EP1007073A4 - Methods of modifying feeding behavior, compounds useful in such methods, and dna encoding a hypothalamic atypical neuropeptide y/peptide yy receptor (y5) - Google Patents

Methods of modifying feeding behavior, compounds useful in such methods, and dna encoding a hypothalamic atypical neuropeptide y/peptide yy receptor (y5)

Info

Publication number
EP1007073A4
EP1007073A4 EP97928786A EP97928786A EP1007073A4 EP 1007073 A4 EP1007073 A4 EP 1007073A4 EP 97928786 A EP97928786 A EP 97928786A EP 97928786 A EP97928786 A EP 97928786A EP 1007073 A4 EP1007073 A4 EP 1007073A4
Authority
EP
European Patent Office
Prior art keywords
methods
hypothalamic
neuropeptide
atypical
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97928786A
Other languages
German (de)
French (fr)
Other versions
EP1007073A1 (en
Inventor
Christophe P G Gerald
Richard L Weinshank
Mary W Walker
Theresa Branchek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synaptic Pharmaceutical Corp
Original Assignee
Synaptic Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/668,650 external-priority patent/US5989920A/en
Application filed by Synaptic Pharmaceutical Corp filed Critical Synaptic Pharmaceutical Corp
Publication of EP1007073A1 publication Critical patent/EP1007073A1/en
Publication of EP1007073A4 publication Critical patent/EP1007073A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EP97928786A 1996-06-04 1997-06-04 Methods of modifying feeding behavior, compounds useful in such methods, and dna encoding a hypothalamic atypical neuropeptide y/peptide yy receptor (y5) Withdrawn EP1007073A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/668,650 US5989920A (en) 1994-12-02 1996-06-04 Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5
US668650 1996-06-04
US80360097A 1997-02-21 1997-02-21
US803600 1997-02-21
PCT/US1997/009504 WO1997046250A1 (en) 1996-06-04 1997-06-04 Methods of modifying feeding behavior, compounds useful in such methods, and dna encoding a hypothalamic atypical neuropeptide y/peptide yy receptor (y5)

Publications (2)

Publication Number Publication Date
EP1007073A1 EP1007073A1 (en) 2000-06-14
EP1007073A4 true EP1007073A4 (en) 2002-03-27

Family

ID=27099966

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97928786A Withdrawn EP1007073A4 (en) 1996-06-04 1997-06-04 Methods of modifying feeding behavior, compounds useful in such methods, and dna encoding a hypothalamic atypical neuropeptide y/peptide yy receptor (y5)

Country Status (3)

Country Link
EP (1) EP1007073A4 (en)
AU (1) AU3295297A (en)
WO (1) WO1997046250A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5989920A (en) 1994-12-02 1999-11-23 Synaptic Pharmaceutical Corporation Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5
US5602024A (en) 1994-12-02 1997-02-11 Synaptic Pharmaceutical Corporation DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof
AUPN646795A0 (en) * 1995-11-09 1995-11-30 Garvan Institute Of Medical Research Neuropeptide Y-Y5 receptor
US6713265B1 (en) 1997-06-04 2004-03-30 Synaptic Pharmaceutical Corporation Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)
SE9703414D0 (en) * 1997-09-23 1997-09-23 Astra Ab New compounds
ATE314371T1 (en) 1998-11-10 2006-01-15 Merck & Co Inc SPIRO-INDOLE AS Y5 RECEPTOR ANTAGONISTS
WO2000063171A1 (en) 1999-04-20 2000-10-26 Meiji Seika Kaisha, Ltd. Tricyclic compounds
CA2403307A1 (en) 2001-10-23 2003-04-23 Neurogen Corporation Substituted 2-cyclohexyl-4-phenyl-1h-imidazole derivatives
ATE486842T1 (en) 2002-03-12 2010-11-15 Merck Sharp & Dohme SUBSTITUTED AMIDES
EP1583549A4 (en) 2003-01-17 2006-10-04 Sod Conseils Rech Applic Peptide yy analogs
JP2004315511A (en) * 2003-03-31 2004-11-11 Taisho Pharmaceut Co Ltd Mch receptor antagonist
US7371871B2 (en) 2003-05-05 2008-05-13 Probiodrug Ag Inhibitors of glutaminyl cyclase
WO2005049027A2 (en) 2003-11-03 2005-06-02 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
CN1918131B (en) 2004-02-05 2011-05-04 前体生物药物股份公司 Novel inhibitors of glutaminyl cyclase
EP1890703B1 (en) 2005-06-14 2016-05-11 Taigen Biotechnology Pyrimidine compounds as chemokine receptors inhibitors
US8193206B2 (en) 2005-06-14 2012-06-05 Taigen Biotechnology Co., Ltd. Pyrimidine compounds
EP2089383B1 (en) 2006-11-09 2015-09-16 Probiodrug AG 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
EP2091948B1 (en) 2006-11-30 2012-04-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase
EP2117540A1 (en) 2007-03-01 2009-11-18 Probiodrug AG New use of glutaminyl cyclase inhibitors
ES2533484T3 (en) 2007-04-18 2015-04-10 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
NZ588989A (en) 2008-04-21 2012-03-30 Taigen Biotechnology Co Ltd Heterocyclic compounds comprising pyrimidine, piperazine and amine.
US20090298834A1 (en) * 2008-06-02 2009-12-03 Hassan Pajouhesh 4-(aminomethyl)cyclohexanamine derivatives as calcium channel blockers
WO2010056847A2 (en) 2008-11-13 2010-05-20 Taigen Biotechnology Co., Ltd. Lyophilization formulation
ES2548913T3 (en) 2009-09-11 2015-10-21 Probiodrug Ag Heterocyclic derivatives such as glutaminyl cyclase inhibitors
US9181233B2 (en) 2010-03-03 2015-11-10 Probiodrug Ag Inhibitors of glutaminyl cyclase
EA022420B1 (en) 2010-03-10 2015-12-30 Пробиодруг Аг Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
DK2686313T3 (en) 2011-03-16 2016-05-02 Probiodrug Ag Benzimidazole derivatives as inhibitors of glutaminyl cyclase
ES2812698T3 (en) 2017-09-29 2021-03-18 Probiodrug Ag Glutaminyl cyclase inhibitors
TW202116314A (en) 2019-07-11 2021-05-01 美商普雷西斯精密藥品公司 Formulations of t-type calcium channel modulators and methods of use thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996016542A1 (en) * 1994-12-02 1996-06-06 Synaptic Pharmaceutical Corporation Methods of modifying feeding behavior, compounds useful in such methods, and dna encoding a hypothalamic atypical neuropeptide y/peptide yy receptor (y5)
WO1997017440A1 (en) * 1995-11-09 1997-05-15 Garvan Institute Of Medical Research Neuropeptide y-y5 receptor
WO1997020820A1 (en) * 1995-12-01 1997-06-12 Novartis Ag Heteroaryl compounds
WO1997020822A1 (en) * 1995-12-01 1997-06-12 Novartis Ag Quinazolin-2,4-diazirines as npy receptor antagonist
WO1997037998A2 (en) * 1996-04-08 1997-10-16 Bayer Corporation Neuropeptide y receptor y5 and nucleic acid sequence

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996016542A1 (en) * 1994-12-02 1996-06-06 Synaptic Pharmaceutical Corporation Methods of modifying feeding behavior, compounds useful in such methods, and dna encoding a hypothalamic atypical neuropeptide y/peptide yy receptor (y5)
WO1997017440A1 (en) * 1995-11-09 1997-05-15 Garvan Institute Of Medical Research Neuropeptide y-y5 receptor
WO1997020820A1 (en) * 1995-12-01 1997-06-12 Novartis Ag Heteroaryl compounds
WO1997020822A1 (en) * 1995-12-01 1997-06-12 Novartis Ag Quinazolin-2,4-diazirines as npy receptor antagonist
WO1997037998A2 (en) * 1996-04-08 1997-10-16 Bayer Corporation Neuropeptide y receptor y5 and nucleic acid sequence

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BARD JONATHAN A ET AL: "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 45, 1995, pages 26762 - 26765, XP002187958, ISSN: 0021-9258 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1993, HERZOG HERBERT ET AL: "Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor: Lack of NPY binding and activation.", XP002187960, Database accession no. PREV199396087299 *
DNA AND CELL BIOLOGY, vol. 12, no. 6, 1993, pages 465 - 471, ISSN: 1044-5498 *
GERALD C ET AL: "A RECEPTOR SUBTYPE INVOLVED IN NEUROPEPTIDE-Y-INDUCED FOOD INTAKE", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 382, 11 July 1996 (1996-07-11), pages 168 - 171, XP000612078, ISSN: 0028-0836 *
GERALD CHRISTOPHE ET AL: "Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 45, 1995, pages 26758 - 26761, XP002187957, ISSN: 0021-9258 *
HU Y ET AL: "IDENTIFICATION OF A NOVEL HYPOTHALAMIC NEUROPEPTIDE Y RECEPTOR ASSOCIATED WITH FEEDING BEHAVIOR", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 271, no. 42, 18 October 1996 (1996-10-18), pages 26315 - 26319, XP002040612, ISSN: 0021-9258 *
LARHAMMAR D ET AL: "CLONING AND FUNCTIONAL EXPRESSION OF A HUMAN NEUROPEPTIDE Y-PEPTIDE YY RECEPTOR OF THE Y1 TYPE", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 16, 1992, pages 10935 - 10938, XP000612077, ISSN: 0021-9258 *
LUNDELL INGRID ET AL: "Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 49, 1995, pages 29123 - 29128, XP002187959, ISSN: 0021-9258 *
ROSE PATRICIA M ET AL: "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 39, 1995, pages 22661 - 22664, XP002187956, ISSN: 0021-9258 *
See also references of WO9746250A1 *

Also Published As

Publication number Publication date
AU3295297A (en) 1998-01-05
EP1007073A1 (en) 2000-06-14
WO1997046250A1 (en) 1997-12-11

Similar Documents

Publication Publication Date Title
EP1007073A4 (en) Methods of modifying feeding behavior, compounds useful in such methods, and dna encoding a hypothalamic atypical neuropeptide y/peptide yy receptor (y5)
GR970300046T1 (en) Nucleic acid encoding neuropeptide y/peptide yy (y2) receptors and uses thereof
GB2347930B (en) IGF-1 receptor interacting proteins (IIPs), genes coding therefor and uses thereof
IL135962A0 (en) Methods and compositions for peptide libraries displayed on light-emitting scaffolds
IL178210A0 (en) Polypeptides and nucleic acids encoding the same
GB9609262D0 (en) Peptide library and method
PL329160A1 (en) Novel phytase and phytase encoding gene
IL136444A0 (en) Cyclosporin-containing microemulsion preconcentrate composition
HUP0002704A3 (en) Gnrh antagonists being modified in positions 5 and 6
HK1020952A1 (en) Polymorphs (iii) of donepezil hydrochloride and preparation processe and use thereof.
EP0948651A4 (en) Recombinant n-smases and nucleic acids encoding same
AUPO224696A0 (en) A novel haemopoietin receptor and genetic sequences encoding same
IL136696A0 (en) Sigirr dna and polypeptides
EP0870198A4 (en) Recombinant c140 receptor, its agonists and antagonists, and nucleic acids encoding the receptor
ZA98256B (en) Tachykinin antagonists
EP0826037A4 (en) Orpinomyces xylanase proteins and coding sequences
AU1101099A (en) Dna encoding a gababr2 polypeptide and uses thereof
EP0881907A4 (en) Cyclic peptide antifungal agents
HUP0100674A3 (en) A dna molecule encoding a mutant prepro-neuropeptide y, a mutant signal peptide, and uses thereof
AU5253898A (en) Recombinant by55 and nucleic acids encoding same
ZA988460B (en) Polypeptides and nucleic acids encoding the same
IL113441A0 (en) Opioid peptide analoog
AU1986501A (en) A novel polypeptide-hexokinase protein 12 and polynucleotide encoding said polypeptide
ZA971483B (en) Pure somatostatin antagonist and methods for use thereof
TW322983U (en) Key cap structure for keyboard (4)

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19990104

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20020213

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

17Q First examination report despatched

Effective date: 20030917

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20050830