JPS6485098A - Glycoprotein and production thereof - Google Patents

Glycoprotein and production thereof

Info

Publication number
JPS6485098A
JPS6485098A JP63184486A JP18448688A JPS6485098A JP S6485098 A JPS6485098 A JP S6485098A JP 63184486 A JP63184486 A JP 63184486A JP 18448688 A JP18448688 A JP 18448688A JP S6485098 A JPS6485098 A JP S6485098A
Authority
JP
Japan
Prior art keywords
human
transformed
mammalian cells
glycoprotein
csf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63184486A
Other languages
Japanese (ja)
Other versions
JPH0657156B2 (en
Inventor
Tatsumi Yamazaki
Masayuki Tsuchiya
Juichi Osada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP63184486A priority Critical patent/JPH0657156B2/en
Publication of JPS6485098A publication Critical patent/JPS6485098A/en
Publication of JPH0657156B2 publication Critical patent/JPH0657156B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

PURPOSE:To enable mass production of a novel glycoprotein having human G-CSF activity by culturing mammalian cells which are transformed with a recombinant vector containing the gene coding the polypeptide with human G-CSF activity. CONSTITUTION:Mammalian cells such as human CHU-1 cells are transformed with a recombinant vector containing the gene having the base sequence participating transcription, originating from the human chromosome which codes the polypeptide having human G-CSF (human granulocyte colonystimulating factor). The transformed mammalian cells are cultured in a usual manner to collect the glycoprotein having G-SCF activity, consisting the peptide moiety and the polysaccharide one.
JP63184486A 1985-09-17 1988-07-26 New glycoprotein manufacturing method Expired - Lifetime JPH0657156B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63184486A JPH0657156B2 (en) 1985-09-17 1988-07-26 New glycoprotein manufacturing method

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
JP20606685 1985-09-17
JP20963885 1985-09-20
JP21715085 1985-09-30
JP26945685 1985-12-02
JP60-206066 1985-12-03
JP60-217150 1985-12-03
JP27083985 1985-12-03
JP60-269456 1985-12-03
JP60-270839 1985-12-03
JP60-209638 1985-12-03
JP63184486A JPH0657156B2 (en) 1985-09-17 1988-07-26 New glycoprotein manufacturing method

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP5183134A Division JPH0783717B2 (en) 1985-09-17 1993-06-30 Gene encoding human granulocyte colony-stimulating factor

Publications (2)

Publication Number Publication Date
JPS6485098A true JPS6485098A (en) 1989-03-30
JPH0657156B2 JPH0657156B2 (en) 1994-08-03

Family

ID=27529395

Family Applications (4)

Application Number Title Priority Date Filing Date
JP61166709A Expired - Lifetime JPH0657152B2 (en) 1985-09-17 1986-07-17 CSF genes
JP61166710A Granted JPS62236497A (en) 1985-09-17 1986-07-17 Novel glycoprotein and production thereof
JP63184486A Expired - Lifetime JPH0657156B2 (en) 1985-09-17 1988-07-26 New glycoprotein manufacturing method
JP5183134A Expired - Lifetime JPH0783717B2 (en) 1985-09-17 1993-06-30 Gene encoding human granulocyte colony-stimulating factor

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP61166709A Expired - Lifetime JPH0657152B2 (en) 1985-09-17 1986-07-17 CSF genes
JP61166710A Granted JPS62236497A (en) 1985-09-17 1986-07-17 Novel glycoprotein and production thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP5183134A Expired - Lifetime JPH0783717B2 (en) 1985-09-17 1993-06-30 Gene encoding human granulocyte colony-stimulating factor

Country Status (1)

Country Link
JP (4) JPH0657152B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010131382A1 (en) 2009-05-14 2010-11-18 Fukuda Keiichi Muscle repair promoter
WO2012067262A1 (en) 2010-11-17 2012-05-24 Fukuda Keiichi Therapeutic agent for muscular dystrophy

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06102021B2 (en) * 1985-12-03 1994-12-14 中外製薬株式会社 Novel polypeptide
US4810643A (en) * 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
JPS63500636A (en) * 1985-08-23 1988-03-10 麒麟麦酒株式会社 DNA encoding multipotent granulocyte colony stimulating factor
JPH0618779B2 (en) * 1986-01-22 1994-03-16 中外製薬株式会社 Hematopoietic function recovery promoter
ZA872705B (en) * 1986-04-22 1987-10-05 Immunex Corporation Human g-csf protein expression
CA2006596C (en) * 1988-12-22 2000-09-05 Rika Ishikawa Chemically-modified g-csf
US6166183A (en) * 1992-11-30 2000-12-26 Kirin-Amgen, Inc. Chemically-modified G-CSF
EP0659759B1 (en) * 1992-09-09 1999-12-08 Nippon Kayaku Kabushiki Kaisha Novel physiologically active substance nk175203, process for producing the same, and pharmaceutical use thereof
US20030053982A1 (en) 1994-09-26 2003-03-20 Kinstler Olaf B. N-terminally chemically modified protein compositions and methods
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US6559322B1 (en) 2001-12-21 2003-05-06 Council Of Scientific And Industrial Research Process for preparation of a lactone from a cyclic ketone
DK1578771T3 (en) 2001-10-10 2013-06-10 Novo Nordisk As Remodeling and glycoconjugation of peptides

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010131382A1 (en) 2009-05-14 2010-11-18 Fukuda Keiichi Muscle repair promoter
WO2012067262A1 (en) 2010-11-17 2012-05-24 Fukuda Keiichi Therapeutic agent for muscular dystrophy

Also Published As

Publication number Publication date
JPH06339381A (en) 1994-12-13
JPS62236497A (en) 1987-10-16
JPH0657156B2 (en) 1994-08-03
JPH0657152B2 (en) 1994-08-03
JPH025395B2 (en) 1990-02-01
JPS62236488A (en) 1987-10-16
JPH0783717B2 (en) 1995-09-13

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Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term