ES8306325A1 - "proceso para la produccion microbiana de interferon fibroblasto humano". - Google Patents

"proceso para la produccion microbiana de interferon fibroblasto humano".

Info

Publication number
ES8306325A1
ES8306325A1 ES515033A ES515033A ES8306325A1 ES 8306325 A1 ES8306325 A1 ES 8306325A1 ES 515033 A ES515033 A ES 515033A ES 515033 A ES515033 A ES 515033A ES 8306325 A1 ES8306325 A1 ES 8306325A1
Authority
ES
Spain
Prior art keywords
human fibroblast
interfered
microbial production
polypeptide
microorganism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515033A
Other languages
English (en)
Other versions
ES515033A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26886463&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8306325(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ES8306325A1 publication Critical patent/ES8306325A1/es
Publication of ES515033A0 publication Critical patent/ES515033A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE MICROORGANISMOS CAPACES DE PRODUCIR UN POLIPEPTIDO DEL TIPO QUE COMPRENDE LA SECUENCIA AMINOACIDA DE UN INTERFERON FIBROBLASTO HUMANO. CONSISTE EN TRANSFORMAR UN MICROORGANISMO CON UN VEHICULO DE EXPRESION MICROBIANA REPETIBLE CAPAZ DE EXPRESAR DICHO POLIPEPTIDO; SEGUIDO DEL CULTIVO DEL MICROORGANISMO TRANSFORMADO. EL MICROORGANISMO TRANSFORMADO PUEDE SER UNA CEPA E. COLI, BACILLUS SUBTILIS O SACHAROMYCES CEREVISIAE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIVIRAL.
ES515033A 1980-09-25 1982-08-16 "proceso para la produccion microbiana de interferon fibroblasto humano". Granted ES515033A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19079980A 1980-09-25 1980-09-25
US29189281A 1981-08-11 1981-08-11

Publications (2)

Publication Number Publication Date
ES8306325A1 true ES8306325A1 (es) 1983-06-01
ES515033A0 ES515033A0 (es) 1983-06-01

Family

ID=26886463

Family Applications (3)

Application Number Title Priority Date Filing Date
ES505742A Expired ES8307297A1 (es) 1980-09-25 1981-09-24 Proceso para la produccion microbiana de interferon fibro- blasto humano
ES515033A Granted ES515033A0 (es) 1980-09-25 1982-08-16 "proceso para la produccion microbiana de interferon fibroblasto humano".
ES515032A Expired ES8306324A1 (es) 1980-09-25 1982-08-16 "proceso para la produccion microbiana de interferon fibroblasto humano".

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES505742A Expired ES8307297A1 (es) 1980-09-25 1981-09-24 Proceso para la produccion microbiana de interferon fibro- blasto humano

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES515032A Expired ES8306324A1 (es) 1980-09-25 1982-08-16 "proceso para la produccion microbiana de interferon fibroblasto humano".

Country Status (33)

Country Link
US (1) US5460811A (es)
EP (1) EP0048970A3 (es)
AT (1) AT380694B (es)
AU (1) AU582110B2 (es)
BR (1) BR8106137A (es)
CA (1) CA1341569C (es)
CH (2) CH656388A5 (es)
DD (3) DD209652A5 (es)
DE (1) DE3138096A1 (es)
DK (1) DK423381A (es)
ES (3) ES8307297A1 (es)
FI (1) FI812993A7 (es)
FR (1) FR2490675B1 (es)
GB (1) GB2098996B (es)
GR (1) GR81946B (es)
HK (1) HK43686A (es)
IE (1) IE51679B1 (es)
IL (1) IL63916A0 (es)
IT (1) IT1139487B (es)
KE (1) KE3630A (es)
LU (1) LU83648A1 (es)
MC (1) MC1423A1 (es)
MT (1) MTP900B (es)
MY (1) MY8600634A (es)
NL (1) NL8104400A (es)
NO (1) NO813248L (es)
NZ (1) NZ198445A (es)
OA (1) OA06908A (es)
PL (1) PL233194A1 (es)
PT (1) PT73728B (es)
SE (1) SE8105657L (es)
YU (1) YU44835B (es)
ZW (1) ZW23981A1 (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK33181A (da) * 1980-02-06 1981-08-07 Searle & Co Fremgangsmaade til fremstilling af et interferonlignende protein
ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
JP2687995B2 (ja) * 1980-04-03 1997-12-08 バイオゲン インコーポレイテッド Ｄｎａ配列、組替えｄｎａ分子およびヒト繊維芽細胞インターフェロン様ポリペプチドの製造方法
EP0042246B1 (en) * 1980-06-12 1987-03-18 The Cancer Institute Of Japanese Foundation For Cancer Research Plasmid
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
JPS58110600A (ja) * 1981-12-25 1983-07-01 Kyowa Hakko Kogyo Co Ltd ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
EP0121569B1 (en) * 1982-10-08 1990-08-22 Kyowa Hakko Kogyo Co., Ltd. Novel vector
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
US4512922A (en) * 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
GR79124B (es) * 1982-12-22 1984-10-02 Genentech Inc
US4599197A (en) * 1982-12-22 1986-07-08 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4620948A (en) * 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511502A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4518526A (en) * 1982-12-22 1985-05-21 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US5683688A (en) 1984-05-31 1997-11-04 Genentech, Inc. Unglycosylated recombinant human lymphotoxin polypeptides and compositions
GB8414354D0 (en) * 1984-06-05 1984-07-11 Biogen Nv Purifying protein
DE3574145D1 (en) * 1984-08-27 1989-12-14 Genentech Inc Novel, distinct family of human leukocyte interferons, compositions containing them, methods for their production, and dna and transfected hosts therefor
US5231176A (en) * 1984-08-27 1993-07-27 Genentech, Inc. Distinct family DNA encoding of human leukocyte interferons
US4680262A (en) * 1984-10-05 1987-07-14 Genentech, Inc. Periplasmic protein recovery
US5618920A (en) 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
EP0237019A3 (en) * 1986-03-14 1988-03-09 Toray Industries, Inc. Interferon conjugate and production thereof using recombinant gene
GB9022543D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Antibody production
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US5723125A (en) * 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
US20050002902A1 (en) * 1995-12-28 2005-01-06 Liming Yu Hybrid with interferon-alpha and an immunoglobulin Fc for treatment of tumors and viral infections
US20030026779A1 (en) * 1999-10-15 2003-02-06 Liming Yu Treatment of tumors and viral infections with a hybrid conjugate of interferon and an immunoglobulin Fc
US6713609B1 (en) * 1996-07-16 2004-03-30 Genentech, Inc. Monoclonal antibodies to type I interferon receptor
JP3576819B2 (ja) 1997-07-30 2004-10-13 キヤノン株式会社 情報処理装置及び印刷制御方法並びに記憶媒体
US20030018174A1 (en) * 1997-10-06 2003-01-23 Genentech, Inc. Monoclonal antibodies to IFNAR2
CA2368672A1 (en) 1999-03-24 2000-09-28 Genset S.A. Genomic sequence of the purh gene and purh-related biallelic markers
JP2003530838A (ja) 2000-04-12 2003-10-21 ヒューマン ゲノム サイエンシズ インコーポレイテッド アルブミン融合タンパク質
AU2002246955B2 (en) * 2001-01-09 2007-03-22 Baylor Research Institute Methods for treating autoimmune diseases in a subject and in vitro diagnostic assays
KR101271635B1 (ko) * 2001-12-21 2013-06-12 휴먼 게놈 사이언시즈, 인코포레이티드 알부민 융합 단백질
ES2425738T3 (es) 2001-12-21 2013-10-17 Human Genome Sciences, Inc. Proteínas de fusión de la albúmina
RS20050502A (sr) 2002-12-26 2007-08-03 Mountain View Pharmaceuticals Inc., Polimerni konjugati interferona- beta sa povećanom biološkom aktivnošću
PL396711A1 (pl) * 2002-12-26 2011-12-19 Mountain View Pharmaceuticals, Inc. Koniugaty polimerów z cytokinami, chemokinami, czynnikami wzrostu, hormonami polipeptydowymi i ich antagonistami, kompozycja farmaceutyczna i sposób zapobiegania, diagnozowania lub leczenia
EP1594530A4 (en) 2003-01-22 2006-10-11 Human Genome Sciences Inc HYBRID PROTEINS OF ALBUMIN
US8778880B2 (en) 2004-02-02 2014-07-15 Ambrx, Inc. Human growth hormone modified at position 35
US20070081995A1 (en) * 2005-06-22 2007-04-12 Genentech, Inc. Methods and compositions for targeting IFNAR2
US9938333B2 (en) 2008-02-08 2018-04-10 Ambrx, Inc. Modified leptin polypeptides and their uses

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1215921A (en) * 1977-11-08 1986-12-30 Arthur D. Riggs Method and means for microbial polypeptide expression
US4411994A (en) * 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
IN150740B (es) * 1978-11-24 1982-12-04 Hoffmann La Roche
US4332892A (en) * 1979-01-15 1982-06-01 President And Fellows Of Harvard College Protein synthesis
US4262090A (en) * 1979-06-04 1981-04-14 Cetus Corporation Interferon production
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4289689A (en) * 1980-03-14 1981-09-15 Hoffmann-La Roche Inc. Preparation of homogeneous human fibroblast interferon
CH648331A5 (de) * 1979-07-31 1985-03-15 Hoffmann La Roche Homogenes fibroblasten-interferon und dessen herstellung.
AU538665B2 (en) * 1979-10-30 1984-08-23 Juridical Foundation, Japanese Foundation For Cancer Research Human interferon dna
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
US4418149A (en) * 1980-01-10 1983-11-29 President And Fellows Of Harvard College Fused hybrid gene
GB2068970B (en) * 1980-02-06 1983-06-22 Searle & Co Recombinant dna technique for the preparation of a protein resembling human interferon
DK33181A (da) * 1980-02-06 1981-08-07 Searle & Co Fremgangsmaade til fremstilling af et interferonlignende protein
DE3005843A1 (de) * 1980-02-16 1981-09-10 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
JP2687995B2 (ja) * 1980-04-03 1997-12-08 バイオゲン インコーポレイテッド Ｄｎａ配列、組替えｄｎａ分子およびヒト繊維芽細胞インターフェロン様ポリペプチドの製造方法
EP0042246B1 (en) * 1980-06-12 1987-03-18 The Cancer Institute Of Japanese Foundation For Cancer Research Plasmid
US4874702A (en) * 1980-09-08 1989-10-17 Biogen, Inc. Vectors and methods for making such vectors and for expressive cloned genes

Also Published As

Publication number Publication date
DD202085A5 (de) 1983-08-24
CA1341569C (en) 2008-03-25
FR2490675B1 (fr) 1985-11-15
GB2098996A (en) 1982-12-01
NO813248L (no) 1982-03-26
EP0048970A2 (en) 1982-04-07
ATA410381A (de) 1985-11-15
IL63916A0 (en) 1981-12-31
HK43686A (en) 1986-06-20
DD209477A5 (de) 1984-05-09
ES515032A0 (es) 1983-06-01
AT380694B (de) 1986-06-25
ZW23981A1 (en) 1982-04-28
AU582110B2 (en) 1989-03-16
ES515033A0 (es) 1983-06-01
DD209652A5 (de) 1984-05-16
BR8106137A (pt) 1982-06-15
NL8104400A (nl) 1982-04-16
CH651309A5 (de) 1985-09-13
OA06908A (fr) 1983-05-31
DK423381A (da) 1982-03-26
FI812993L (fi) 1982-03-26
US5460811A (en) 1995-10-24
PT73728B (en) 1984-05-08
AU7564981A (en) 1982-04-01
NZ198445A (en) 1984-05-31
MY8600634A (en) 1986-12-31
PT73728A (en) 1981-10-01
YU229781A (en) 1984-02-29
ES8306324A1 (es) 1983-06-01
IE51679B1 (en) 1987-02-04
EP0048970A3 (en) 1982-08-18
IT8124109A0 (it) 1981-09-23
PL233194A1 (en) 1983-07-18
IT1139487B (it) 1986-09-24
LU83648A1 (de) 1983-06-08
MTP900B (en) 1985-02-28
FR2490675A1 (fr) 1982-03-26
YU44835B (en) 1991-04-30
DE3138096A1 (de) 1982-06-09
KE3630A (en) 1986-05-16
GB2098996B (en) 1985-02-06
FI812993A7 (fi) 1982-03-26
SE8105657L (sv) 1982-03-26
IE812224L (en) 1982-03-25
ES505742A0 (es) 1983-07-01
GR81946B (es) 1984-12-12
MC1423A1 (fr) 1982-10-18
ES8307297A1 (es) 1983-07-01
CH656388A5 (de) 1986-06-30

Similar Documents

Publication Publication Date Title
ES8306325A1 (es) "proceso para la produccion microbiana de interferon fibroblasto humano".
ES8402351A1 (es) Procedimiento para producir interferon inmune humano.
AR241314A1 (es) Aislado de adn, vector en base en dicho aislado cultivo de celulas tratadas con dicho vector y preparacion de factor viii humano funcional.
ES8207514A1 (es) Un procedimiento para la preparacion de interferon
AU1672388A (en) Expression of human proapolipoprotein a-i
MX9700818A (es) Produccion bacteriana de polipeptidos hidrofobicos.
ES8401133A1 (es) Metodo para preparar albumina de suero humano o una proteina de fusion de la misma.
AU566348B2 (en) Yeast hybrid vectors and their use for the production of polypeptides
DK0559884T4 (da) Rekombinante virusvektorer til ekspression i muskelceller
ES2121854T3 (es) Enzimas estabilizadas.
MD1652G2 (ro) Proteină cu activitate de tip citochină, ADN recombinant, codificator pentru această proteină, celule şi microorganisme transformate, vector de expresie, procedeu de obţinere a proteinei şi remediu care conţine această proteină
ES420458A1 (es) Procedimiento para la preparacion de heptapeptidos.
ES2108228T3 (es) Factor de diferenciacion de megacariocitos.
ES2006476A6 (es) Un procedimiento para obtener interleukin-2 humana
ES2055684T5 (es) Composicion farmaceutica que contiene un factor estimulante de colonias de granulocitos para el tratamiento de la leucopenia.
ES2068201T3 (es) Produccion de kalicreina.
AU1299588A (en) Polypeptides with activity against gram-positive and gram-negative bacteria
ES2045009T3 (es) El acido taurohyodesoxicolico para la terapia de calculosis del tracto biliar y de la dispepsia biliar.
ES8300857A1 (es) Un procedimiento para la sintesis de insulina humana
ES2063837T3 (es) Nuevo procedimiento para la sintesis de la levodopa.
ES8205416A1 (es) Un procedimiento para obtener el factor a2 del antibiotico a-16686.
ES8707554A1 (es) Procedimiento para preparar interferon-a recombinante
Sheehan et al. The synthesis and reactions of N-acyl thiol amino acids
ES8800722A1 (es) Metodo de produccion de un factor liberador de la hormona del crecimiento por la expresion en e. coli de polipeptidos hibridos
Benesch et al. a Model for the Configuration of Sulf-Hydryl Groups in Proteins

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970505