ES8203964A1 - Un procedimiento para la preparacion de compuestos de polie-ter antibioticos - Google Patents

Un procedimiento para la preparacion de compuestos de polie-ter antibioticos

Info

Publication number
ES8203964A1
ES8203964A1 ES498922A ES498922A ES8203964A1 ES 8203964 A1 ES8203964 A1 ES 8203964A1 ES 498922 A ES498922 A ES 498922A ES 498922 A ES498922 A ES 498922A ES 8203964 A1 ES8203964 A1 ES 8203964A1
Authority
ES
Spain
Prior art keywords
ruminants
medicaments
manufacture
products
growth promoting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES498922A
Other languages
English (en)
Other versions
ES498922A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22368677&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8203964(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES498922A0 publication Critical patent/ES498922A0/es
Publication of ES8203964A1 publication Critical patent/ES8203964A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/365—Nocardia

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE POLIETER ANTIBIOTICOS DE FORMULA (I), EN LA QUE R ES HIDROGENO O RADICAL METILO, Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES. CONSISTE EN EL CULTIVO DE LA CEPA NOCARDIA X-14868 ATCC 31585 EN UNA DISOLUCION ACUOSA DE CARBOHIDRATOS QUE CONTIENE UN NUTRIENTE NITROGENADO, EN PRESENCIA DE SALES MINERALES, A PH SUSTANCIALMENTE NEUTRO, EN CONDICIONES AEROBICAS SUMERGIDAS Y A UNA TEMPERATURA ENTRE 20 Y 30 C, SEGUIDO DE LA SEPARACION Y PURIFICACION DE LOS PRODUCTOS OBTENIDOS, SIGUIENDO METODOS CONVENCIONALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIMICROBIANA.
ES498922A 1980-01-30 1981-01-29 Un procedimiento para la preparacion de compuestos de polie-ter antibioticos Expired ES8203964A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/116,696 US4278663A (en) 1980-01-30 1980-01-30 Antibiotic X-14868A, B, C and D

Publications (2)

Publication Number Publication Date
ES498922A0 ES498922A0 (es) 1982-05-01
ES8203964A1 true ES8203964A1 (es) 1982-05-01

Family

ID=22368677

Family Applications (1)

Application Number Title Priority Date Filing Date
ES498922A Expired ES8203964A1 (es) 1980-01-30 1981-01-29 Un procedimiento para la preparacion de compuestos de polie-ter antibioticos

Country Status (22)

Country Link
US (1) US4278663A (es)
EP (1) EP0035119B1 (es)
JP (1) JPS56120696A (es)
KR (1) KR840000750B1 (es)
AR (1) AR227660A1 (es)
AT (1) ATE4217T1 (es)
AU (1) AU536300B2 (es)
CA (1) CA1160972A (es)
DE (1) DE3160616D1 (es)
DK (1) DK149639C (es)
ES (1) ES8203964A1 (es)
FI (1) FI70247C (es)
GR (1) GR73021B (es)
HU (1) HU187763B (es)
IE (1) IE50886B1 (es)
IL (1) IL61971A (es)
MC (1) MC1364A1 (es)
NO (1) NO156612C (es)
NZ (1) NZ196099A (es)
PH (1) PH16583A (es)
PT (1) PT72417B (es)
ZA (1) ZA81151B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS577492A (en) 1980-06-13 1982-01-14 Shionogi & Co Ltd K-41 derivative
US4407946A (en) * 1981-10-22 1983-10-04 American Cyanamid Company Process for producing antibiotic X-14868A
CA1198386A (en) * 1981-10-22 1985-12-24 Donald B. Borders ANTIBACTERIAL AGENTS LL-C23024.beta. AND IOTA AND MICROORGANISM ACTINOMADURA YUMAENSE NRRL 12515
US4510134A (en) * 1982-05-07 1985-04-09 American Cyanamid Co. Controlling nematodes in animals and soil with nematocidal antibiotics
US4565862A (en) * 1982-11-29 1986-01-21 Hoffmann-La Roche Inc. Ethers of antibiotic X-14868A
ZA838562B (en) * 1982-11-29 1984-07-25 Hoffmann La Roche Ethers
US4496549A (en) * 1983-01-17 1985-01-29 American Cyanamid Company Treatment of malaria with antibiotics
US4628046A (en) * 1983-06-20 1986-12-09 American Cyanamid Company Antibiotic LL-C23201δ
GB8417785D0 (en) * 1984-07-12 1984-08-15 Pfizer Ltd Polycyclic ether antibiotic
US4824829A (en) * 1984-08-15 1989-04-25 American Cyanamid Company Non-dusting antibiotic, anticoccidial premix compositions and a process for their manufacture
US4582822A (en) * 1984-10-09 1986-04-15 Eli Lilly And Company Antibiotic A80190, pharmaceutical compositions containing same and method of use
EP0182117B1 (en) * 1984-11-15 1989-10-18 American Cyanamid Company Anticoccidial compostions
US4824863A (en) * 1985-05-28 1989-04-25 Eli Lilly And Company Antibiotic A80438
GB8618844D0 (en) * 1986-08-01 1986-09-10 Pfizer Ltd Polycyclic ether antibiotics
DE3638445A1 (de) * 1986-11-11 1988-05-26 Hoechst Ag Coccidiozide mittel
US4816480A (en) * 1987-05-12 1989-03-28 American Cyanamid Company Method for the preparation of feed premix in compositions of maduramicin
DE3884741T2 (de) * 1987-10-26 1994-01-27 Pfizer Mikrobiologisches Verfahren zur Herstellung von UK-61.689 und Mikroorganismen zur Verwendung darin.
US5034224A (en) * 1989-05-30 1991-07-23 American Cyanamid Company Method and composition for treating protozoal infections
US5242814A (en) * 1989-10-10 1993-09-07 Eli Lilly And Company Polyether antibiotic
US5043353A (en) * 1989-10-10 1991-08-27 Eli Lilly And Company A80789 polyether antibiotic
FR2700778B1 (fr) * 1993-01-27 1995-04-14 Agronomique Inst Nat Rech Milieu sélectif et procédé pour le dénombrement des bactéries propioniques.
CN106008625B (zh) * 2016-05-19 2018-07-20 宁夏泰瑞制药股份有限公司 一种利用马杜霉素发酵液制备马杜米星铵的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4138481A (en) * 1976-06-30 1979-02-06 American Cyanamid Company Antibiotic BL580Δ and method of use

Also Published As

Publication number Publication date
JPS56120696A (en) 1981-09-22
DE3160616D1 (en) 1983-08-25
AR227660A1 (es) 1982-11-30
KR840000750B1 (ko) 1984-05-31
NO156612B (no) 1987-07-13
ES498922A0 (es) 1982-05-01
EP0035119B1 (de) 1983-07-20
IL61971A0 (en) 1981-02-27
IL61971A (en) 1984-01-31
EP0035119A2 (de) 1981-09-09
IE810172L (en) 1981-07-30
GR73021B (es) 1984-01-25
IE50886B1 (en) 1986-08-06
AU536300B2 (en) 1984-05-03
CA1160972A (en) 1984-01-24
FI810252L (fi) 1981-07-31
DK149639B (da) 1986-08-18
ATE4217T1 (de) 1983-08-15
DK29881A (da) 1981-07-31
FI70247C (fi) 1986-09-15
JPH0250918B2 (es) 1990-11-05
FI70247B (fi) 1986-02-28
US4278663A (en) 1981-07-14
KR830005358A (ko) 1983-08-13
NZ196099A (en) 1984-07-06
DK149639C (da) 1987-02-02
PH16583A (en) 1983-11-22
EP0035119A3 (en) 1981-12-16
PT72417A (en) 1981-02-01
PT72417B (en) 1982-07-26
MC1364A1 (fr) 1981-10-23
AU6657281A (en) 1981-08-06
NO810319L (no) 1981-07-31
NO156612C (no) 1987-10-21
ZA81151B (en) 1982-01-27
HU187763B (en) 1986-02-28

Similar Documents

Publication Publication Date Title
ES8203964A1 (es) Un procedimiento para la preparacion de compuestos de polie-ter antibioticos
ES468475A1 (es) Procedimiento para la preparacion de derivados de cefem
DE3269875D1 (en) Derivatives of cis, endo-2-azabicyclo-(3.3.0)-octane-3-carboxylic acid, process for their preparation, medicines containing them and their use
HRP940723B1 (en) New thienylcarboxylic acid esters of aminoalcohols, their quarternary products, their preparation and use of the compounds
EP0131302A3 (en) Imidazoliums, intermediates thereto and their use
AU577595B2 (en) Crystalline calcium pseudomonate
DE3566404D1 (en) Substituted benzopyrans, process for their preparation and their use in medicines
HUT46837A (en) Compositions of insectifuge and acarifuge activity containing alpha, omega-amino-alkohol derivatives as active components and process for producing the active components
EP0033156A3 (en) 1-phenyl-2-cyclohexene-1-alkylamine derivatives, intermediates and process for their preparation, medicines containing them and their use as pharmaceutically active compounds
ES8101610A1 (es) Un procedimiento para la preparacion de acido 7-metoxi-5-oxo-5h-tiazolo (2,3-b)quinazolin-2-carboxilico
HU206669B (en) Process for producing new salts of diphenyl-acetic acid and aryl-propanol-amines
ES8203086A1 (es) Un procedimiento para la produccion de n,n'-bis-(3-picolil) -4-metoxi-isoftalamida monohidratada
ES8202561A1 (es) Un procedimiento para la produccion de 11,12-carbonato de eritromicilamina
IL71413A (en) 6-hydroxyethyl-2-carbamoyl ethylthio penem-3-carboxylic acid and esters thereof,pharmaceutical compositions comprising them and process for their preparation
ES8605261A1 (es) Un procedimiento para la preparacion de 1,4-aminoalquilamino-9-h-tioxaten-9-onas.
HUT47579A (en) Process for production of new imidazo /1,2-a/-pirimidins and their salts and medical compositions containing them as active substance
ES520955A1 (es) Procedimiento para la obtencion de 7-alfa aminoacil-3-clorocefaloesporinas.
ZA871059B (en) Novel antibiotics of the streptogramin type,a microbiological process for their preparation and their use as medicaments and feed additives
ES8405034A1 (es) Procedimiento para purificar sales de metales alcalinos de esteres de acido fosforico de corticoesteroides.
ZA823896B (en) Mandelic acid derivatives and mandelonitriles, processes for producing them, and their use for combating microorganisms
SU1132513A1 (ru) 2-метиламино-4-оксо-3,6,6-триметил-5,6-дигидро-8н-пирано[4′,3′ : 4,5]тиено[2,3-d]пиримидин или его соли, обладающие противосудорожной активностью
JPS5366494A (en) Preparation of antibiotics pa-399
SU1067801A1 (ru) 5-(n-НИТРО-β-ОКСИФЕНЕТИЛ)-1-МЕТИЛ-4,5,6,7-ТЕТРАГИДРОИМИДАЗО(4,5-С)ПИРИДИНДИГИДРОХЛОРИД, ОБЛАДАЮЩИЙ АНАЛЬГЕТИЧЕСКОЙ И ПРОТИВОВОСПАЛИТЕЛЬНОЙ АКТИВНОСТЬЮ
HU9201483D0 (en) Process for the production of 1h-rh-analogues'acid additive salts, and for the production of medical preparations containing them
ZA843615B (en) 2-alkylthio-1-aminoalkyl-2-pyrroline-3-carbonitriles,processes for their preparation,as well as their use in the prophylaxis and therapy of thrombotic states