KR101755737B1 - 글루타미닐 사이클라제의 억제제로서 헤테로사이클릭 유도체 - Google Patents

글루타미닐 사이클라제의 억제제로서 헤테로사이클릭 유도체 Download PDF

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KR101755737B1
KR101755737B1 KR1020127008546A KR20127008546A KR101755737B1 KR 101755737 B1 KR101755737 B1 KR 101755737B1 KR 1020127008546 A KR1020127008546 A KR 1020127008546A KR 20127008546 A KR20127008546 A KR 20127008546A KR 101755737 B1 KR101755737 B1 KR 101755737B1
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benzo
imidazol
phenyl
alkyl
imidazolidin
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KR20120105421A (ko
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울리히 헤이설
로버트 소머
다니엘 람스베크
안체 메이어
톨스텐 호프만
리비아 보흐메
한스-울리히 데무스
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프로비오드룩 아게
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/42—Oxazoles
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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KR1020127008546A 2009-09-11 2010-09-13 글루타미닐 사이클라제의 억제제로서 헤테로사이클릭 유도체 Active KR101755737B1 (ko)

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Application Number Priority Date Filing Date Title
US24143209P 2009-09-11 2009-09-11
US61/241,432 2009-09-11
PCT/EP2010/063341 WO2011029920A1 (en) 2009-09-11 2010-09-13 Heterocylcic derivatives as inhibitors of glutaminyl cyclase

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KR20120105421A KR20120105421A (ko) 2012-09-25
KR101755737B1 true KR101755737B1 (ko) 2017-07-07

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