ATE449175T1 - Bakterielle produktion von interferon-beta polypeptiden - Google Patents

Bakterielle produktion von interferon-beta polypeptiden

Info

Publication number
ATE449175T1
ATE449175T1 AT96919131T AT96919131T ATE449175T1 AT E449175 T1 ATE449175 T1 AT E449175T1 AT 96919131 T AT96919131 T AT 96919131T AT 96919131 T AT96919131 T AT 96919131T AT E449175 T1 ATE449175 T1 AT E449175T1
Authority
AT
Austria
Prior art keywords
interferon
beta polypeptides
bacterial production
beta
production
Prior art date
Application number
AT96919131T
Other languages
English (en)
Inventor
Glenn Dorin
Patrick J Mcalary
Kathleen M Wong
Original Assignee
Novartis Vaccines & Diagnostic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines & Diagnostic filed Critical Novartis Vaccines & Diagnostic
Application granted granted Critical
Publication of ATE449175T1 publication Critical patent/ATE449175T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT96919131T 1995-06-06 1996-06-05 Bakterielle produktion von interferon-beta polypeptiden ATE449175T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/477,310 US5814485A (en) 1995-06-06 1995-06-06 Production of interferon-β (IFN-β) in E. coli
PCT/US1996/009155 WO1996039523A2 (en) 1995-06-06 1996-06-05 Bacterial production of hydrophobic polypeptides

Publications (1)

Publication Number Publication Date
ATE449175T1 true ATE449175T1 (de) 2009-12-15

Family

ID=23895395

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96919131T ATE449175T1 (de) 1995-06-06 1996-06-05 Bakterielle produktion von interferon-beta polypeptiden

Country Status (17)

Country Link
US (1) US5814485A (de)
EP (1) EP0778893B1 (de)
JP (3) JP4131554B2 (de)
AT (1) ATE449175T1 (de)
AU (1) AU6154996A (de)
BR (1) BR9606491A (de)
CA (1) CA2195799C (de)
DE (1) DE69638077D1 (de)
FI (1) FI970445A7 (de)
IL (1) IL120009A0 (de)
IN (1) IN190514B (de)
MX (1) MX9700818A (de)
MY (1) MY118492A (de)
NO (1) NO324529B1 (de)
NZ (1) NZ310710A (de)
TW (1) TW494138B (de)
WO (1) WO1996039523A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997048808A1 (en) * 1996-06-19 1997-12-24 Chiron Corporation Bacterial production of interferon-beta using low levels of sodium and potassium ions
US6514729B1 (en) 1999-05-12 2003-02-04 Xencor, Inc. Recombinant interferon-beta muteins
RU2180687C1 (ru) * 2000-07-05 2002-03-20 Общество с ограниченной ответственностью "Биотех" Штамм дрожжей pichia pastoris - продуцент фибробластного интерферона человека, рекомбинантная плазмидная днк phif и способ ее конструирования
US7544354B2 (en) * 2000-10-27 2009-06-09 Novartis Vaccines And Diagnostics Methods of protein purification and recovery
AU2002236477A1 (en) * 2000-11-21 2002-06-03 The Texas A & M University System Fgf-affinity chromatography
WO2002043752A1 (fr) * 2000-11-29 2002-06-06 Morinaga Milk Industry Co., Ltd. Agents therapeutiques de potentialisation d'effet a base d'interferon
US6887462B2 (en) 2001-04-09 2005-05-03 Chiron Corporation HSA-free formulations of interferon-beta
AR034749A1 (es) * 2001-07-09 2004-03-17 Schering Ag Formulaciones de interferon beta humano
DE60332358D1 (de) * 2002-09-09 2010-06-10 Hanall Pharmaceutical Co Ltd Protease-resistente modifizierte interferon alpha polypeptide
EP1646397B1 (de) * 2003-07-11 2012-08-22 Bayer Pharma Aktiengesellschaft Verbesserte rekombinante humane interferon-beta-1b polypeptide
WO2005058346A1 (en) * 2003-12-11 2005-06-30 Ares Trading S.A. Stabilized interferon liquid formulations
EP2327724A3 (de) 2004-02-02 2011-07-27 Ambrx, Inc. Modifizierte humane Wachstumshormon-Polypeptide und deren Verwendungen
US20080076729A1 (en) * 2005-05-19 2008-03-27 Schering Aktiengesellachaft Interferon-beta gene therapy using an improved, regulated expression system
US20070179113A1 (en) * 2005-05-19 2007-08-02 Schering Aktiengesellachaft GM-CSF gene therapy for Crohn's disease using an improved regulated expression system
CN101238214A (zh) * 2005-05-19 2008-08-06 拜尔先灵制药股份公司 使用改进的调节表达系统治疗疾病
AR053284A1 (es) * 2005-05-19 2007-04-25 Schering Ag Terapia genica de interferon -beta usando un sistema mejorado de expresion regulada
US20080038224A1 (en) * 2006-03-28 2008-02-14 Thierry Guyon Modified interferon-beta (IFN-beta) polypeptides
WO2008130382A2 (en) 2006-10-31 2008-10-30 East Carolina University Fusion proteins comprising an anti -inflammatory cytokine and an antigen for treatment of immune disorders
WO2008125222A2 (en) * 2007-04-11 2008-10-23 Bayer Schering Pharma Aktiengesellschaft New modulation molecules for an improved regulated expression system
MX2009011870A (es) 2007-05-02 2009-11-12 Ambrx Inc Polipeptidos de interferon beta modificados y usos de los mismos.
US8273561B2 (en) * 2007-10-05 2012-09-25 Nuron Biotech, Inc. High pressure treatment of aggregated interferons
BRPI0821029A2 (pt) * 2007-12-20 2015-06-16 Merck Serono Sa Fomulações de peg-interferon-beta
NZ586947A (en) 2008-02-08 2012-11-30 Ambrx Inc Modified leptin polypeptides and their uses
KR20090124204A (ko) * 2008-05-29 2009-12-03 (주)바이오큐어팜 아미노 말단의 메티오닌이 제거된 재조합 사람 변이인터페론-베타 단백질을 생산하는 재조합 대장균 및 이의제조방법
CA2757287C (en) 2009-03-31 2019-09-10 East Carolina University Cytokines and neuroantigens for treatment of immune disorders
CA2788607C (en) * 2010-02-01 2018-03-20 Digna Biotech,S.L. Process for the production of interferon alpha 5
WO2011109556A2 (en) * 2010-03-04 2011-09-09 Pfenex Inc. Method for producing soluble recombinant interferon protein without denaturing
RU2473696C1 (ru) * 2011-07-14 2013-01-27 Закрытое акционерное общество "ГЕНЕРИУМ" ПРОМЫШЛЕННЫЙ СПОСОБ ПОЛУЧЕНИЯ И ОЧИСТКИ РЕКОМБИНАНТНОГО ИНТЕРФЕРОНА β-1b ЧЕЛОВЕКА ИЗ ТЕЛЕЦ ВКЛЮЧЕНИЯ
JP6363326B2 (ja) * 2013-03-11 2018-07-25 株式会社コーセー 酵母・細菌共通培養方法およびこれに用いる酵母・細菌共通培養培地
JP7151049B2 (ja) * 2018-03-30 2022-10-12 三井化学株式会社 微生物を増殖させる方法
JP2023159758A (ja) * 2022-04-20 2023-11-01 東ソー株式会社 遺伝子組換え大腸菌を用いたタンパク質の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4499188A (en) * 1982-05-05 1985-02-12 Cetus Corporation Bacterial production of heterologous polypeptides under the control of a repressible promoter-operator
FI82266C (fi) * 1982-10-19 1991-02-11 Cetus Corp Foerfarande foer framstaellning av il-2 -mutein.
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
JPS60118196A (ja) * 1983-11-30 1985-06-25 Takeda Chem Ind Ltd インタ−フェロンの製造法
US4656132A (en) * 1984-03-28 1987-04-07 Cetus Corporation Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria
JPH0755152B2 (ja) * 1986-06-02 1995-06-14 日本化薬株式会社 組換え遺伝子産物の製法及び培地

Also Published As

Publication number Publication date
AU6154996A (en) 1996-12-24
WO1996039523A2 (en) 1996-12-12
IN190514B (de) 2003-08-02
NO970514D0 (no) 1997-02-05
JP4317890B2 (ja) 2009-08-19
TW494138B (en) 2002-07-11
DE69638077D1 (de) 2009-12-31
MX9700818A (es) 1997-05-31
JP4131554B2 (ja) 2008-08-13
EP0778893A2 (de) 1997-06-18
BR9606491A (pt) 1997-09-02
CA2195799C (en) 2010-02-09
FI970445L (fi) 1997-03-26
JP2008283988A (ja) 2008-11-27
FI970445A0 (fi) 1997-02-03
NZ310710A (en) 1999-01-28
IL120009A0 (en) 1997-04-15
NO970514L (no) 1997-03-17
MY118492A (en) 2004-11-30
WO1996039523A3 (en) 1997-01-30
CA2195799A1 (en) 1996-12-12
EP0778893B1 (de) 2009-11-18
JP2008086331A (ja) 2008-04-17
US5814485A (en) 1998-09-29
JPH11501820A (ja) 1999-02-16
NO324529B1 (no) 2007-11-12
FI970445A7 (fi) 1997-03-26

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