RU2153495C2 - Производные хиназолина, способ их получения, фармацевтическая композиция и способ достижения антипролиферативного эффекта - Google Patents

Производные хиназолина, способ их получения, фармацевтическая композиция и способ достижения антипролиферативного эффекта Download PDF

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RU2153495C2
RU2153495C2 RU97119521/04A RU97119521A RU2153495C2 RU 2153495 C2 RU2153495 C2 RU 2153495C2 RU 97119521/04 A RU97119521/04 A RU 97119521/04A RU 97119521 A RU97119521 A RU 97119521A RU 2153495 C2 RU2153495 C2 RU 2153495C2
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formula
pharmaceutically acceptable
chloro
alkoxy
quinazoline
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RU97119521/04A
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English (en)
Russian (ru)
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RU97119521A (ru
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Хопкинсон ГИБСОН Кейт (GB)
Хопкинсон Гибсон Кейт
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Зенека Лимитед
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU97119521/04A 1995-04-27 1996-04-23 Производные хиназолина, способ их получения, фармацевтическая композиция и способ достижения антипролиферативного эффекта RU2153495C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9508538.7 1995-04-27
GBGB9508538.7A GB9508538D0 (en) 1995-04-27 1995-04-27 Quinazoline derivatives

Publications (2)

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RU97119521A RU97119521A (ru) 1999-10-27
RU2153495C2 true RU2153495C2 (ru) 2000-07-27

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RU97119521/04A RU2153495C2 (ru) 1995-04-27 1996-04-23 Производные хиназолина, способ их получения, фармацевтическая композиция и способ достижения антипролиферативного эффекта

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US (1) US5770599A (OSRAM)
EP (1) EP0823900B1 (OSRAM)
JP (1) JP3040486B2 (OSRAM)
KR (1) KR100296656B1 (OSRAM)
CN (1) CN1100046C (OSRAM)
AR (1) AR003944A1 (OSRAM)
AT (1) ATE198329T1 (OSRAM)
AU (1) AU699163B2 (OSRAM)
BG (1) BG62730B1 (OSRAM)
BR (1) BRPI9608082B8 (OSRAM)
CA (1) CA2215732C (OSRAM)
CZ (1) CZ288489B6 (OSRAM)
DE (2) DE69611361T2 (OSRAM)
DK (1) DK0823900T3 (OSRAM)
EE (1) EE03482B1 (OSRAM)
EG (1) EG24134A (OSRAM)
ES (1) ES2153098T3 (OSRAM)
FR (1) FR09C0065I2 (OSRAM)
GB (1) GB9508538D0 (OSRAM)
GR (1) GR3035211T3 (OSRAM)
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NZ (1) NZ305444A (OSRAM)
PL (1) PL189182B1 (OSRAM)
PT (1) PT823900E (OSRAM)
RO (1) RO117849B1 (OSRAM)
RU (1) RU2153495C2 (OSRAM)
SI (1) SI0823900T1 (OSRAM)
SK (1) SK282236B6 (OSRAM)
TW (1) TW436486B (OSRAM)
UA (1) UA52602C2 (OSRAM)
WO (1) WO1996033980A1 (OSRAM)
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RU2323215C2 (ru) * 2001-12-24 2008-04-27 Астразенека Аб Замещенные производные хиназолина как ингибиторы ауроракиназы
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RU2350618C2 (ru) * 2002-11-04 2009-03-27 Астразенека Аб ПРОИЗВОДНЫЕ ХИНАЗОЛИНА В КАЧЕСТВЕ ИНГИБИТОРОВ Src ТИРОЗИНКИНАЗЫ
RU2350605C2 (ru) * 2003-08-14 2009-03-27 Эррей Байофарма Инк. Аналоги хиназолина в качестве ингибиторов рецепторных тирозинкиназ
US7812159B2 (en) 2005-01-10 2010-10-12 Arena Pharamaceuticals, Inc. Processes for preparing aromatic ethers
US8546429B2 (en) 2003-07-11 2013-10-01 Arena Pharmaceuticals, Inc. 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
US8933083B2 (en) 2003-01-14 2015-01-13 Arena Pharmaceuticals, Inc. 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
RU2577518C2 (ru) * 2014-06-02 2016-03-20 Олег Ростиславович Михайлов КРИСТАЛЛИЧЕСКАЯ БЕЗВОДНАЯ γ-МОДИФИКАЦИЯ 4-(3'-ХЛОР-4'-ФТОРАНИЛИНО)-7-МЕТОКСИ-6-(3-МОРФОЛИНОПРОПОКСИ)ХИНАЗОЛИНА, СПОСОБ ЕЕ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЕ ОСНОВЕ
RU2656597C2 (ru) * 2013-03-06 2018-06-06 Астразенека Аб Хиназолиновые ингибиторы активирующих мутированных форм рецептора эпидермального фактора роста
RU2720810C2 (ru) * 2015-03-20 2020-05-13 Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. Соли производного хиназолина и способ их получения
US10894787B2 (en) 2010-09-22 2021-01-19 Arena Pharmaceuticals, Inc. Modulators of the GPR119 receptor and the treatment of disorders related thereto
US11007175B2 (en) 2015-01-06 2021-05-18 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
US11884626B2 (en) 2015-06-22 2024-01-30 Arena Pharmaceuticals, Inc. Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compound1) for use in S1P1 receptor-associated disorders
US12156866B2 (en) 2018-06-06 2024-12-03 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor

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