publication Number Publication Date
GR75714B true GR75714B (el) 1984-08-02

Family

ID=27496622

Family Applications (1)

Application Number Title Priority Date Filing Date
GR65379A GR75714B (el) 1980-07-01 1981-06-30

Country Status (36)

Country Link
EP (2) EP0043980B1 (el)
AR (1) AR242833A1 (el)
AT (3) AT380272B (el)
AU (1) AU552004B2 (el)
BG (1) BG42189A3 (el)
BR (1) BR8104189A (el)
CH (2) CH651308A5 (el)
CS (1) CS273152B2 (el)
DD (3) DD202307A5 (el)
DE (3) DE3176448D1 (el)
DK (1) DK173543B1 (el)
DZ (1) DZ312A1 (el)
ES (1) ES8207514A1 (el)
FI (1) FI82712C (el)
FR (1) FR2486098B1 (el)
GB (1) GB2079291B (el)
GE (1) GEP19960519B (el)
GR (1) GR75714B (el)
HK (1) HK49285A (el)
HU (1) HU196457B (el)
IE (1) IE49255B1 (el)
IT (1) IT1137272B (el)
KE (1) KE3534A (el)
LU (1) LU83461A1 (el)
MC (1) MC1396A1 (el)
MY (1) MY8700711A (el)
NL (1) NL8103151A (el)
NO (1) NO159392C (el)
NZ (1) NZ197572A (el)
PH (1) PH18036A (el)
PL (3) PL148260B1 (el)
PT (1) PT73289B (el)
RO (1) RO87590A (el)
SE (2) SE8104093L (el)
SU (1) SU1414319A3 (el)
YU (1) YU47700B (el)

Families Citing this family (50)

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ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
GR74498B (el) 1980-04-03 1984-06-28 Biogen Inc
DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
WO1983000693A1 (en) * 1981-08-14 1983-03-03 Berg, Kurt, Frimann SUBJECTS RELATING TO HUMAN INTEFERON-'alpha' SUBTYPE PROTEINS AND CORRESPONDING ANTIBODIES
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
US4975276A (en) * 1982-01-15 1990-12-04 Cetus Corporation Interferon-alpha 54
US4973479A (en) * 1982-01-15 1990-11-27 Cetus Corporation Interferon-α61
US5098703A (en) * 1982-01-15 1992-03-24 Cetus Corporation Interferon-alpha 76
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
EP0088994B1 (en) * 1982-03-15 1991-06-19 Schering Corporation Hybrid dna, binding composition prepared thereby and processes therefor
US4748233A (en) * 1982-03-23 1988-05-31 Bristol-Myers Company Alpha-interferon Gx-1
US4695543A (en) * 1982-03-23 1987-09-22 Bristol-Myers Company Alpha Interferon GX-1
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
US6936694B1 (en) * 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
US4751287A (en) * 1983-02-24 1988-06-14 Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr Human leukocyte interferon N and a method of producing same in bacterial cells
WO1985002862A1 (en) * 1983-12-23 1985-07-04 Monash University PRODUCTION OF HUMAN INTERFERON-alpha
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
WO1986002068A1 (en) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Mutual separation of proteins
DE3515336C2 (de) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Verfahren zur Herstellung und Reinigung von â-Interferon
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
JP2514950B2 (ja) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
CA1309044C (en) * 1987-11-09 1992-10-20 Toshiya Takano Method of producing foreign gene products
GB8813032D0 (en) * 1988-06-02 1988-07-06 Boehringer Ingelheim Int Antiviral pharmaceutical composition
WO1991003251A1 (en) * 1989-09-08 1991-03-21 California Institute Of Biological Research Cr2 ligand compositions and methods for modulating immune cell functions
DE3932311A1 (de) * 1989-09-28 1991-04-11 Boehringer Ingelheim Int Verfahren zur reinigung von beta-interferon
DK0741577T3 (da) * 1994-03-07 2003-02-17 Imperial College Anvendelsen af enterferon, subtype alfa 8, til fremstilling af lægemidler til behandling af virusinfektioner i leveren
ATE205256T1 (de) * 1994-04-09 2001-09-15 Hoffmann La Roche Verfahren zur herstellung von alpha-interferon
GB9609932D0 (en) * 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
AU761577C (en) 1997-12-08 2004-02-05 Genentech Inc. Human interferon-epsilon: a type I interferon
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
PT1100542E (pt) 1998-08-06 2005-11-30 Mountain View Pharmaceuticals Conjugado de peg-uricase oxidase e seu uso
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
CA2427850A1 (en) * 2000-11-03 2002-05-10 Sidney Pestka Interferons, uses and compositions related thereto
FR2822845B1 (fr) 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr) 2001-06-11 2004-09-24 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
SI3321359T1 (sl) 2005-04-11 2021-07-30 Horizon Pharma Rheumatology Llc Variantne oblike urat oksidaze in uporaba le-teh
CN107033233A (zh) * 2008-01-18 2017-08-11 弗·哈夫曼-拉罗切有限公司 非糖基化蛋白质的纯化
RU2535038C2 (ru) 2009-06-25 2014-12-10 Криэлта Фармасьютикалз ЭлЭлСи Способы и наборы для прогнозирования риска инфузионных реакций и опосредованной антителами потери ответа при терапии пэгилированной уриказой с помощью мониторинга содержания мочевой кислоты в сыворотке крови
WO2018087345A1 (en) 2016-11-14 2018-05-17 F. Hoffmann-La Roche Ag COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (el) * 1978-11-24 1982-12-04 Hoffmann La Roche
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
DE3165463D1 (en) * 1980-01-08 1984-09-20 Biogen Nv Dna sequences, recombinant dna molecules and processes for producing human interferon-alpha like polypeptides
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
ES506955A0 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
FI64813C (fi) * 1980-12-31 1984-01-10 Ilkka Antero Palva Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
EP0062971B1 (en) * 1981-03-27 1990-03-07 Imperial Chemical Industries Plc Genetically modified microorganisms

Also Published As

Publication number Publication date
ATE79901T1 (de) 1992-09-15
GB2079291B (en) 1984-06-13
PT73289B (en) 1983-05-11
DK291081A (da) 1982-01-02
ATA290981A (de) 1985-09-15
HU196457B (en) 1988-11-28
FR2486098A1 (fr) 1982-01-08
DK173543B1 (da) 2001-02-05
NO159392B (no) 1988-09-12
RO87590A (ro) 1986-07-30
MY8700711A (en) 1987-12-31
GEP19960519B (en) 1996-07-02
CH657141A5 (de) 1986-08-15
PL231940A1 (en) 1983-07-18
AU7246281A (en) 1982-01-07
AT380272B (de) 1986-05-12
EP0043980B1 (en) 1987-09-16
IE811463L (en) 1982-01-01
DE3177288T3 (de) 2000-03-16
EP0043980A2 (en) 1982-01-20
PL148260B1 (en) 1989-09-30
HK49285A (en) 1985-07-05
DE3177288D1 (de) 1992-10-01
LU83461A1 (de) 1983-04-06
SE8104093L (sv) 1982-01-02
DE3176448D1 (en) 1987-10-22
SU1414319A3 (ru) 1988-07-30
CH651308A5 (de) 1985-09-13
FI82712C (fi) 1991-04-10
GB2079291A (en) 1982-01-20
NO812247L (no) 1982-01-04
DE3125706C2 (de) 1995-05-24
AR242833A1 (es) 1993-05-31
NO159392C (no) 1988-12-21
DD210304A5 (de) 1984-06-06
NL8103151A (nl) 1982-02-01
YU162281A (en) 1984-02-29
DE3125706A1 (de) 1982-04-15
PL148261B1 (en) 1989-09-30
EP0211148B1 (en) 1992-08-26
DD210305A5 (de) 1984-06-06
DD202307A5 (de) 1983-09-07
CS273152B2 (en) 1991-03-12
FI82712B (fi) 1990-12-31
YU47700B (sh) 1996-01-08
BG42189A3 (en) 1987-10-15
EP0211148A1 (en) 1987-02-25
PH18036A (en) 1985-03-06
ES503528A0 (es) 1982-10-01
DE3177288T2 (de) 1992-12-10
SE465223B (sv) 1991-08-12
NZ197572A (en) 1985-07-31
SE465223C5 (sv) 1998-02-10
KE3534A (en) 1985-06-07
DZ312A1 (fr) 2004-09-13
IT8122682A0 (it) 1981-07-01
EP0043980A3 (en) 1982-09-15
PL148276B1 (en) 1989-09-30
MC1396A1 (fr) 1982-04-27
PT73289A (en) 1981-07-01
FI812067L (fi) 1982-01-02
IT1137272B (it) 1986-09-03
IE49255B1 (en) 1985-09-04
CS503781A2 (en) 1990-07-12
EP0211148B2 (en) 1999-11-24
FR2486098B1 (fr) 1985-12-27
ES8207514A1 (es) 1982-10-01
ATE29727T1 (de) 1987-10-15
AU552004B2 (en) 1986-05-22
BR8104189A (pt) 1982-03-16

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