IT1169276B - Interferoni di leucociti umani ibridi - Google Patents

Interferoni di leucociti umani ibridi

Info

Publication number
IT1169276B
IT1169276B IT24967/81A IT2496781A IT1169276B IT 1169276 B IT1169276 B IT 1169276B IT 24967/81 A IT24967/81 A IT 24967/81A IT 2496781 A IT2496781 A IT 2496781A IT 1169276 B IT1169276 B IT 1169276B
Authority
IT
Italy
Prior art keywords
interferons
hybrid human
interphones
human leukocytes
host organisms
Prior art date
Application number
IT24967/81A
Other languages
English (en)
Other versions
IT8124967A0 (it
Inventor
David Van Norman Goeddel
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/237,388 external-priority patent/US4414150A/en
Priority claimed from US06/305,657 external-priority patent/US4456748A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IT8124967A0 publication Critical patent/IT8124967A0/it
Application granted granted Critical
Publication of IT1169276B publication Critical patent/IT1169276B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
IT24967/81A 1980-11-10 1981-11-10 Interferoni di leucociti umani ibridi IT1169276B (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20557980A 1980-11-10 1980-11-10
US06/237,388 US4414150A (en) 1980-11-10 1981-02-23 Hybrid human leukocyte interferons
US06/305,657 US4456748A (en) 1981-02-23 1981-09-25 Hybrid human leukocyte interferons

Publications (2)

Publication Number Publication Date
IT8124967A0 IT8124967A0 (it) 1981-11-10
IT1169276B true IT1169276B (it) 1987-05-27

Family

ID=27394813

Family Applications (1)

Application Number Title Priority Date Filing Date
IT24967/81A IT1169276B (it) 1980-11-10 1981-11-10 Interferoni di leucociti umani ibridi

Country Status (34)

Country Link
EP (1) EP0051873B1 (it)
JP (1) JP2642291B2 (it)
KR (1) KR920007439B1 (it)
AT (1) ATE46718T1 (it)
AU (1) AU555293B2 (it)
BR (1) BR8107293A (it)
CA (2) CA1212915A (it)
CH (2) CH663032A5 (it)
DE (2) DE3144469A1 (it)
DK (1) DK173590B1 (it)
DO (1) DOP1981004064A (it)
DZ (1) DZ350A1 (it)
ES (2) ES506955A0 (it)
FI (1) FI79550C (it)
FR (1) FR2493867B1 (it)
GB (1) GB2090258B (it)
GR (1) GR81947B (it)
HK (1) HK51685A (it)
IE (1) IE51850B1 (it)
IL (1) IL64243A (it)
IT (1) IT1169276B (it)
KE (1) KE3536A (it)
LU (1) LU83745A1 (it)
MC (1) MC1424A1 (it)
MY (2) MY8700710A (it)
NL (1) NL189092C (it)
NO (1) NO165201C (it)
NZ (1) NZ198906A (it)
PH (1) PH18565A (it)
PL (1) PL233748A1 (it)
PT (1) PT73955B (it)
SE (1) SE460539B (it)
YU (1) YU46597B (it)
ZW (1) ZW26981A1 (it)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH657141A5 (de) * 1980-07-01 1986-08-15 Hoffmann La Roche Dns-sequenzen, rekombinante expressionsvektoren zur mikrobiellen herstellung von human-leukozyten-interferonen und transformierte mikroorganismen.
EP0072541A3 (en) * 1981-08-14 1984-04-18 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Human leukocyte interferons, process for their microbial production, intermediates therefor and compositions containing them
WO1983000693A1 (en) * 1981-08-14 1983-03-03 Berg, Kurt, Frimann SUBJECTS RELATING TO HUMAN INTEFERON-'alpha' SUBTYPE PROTEINS AND CORRESPONDING ANTIBODIES
GB2108510B (en) * 1981-10-03 1984-12-12 Ciba Geigy Ag Dnas, recombinant dnas, hosts containing them, polypeptides and processes for the production thereof
WO1983002461A1 (en) * 1982-01-19 1983-07-21 Cetus Corp Multiclass hybrid interferons
DE3220116A1 (de) * 1982-05-28 1983-12-01 Dr. Karl Thomae Gmbh, 7950 Biberach Mikrobiologisch hergestellte (alpha)- und ss-interferone, dna-sequenzen, die fuer diese interferone codieren, mikroorganismen, die diese genetische information enthalten, und verfahren zu ihrer herstellung
IE56509B1 (en) * 1982-11-04 1991-08-28 Univ California Methods for oncogenic detection
GB2150573B (en) * 1983-02-24 1987-11-11 Inst Organicheskogo Sinteza Ak Leukocytic human interferon n and method to obtain it in bacterial cells
GB8315980D0 (en) * 1983-06-10 1983-07-13 Biogen Nv Producing hybrid dna sequences
GB8317880D0 (en) * 1983-07-01 1983-08-03 Searle & Co Structure and synthesis of interferons
US4892743A (en) * 1983-12-21 1990-01-09 Schering Corporation Novel hybrid interferon species
EP0146903A3 (en) * 1983-12-19 1987-07-22 Schering Corporation Production of a vector encoding a novel hybrid interferon species
DE3409966A1 (de) * 1984-03-19 1985-09-26 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von human-gammainterferon und mittel zur durchfuehrung dieses verfahrens
JPS6156199A (ja) * 1984-08-27 1986-03-20 Shionogi & Co Ltd 新規ヒトインタ−フエロンα類
EP0173935A1 (en) * 1984-08-31 1986-03-12 University Patents, Inc. Hybrid lymphoblastoid-leukocyte human interferons
DE3434345A1 (de) * 1984-09-19 1986-03-27 Hoechst Ag, 6230 Frankfurt Verwendung von (alpha)-interferonen zur bekaempfung von durchfaellen
DE3685044D1 (de) * 1985-02-01 1992-06-04 Ici Plc Analoge interferon-polypeptide, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4885166A (en) * 1985-06-11 1989-12-05 Ciba-Geigy Corporation Hybrid interferons
WO1987002037A1 (en) * 1985-09-26 1987-04-09 Genetics Institute, Inc. Pulmonary surfactant proteins
US4806347A (en) * 1985-12-11 1989-02-21 Schering Corporation Interferon combinations
DE3607835A1 (de) * 1986-03-10 1987-09-24 Boehringer Ingelheim Int Hybridinterferone, deren verwendung als arzneimittel und als zwischenprodukte zur herstellung von antikoerpern und deren verwendung sowie verfahren zu ihrer herstellung
EP0490233A1 (de) * 1986-03-10 1992-06-17 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Monoclonale Antikörper gegen BgIII-Hybridinterferone, deren Verwendung und Verfahren zu ihrer Herstellung
US4851220A (en) * 1986-11-26 1989-07-25 Schering Corporation Stable oleaginous gel
US4853218A (en) * 1987-02-24 1989-08-01 Schering Corporation Zinc-protamine-alpha interferon complex
EP0331635A3 (en) * 1988-02-29 1990-02-28 The Board of Regents of the University of Texas System Preparations for treating bladder cancer
US5372808A (en) † 1990-10-17 1994-12-13 Amgen Inc. Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
GB2273931A (en) * 1992-09-28 1994-07-06 Unilever Plc Mutant polypeptides
AU701106B2 (en) 1995-06-07 1999-01-21 Promega Biosciences, Inc. Novel carbamate-based cationic lipids
TW442492B (en) * 1995-07-26 2001-06-23 Novartis Ag Process for the enrichment of interferon
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
US7314613B2 (en) 2002-11-18 2008-01-01 Maxygen, Inc. Interferon-alpha polypeptides and conjugates
MXPA06013412A (es) 2004-05-19 2007-01-23 Maxygen Inc Polipeptidos de interferon-alfa y conjugados.
EP1888633A4 (en) 2005-05-18 2010-01-27 Maxygen Inc UNFOLDED INTERFERON ALPHA POLYPEPTIDE

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY1346A (en) * 1980-01-08 1987-01-16 Biogen Nv Dna sequences,recombinant dna molecules and processes for producing human interferon-like polypeptides

Also Published As

Publication number Publication date
CH660743A5 (de) 1987-06-15
DOP1981004064A (es) 1988-03-16
IT8124967A0 (it) 1981-11-10
DK494681A (da) 1982-05-11
IL64243A0 (en) 1982-02-28
AU7730481A (en) 1982-05-20
FI813539L (fi) 1982-05-11
PT73955B (en) 1983-11-23
NO165201C (no) 1991-01-16
HK51685A (en) 1985-07-12
CA1277616C (en) 1990-12-11
ES512354A0 (es) 1983-03-01
ZW26981A1 (en) 1982-06-02
FI79550C (fi) 1990-01-10
KE3536A (en) 1985-06-07
PL233748A1 (en) 1983-07-18
IE812622L (en) 1982-05-10
KR920007439B1 (ko) 1992-09-01
FR2493867A1 (fr) 1982-05-14
IL64243A (en) 1985-11-29
NL189092C (nl) 1993-01-04
MY8700710A (en) 1987-12-31
CH663032A5 (de) 1987-11-13
MY8800066A (en) 1988-12-31
AU555293B2 (en) 1986-09-18
KR830007825A (ko) 1983-11-07
ES8302778A1 (es) 1983-02-01
EP0051873A2 (en) 1982-05-19
EP0051873A3 (en) 1982-09-22
PH18565A (en) 1985-08-09
DE3177106D1 (en) 1989-11-02
JPH07308191A (ja) 1995-11-28
ATE46718T1 (de) 1989-10-15
PT73955A (en) 1981-12-01
NO813785L (no) 1982-05-11
FR2493867B1 (fr) 1986-06-27
GR81947B (it) 1984-12-12
LU83745A1 (de) 1983-09-01
NZ198906A (en) 1985-12-13
GB2090258A (en) 1982-07-07
IE51850B1 (en) 1987-04-15
DE3144469A1 (de) 1982-09-02
GB2090258B (en) 1984-05-02
NL189092B (nl) 1992-08-03
MC1424A1 (fr) 1982-10-18
SE8106641L (sv) 1982-06-24
EP0051873B1 (en) 1989-09-27
DK173590B1 (da) 2001-04-02
BR8107293A (pt) 1982-08-03
ES8304200A1 (es) 1983-03-01
NL8105078A (nl) 1982-06-01
FI79550B (fi) 1989-09-29
YU46597B (sh) 1994-01-20
ES506955A0 (es) 1983-02-01
CA1212915A (en) 1986-10-21
DZ350A1 (fr) 2004-09-13
SE460539B (sv) 1989-10-23
YU265681A (en) 1984-08-31
NO165201B (no) 1990-10-01
JP2642291B2 (ja) 1997-08-20

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Effective date: 19971127