ES8306325A1 - "proceso para la produccion microbiana de interferon fibroblasto humano". - Google Patents

"proceso para la produccion microbiana de interferon fibroblasto humano".

Info

Publication number
ES8306325A1
ES8306325A1 ES515033A ES515033A ES8306325A1 ES 8306325 A1 ES8306325 A1 ES 8306325A1 ES 515033 A ES515033 A ES 515033A ES 515033 A ES515033 A ES 515033A ES 8306325 A1 ES8306325 A1 ES 8306325A1
Authority
ES
Spain
Prior art keywords
polypeptides
compositions containing
interferon
microbial production
intermediates therefor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515033A
Other languages
English (en)
Other versions
ES515033A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26886463&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8306325(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ES515033A0 publication Critical patent/ES515033A0/es
Publication of ES8306325A1 publication Critical patent/ES8306325A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE MICROORGANISMOS CAPACES DE PRODUCIR UN POLIPEPTIDO DEL TIPO QUE COMPRENDE LA SECUENCIA AMINOACIDA DE UN INTERFERON FIBROBLASTO HUMANO. CONSISTE EN TRANSFORMAR UN MICROORGANISMO CON UN VEHICULO DE EXPRESION MICROBIANA REPETIBLE CAPAZ DE EXPRESAR DICHO POLIPEPTIDO; SEGUIDO DEL CULTIVO DEL MICROORGANISMO TRANSFORMADO. EL MICROORGANISMO TRANSFORMADO PUEDE SER UNA CEPA E. COLI, BACILLUS SUBTILIS O SACHAROMYCES CEREVISIAE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIVIRAL.
ES515033A 1980-09-25 1982-08-16 "proceso para la produccion microbiana de interferon fibroblasto humano". Expired ES8306325A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19079980A 1980-09-25 1980-09-25
US29189281A 1981-08-11 1981-08-11

Publications (2)

Publication Number Publication Date
ES515033A0 ES515033A0 (es) 1983-06-01
ES8306325A1 true ES8306325A1 (es) 1983-06-01

Family

ID=26886463

Family Applications (3)

Application Number Title Priority Date Filing Date
ES505742A Expired ES8307297A1 (es) 1980-09-25 1981-09-24 Proceso para la produccion microbiana de interferon fibro- blasto humano
ES515033A Expired ES8306325A1 (es) 1980-09-25 1982-08-16 "proceso para la produccion microbiana de interferon fibroblasto humano".
ES515032A Expired ES8306324A1 (es) 1980-09-25 1982-08-16 "proceso para la produccion microbiana de interferon fibroblasto humano".

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES505742A Expired ES8307297A1 (es) 1980-09-25 1981-09-24 Proceso para la produccion microbiana de interferon fibro- blasto humano

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES515032A Expired ES8306324A1 (es) 1980-09-25 1982-08-16 "proceso para la produccion microbiana de interferon fibroblasto humano".

Country Status (33)

Country Link
US (1) US5460811A (es)
EP (1) EP0048970A3 (es)
AT (1) AT380694B (es)
AU (1) AU582110B2 (es)
BR (1) BR8106137A (es)
CA (1) CA1341569C (es)
CH (2) CH651309A5 (es)
DD (3) DD202085A5 (es)
DE (1) DE3138096A1 (es)
DK (1) DK423381A (es)
ES (3) ES8307297A1 (es)
FI (1) FI812993L (es)
FR (1) FR2490675B1 (es)
GB (1) GB2098996B (es)
GR (1) GR81946B (es)
HK (1) HK43686A (es)
IE (1) IE51679B1 (es)
IL (1) IL63916A0 (es)
IT (1) IT1139487B (es)
KE (1) KE3630A (es)
LU (1) LU83648A1 (es)
MC (1) MC1423A1 (es)
MT (1) MTP900B (es)
MY (1) MY8600634A (es)
NL (1) NL8104400A (es)
NO (1) NO813248L (es)
NZ (1) NZ198445A (es)
OA (1) OA06908A (es)
PL (1) PL233194A1 (es)
PT (1) PT73728B (es)
SE (1) SE8105657L (es)
YU (1) YU44835B (es)
ZW (1) ZW23981A1 (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK33181A (da) * 1980-02-06 1981-08-07 Searle & Co Fremgangsmaade til fremstilling af et interferonlignende protein
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
ES8302096A1 (es) 1980-04-03 1982-12-16 Biogen Nv Un metodo de producir un polipeptido que muestra una actividad immunologica obiologica de interferon de fibroblasto hu- mano.
ATE25985T1 (de) * 1980-06-12 1987-04-15 Japan Found Cancer Plasmid.
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
JPS58110600A (ja) * 1981-12-25 1983-07-01 Kyowa Hakko Kogyo Co Ltd ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
EP0121569B1 (en) * 1982-10-08 1990-08-22 Kyowa Hakko Kogyo Co., Ltd. Novel vector
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
US4518526A (en) * 1982-12-22 1985-05-21 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4599197A (en) * 1982-12-22 1986-07-08 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4620948A (en) * 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511502A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4512922A (en) * 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
GR79124B (es) * 1982-12-22 1984-10-02 Genentech Inc
US5683688A (en) * 1984-05-31 1997-11-04 Genentech, Inc. Unglycosylated recombinant human lymphotoxin polypeptides and compositions
GB8414354D0 (en) * 1984-06-05 1984-07-11 Biogen Nv Purifying protein
US5231176A (en) * 1984-08-27 1993-07-27 Genentech, Inc. Distinct family DNA encoding of human leukocyte interferons
DE3574145D1 (en) * 1984-08-27 1989-12-14 Genentech Inc Novel, distinct family of human leukocyte interferons, compositions containing them, methods for their production, and dna and transfected hosts therefor
US4680262A (en) * 1984-10-05 1987-07-14 Genentech, Inc. Periplasmic protein recovery
US5618920A (en) 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
EP0237019A3 (en) * 1986-03-14 1988-03-09 Toray Industries, Inc. Interferon conjugate and production thereof using recombinant gene
GB9022543D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Antibody production
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US5723125A (en) * 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
US20030026779A1 (en) * 1999-10-15 2003-02-06 Liming Yu Treatment of tumors and viral infections with a hybrid conjugate of interferon and an immunoglobulin Fc
US20050002902A1 (en) * 1995-12-28 2005-01-06 Liming Yu Hybrid with interferon-alpha and an immunoglobulin Fc for treatment of tumors and viral infections
US6713609B1 (en) * 1996-07-16 2004-03-30 Genentech, Inc. Monoclonal antibodies to type I interferon receptor
JP3576819B2 (ja) 1997-07-30 2004-10-13 キヤノン株式会社 情報処理装置及び印刷制御方法並びに記憶媒体
US20030018174A1 (en) * 1997-10-06 2003-01-23 Genentech, Inc. Monoclonal antibodies to IFNAR2
CA2368672A1 (en) * 1999-03-24 2000-09-28 Genset S.A. Genomic sequence of the purh gene and purh-related biallelic markers
AU2001266557A1 (en) 2000-04-12 2001-10-23 Human Genome Sciences, Inc. Albumin fusion proteins
DK1351707T3 (da) * 2001-01-09 2011-07-11 Baylor Res Inst Fremgangsmåder til behandling af autoimmunsygdomme hos et individ og in vitro-diagnostiske analyser
KR101271635B1 (ko) * 2001-12-21 2013-06-12 휴먼 게놈 사이언시즈, 인코포레이티드 알부민 융합 단백질
EP2261250B1 (en) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. GCSF-Albumin fusion proteins
WO2004060300A2 (en) * 2002-12-26 2004-07-22 Mountain View Pharmaceuticals, Inc. Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity
BR0317742A (pt) 2002-12-26 2005-11-22 Mountain View Pharmaceuticals Conjugados poliméricos de interferon-beta com potência biológica aumentada
CA2513213C (en) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
WO2005074650A2 (en) 2004-02-02 2005-08-18 Ambrx, Inc. Modified human four helical bundle polypeptides and their uses
CN101243105A (zh) * 2005-06-22 2008-08-13 健泰科生物技术公司 用于靶向ifnar2的方法和组合物
JP5702150B2 (ja) 2008-02-08 2015-04-15 アンブルックス, インコーポレイテッドAmbrx, Inc. 修飾されているレプチンポリペプチドおよびそれらの使用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI783365A (fi) * 1977-11-08 1979-05-09 Genentech Inc Foerfarande foer mikrobipolypeptiduttryck
US4411994A (en) * 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
IN150740B (es) * 1978-11-24 1982-12-04 Hoffmann La Roche
US4332892A (en) * 1979-01-15 1982-06-01 President And Fellows Of Harvard College Protein synthesis
US4262090A (en) * 1979-06-04 1981-04-14 Cetus Corporation Interferon production
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4289689A (en) * 1980-03-14 1981-09-15 Hoffmann-La Roche Inc. Preparation of homogeneous human fibroblast interferon
ZA803943B (en) * 1979-07-31 1981-06-24 Hoffmann La Roche Homogeneous fibroblast interferon and method for manufacture thereof
AU538665B2 (en) * 1979-10-30 1984-08-23 Juridical Foundation, Japanese Foundation For Cancer Research Human interferon dna
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
US4418149A (en) * 1980-01-10 1983-11-29 President And Fellows Of Harvard College Fused hybrid gene
DK33181A (da) * 1980-02-06 1981-08-07 Searle & Co Fremgangsmaade til fremstilling af et interferonlignende protein
GB2068970B (en) * 1980-02-06 1983-06-22 Searle & Co Recombinant dna technique for the preparation of a protein resembling human interferon
DE3005843A1 (de) * 1980-02-16 1981-09-10 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
ES8302096A1 (es) * 1980-04-03 1982-12-16 Biogen Nv Un metodo de producir un polipeptido que muestra una actividad immunologica obiologica de interferon de fibroblasto hu- mano.
ATE25985T1 (de) * 1980-06-12 1987-04-15 Japan Found Cancer Plasmid.
US4874702A (en) * 1980-09-08 1989-10-17 Biogen, Inc. Vectors and methods for making such vectors and for expressive cloned genes

Also Published As

Publication number Publication date
GB2098996B (en) 1985-02-06
YU229781A (en) 1984-02-29
SE8105657L (sv) 1982-03-26
EP0048970A2 (en) 1982-04-07
NO813248L (no) 1982-03-26
ZW23981A1 (en) 1982-04-28
ES515033A0 (es) 1983-06-01
FR2490675B1 (fr) 1985-11-15
EP0048970A3 (en) 1982-08-18
PT73728A (en) 1981-10-01
ES515032A0 (es) 1983-06-01
US5460811A (en) 1995-10-24
DE3138096A1 (de) 1982-06-09
IT1139487B (it) 1986-09-24
GB2098996A (en) 1982-12-01
DD202085A5 (de) 1983-08-24
IE51679B1 (en) 1987-02-04
DD209477A5 (de) 1984-05-09
AT380694B (de) 1986-06-25
OA06908A (fr) 1983-05-31
HK43686A (en) 1986-06-20
ES8306324A1 (es) 1983-06-01
PT73728B (en) 1984-05-08
MY8600634A (en) 1986-12-31
KE3630A (en) 1986-05-16
FR2490675A1 (fr) 1982-03-26
IT8124109A0 (it) 1981-09-23
CH651309A5 (de) 1985-09-13
NL8104400A (nl) 1982-04-16
NZ198445A (en) 1984-05-31
ES505742A0 (es) 1983-07-01
ES8307297A1 (es) 1983-07-01
CH656388A5 (de) 1986-06-30
BR8106137A (pt) 1982-06-15
IL63916A0 (en) 1981-12-31
AU7564981A (en) 1982-04-01
YU44835B (en) 1991-04-30
AU582110B2 (en) 1989-03-16
PL233194A1 (en) 1983-07-18
FI812993L (fi) 1982-03-26
MTP900B (en) 1985-02-28
DK423381A (da) 1982-03-26
ATA410381A (de) 1985-11-15
LU83648A1 (de) 1983-06-08
IE812224L (en) 1982-03-25
DD209652A5 (de) 1984-05-16
MC1423A1 (fr) 1982-10-18
CA1341569C (en) 2008-03-25
GR81946B (es) 1984-12-12

Similar Documents

Publication Publication Date Title
ES8306325A1 (es) "proceso para la produccion microbiana de interferon fibroblasto humano".
ES8207514A1 (es) Un procedimiento para la preparacion de interferon
ES8304200A1 (es) "un procedimiento para formar dna doble filamentado".
HK1013847A1 (en) Gdf-1 and uog-1 proteins
IE822479L (en) Dna molecules encoding certain mammalian proteins
HUT46061A (en) Dna sequences encoding hirudin-like protein and process for producing such proteins
IE832259L (en) Dna sequences swine growth hormone polypeptides
ES8506347A1 (es) Un metodo para producir un polipeptido de tipo il-2-".
MX9203645A (es) Nuevos interferones de humano y proceso biotecnologico para su produccion.
EP0422217A4 (en) Human recombinant placental ribonuclease inhibitor and method of production
EP0146903A3 (en) Production of a vector encoding a novel hybrid interferon species

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970505