ES8300857A1 - Un procedimiento para la sintesis de insulina humana - Google Patents

Un procedimiento para la sintesis de insulina humana

Info

Publication number
ES8300857A1
ES8300857A1 ES503568A ES503568A ES8300857A1 ES 8300857 A1 ES8300857 A1 ES 8300857A1 ES 503568 A ES503568 A ES 503568A ES 503568 A ES503568 A ES 503568A ES 8300857 A1 ES8300857 A1 ES 8300857A1
Authority
ES
Spain
Prior art keywords
proinsulin
human
transfer vectors
substances
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503568A
Other languages
English (en)
Other versions
ES503568A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of ES8300857A1 publication Critical patent/ES8300857A1/es
Publication of ES503568A0 publication Critical patent/ES503568A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA LA SINTESIS DE INSULINA HUMANA. CONSISTE EN LA PREPARACION DE PROINSULINA HUMANA QUE CONTIENE LOS PEPTIDOS A Y B SEPARADOS POR UN PEPTIDO C, INCUBANDO UN MICROORGANISMO, TRANSFORMADO POR UN VECTOR DE TRANSFERENCIA DE EXPRESION QUE COMPRENDE UNA SECUENCIA DE DESOXINUCLEOTIDOS CODIFICADORES DE LA PROINSULINA; PURIFICACION DE LA PROINSULINA A PARTIR DEL LISADO O MEDIO DE CULTIVO; OXIDACION DE LOS GRUPOS SULFHIDRILO DE LOS PEPTIDOS A Y B PARA FORMAR ENLACES DISULFURO ENTRE DICHOS PEPTIDOS; Y ESCISION DEL PEPTIDO C POR HIDROLISIS CATALIZADA POR ENZIMAS. >LA INSULINA TIENE APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA DIABETES.
ES503568A 1979-09-12 1981-06-30 Un procedimiento para la sintesis de insulina humana Granted ES503568A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7519279A 1979-09-12 1979-09-12

Publications (2)

Publication Number Publication Date
ES8300857A1 true ES8300857A1 (es) 1982-11-16
ES503568A0 ES503568A0 (es) 1982-11-16

Family

ID=22124154

Family Applications (3)

Application Number Title Priority Date Filing Date
ES495030A Expired ES8107307A1 (es) 1979-09-12 1980-09-12 Un procedimiento de preparacion de un vector de transferen- cia de adn
ES503568A Granted ES503568A0 (es) 1979-09-12 1981-06-30 Un procedimiento para la sintesis de insulina humana
ES503567A Granted ES503567A0 (es) 1979-09-12 1981-06-30 Un procedimiento de sintesis de proinsulina humana

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES495030A Expired ES8107307A1 (es) 1979-09-12 1980-09-12 Un procedimiento de preparacion de un vector de transferen- cia de adn

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES503567A Granted ES503567A0 (es) 1979-09-12 1981-06-30 Un procedimiento de sintesis de proinsulina humana

Country Status (28)

Country Link
EP (1) EP0026598A1 (es)
JP (1) JP2637393B2 (es)
KR (1) KR870000501B1 (es)
AT (1) AT377003B (es)
AU (1) AU538154B2 (es)
BE (1) BE885196A (es)
BG (2) BG41137A3 (es)
CA (1) CA1180289A (es)
CZ (2) CZ278883B6 (es)
DD (3) DD155004A5 (es)
DK (1) DK385980A (es)
ES (3) ES8107307A1 (es)
FI (1) FI802837A (es)
FR (1) FR2464997B1 (es)
GR (1) GR70279B (es)
IE (1) IE52781B1 (es)
IL (1) IL61041A (es)
IT (1) IT1129250B (es)
LU (1) LU82757A1 (es)
NZ (1) NZ194786A (es)
PH (1) PH26475A (es)
PL (1) PL226725A1 (es)
PT (1) PT71790B (es)
RO (1) RO80005A (es)
SK (1) SK621580A3 (es)
SU (1) SU1491345A3 (es)
YU (1) YU233480A (es)
ZA (1) ZA805341B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
DE3001928A1 (de) * 1980-01-19 1981-08-06 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
US4249952A (en) * 1980-03-03 1981-02-10 Pennsylvania Engineering Corporation Method for producing cement clinker from cement kiln waste dust
AU545912B2 (en) * 1980-03-10 1985-08-08 Cetus Corporation Cloned heterologous jive products in bacillies
US4338397A (en) * 1980-04-11 1982-07-06 President And Fellows Of Harvard College Mature protein synthesis
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
ZA824218B (en) * 1981-06-29 1983-04-27 Cetus Corp Plasmid for producing human insulin
JPS58183659A (ja) * 1982-03-31 1983-10-26 ジェネテイックス、インスチチュ−ト、インコ−ポレ−テッド 修飾プロインシュリン前駆体、これを暗号化するｄｎａ配列およびそれらの産生方法
NZ206534A (en) * 1982-12-13 1988-05-30 Florey Howard Inst Molecular cloning and characterisation of gene sequence coding for human relaxin
US5023321A (en) * 1982-12-13 1991-06-11 Howard Florey Institute Of Experimental Physiology & Medicine Molecular cloning and characterization of a further gene sequence coding for human relaxin
IL71991A (en) * 1983-06-06 1994-05-30 Genentech Inc Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes
DE3751863T2 (de) * 1986-05-20 1996-12-12 Gen Hospital Corp Bestimmung der Insulin Expression
ES2301178T3 (es) 1996-04-05 2008-06-16 Novartis Vaccines & Diagnostic Vectores basados en alfavirus recombinantes con inhibicion reducida de la sintesis macromolecular celular.
AUPP655698A0 (en) * 1998-10-16 1998-11-05 Commonwealth Scientific And Industrial Research Organisation Delivery system for porcine somatotropin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ187300A (en) * 1977-05-27 1982-08-17 Univ California Dna transfer vector and micro-organism modified to contain a nucleotide sequence equivalent to the gene of a higher organism
DE2848053A1 (de) * 1977-11-08 1979-05-10 Genentech Inc Synthetische dna und verfahren zu ihrer herstellung
NL7811040A (nl) * 1977-11-08 1979-05-10 Genentech Inc Synthetische dna en werkwijze ter bereiding daarvan.
US4411994A (en) * 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
GR71912B (es) * 1978-08-11 1983-08-16 Univ California

Also Published As

Publication number Publication date
RO80005B (ro) 1983-06-30
PL226725A1 (en) 1983-07-18
CZ278883B6 (en) 1994-08-17
JPS5695199A (en) 1981-08-01
BE885196A (fr) 1980-12-31
GR70279B (es) 1982-09-03
SK278191B6 (en) 1996-03-06
RO80005A (ro) 1983-07-07
ES8305420A1 (es) 1983-04-01
KR870000501B1 (ko) 1987-03-12
SU1491345A3 (ru) 1989-06-30
DD208989A5 (de) 1984-04-18
ES503568A0 (es) 1982-11-16
PT71790B (en) 1981-07-07
FR2464997A1 (fr) 1981-03-20
FR2464997B1 (fr) 1985-05-24
BG41137A3 (en) 1987-04-15
AU6232480A (en) 1981-03-19
IT8068405A0 (it) 1980-09-11
JP2637393B2 (ja) 1997-08-06
EP0026598A1 (en) 1981-04-08
IL61041A0 (en) 1980-11-30
AT377003B (de) 1985-01-25
ES495030A0 (es) 1981-10-01
IL61041A (en) 1984-02-29
ES503567A0 (es) 1983-04-01
ATA458580A (de) 1984-06-15
ES8107307A1 (es) 1981-10-01
ZA805341B (en) 1982-01-27
YU233480A (en) 1984-02-29
NZ194786A (en) 1984-02-03
LU82757A1 (fr) 1981-02-02
IE801912L (en) 1981-03-12
PH26475A (en) 1992-07-27
SK621580A3 (en) 1996-03-06
CZ548884A3 (en) 1996-08-14
BG41136A3 (en) 1987-04-15
FI802837A (fi) 1981-03-13
DK385980A (da) 1981-03-13
AU538154B2 (en) 1984-08-02
PT71790A (en) 1980-10-01
CZ621580A3 (en) 1994-03-16
KR830003576A (ko) 1983-06-21
DD201693A5 (de) 1983-08-03
CA1180289A (en) 1985-01-02
DD155004A5 (de) 1982-05-05
IE52781B1 (en) 1988-03-02
IT1129250B (it) 1986-06-04

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