ES8302778A1 - Un procedimiento para producir un polipeptido antiviral. - Google Patents

Un procedimiento para producir un polipeptido antiviral.

Info

Publication number
ES8302778A1
ES8302778A1 ES506955A ES506955A ES8302778A1 ES 8302778 A1 ES8302778 A1 ES 8302778A1 ES 506955 A ES506955 A ES 506955A ES 506955 A ES506955 A ES 506955A ES 8302778 A1 ES8302778 A1 ES 8302778A1
Authority
ES
Spain
Prior art keywords
human leukocyte
interferons
hybrid human
compositions containing
microbial production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES506955A
Other languages
English (en)
Other versions
ES506955A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/237,388 external-priority patent/US4414150A/en
Priority claimed from US06/305,657 external-priority patent/US4456748A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ES8302778A1 publication Critical patent/ES8302778A1/es
Publication of ES506955A0 publication Critical patent/ES506955A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

UN PROCEDIMIENTO PARA PRODUCIR UN POLIPEPTIDO ANTIVIRAL DE APROXIMADAMENTE 165 A 166 AMINOACIDOS. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE DESPLIEGA UN FRAGMENTO DE DNA, QUE COMPRENDE UN FILAMENTE QUE CODIFICA EL POLIPEPTIDO DENTRO DE UN VEHICULO DE EXPRESION PLASMIDICO; SEGUNDA, SE CULTIVA UN MICROORGANISMO QUE OCASIONA LA EXPRESION DEL SEGUNDO POLIPEPTIDO CODIFICADO; TERCERA, SE LISA EL MICROORGANISMO RESULTANTE; Y POR ULTIMO, SE RECUPERA DE DICHO MICROORGANISMO EL POLIPEPTIDO. DE APLICACION EN EL TRATAMIENTO DE ENFERMEDADES NEOPLASTICAS VIRALES.
ES506955A 1980-11-10 1981-11-07 Un procedimiento para producir un polipeptido antiviral. Granted ES506955A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20557980A 1980-11-10 1980-11-10
US06/237,388 US4414150A (en) 1980-11-10 1981-02-23 Hybrid human leukocyte interferons
US06/305,657 US4456748A (en) 1981-02-23 1981-09-25 Hybrid human leukocyte interferons

Publications (2)

Publication Number Publication Date
ES8302778A1 true ES8302778A1 (es) 1983-02-01
ES506955A0 ES506955A0 (es) 1983-02-01

Family

ID=27394813

Family Applications (2)

Application Number Title Priority Date Filing Date
ES506955A Granted ES506955A0 (es) 1980-11-10 1981-11-07 Un procedimiento para producir un polipeptido antiviral.
ES512354A Expired ES8304200A1 (es) 1980-11-10 1982-05-19 "un procedimiento para formar dna doble filamentado".

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES512354A Expired ES8304200A1 (es) 1980-11-10 1982-05-19 "un procedimiento para formar dna doble filamentado".

Country Status (34)

Country Link
EP (1) EP0051873B1 (es)
JP (1) JP2642291B2 (es)
KR (1) KR920007439B1 (es)
AT (1) ATE46718T1 (es)
AU (1) AU555293B2 (es)
BR (1) BR8107293A (es)
CA (2) CA1212915A (es)
CH (2) CH663032A5 (es)
DE (2) DE3177106D1 (es)
DK (1) DK173590B1 (es)
DO (1) DOP1981004064A (es)
DZ (1) DZ350A1 (es)
ES (2) ES506955A0 (es)
FI (1) FI79550C (es)
FR (1) FR2493867B1 (es)
GB (1) GB2090258B (es)
GR (1) GR81947B (es)
HK (1) HK51685A (es)
IE (1) IE51850B1 (es)
IL (1) IL64243A (es)
IT (1) IT1169276B (es)
KE (1) KE3536A (es)
LU (1) LU83745A1 (es)
MC (1) MC1424A1 (es)
MY (2) MY8700710A (es)
NL (1) NL189092C (es)
NO (1) NO165201C (es)
NZ (1) NZ198906A (es)
PH (1) PH18565A (es)
PL (1) PL233748A1 (es)
PT (1) PT73955B (es)
SE (1) SE460539B (es)
YU (1) YU46597B (es)
ZW (1) ZW26981A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH651308A5 (de) * 1980-07-01 1985-09-13 Hoffmann La Roche Interferone und deren herstellung.
WO1983000693A1 (en) * 1981-08-14 1983-03-03 Berg, Kurt, Frimann SUBJECTS RELATING TO HUMAN INTEFERON-'alpha' SUBTYPE PROTEINS AND CORRESPONDING ANTIBODIES
EP0072541A3 (en) * 1981-08-14 1984-04-18 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Human leukocyte interferons, process for their microbial production, intermediates therefor and compositions containing them
GB2108510B (en) * 1981-10-03 1984-12-12 Ciba Geigy Ag Dnas, recombinant dnas, hosts containing them, polypeptides and processes for the production thereof
EP0098876A1 (en) * 1982-01-19 1984-01-25 Cetus Corporation Multiclass hybrid interferons
DE3220116A1 (de) * 1982-05-28 1983-12-01 Dr. Karl Thomae Gmbh, 7950 Biberach Mikrobiologisch hergestellte (alpha)- und ss-interferone, dna-sequenzen, die fuer diese interferone codieren, mikroorganismen, die diese genetische information enthalten, und verfahren zu ihrer herstellung
CA1252046A (en) * 1982-11-04 1989-04-04 Martin J. Cline Methods for oncogenic detection
WO1984003300A1 (en) * 1983-02-24 1984-08-30 Inst Organicheskogo Sinteza Ak Leukocytic human interferon n and method to obtain it in bacterial cells
GB8315980D0 (en) * 1983-06-10 1983-07-13 Biogen Nv Producing hybrid dna sequences
GB8317880D0 (en) * 1983-07-01 1983-08-03 Searle & Co Structure and synthesis of interferons
US4892743A (en) * 1983-12-21 1990-01-09 Schering Corporation Novel hybrid interferon species
EP0146903A3 (en) * 1983-12-19 1987-07-22 Schering Corporation Production of a vector encoding a novel hybrid interferon species
DE3409966A1 (de) * 1984-03-19 1985-09-26 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von human-gammainterferon und mittel zur durchfuehrung dieses verfahrens
JPS6156199A (ja) * 1984-08-27 1986-03-20 Shionogi & Co Ltd 新規ヒトインタ−フエロンα類
EP0173935A1 (en) * 1984-08-31 1986-03-12 University Patents, Inc. Hybrid lymphoblastoid-leukocyte human interferons
DE3434345A1 (de) * 1984-09-19 1986-03-27 Hoechst Ag, 6230 Frankfurt Verwendung von (alpha)-interferonen zur bekaempfung von durchfaellen
DE3685044D1 (de) * 1985-02-01 1992-06-04 Ici Plc Analoge interferon-polypeptide, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
EP0205404B1 (en) * 1985-06-11 1992-07-15 Ciba-Geigy Ag Hybrid interferons
EP0240550A4 (en) * 1985-09-26 1989-09-19 Genetics Inst LUNG SURFACE ACTIVE PROTEINS.
US4806347A (en) * 1985-12-11 1989-02-21 Schering Corporation Interferon combinations
DE3607835A1 (de) * 1986-03-10 1987-09-24 Boehringer Ingelheim Int Hybridinterferone, deren verwendung als arzneimittel und als zwischenprodukte zur herstellung von antikoerpern und deren verwendung sowie verfahren zu ihrer herstellung
EP0490233A1 (de) * 1986-03-10 1992-06-17 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Monoclonale Antikörper gegen BgIII-Hybridinterferone, deren Verwendung und Verfahren zu ihrer Herstellung
US4851220A (en) * 1986-11-26 1989-07-25 Schering Corporation Stable oleaginous gel
US4853218A (en) * 1987-02-24 1989-08-01 Schering Corporation Zinc-protamine-alpha interferon complex
EP0331635A3 (en) * 1988-02-29 1990-02-28 The Board of Regents of the University of Texas System Preparations for treating bladder cancer
US5372808A (en) † 1990-10-17 1994-12-13 Amgen Inc. Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
GB2273931A (en) * 1992-09-28 1994-07-06 Unilever Plc Mutant polypeptides
JPH11507352A (ja) 1995-06-07 1999-06-29 ジンタ・インコーポレイテッド 新規カルバメート基本カチオン性脂質
TW442492B (en) * 1995-07-26 2001-06-23 Novartis Ag Process for the enrichment of interferon
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
US7314613B2 (en) 2002-11-18 2008-01-01 Maxygen, Inc. Interferon-alpha polypeptides and conjugates
CN101115769A (zh) 2004-05-19 2008-01-30 马克西根公司 干扰素-α多肽和偶联物
JP2008545393A (ja) 2005-05-18 2008-12-18 マキシジェン， インコーポレイテッド 進歩したインターフェロンαポリペプチド

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT72322B (en) * 1980-01-08 1982-09-23 Biogen Nv Process for preparation of recombinant dna molecules and of polipeptides similar to human interferon

Also Published As

Publication number Publication date
YU46597B (sh) 1994-01-20
CH663032A5 (de) 1987-11-13
ZW26981A1 (en) 1982-06-02
FI79550B (fi) 1989-09-29
FR2493867A1 (fr) 1982-05-14
CA1212915A (en) 1986-10-21
FI813539L (fi) 1982-05-11
EP0051873A3 (en) 1982-09-22
YU265681A (en) 1984-08-31
SE8106641L (sv) 1982-06-24
PH18565A (en) 1985-08-09
HK51685A (en) 1985-07-12
FI79550C (fi) 1990-01-10
ATE46718T1 (de) 1989-10-15
KR830007825A (ko) 1983-11-07
PL233748A1 (en) 1983-07-18
NL189092B (nl) 1992-08-03
EP0051873A2 (en) 1982-05-19
DOP1981004064A (es) 1988-03-16
MY8800066A (en) 1988-12-31
EP0051873B1 (en) 1989-09-27
PT73955A (en) 1981-12-01
NO813785L (no) 1982-05-11
JPH07308191A (ja) 1995-11-28
NZ198906A (en) 1985-12-13
SE460539B (sv) 1989-10-23
IT1169276B (it) 1987-05-27
DZ350A1 (fr) 2004-09-13
KE3536A (en) 1985-06-07
DK494681A (da) 1982-05-11
AU555293B2 (en) 1986-09-18
IE812622L (en) 1982-05-10
IL64243A (en) 1985-11-29
FR2493867B1 (fr) 1986-06-27
GR81947B (es) 1984-12-12
NL189092C (nl) 1993-01-04
NO165201C (no) 1991-01-16
LU83745A1 (de) 1983-09-01
GB2090258A (en) 1982-07-07
NO165201B (no) 1990-10-01
ES506955A0 (es) 1983-02-01
IL64243A0 (en) 1982-02-28
IE51850B1 (en) 1987-04-15
ES512354A0 (es) 1983-03-01
MC1424A1 (fr) 1982-10-18
JP2642291B2 (ja) 1997-08-20
DE3177106D1 (en) 1989-11-02
DE3144469A1 (de) 1982-09-02
KR920007439B1 (ko) 1992-09-01
CA1277616C (en) 1990-12-11
DK173590B1 (da) 2001-04-02
BR8107293A (pt) 1982-08-03
AU7730481A (en) 1982-05-20
CH660743A5 (de) 1987-06-15
NL8105078A (nl) 1982-06-01
IT8124967A0 (it) 1981-11-10
PT73955B (en) 1983-11-23
ES8304200A1 (es) 1983-03-01
MY8700710A (en) 1987-12-31
GB2090258B (en) 1984-05-02

Similar Documents

Publication Publication Date Title
ES8304200A1 (es) "un procedimiento para formar dna doble filamentado".
ES8207514A1 (es) Un procedimiento para la preparacion de interferon
ES8307297A1 (es) Proceso para la produccion microbiana de interferon fibro- blasto humano
SG38692G (en) Microbially prepared interferon alpha 2(arg),dna sequence coding for said interferon,microorganisms containing this genetic information and process for their production
IE822479L (en) Dna molecules encoding certain mammalian proteins
EP0072541A3 (en) Human leukocyte interferons, process for their microbial production, intermediates therefor and compositions containing them
ATE43139T1 (de) Klonierungs- und expressionsvektoren fuer gammainterferon, transformierte bakterien und verfahren zur herstellung von gamma-interferon.