AT380272B - Verfahren zur herstellung von mikroorganismen - Google Patents

Verfahren zur herstellung von mikroorganismen

Info

Publication number
AT380272B
AT380272B AT0290981A AT290981A AT380272B AT 380272 B AT380272 B AT 380272B AT 0290981 A AT0290981 A AT 0290981A AT 290981 A AT290981 A AT 290981A AT 380272 B AT380272 B AT 380272B
Authority
AT
Austria
Prior art keywords
producing microorganisms
microorganisms
producing
Prior art date
Application number
AT0290981A
Other languages
English (en)
Other versions
ATA290981A (de
Original Assignee
Hoffmann La Roche
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT380272(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/256,204 external-priority patent/US6610830B1/en
Application filed by Hoffmann La Roche, Genentech Inc filed Critical Hoffmann La Roche
Priority to AT0170385A priority Critical patent/AT394208B/de
Priority to AT0170285A priority patent/AT394207B/de
Publication of ATA290981A publication Critical patent/ATA290981A/de
Application granted granted Critical
Publication of AT380272B publication Critical patent/AT380272B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT0290981A 1980-07-01 1981-06-30 Verfahren zur herstellung von mikroorganismen AT380272B (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AT0170385A AT394208B (de) 1980-07-01 1985-06-05 Verfahren zur herstelluung von vektoren
AT0170285A AT394207B (de) 1980-07-01 1985-06-05 Verfahren zur herstellung von human-leukozyteninterferonen

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16498680A 1980-07-01 1980-07-01
US18490980A 1980-09-08 1980-09-08
US20557880A 1980-11-10 1980-11-10
US06/256,204 US6610830B1 (en) 1980-07-01 1981-04-21 Microbial production of mature human leukocyte interferons

Publications (2)

Publication Number Publication Date
ATA290981A ATA290981A (de) 1985-09-15
AT380272B true AT380272B (de) 1986-05-12

Family

ID=27496622

Family Applications (3)

Application Number Title Priority Date Filing Date
AT86105365T ATE79901T1 (de) 1980-07-01 1981-06-30 Reife menschliche leukozyten-interferone, verfahren zu ihrer bacteriellen herstellung, zwischenprodukte hierfuer und zusammensetzungen diese enthaltend.
AT0290981A AT380272B (de) 1980-07-01 1981-06-30 Verfahren zur herstellung von mikroorganismen
AT81105067T ATE29727T1 (de) 1980-07-01 1981-06-30 Reifes menschliches leukozyteninterferon a, verfahren zu seiner mikrobiellen produktion, zwischenprodukte dazu und es enthaltende zusammensetzungen.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT86105365T ATE79901T1 (de) 1980-07-01 1981-06-30 Reife menschliche leukozyten-interferone, verfahren zu ihrer bacteriellen herstellung, zwischenprodukte hierfuer und zusammensetzungen diese enthaltend.

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT81105067T ATE29727T1 (de) 1980-07-01 1981-06-30 Reifes menschliches leukozyteninterferon a, verfahren zu seiner mikrobiellen produktion, zwischenprodukte dazu und es enthaltende zusammensetzungen.

Country Status (36)

Country Link
EP (2) EP0211148B2 (de)
AR (1) AR242833A1 (de)
AT (3) ATE79901T1 (de)
AU (1) AU552004B2 (de)
BG (1) BG42189A3 (de)
BR (1) BR8104189A (de)
CH (2) CH657141A5 (de)
CS (1) CS273152B2 (de)
DD (3) DD202307A5 (de)
DE (3) DE3177288T3 (de)
DK (1) DK173543B1 (de)
DZ (1) DZ312A1 (de)
ES (1) ES8207514A1 (de)
FI (1) FI82712C (de)
FR (1) FR2486098B1 (de)
GB (1) GB2079291B (de)
GE (1) GEP19960519B (de)
GR (1) GR75714B (de)
HK (1) HK49285A (de)
HU (1) HU196457B (de)
IE (1) IE49255B1 (de)
IT (1) IT1137272B (de)
KE (1) KE3534A (de)
LU (1) LU83461A1 (de)
MC (1) MC1396A1 (de)
MY (1) MY8700711A (de)
NL (1) NL8103151A (de)
NO (1) NO159392C (de)
NZ (1) NZ197572A (de)
PH (1) PH18036A (de)
PL (3) PL148276B1 (de)
PT (1) PT73289B (de)
RO (1) RO87590A (de)
SE (2) SE465223C5 (de)
SU (1) SU1414319A3 (de)
YU (1) YU47700B (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
FI88175C (fi) 1980-04-03 1993-04-13 Biogen Inc Rekombinant-dna-molekyler och foerfaranden foer framstaellning av polypeptider liknande humant -interferon
ATE25985T1 (de) * 1980-06-12 1987-04-15 Japan Found Cancer Plasmid.
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
WO1983000693A1 (en) * 1981-08-14 1983-03-03 Berg, Kurt, Frimann SUBJECTS RELATING TO HUMAN INTEFERON-'alpha' SUBTYPE PROTEINS AND CORRESPONDING ANTIBODIES
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
US4973479A (en) * 1982-01-15 1990-11-27 Cetus Corporation Interferon-α61
US5098703A (en) * 1982-01-15 1992-03-24 Cetus Corporation Interferon-alpha 76
US4975276A (en) * 1982-01-15 1990-12-04 Cetus Corporation Interferon-alpha 54
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
EP0088994B1 (de) * 1982-03-15 1991-06-19 Schering Corporation Hybride DNS, damit hergestellte Bindungszusammensetzung und Verfahren dafür
US4748233A (en) * 1982-03-23 1988-05-31 Bristol-Myers Company Alpha-interferon Gx-1
US4695543A (en) * 1982-03-23 1987-09-22 Bristol-Myers Company Alpha Interferon GX-1
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
GB2150573B (en) * 1983-02-24 1987-11-11 Inst Organicheskogo Sinteza Ak Leukocytic human interferon n and method to obtain it in bacterial cells
EP0165942A1 (de) * 1983-12-23 1986-01-02 Monash University Herstellung menschlichen g(a)-interferons
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
WO1986002068A1 (en) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Mutual separation of proteins
DE3515336C2 (de) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Verfahren zur Herstellung und Reinigung von â-Interferon
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
JP2514950B2 (ja) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
CA1309044C (en) * 1987-11-09 1992-10-20 Toshiya Takano Method of producing foreign gene products
GB8813032D0 (en) * 1988-06-02 1988-07-06 Boehringer Ingelheim Int Antiviral pharmaceutical composition
WO1991003251A1 (en) * 1989-09-08 1991-03-21 California Institute Of Biological Research Cr2 ligand compositions and methods for modulating immune cell functions
DE3932311A1 (de) * 1989-09-28 1991-04-11 Boehringer Ingelheim Int Verfahren zur reinigung von beta-interferon
US6007805A (en) * 1994-03-07 1999-12-28 Imperial College Of Science And Technology Use of interferon subtype alpha-8 (IFN-α8) to treat viral infections of the liver
DK0679718T3 (da) * 1994-04-09 2001-10-22 Hoffmann La Roche Fremgangsmåde til fremstilling af alfa-interferon
GB9609932D0 (en) * 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
CA2311681A1 (en) 1997-12-08 1999-06-17 Genentech, Inc. Human interferon-epsilon: a type i interferon
ES2361190T3 (es) 1998-08-06 2011-06-14 Mountain View Pharmaceuticals, Inc. Conjugados de peg-oxidasa de urato y su uso.
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
EP2292652A2 (de) * 2000-11-03 2011-03-09 Pestka Biomedical Laboratories, Inc. Interferone, deren Verwendungen und Zusammensetzungen
FR2822845B1 (fr) 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr) 2001-06-11 2004-09-24 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
CZ2007695A3 (cs) 2005-04-11 2008-02-27 Savient Pharmaceuticals, Inc. Variantní formy urátoxidázy a jejich použití
CA2711375C (en) * 2008-01-18 2019-04-16 F. Hoffmann-La Roche Ag Purification of not-glycosylated polypeptides
SG176897A1 (en) 2009-06-25 2012-01-30 Savient Pharmaceuticals Inc Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
WO2018087345A1 (en) 2016-11-14 2018-05-17 F. Hoffmann-La Roche Ag COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (de) * 1978-11-24 1982-12-04 Hoffmann La Roche
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
ES8308534A1 (es) * 1980-01-08 1983-09-01 Biogen Nv Un metodo de producir un polipeptido que exhibe actividad inmunologica o biologica del interferon de leucocitos humanos.
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
ATE25985T1 (de) * 1980-06-12 1987-04-15 Japan Found Cancer Plasmid.
ES8302778A1 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
FI64813C (fi) * 1980-12-31 1984-01-10 Ilkka Antero Palva Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
DE3280127D1 (de) * 1981-03-27 1990-04-12 Ici Plc Genetisch modifizierte mikroorganismen.

Also Published As

Publication number Publication date
NL8103151A (nl) 1982-02-01
PH18036A (en) 1985-03-06
IE49255B1 (en) 1985-09-04
HK49285A (en) 1985-07-05
DD210305A5 (de) 1984-06-06
NO159392B (no) 1988-09-12
EP0211148A1 (de) 1987-02-25
FR2486098A1 (fr) 1982-01-08
DE3177288T3 (de) 2000-03-16
GEP19960519B (en) 1996-07-02
DE3176448D1 (en) 1987-10-22
KE3534A (en) 1985-06-07
NO812247L (no) 1982-01-04
FI82712C (fi) 1991-04-10
BR8104189A (pt) 1982-03-16
GR75714B (de) 1984-08-02
DD210304A5 (de) 1984-06-06
AU7246281A (en) 1982-01-07
DD202307A5 (de) 1983-09-07
CH651308A5 (de) 1985-09-13
PL148276B1 (en) 1989-09-30
SE465223C5 (sv) 1998-02-10
EP0043980A3 (en) 1982-09-15
DK291081A (da) 1982-01-02
CS503781A2 (en) 1990-07-12
ATA290981A (de) 1985-09-15
CH657141A5 (de) 1986-08-15
BG42189A3 (en) 1987-10-15
NO159392C (no) 1988-12-21
IE811463L (en) 1982-01-01
ES503528A0 (es) 1982-10-01
DE3177288T2 (de) 1992-12-10
PT73289B (en) 1983-05-11
HU196457B (en) 1988-11-28
EP0043980A2 (de) 1982-01-20
EP0211148B2 (de) 1999-11-24
SU1414319A3 (ru) 1988-07-30
PL148261B1 (en) 1989-09-30
AU552004B2 (en) 1986-05-22
ATE79901T1 (de) 1992-09-15
IT8122682A0 (it) 1981-07-01
PT73289A (en) 1981-07-01
EP0211148B1 (de) 1992-08-26
RO87590A (ro) 1986-07-30
PL231940A1 (en) 1983-07-18
MY8700711A (en) 1987-12-31
NZ197572A (en) 1985-07-31
EP0043980B1 (de) 1987-09-16
AR242833A1 (es) 1993-05-31
YU47700B (sh) 1996-01-08
GB2079291A (en) 1982-01-20
GB2079291B (en) 1984-06-13
DE3125706C2 (de) 1995-05-24
PL148260B1 (en) 1989-09-30
LU83461A1 (de) 1983-04-06
CS273152B2 (en) 1991-03-12
FI82712B (fi) 1990-12-31
DE3125706A1 (de) 1982-04-15
SE465223B (sv) 1991-08-12
DE3177288D1 (de) 1992-10-01
SE8104093L (sv) 1982-01-02
ATE29727T1 (de) 1987-10-15
DZ312A1 (fr) 2004-09-13
MC1396A1 (fr) 1982-04-27
FI812067L (fi) 1982-01-02
IT1137272B (it) 1986-09-03
DK173543B1 (da) 2001-02-05
FR2486098B1 (fr) 1985-12-27
YU162281A (en) 1984-02-29
ES8207514A1 (es) 1982-10-01

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EIH Change in the person of patent owner
ELA Expired due to lapse of time