ES8205416A1 - Un procedimiento para obtener el factor a2 del antibiotico a-16686. - Google Patents

Un procedimiento para obtener el factor a2 del antibiotico a-16686.

Info

Publication number
ES8205416A1
ES8205416A1 ES504749A ES504749A ES8205416A1 ES 8205416 A1 ES8205416 A1 ES 8205416A1 ES 504749 A ES504749 A ES 504749A ES 504749 A ES504749 A ES 504749A ES 8205416 A1 ES8205416 A1 ES 8205416A1
Authority
ES
Spain
Prior art keywords
antibiotic
factors
factor
produced
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES504749A
Other languages
English (en)
Other versions
ES504749A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Gruppo Lepetit SpA
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruppo Lepetit SpA, Lepetit SpA filed Critical Gruppo Lepetit SpA
Publication of ES8205416A1 publication Critical patent/ES8205416A1/es
Publication of ES504749A0 publication Critical patent/ES504749A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/045—Actinoplanes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/827—Actinoplanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DEL FACTOR A2 DEL ANTIBIOTICO A-16686 COMO COMPUESTO PURO,ASI COMO DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES Y NO TOXICAS. CONSISTE EN EL CULTIVO DE LA CEPA "ACTINOPLANES SP" ATCC 33076 EN CONDICIONES DE FERMENTACION AEROBICA SUMERGIDA, EN MEDIO DE CULTIVO ACUOSO QUE CONTIENE FUENTES ASIMILADAS DE CARBONO Y NITROGENO Y SALES INORGANICAS, RECUPERACION DE LA ACTIVIDAD ANTIBIOTICA PRODUCIDA DEL MEDIO DE FERMENTACION, POR EXTRACCION CON UN DISOLVENTE ORGANICO TAL COMO UN ALCANOL INFERIOR O ACETONA, EN FORMA DE UN COMPLEJO DE LOS FACTORES A1, A2 Y A3, SE PARACION DEL FACTOR A2 DEL ANTIBIOTICO A-16686 A PARTIR DEL C OMPLEJO POR CROMATOGRAFIA EN COLUMNA Y PURIFICACION DEL MISMO. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS COMO INHIBIDOR DE BACTERIAS PATOGENAS Y GRAM-POSITIVAS Y PARA EL TRATAMIENTO DE LA CARIES DENTA.
ES504749A 1980-08-16 1981-08-14 Un procedimiento para obtener el factor a2 del antibiotico a-16686. Granted ES504749A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8026758 1980-08-16

Publications (2)

Publication Number Publication Date
ES8205416A1 true ES8205416A1 (es) 1982-06-01
ES504749A0 ES504749A0 (es) 1982-06-01

Family

ID=10515502

Family Applications (1)

Application Number Title Priority Date Filing Date
ES504749A Granted ES504749A0 (es) 1980-08-16 1981-08-14 Un procedimiento para obtener el factor a2 del antibiotico a-16686.

Country Status (25)

Country Link
US (1) US4427656A (es)
EP (1) EP0046201B1 (es)
JP (2) JPS5754592A (es)
KR (1) KR840001255B1 (es)
AR (1) AR225540A1 (es)
AT (1) ATE7031T1 (es)
AU (1) AU548780B2 (es)
CA (1) CA1178227A (es)
DE (1) DE3163075D1 (es)
DK (1) DK149337C (es)
ES (1) ES504749A0 (es)
FI (1) FI66022C (es)
GR (1) GR74561B (es)
HK (1) HK97986A (es)
HU (1) HU188684B (es)
IE (1) IE52026B1 (es)
IL (1) IL63478A (es)
MX (1) MX6964E (es)
MY (1) MY8700106A (es)
NO (1) NO155814B (es)
NZ (1) NZ198041A (es)
PH (1) PH17270A (es)
PT (1) PT73526B (es)
YU (1) YU42725B (es)
ZA (1) ZA815374B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4613503A (en) * 1984-10-11 1986-09-23 The Dow Chemical Company Antibiotic A26201-1 and antibiotic A26201-2 produced by a novel strain of actinoplanes
GB8621911D0 (en) * 1986-09-11 1986-10-15 Lepetit Spa Increasing ratio of components of anti-biotic complex
GB8727807D0 (en) * 1987-11-27 1987-12-31 Lepetit Spa Novel antibiotic compounds named a/16686 factors a'1,a'2 and a'3
GB8729989D0 (en) * 1987-12-23 1988-02-03 Lepetit Spa Novel hydrogenated derivatives of antibiotic a/16686
GB8808658D0 (en) * 1988-04-13 1988-05-18 Lepetit Spa Aglycons of a/16686 antibiotics
AU2002212014A1 (en) * 2000-10-13 2002-04-22 Ecopia Biosciences Inc. Gene cluster for ramoplanin biosynthesis
US20030211567A1 (en) * 2001-07-24 2003-11-13 Ecopia Biosciences, Inc. Compositions, methods and systems for discovery of lipopeptides
US7235651B2 (en) * 2001-12-26 2007-06-26 Cubist Pharmaceuticals, Inc. Genes and proteins involved in the biosynthesis of lipopeptides
AU2003267962A1 (en) * 2002-05-31 2003-12-19 The Trustees Of The University Of Pennsylvania Antibacterial compounds and methods for treating gram positive bacterial infections
AU2003240545A1 (en) * 2002-06-06 2003-12-22 Therapeutics Corporation Genome Use of ramoplanin to treat diseases associated with the use of antibiotics
AU2003274927A1 (en) * 2002-08-23 2004-03-11 Genome Therapeutics Corporation Methods and reagents for preventing bacteremias
US20040127403A1 (en) * 2002-09-06 2004-07-01 Francesco Parenti Methods for treating and preventing Gram-positive bacteremias
US20050043223A1 (en) * 2003-04-25 2005-02-24 Leach Timothy S. Methods for reducing or preventing transmission of nosocomial pathogens in a health care facility
CN101024661B (zh) * 2006-02-24 2010-05-12 上海医药工业研究院 一种雷莫拉宁三种单组分的分离方法
US20180002741A1 (en) 2016-07-01 2018-01-04 The United States Of America As Represented By The Department Of Veterans Affairs Method of diagnosis and treating gastrointestinal and neurological diseases associated with species of genus clostridium

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE790627A (fr) * 1971-10-27 1973-04-27 Lilly Co Eli L'antibiotique a477 et son procede de preparation
US3824305A (en) 1973-01-22 1974-07-16 Lilly Co Eli Antibiotic a-287 and process for production thereof
GB1458512A (en) * 1973-11-22 1976-12-15 Lepetit Spa Antibiotic substance
GB1496386A (en) 1975-03-05 1977-12-30 Lepetit Spa Antibiotics
US4115552A (en) * 1976-04-19 1978-09-19 Eli Lilly And Company Factor A and B of antibiotic A-4696
GB2045231B (en) * 1979-04-07 1983-08-03 Lepetit Spa Antibiotic a/16686 and its preparation from actinoplanes
ZA801629B (en) 1979-04-07 1981-03-25 Lepetit Spa Antibiotic a/16686 and process for the preparation thereof

Also Published As

Publication number Publication date
FI812496L (fi) 1982-02-17
MX6964E (es) 1987-01-08
JPS5754592A (en) 1982-04-01
EP0046201A2 (en) 1982-02-24
FI66022C (fi) 1984-08-10
AR225540A1 (es) 1982-03-31
NO812732L (no) 1982-02-17
JPS63126890A (ja) 1988-05-30
ZA815374B (en) 1982-08-25
AU7355381A (en) 1982-02-25
JPS6254432B2 (es) 1987-11-14
ATE7031T1 (de) 1984-04-15
DK149337B (da) 1986-05-05
JPH0225919B2 (es) 1990-06-06
GR74561B (es) 1984-06-29
CA1178227A (en) 1984-11-20
DK149337C (da) 1986-10-13
PT73526B (en) 1982-11-03
EP0046201A3 (en) 1982-03-03
US4427656A (en) 1984-01-24
HK97986A (en) 1986-12-19
IL63478A0 (en) 1981-10-30
IL63478A (en) 1984-06-29
ES504749A0 (es) 1982-06-01
YU198181A (en) 1983-10-31
HU188684B (en) 1986-05-28
NO155814B (no) 1987-02-23
DE3163075D1 (en) 1984-05-17
KR840001255B1 (ko) 1984-09-01
IE811869L (en) 1982-02-16
PH17270A (en) 1984-07-03
DK362681A (da) 1982-02-17
YU42725B (en) 1988-12-31
FI66022B (fi) 1984-04-30
PT73526A (en) 1981-09-01
IE52026B1 (en) 1987-05-27
NZ198041A (en) 1985-01-31
EP0046201B1 (en) 1984-04-11
MY8700106A (en) 1987-12-31
AU548780B2 (en) 1986-01-02

Similar Documents

Publication Publication Date Title
ES8205416A1 (es) Un procedimiento para obtener el factor a2 del antibiotico a-16686.
HUT34746A (en) Process for the production of 2-pyrimidinil-1-piperazine-derivatives and of medical preparations containing them as agent
ES478047A1 (es) Procedimiento para la obtencion de acidos 4-piridon-3-car- boxilicos.
ZM4185A1 (en) Novel compounds
MY110747A (en) Quinolone-and naphthyridonecarboxylic acid derivatives
ES8203964A1 (es) Un procedimiento para la preparacion de compuestos de polie-ter antibioticos
MD1688G2 (ro) Benzotiofen, benzofuran şi indoltiazepinone, oxazepinone şi diazepinone, compoziţie farmaceutică, metodă de inhibare a aderării leucocitelor la celulele endoteliale pentru tratamentul proceselor inflamatorii şi metodă de tratament al mamiferelor infectate cu HIV infecţie .
ES8500931A1 (es) Procedimiento para la obtencion de acidos quinoloncarboxilicos
ES8702427A1 (es) Un procedimiento para preparar derivados de 1,3-difosfonato
ES2010729A6 (es) Un procedimiento para prerparar un des-acil- antibiotico a 40926.
UA19149A (uk) Спосіб одержаhhя кристалічhого моhогідратhої форми 1-карбацефалоспориhу
ES8304919A1 (es) Un procedimiento para la preparacion de dicloroamino-acidos.
DE2967356D1 (en) Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them
ES8308833A1 (es) "un metodo para la preparacion de 3-fenil-1-indanaminas".
GB1394034A (en) Mouth and teeth care means for the prevention of tartar formation
ES8302634A1 (es) Procedimiento de preparacion de derivados del acido metilen-2-succinamico
GB1529598A (en) Preparation of 3-cephem compounds
GB1434582A (en) Animal feed supplements
HUT46212A (en) Process for production of antibacterial liofilized compounds
GB1312129A (en) Antibiotic and process for preparing same
ES434945A1 (es) Procedimiento para la obtencion de derivados del acido 2- cloroetanofosfonico.
IL71413A (en) 6-hydroxyethyl-2-carbamoyl ethylthio penem-3-carboxylic acid and esters thereof,pharmaceutical compositions comprising them and process for their preparation
ES453057A1 (es) Procedimiento para preparar derivados de imidazolidindiona.
ES8303297A1 (es) Un procedimiento para la preparacion de un nuevo reptido activo.
EP0189587A3 (en) Method of sterilizing recombinant microorganism