AR242833A1 - Procedimiento para la produccion microbiana de un interferon de leucocito humano maduro y procedimiento para producir microorganismos capaces de producir dicho interferon. - Google Patents

Procedimiento para la produccion microbiana de un interferon de leucocito humano maduro y procedimiento para producir microorganismos capaces de producir dicho interferon.

Info

Publication number
AR242833A1
AR242833A1 AR81285934A AR28593481A AR242833A1 AR 242833 A1 AR242833 A1 AR 242833A1 AR 81285934 A AR81285934 A AR 81285934A AR 28593481 A AR28593481 A AR 28593481A AR 242833 A1 AR242833 A1 AR 242833A1
Authority
AR
Argentina
Prior art keywords
polypeptides
compositions containing
microbial production
intermediates therefor
intermediates
Prior art date
Application number
AR81285934A
Other languages
English (en)
Original Assignee
Hoffman La Roche Ag Genentech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR242833(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/256,204 external-priority patent/US6610830B1/en
Application filed by Hoffman La Roche Ag Genentech filed Critical Hoffman La Roche Ag Genentech
Application granted granted Critical
Publication of AR242833A1 publication Critical patent/AR242833A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AR81285934A 1980-07-01 1981-06-30 Procedimiento para la produccion microbiana de un interferon de leucocito humano maduro y procedimiento para producir microorganismos capaces de producir dicho interferon. AR242833A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16498680A 1980-07-01 1980-07-01
US18490980A 1980-09-08 1980-09-08
US20557880A 1980-11-10 1980-11-10
US06/256,204 US6610830B1 (en) 1980-07-01 1981-04-21 Microbial production of mature human leukocyte interferons

Publications (1)

Publication Number Publication Date
AR242833A1 true AR242833A1 (es) 1993-05-31

Family

ID=27496622

Family Applications (1)

Application Number Title Priority Date Filing Date
AR81285934A AR242833A1 (es) 1980-07-01 1981-06-30 Procedimiento para la produccion microbiana de un interferon de leucocito humano maduro y procedimiento para producir microorganismos capaces de producir dicho interferon.

Country Status (36)

Country Link
EP (2) EP0211148B2 (es)
AR (1) AR242833A1 (es)
AT (3) ATE29727T1 (es)
AU (1) AU552004B2 (es)
BG (1) BG42189A3 (es)
BR (1) BR8104189A (es)
CH (2) CH657141A5 (es)
CS (1) CS273152B2 (es)
DD (3) DD210304A5 (es)
DE (3) DE3176448D1 (es)
DK (1) DK173543B1 (es)
DZ (1) DZ312A1 (es)
ES (1) ES503528A0 (es)
FI (1) FI82712C (es)
FR (1) FR2486098B1 (es)
GB (1) GB2079291B (es)
GE (1) GEP19960519B (es)
GR (1) GR75714B (es)
HK (1) HK49285A (es)
HU (1) HU196457B (es)
IE (1) IE49255B1 (es)
IT (1) IT1137272B (es)
KE (1) KE3534A (es)
LU (1) LU83461A1 (es)
MC (1) MC1396A1 (es)
MY (1) MY8700711A (es)
NL (1) NL8103151A (es)
NO (1) NO159392C (es)
NZ (1) NZ197572A (es)
PH (1) PH18036A (es)
PL (3) PL148260B1 (es)
PT (1) PT73289B (es)
RO (1) RO87590A (es)
SE (2) SE8104093L (es)
SU (1) SU1414319A3 (es)
YU (1) YU47700B (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
ES500966A0 (es) 1980-04-03 1982-12-16 Biogen Nv Un metodo de producir un polipeptido que muestra una actividad immunologica obiologica de interferon de fibroblasto hu- mano.
ATE25985T1 (de) * 1980-06-12 1987-04-15 Japan Found Cancer Plasmid.
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
JPS58501543A (ja) * 1981-08-14 1983-09-16 エイ／エス　アルフレツド　ベンツオン ヒトインタ−フエロン蛋白とヒトインタ−フエロン蛋白に対する抗体に関する改良
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
US5098703A (en) * 1982-01-15 1992-03-24 Cetus Corporation Interferon-alpha 76
US4975276A (en) * 1982-01-15 1990-12-04 Cetus Corporation Interferon-alpha 54
US4973479A (en) * 1982-01-15 1990-11-27 Cetus Corporation Interferon-α61
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
EP0088994B1 (en) * 1982-03-15 1991-06-19 Schering Corporation Hybrid dna, binding composition prepared thereby and processes therefor
US4748233A (en) * 1982-03-23 1988-05-31 Bristol-Myers Company Alpha-interferon Gx-1
US4695543A (en) * 1982-03-23 1987-09-22 Bristol-Myers Company Alpha Interferon GX-1
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
US6936694B1 (en) * 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
FR2541579B1 (fr) * 1983-02-24 1987-12-18 Inst Organicheskogo Sinteza Ak Interferon n leucocytaire humain et procede d'obtention de celui-ci dans les cellules bacteriennes
WO1985002862A1 (en) * 1983-12-23 1985-07-04 Monash University PRODUCTION OF HUMAN INTERFERON-alpha
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
WO1986002068A1 (en) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Mutual separation of proteins
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
DE3515336C2 (de) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Verfahren zur Herstellung und Reinigung von â-Interferon
JP2514950B2 (ja) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
CA1309044C (en) * 1987-11-09 1992-10-20 Toshiya Takano Method of producing foreign gene products
GB8813032D0 (en) * 1988-06-02 1988-07-06 Boehringer Ingelheim Int Antiviral pharmaceutical composition
WO1991003251A1 (en) * 1989-09-08 1991-03-21 California Institute Of Biological Research Cr2 ligand compositions and methods for modulating immune cell functions
DE3932311A1 (de) * 1989-09-28 1991-04-11 Boehringer Ingelheim Int Verfahren zur reinigung von beta-interferon
DK0741577T3 (da) * 1994-03-07 2003-02-17 Imperial College Anvendelsen af enterferon, subtype alfa 8, til fremstilling af lægemidler til behandling af virusinfektioner i leveren
EP1104809A1 (en) * 1994-04-09 2001-06-06 F. Hoffmann-La Roche Ag Process for producing alpha-interferon
GB9609932D0 (en) * 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
US6299869B1 (en) 1997-12-08 2001-10-09 Genentech, Inc. Human interferon-epsilon: a type I interferon
CN1896231B (zh) 1998-08-06 2012-09-05 山景药品公司 分离四聚体尿酸氧化酶的方法
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
AU2002228886B2 (en) * 2000-11-03 2007-08-30 Pestka Biomedical Laboratories, Inc. Interferons, uses and compositions related thereto
FR2822845B1 (fr) 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr) 2001-06-11 2004-09-24 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
CA2604399A1 (en) 2005-04-11 2006-10-19 Savient Pharmaceuticals, Inc. Variant forms of urate oxidase and use thereof
KR20100103595A (ko) * 2008-01-18 2010-09-27 에프. 호프만-라 로슈 아게 비-글라이코실화된 단백질의 정제
EP3482768A1 (en) 2009-06-25 2019-05-15 Horizon Pharma Rheumatology LLC Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
WO2018087345A1 (en) 2016-11-14 2018-05-17 F. Hoffmann-La Roche Ag COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (es) * 1978-11-24 1982-12-04 Hoffmann La Roche
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
CA1341567C (en) * 1980-01-08 2008-02-19 Charles Weissmann Dna sequences, recombinant dna molecules and processes for producing human interferon - like polypeptides
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
ATE25985T1 (de) * 1980-06-12 1987-04-15 Japan Found Cancer Plasmid.
ES8302778A1 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
FI64813C (fi) * 1980-12-31 1984-01-10 Ilkka Antero Palva Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
EP0062971B1 (en) * 1981-03-27 1990-03-07 Imperial Chemical Industries Plc Genetically modified microorganisms

Also Published As

Publication number Publication date
BG42189A3 (en) 1987-10-15
PL148261B1 (en) 1989-09-30
MY8700711A (en) 1987-12-31
AU552004B2 (en) 1986-05-22
PL148276B1 (en) 1989-09-30
EP0211148A1 (en) 1987-02-25
NZ197572A (en) 1985-07-31
DE3125706C2 (de) 1995-05-24
IT1137272B (it) 1986-09-03
NL8103151A (nl) 1982-02-01
DE3177288D1 (de) 1992-10-01
PL231940A1 (en) 1983-07-18
DD202307A5 (de) 1983-09-07
PL148260B1 (en) 1989-09-30
NO159392B (no) 1988-09-12
CS273152B2 (en) 1991-03-12
HU196457B (en) 1988-11-28
FI812067L (fi) 1982-01-02
NO812247L (no) 1982-01-04
EP0211148B2 (en) 1999-11-24
FI82712C (fi) 1991-04-10
DE3176448D1 (en) 1987-10-22
IE49255B1 (en) 1985-09-04
SE8104093L (sv) 1982-01-02
CS503781A2 (en) 1990-07-12
BR8104189A (pt) 1982-03-16
DK291081A (da) 1982-01-02
DD210304A5 (de) 1984-06-06
EP0043980B1 (en) 1987-09-16
SU1414319A3 (ru) 1988-07-30
KE3534A (en) 1985-06-07
EP0043980A3 (en) 1982-09-15
ES8207514A1 (es) 1982-10-01
EP0211148B1 (en) 1992-08-26
YU162281A (en) 1984-02-29
AT380272B (de) 1986-05-12
DE3125706A1 (de) 1982-04-15
ATA290981A (de) 1985-09-15
LU83461A1 (de) 1983-04-06
DE3177288T2 (de) 1992-12-10
CH657141A5 (de) 1986-08-15
NO159392C (no) 1988-12-21
YU47700B (sh) 1996-01-08
DZ312A1 (fr) 2004-09-13
FI82712B (fi) 1990-12-31
IE811463L (en) 1982-01-01
HK49285A (en) 1985-07-05
GB2079291B (en) 1984-06-13
FR2486098A1 (fr) 1982-01-08
EP0043980A2 (en) 1982-01-20
SE465223B (sv) 1991-08-12
DE3177288T3 (de) 2000-03-16
FR2486098B1 (fr) 1985-12-27
ES503528A0 (es) 1982-10-01
DK173543B1 (da) 2001-02-05
CH651308A5 (de) 1985-09-13
PT73289A (en) 1981-07-01
MC1396A1 (fr) 1982-04-27
GB2079291A (en) 1982-01-20
IT8122682A0 (it) 1981-07-01
DD210305A5 (de) 1984-06-06
GEP19960519B (en) 1996-07-02
ATE29727T1 (de) 1987-10-15
PT73289B (en) 1983-05-11
ATE79901T1 (de) 1992-09-15
RO87590A (ro) 1986-07-30
SE465223C5 (sv) 1998-02-10
PH18036A (en) 1985-03-06
AU7246281A (en) 1982-01-07
GR75714B (es) 1984-08-02

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