MX9700818A - Produccion bacteriana de polipeptidos hidrofobicos. - Google Patents

Produccion bacteriana de polipeptidos hidrofobicos.

Info

Publication number
MX9700818A
MX9700818A MX9700818A MX9700818A MX9700818A MX 9700818 A MX9700818 A MX 9700818A MX 9700818 A MX9700818 A MX 9700818A MX 9700818 A MX9700818 A MX 9700818A MX 9700818 A MX9700818 A MX 9700818A
Authority
MX
Mexico
Prior art keywords
beta
bacterial production
production
polypeptides
hydrophobic polypeptides
Prior art date
Application number
MX9700818A
Other languages
English (en)
Inventor
Glenn Dorin
Patrick J Mcalary
Kathleen M Wong
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of MX9700818A publication Critical patent/MX9700818A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen métodos para la produccion de polipéptidos de interferon beta por células bacterianas, al cultivar células capaces de producir el polipéptido IFN- beta bajo condiciones que inducen una produccion aumentada del polipéptido de IFN- beta. Tales condiciones incluyen, por ejemplo, una concentracion baja del cation potasio y/o una muy baja concentracion del cation sodio y/o intervalos de pH específicos.
MX9700818A 1995-06-06 1996-06-05 Produccion bacteriana de polipeptidos hidrofobicos. MX9700818A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/477,310 US5814485A (en) 1995-06-06 1995-06-06 Production of interferon-β (IFN-β) in E. coli
PCT/US1996/009155 WO1996039523A2 (en) 1995-06-06 1996-06-05 Bacterial production of hydrophobic polypeptides

Publications (1)

Publication Number Publication Date
MX9700818A true MX9700818A (es) 1997-05-31

Family

ID=23895395

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9700818A MX9700818A (es) 1995-06-06 1996-06-05 Produccion bacteriana de polipeptidos hidrofobicos.

Country Status (17)

Country Link
US (1) US5814485A (es)
EP (1) EP0778893B1 (es)
JP (3) JP4131554B2 (es)
AT (1) ATE449175T1 (es)
AU (1) AU6154996A (es)
BR (1) BR9606491A (es)
CA (1) CA2195799C (es)
DE (1) DE69638077D1 (es)
FI (1) FI970445A (es)
IL (1) IL120009A0 (es)
IN (1) IN190514B (es)
MX (1) MX9700818A (es)
MY (1) MY118492A (es)
NO (1) NO324529B1 (es)
NZ (1) NZ310710A (es)
TW (1) TW494138B (es)
WO (1) WO1996039523A2 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6399996A (en) * 1996-06-19 1998-01-07 Chiron Corporation Bacterial production of interferon-beta using low levels of sodium and potassium ions
US6514729B1 (en) 1999-05-12 2003-02-04 Xencor, Inc. Recombinant interferon-beta muteins
US7544354B2 (en) * 2000-10-27 2009-06-09 Novartis Vaccines And Diagnostics Methods of protein purification and recovery
JP4262979B2 (ja) * 2000-11-21 2009-05-13 ザ・テキサス・エイ・アンド・エム・ユニバーシテイ・システム Ｆｇｆアフィニティークロマトグラフィー
US20040013642A1 (en) * 2000-11-29 2004-01-22 Katsuaki Tanaka Interferon therapeutic effect-potentiating agents
US6887462B2 (en) 2001-04-09 2005-05-03 Chiron Corporation HSA-free formulations of interferon-beta
UY27373A1 (es) * 2001-07-09 2003-02-28 Schering Ag Formulaciones de interferón beta-humano
CA2498319A1 (en) 2002-09-09 2004-03-18 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
KR20060034286A (ko) * 2003-07-11 2006-04-21 쉐링 악티엔게젤샤프트 개량된 재조합 인간 인터페론-베타-1ｂ 폴리펩티드
JP4658961B2 (ja) * 2003-12-11 2011-03-23 アレス トレーディング エス．エー． 安定化されたインターフェロン液体製剤
MXPA06008507A (es) 2004-02-02 2008-02-13 Ambrx Inc Cuatro polipeptidos en haz helicoidal humanos modificados y sus usos.
UY29544A1 (es) * 2005-05-19 2006-12-29 Schering Ag Tratamiento de enfermedades usando un sistema mejorado de expresión regulada
US20080076729A1 (en) * 2005-05-19 2008-03-27 Schering Aktiengesellachaft Interferon-beta gene therapy using an improved, regulated expression system
EP1891224A1 (en) * 2005-05-19 2008-02-27 Bayer Schering Pharma Aktiengesellschaft Interferon-beta gene therapy using an improved, regulated expression system
US20070179113A1 (en) * 2005-05-19 2007-08-02 Schering Aktiengesellachaft GM-CSF gene therapy for Crohn's disease using an improved regulated expression system
US20080003202A1 (en) * 2006-03-28 2008-01-03 Thierry Guyon Modified interferon-beta (IFN-beta) polypeptides
WO2008130382A2 (en) 2006-10-31 2008-10-30 East Carolina University Fusion proteins comprising an anti -inflammatory cytokine and an antigen for treatment of immune disorders
WO2008125222A2 (en) * 2007-04-11 2008-10-23 Bayer Schering Pharma Aktiengesellschaft New modulation molecules for an improved regulated expression system
BRPI0810622A2 (pt) 2007-05-02 2020-10-13 Ambrx, Inc. polipeptídeos de interferon beta modificados e seus usos
US8273561B2 (en) * 2007-10-05 2012-09-25 Nuron Biotech, Inc. High pressure treatment of aggregated interferons
SI2234645T1 (sl) * 2007-12-20 2012-07-31 Merck Serono Sa Formulacije peg interferon beta
MX344166B (es) 2008-02-08 2016-12-07 Ambrx Inc Leptina-polipeptidos modificados y sus usos.
KR20090124204A (ko) * 2008-05-29 2009-12-03 (주)바이오큐어팜 아미노 말단의 메티오닌이 제거된 재조합 사람 변이인터페론-베타 단백질을 생산하는 재조합 대장균 및 이의제조방법
EP2413958A4 (en) 2009-03-31 2014-04-02 Univ East Carolina CYTOKINES AND NEUROANTIGENES FOR THE TREATMENT OF IMMUNE DISEASES
EP2532734B1 (en) * 2010-02-01 2017-03-15 Proyecto de Biomedicina CIMA, S.L. Process for the production of interferon alpha 5
RU2573909C2 (ru) 2010-03-04 2016-01-27 Пфенекс Инк. Способ получения растворимого рекомбинантного белка интерферона без денатурирования
RU2473696C1 (ru) * 2011-07-14 2013-01-27 Закрытое акционерное общество "ГЕНЕРИУМ" ПРОМЫШЛЕННЫЙ СПОСОБ ПОЛУЧЕНИЯ И ОЧИСТКИ РЕКОМБИНАНТНОГО ИНТЕРФЕРОНА β-1b ЧЕЛОВЕКА ИЗ ТЕЛЕЦ ВКЛЮЧЕНИЯ
JP6363326B2 (ja) * 2013-03-11 2018-07-25 株式会社コーセー 酵母・細菌共通培養方法およびこれに用いる酵母・細菌共通培養培地
JP7151049B2 (ja) * 2018-03-30 2022-10-12 三井化学株式会社 微生物を増殖させる方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4499188A (en) * 1982-05-05 1985-02-12 Cetus Corporation Bacterial production of heterologous polypeptides under the control of a repressible promoter-operator
IE56026B1 (en) * 1982-10-19 1991-03-27 Cetus Corp Cysteine-depleted muteins of biologically active proteins
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
JPS60118196A (ja) * 1983-11-30 1985-06-25 Takeda Chem Ind Ltd インタ−フェロンの製造法
US4656132A (en) * 1984-03-28 1987-04-07 Cetus Corporation Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria
JPH0755152B2 (ja) * 1986-06-02 1995-06-14 日本化薬株式会社 組換え遺伝子産物の製法及び培地

Also Published As

Publication number Publication date
JPH11501820A (ja) 1999-02-16
NO970514L (no) 1997-03-17
FI970445A (fi) 1997-03-26
BR9606491A (pt) 1997-09-02
ATE449175T1 (de) 2009-12-15
JP2008283988A (ja) 2008-11-27
JP4131554B2 (ja) 2008-08-13
NO970514D0 (no) 1997-02-05
MY118492A (en) 2004-11-30
AU6154996A (en) 1996-12-24
NZ310710A (en) 1999-01-28
JP4317890B2 (ja) 2009-08-19
WO1996039523A2 (en) 1996-12-12
JP2008086331A (ja) 2008-04-17
EP0778893B1 (en) 2009-11-18
TW494138B (en) 2002-07-11
IN190514B (es) 2003-08-02
CA2195799A1 (en) 1996-12-12
EP0778893A2 (en) 1997-06-18
IL120009A0 (en) 1997-04-15
CA2195799C (en) 2010-02-09
US5814485A (en) 1998-09-29
NO324529B1 (no) 2007-11-12
WO1996039523A3 (en) 1997-01-30
DE69638077D1 (de) 2009-12-31
FI970445A0 (fi) 1997-02-03

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Legal Events

Date Code Title Description
FG Grant or registration
HC Change of company name or juridical status

Owner name: GENERAL MILLS MARKETING, INC.

MM Annulment or lapse due to non-payment of fees