ES8307297A1 - Proceso para la produccion microbiana de interferon fibro- blasto humano - Google Patents

Proceso para la produccion microbiana de interferon fibro- blasto humano

Info

Publication number
ES8307297A1
ES8307297A1 ES505742A ES505742A ES8307297A1 ES 8307297 A1 ES8307297 A1 ES 8307297A1 ES 505742 A ES505742 A ES 505742A ES 505742 A ES505742 A ES 505742A ES 8307297 A1 ES8307297 A1 ES 8307297A1
Authority
ES
Spain
Prior art keywords
polypeptides
compositions containing
interferon
microbial production
intermediates therefor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505742A
Other languages
English (en)
Other versions
ES505742A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26886463&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8307297(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ES8307297A1 publication Critical patent/ES8307297A1/es
Publication of ES505742A0 publication Critical patent/ES505742A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCESO PARA LA PRODUCCION MICROBIANA DE INTERFERON FIBROBLASTO HUMANO. CONSISTE EN CULTIVAR UN MICROORGANISMO TRANSFORMADO CON UN VEHICULO DE EXPRESION MICROBIANA REPLICABLE, CAPAZ DE EXPRESAR DICHO POLIPEPTIDO EN UN MEDIO NUTRIENTE CONVENCIONAL QUE CONTENGA UN CARBONO Y UNA FUENTE DE NITROGENO, SEPARAR LOS MICROORGANISMOS OBTENIDOS DEL MEDIO NUTRIENTE Y AISLAR Y PURIFICAR DICHO POLIPEPTIDO UTILIZANDO METODOS CONOCIDOS. DICHO POLIPEPTIDO CONTIENE OPCIONALMENTE LA METIONINA AMINOACIDA COMO PRIMER AMINOACIDO DEL INTERFERON FIBROBLASTO. ADICIONALMENTE CONTIENE UN ACOPLADO SEGMENTABLE O PROTEINA DE SEÑAL MICROBIANA UNIDO AL TERMINAL-N DEL ORDINARIAMENTE PRIMER AMINOACIDO DEL INTERFERO
ES505742A 1980-09-25 1981-09-24 Proceso para la produccion microbiana de interferon fibro- blasto humano Granted ES505742A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19079980A 1980-09-25 1980-09-25
US29189281A 1981-08-11 1981-08-11

Publications (2)

Publication Number Publication Date
ES8307297A1 true ES8307297A1 (es) 1983-07-01
ES505742A0 ES505742A0 (es) 1983-07-01

Family

ID=26886463

Family Applications (3)

Application Number Title Priority Date Filing Date
ES505742A Granted ES505742A0 (es) 1980-09-25 1981-09-24 Proceso para la produccion microbiana de interferon fibro- blasto humano
ES515033A Granted ES515033A0 (es) 1980-09-25 1982-08-16 "proceso para la produccion microbiana de interferon fibroblasto humano".
ES515032A Granted ES515032A0 (es) 1980-09-25 1982-08-16 "proceso para la produccion microbiana de interferon fibroblasto humano".

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES515033A Granted ES515033A0 (es) 1980-09-25 1982-08-16 "proceso para la produccion microbiana de interferon fibroblasto humano".
ES515032A Granted ES515032A0 (es) 1980-09-25 1982-08-16 "proceso para la produccion microbiana de interferon fibroblasto humano".

Country Status (33)

Country Link
US (1) US5460811A (es)
EP (1) EP0048970A3 (es)
AT (1) AT380694B (es)
AU (1) AU582110B2 (es)
BR (1) BR8106137A (es)
CA (1) CA1341569C (es)
CH (2) CH656388A5 (es)
DD (3) DD209652A5 (es)
DE (1) DE3138096A1 (es)
DK (1) DK423381A (es)
ES (3) ES505742A0 (es)
FI (1) FI812993L (es)
FR (1) FR2490675B1 (es)
GB (1) GB2098996B (es)
GR (1) GR81946B (es)
HK (1) HK43686A (es)
IE (1) IE51679B1 (es)
IL (1) IL63916A0 (es)
IT (1) IT1139487B (es)
KE (1) KE3630A (es)
LU (1) LU83648A1 (es)
MC (1) MC1423A1 (es)
MT (1) MTP900B (es)
MY (1) MY8600634A (es)
NL (1) NL8104400A (es)
NO (1) NO813248L (es)
NZ (1) NZ198445A (es)
OA (1) OA06908A (es)
PL (1) PL233194A1 (es)
PT (1) PT73728B (es)
SE (1) SE8105657L (es)
YU (1) YU44835B (es)
ZW (1) ZW23981A1 (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK33181A (da) * 1980-02-06 1981-08-07 Searle & Co Fremgangsmaade til fremstilling af et interferonlignende protein
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
DK170476B1 (da) 1980-04-03 1995-09-11 Biogen Inc Rekombinant DNA-molekyle, uni-cellulær vært transformeret med mindst ét rekombinant DNA-molekyle, fremgangsmåde til transformering af en uni-cellulær vært, samt fremgangsmåder til fremstilling af et polpeptid, der udviser den immunologiske eller biologiske aktivitet af human beta-interferon
ATE25985T1 (de) * 1980-06-12 1987-04-15 Japan Found Cancer Plasmid.
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
JPS58110600A (ja) * 1981-12-25 1983-07-01 Kyowa Hakko Kogyo Co Ltd ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
AU575301B2 (en) * 1982-10-08 1988-07-28 Juridical Foundation, Japanese Foundation For Cancer Research Novel vector
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
US4511502A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4599197A (en) * 1982-12-22 1986-07-08 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4512922A (en) * 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4518526A (en) * 1982-12-22 1985-05-21 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
GR79124B (es) * 1982-12-22 1984-10-02 Genentech Inc
US4620948A (en) * 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US5683688A (en) 1984-05-31 1997-11-04 Genentech, Inc. Unglycosylated recombinant human lymphotoxin polypeptides and compositions
GB8414354D0 (en) * 1984-06-05 1984-07-11 Biogen Nv Purifying protein
DE3574145D1 (en) * 1984-08-27 1989-12-14 Genentech Inc Novel, distinct family of human leukocyte interferons, compositions containing them, methods for their production, and dna and transfected hosts therefor
US5231176A (en) * 1984-08-27 1993-07-27 Genentech, Inc. Distinct family DNA encoding of human leukocyte interferons
US4680262A (en) * 1984-10-05 1987-07-14 Genentech, Inc. Periplasmic protein recovery
US5618920A (en) 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
EP0237019A3 (en) * 1986-03-14 1988-03-09 Toray Industries, Inc. Interferon conjugate and production thereof using recombinant gene
GB9022543D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Antibody production
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US20050002902A1 (en) * 1995-12-28 2005-01-06 Liming Yu Hybrid with interferon-alpha and an immunoglobulin Fc for treatment of tumors and viral infections
US5723125A (en) * 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
US20030026779A1 (en) * 1999-10-15 2003-02-06 Liming Yu Treatment of tumors and viral infections with a hybrid conjugate of interferon and an immunoglobulin Fc
US6713609B1 (en) 1996-07-16 2004-03-30 Genentech, Inc. Monoclonal antibodies to type I interferon receptor
JP3576819B2 (ja) 1997-07-30 2004-10-13 キヤノン株式会社 情報処理装置及び印刷制御方法並びに記憶媒体
US20030018174A1 (en) * 1997-10-06 2003-01-23 Genentech, Inc. Monoclonal antibodies to IFNAR2
EP1165835A2 (en) 1999-03-24 2002-01-02 Serono Genetics Institute S.A. GENOMIC SEQUENCE OF THE $i(PURH) GENE AND $i(PURH)-RELATED BIALLELIC MARKERS
EP2213743A1 (en) 2000-04-12 2010-08-04 Human Genome Sciences, Inc. Albumin fusion proteins
ATE502648T1 (de) * 2001-01-09 2011-04-15 Baylor Res Inst Verfahren zur behandlung von autoimmunerkrankungen bei einem probanden und diagnostische in-vitro-assays
ES2500918T3 (es) 2001-12-21 2014-10-01 Human Genome Sciences, Inc. Proteínas de fusión de albúmina e interferón beta
KR101271635B1 (ko) * 2001-12-21 2013-06-12 휴먼 게놈 사이언시즈, 인코포레이티드 알부민 융합 단백질
AU2003303635B2 (en) 2002-12-26 2009-07-23 Mountain View Pharmaceuticals, Inc. Polymer conjugates of interferon-beta with enhanced biological potency
PL380269A1 (pl) * 2002-12-26 2007-01-08 Mountain View Pharmaceuticals, Inc. Koniugaty polimerowe cytokin, czynników wzrostu, hormonów polipeptydowych i ich antagonistów o zachowanej zdolności do wiązania receptora
CA2513213C (en) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
AU2005209926B2 (en) 2004-02-02 2007-09-06 Ambrx, Inc. Modified human four helical bundle polypeptides and their uses
CA2612378A1 (en) * 2005-06-22 2007-01-04 Genentech, Inc. Methods and compositions for targeting ifnar2
EP3103880A1 (en) 2008-02-08 2016-12-14 Ambrx, Inc. Modified leptin polypeptides and their uses

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL55892A (en) * 1977-11-08 1983-10-31 Genentech Inc Cloning vehicle for transforming microbial host to render it capable of polypeptide expression,and products therefrom
US4411994A (en) * 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
IN150740B (es) * 1978-11-24 1982-12-04 Hoffmann La Roche
US4332892A (en) * 1979-01-15 1982-06-01 President And Fellows Of Harvard College Protein synthesis
US4262090A (en) * 1979-06-04 1981-04-14 Cetus Corporation Interferon production
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
CH648331A5 (de) * 1979-07-31 1985-03-15 Hoffmann La Roche Homogenes fibroblasten-interferon und dessen herstellung.
US4289689A (en) * 1980-03-14 1981-09-15 Hoffmann-La Roche Inc. Preparation of homogeneous human fibroblast interferon
AU538665B2 (en) * 1979-10-30 1984-08-23 Juridical Foundation, Japanese Foundation For Cancer Research Human interferon dna
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
US4418149A (en) * 1980-01-10 1983-11-29 President And Fellows Of Harvard College Fused hybrid gene
DK33181A (da) * 1980-02-06 1981-08-07 Searle & Co Fremgangsmaade til fremstilling af et interferonlignende protein
GB2068970B (en) * 1980-02-06 1983-06-22 Searle & Co Recombinant dna technique for the preparation of a protein resembling human interferon
DE3005843A1 (de) * 1980-02-16 1981-09-10 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
DK170476B1 (da) * 1980-04-03 1995-09-11 Biogen Inc Rekombinant DNA-molekyle, uni-cellulær vært transformeret med mindst ét rekombinant DNA-molekyle, fremgangsmåde til transformering af en uni-cellulær vært, samt fremgangsmåder til fremstilling af et polpeptid, der udviser den immunologiske eller biologiske aktivitet af human beta-interferon
ATE25985T1 (de) * 1980-06-12 1987-04-15 Japan Found Cancer Plasmid.
US4874702A (en) * 1980-09-08 1989-10-17 Biogen, Inc. Vectors and methods for making such vectors and for expressive cloned genes

Also Published As

Publication number Publication date
FR2490675A1 (fr) 1982-03-26
LU83648A1 (de) 1983-06-08
EP0048970A3 (en) 1982-08-18
SE8105657L (sv) 1982-03-26
DK423381A (da) 1982-03-26
FI812993L (fi) 1982-03-26
ES8306325A1 (es) 1983-06-01
FR2490675B1 (fr) 1985-11-15
EP0048970A2 (en) 1982-04-07
AU582110B2 (en) 1989-03-16
HK43686A (en) 1986-06-20
NZ198445A (en) 1984-05-31
ES8306324A1 (es) 1983-06-01
GB2098996B (en) 1985-02-06
ZW23981A1 (en) 1982-04-28
IE51679B1 (en) 1987-02-04
KE3630A (en) 1986-05-16
YU44835B (en) 1991-04-30
GR81946B (es) 1984-12-12
PT73728A (en) 1981-10-01
US5460811A (en) 1995-10-24
PL233194A1 (en) 1983-07-18
MTP900B (en) 1985-02-28
ES515033A0 (es) 1983-06-01
ES515032A0 (es) 1983-06-01
AT380694B (de) 1986-06-25
DD209477A5 (de) 1984-05-09
IL63916A0 (en) 1981-12-31
IT8124109A0 (it) 1981-09-23
AU7564981A (en) 1982-04-01
IE812224L (en) 1982-03-25
MY8600634A (en) 1986-12-31
CH656388A5 (de) 1986-06-30
CA1341569C (en) 2008-03-25
DD202085A5 (de) 1983-08-24
NO813248L (no) 1982-03-26
NL8104400A (nl) 1982-04-16
DD209652A5 (de) 1984-05-16
ES505742A0 (es) 1983-07-01
PT73728B (en) 1984-05-08
CH651309A5 (de) 1985-09-13
DE3138096A1 (de) 1982-06-09
MC1423A1 (fr) 1982-10-18
OA06908A (fr) 1983-05-31
BR8106137A (pt) 1982-06-15
GB2098996A (en) 1982-12-01
YU229781A (en) 1984-02-29
IT1139487B (it) 1986-09-24
ATA410381A (de) 1985-11-15

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Legal Events

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FD1A Patent lapsed

Effective date: 19970519