DE3177288D1 - Reife menschliche leukozyten-interferone, verfahren zu ihrer bacteriellen herstellung, zwischenprodukte hierfuer und zusammensetzungen diese enthaltend. - Google Patents

Reife menschliche leukozyten-interferone, verfahren zu ihrer bacteriellen herstellung, zwischenprodukte hierfuer und zusammensetzungen diese enthaltend.

Info

Publication number
DE3177288D1
DE3177288D1 DE8686105365T DE3177288T DE3177288D1 DE 3177288 D1 DE3177288 D1 DE 3177288D1 DE 8686105365 T DE8686105365 T DE 8686105365T DE 3177288 T DE3177288 T DE 3177288T DE 3177288 D1 DE3177288 D1 DE 3177288D1
Authority
DE
Germany
Prior art keywords
compositions containing
intermediate products
mature human
human leukocyte
leukocyte interferon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686105365T
Other languages
English (en)
Other versions
DE3177288T3 (de
DE3177288T2 (de
Inventor
David Van Norman Goeddel
Sidney Pestka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Genentech Inc
Original Assignee
F Hoffmann La Roche AG
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3177288(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/256,204 external-priority patent/US6610830B1/en
Application filed by F Hoffmann La Roche AG, Genentech Inc filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE3177288D1 publication Critical patent/DE3177288D1/de
Publication of DE3177288T2 publication Critical patent/DE3177288T2/de
Publication of DE3177288T3 publication Critical patent/DE3177288T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE3177288T 1980-07-01 1981-06-30 Reife menschliche Leukozyten-Interferone, Verfahren zu ihrer bacteriellen Herstellung, Zwischenprodukte hierfür und Zusammensetzungen diese enthaltend. Expired - Lifetime DE3177288T3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16498680A 1980-07-01 1980-07-01
US18490980A 1980-09-08 1980-09-08
US20557880A 1980-11-10 1980-11-10
US06/256,204 US6610830B1 (en) 1980-07-01 1981-04-21 Microbial production of mature human leukocyte interferons

Publications (3)

Publication Number Publication Date
DE3177288D1 true DE3177288D1 (de) 1992-10-01
DE3177288T2 DE3177288T2 (de) 1992-12-10
DE3177288T3 DE3177288T3 (de) 2000-03-16

Family

ID=27496622

Family Applications (3)

Application Number Title Priority Date Filing Date
DE3125706A Expired - Lifetime DE3125706C2 (de) 1980-07-01 1981-06-30 Polypeptide mit der Aminosäuresequenz eines reifen Human-Leukozyten-Interferons ohne Präsequenz, deren Herstellung und Verwendung
DE8181105067T Expired DE3176448D1 (en) 1980-07-01 1981-06-30 Mature human leukocyte interferon a, process for its microbial preparation, intermediates therefor and compositions containing it.
DE3177288T Expired - Lifetime DE3177288T3 (de) 1980-07-01 1981-06-30 Reife menschliche Leukozyten-Interferone, Verfahren zu ihrer bacteriellen Herstellung, Zwischenprodukte hierfür und Zusammensetzungen diese enthaltend.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE3125706A Expired - Lifetime DE3125706C2 (de) 1980-07-01 1981-06-30 Polypeptide mit der Aminosäuresequenz eines reifen Human-Leukozyten-Interferons ohne Präsequenz, deren Herstellung und Verwendung
DE8181105067T Expired DE3176448D1 (en) 1980-07-01 1981-06-30 Mature human leukocyte interferon a, process for its microbial preparation, intermediates therefor and compositions containing it.

Country Status (36)

Country Link
EP (2) EP0211148B2 (de)
AR (1) AR242833A1 (de)
AT (3) ATE29727T1 (de)
AU (1) AU552004B2 (de)
BG (1) BG42189A3 (de)
BR (1) BR8104189A (de)
CH (2) CH651308A5 (de)
CS (1) CS273152B2 (de)
DD (3) DD210305A5 (de)
DE (3) DE3125706C2 (de)
DK (1) DK173543B1 (de)
DZ (1) DZ312A1 (de)
ES (1) ES503528A0 (de)
FI (1) FI82712C (de)
FR (1) FR2486098B1 (de)
GB (1) GB2079291B (de)
GE (1) GEP19960519B (de)
GR (1) GR75714B (de)
HK (1) HK49285A (de)
HU (1) HU196457B (de)
IE (1) IE49255B1 (de)
IT (1) IT1137272B (de)
KE (1) KE3534A (de)
LU (1) LU83461A1 (de)
MC (1) MC1396A1 (de)
MY (1) MY8700711A (de)
NL (1) NL8103151A (de)
NO (1) NO159392C (de)
NZ (1) NZ197572A (de)
PH (1) PH18036A (de)
PL (3) PL148261B1 (de)
PT (1) PT73289B (de)
RO (1) RO87590A (de)
SE (2) SE8104093L (de)
SU (1) SU1414319A3 (de)
YU (1) YU47700B (de)

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ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
KR860001471B1 (ko) 1980-04-03 1986-09-26 비오겐 엔. 브이 인체의 섬유아세포 인터페론(IFN-β)폴리펩티드의 제조방법
EP0042246B1 (de) * 1980-06-12 1987-03-18 The Cancer Institute Of Japanese Foundation For Cancer Research Plasmid
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
EP0085693A1 (de) * 1981-08-14 1983-08-17 A/S Alfred Benzon Gegenstände betreffend menschliche interferon-alpha-subtyp-eiweissstoffe sowie übereinstimmende antikörper
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
US4975276A (en) * 1982-01-15 1990-12-04 Cetus Corporation Interferon-alpha 54
US4973479A (en) * 1982-01-15 1990-11-27 Cetus Corporation Interferon-α61
US5098703A (en) * 1982-01-15 1992-03-24 Cetus Corporation Interferon-alpha 76
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
ATE64618T1 (de) * 1982-03-15 1991-07-15 Schering Corp Hybride dns, damit hergestellte bindungszusammensetzung und verfahren dafuer.
US4695543A (en) * 1982-03-23 1987-09-22 Bristol-Myers Company Alpha Interferon GX-1
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
US4748233A (en) * 1982-03-23 1988-05-31 Bristol-Myers Company Alpha-interferon Gx-1
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
FR2541579B1 (fr) * 1983-02-24 1987-12-18 Inst Organicheskogo Sinteza Ak Interferon n leucocytaire humain et procede d'obtention de celui-ci dans les cellules bacteriennes
EP0165942A1 (de) * 1983-12-23 1986-01-02 Monash University Herstellung menschlichen g(a)-interferons
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
WO1986002068A1 (en) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Mutual separation of proteins
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
DE3515336C2 (de) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Verfahren zur Herstellung und Reinigung von â-Interferon
JP2514950B2 (ja) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
CA1309044C (en) * 1987-11-09 1992-10-20 Toshiya Takano Method of producing foreign gene products
GB8813032D0 (en) * 1988-06-02 1988-07-06 Boehringer Ingelheim Int Antiviral pharmaceutical composition
WO1991003251A1 (en) * 1989-09-08 1991-03-21 California Institute Of Biological Research Cr2 ligand compositions and methods for modulating immune cell functions
DE3932311A1 (de) * 1989-09-28 1991-04-11 Boehringer Ingelheim Int Verfahren zur reinigung von beta-interferon
AU1854695A (en) * 1994-03-07 1995-09-25 Imperial College Of Science, Technology And Medicine The use of interferon subtypes in the preparation of medicaments to treat viral infections
EP1104809A1 (de) * 1994-04-09 2001-06-06 F. Hoffmann-La Roche Ag Verfahren zur Herstellung von Alpha-Interferon
GB9609932D0 (en) * 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
CA2311681A1 (en) 1997-12-08 1999-06-17 Genentech, Inc. Human interferon-epsilon: a type i interferon
DK1588716T3 (da) 1998-08-06 2011-05-23 Mountain View Pharmaceuticals Peg-uratoxidase-konjugater og anvendelse deraf
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
WO2002036627A2 (en) * 2000-11-03 2002-05-10 Pbl Biomedical Laboratories Interferons, uses and compositions related thereto
FR2822845B1 (fr) 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr) 2001-06-11 2004-09-24 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
SI3321359T1 (sl) 2005-04-11 2021-07-30 Horizon Pharma Rheumatology Llc Variantne oblike urat oksidaze in uporaba le-teh
CN107033233A (zh) * 2008-01-18 2017-08-11 弗·哈夫曼-拉罗切有限公司 非糖基化蛋白质的纯化
HUP1200205A3 (en) 2009-06-25 2012-09-28 Savient Pharmaceuticals Method and kits for perdicting infusion reaction risk and antibody-mediated low of response by monitoring serum uric acid during pegylated uricare therapy
WO2018087345A1 (en) 2016-11-14 2018-05-17 F. Hoffmann-La Roche Ag COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON

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IN150740B (de) * 1978-11-24 1982-12-04 Hoffmann La Roche
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
CY1346A (en) * 1980-01-08 1987-01-16 Biogen Nv Dna sequences,recombinant dna molecules and processes for producing human interferon-like polypeptides
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
EP0042246B1 (de) * 1980-06-12 1987-03-18 The Cancer Institute Of Japanese Foundation For Cancer Research Plasmid
ES8302778A1 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
FI64813C (fi) * 1980-12-31 1984-01-10 Ilkka Antero Palva Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
DE3280127D1 (de) * 1981-03-27 1990-04-12 Ici Plc Genetisch modifizierte mikroorganismen.

Also Published As

Publication number Publication date
YU162281A (en) 1984-02-29
DE3125706C2 (de) 1995-05-24
FI82712B (fi) 1990-12-31
MY8700711A (en) 1987-12-31
SE465223B (sv) 1991-08-12
MC1396A1 (fr) 1982-04-27
IE811463L (en) 1982-01-01
AU7246281A (en) 1982-01-07
ATA290981A (de) 1985-09-15
AU552004B2 (en) 1986-05-22
NO159392B (no) 1988-09-12
PL231940A1 (en) 1983-07-18
EP0211148B2 (de) 1999-11-24
PH18036A (en) 1985-03-06
SE465223C5 (sv) 1998-02-10
IT8122682A0 (it) 1981-07-01
AR242833A1 (es) 1993-05-31
DK291081A (da) 1982-01-02
CS273152B2 (en) 1991-03-12
DE3177288T3 (de) 2000-03-16
GB2079291B (en) 1984-06-13
HK49285A (en) 1985-07-05
FI82712C (fi) 1991-04-10
DE3125706A1 (de) 1982-04-15
DK173543B1 (da) 2001-02-05
EP0211148A1 (de) 1987-02-25
NO812247L (no) 1982-01-04
PL148261B1 (en) 1989-09-30
PT73289B (en) 1983-05-11
CH657141A5 (de) 1986-08-15
FR2486098B1 (fr) 1985-12-27
NZ197572A (en) 1985-07-31
DD210305A5 (de) 1984-06-06
FR2486098A1 (fr) 1982-01-08
DE3177288T2 (de) 1992-12-10
GB2079291A (en) 1982-01-20
PT73289A (en) 1981-07-01
YU47700B (sh) 1996-01-08
DD202307A5 (de) 1983-09-07
PL148276B1 (en) 1989-09-30
BR8104189A (pt) 1982-03-16
DZ312A1 (fr) 2004-09-13
HU196457B (en) 1988-11-28
BG42189A3 (en) 1987-10-15
RO87590A (ro) 1986-07-30
SE8104093L (sv) 1982-01-02
LU83461A1 (de) 1983-04-06
GEP19960519B (en) 1996-07-02
NO159392C (no) 1988-12-21
FI812067L (fi) 1982-01-02
CH651308A5 (de) 1985-09-13
EP0043980A3 (en) 1982-09-15
DE3176448D1 (en) 1987-10-22
IT1137272B (it) 1986-09-03
NL8103151A (nl) 1982-02-01
PL148260B1 (en) 1989-09-30
DD210304A5 (de) 1984-06-06
SU1414319A3 (ru) 1988-07-30
CS503781A2 (en) 1990-07-12
GR75714B (de) 1984-08-02
ES8207514A1 (es) 1982-10-01
EP0043980A2 (de) 1982-01-20
EP0211148B1 (de) 1992-08-26
ES503528A0 (es) 1982-10-01
KE3534A (en) 1985-06-07
ATE29727T1 (de) 1987-10-15
EP0043980B1 (de) 1987-09-16
AT380272B (de) 1986-05-12
ATE79901T1 (de) 1992-09-15
IE49255B1 (en) 1985-09-04

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