JP5647981B2 - リンパ球活性化遺伝子−３（ｌａｇ−３）へ結合するヒト抗体およびその使用 - Google Patents
リンパ球活性化遺伝子−３（ｌａｇ−３）へ結合するヒト抗体およびその使用 Download PDFInfo
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- JP5647981B2 JP5647981B2 JP2011523095A JP2011523095A JP5647981B2 JP 5647981 B2 JP5647981 B2 JP 5647981B2 JP 2011523095 A JP2011523095 A JP 2011523095A JP 2011523095 A JP2011523095 A JP 2011523095A JP 5647981 B2 JP5647981 B2 JP 5647981B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18854808P | 2008-08-11 | 2008-08-11 | |
| US61/188,548 | 2008-08-11 | ||
| PCT/US2009/053405 WO2010019570A2 (en) | 2008-08-11 | 2009-08-11 | Human antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014227725A Division JP2015096503A (ja) | 2008-08-11 | 2014-11-10 | リンパ球活性化遺伝子−３（ｌａｇ−３）へ結合するヒト抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012500006A JP2012500006A (ja) | 2012-01-05 |
| JP2012500006A5 JP2012500006A5 (enExample) | 2012-08-30 |
| JP5647981B2 true JP5647981B2 (ja) | 2015-01-07 |
Family
ID=41669613
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011523095A Active JP5647981B2 (ja) | 2008-08-11 | 2009-08-11 | リンパ球活性化遺伝子−３（ｌａｇ−３）へ結合するヒト抗体およびその使用 |
| JP2014227725A Pending JP2015096503A (ja) | 2008-08-11 | 2014-11-10 | リンパ球活性化遺伝子−３（ｌａｇ−３）へ結合するヒト抗体およびその使用 |
| JP2016203692A Pending JP2017052765A (ja) | 2008-08-11 | 2016-10-17 | リンパ球活性化遺伝子−３（ｌａｇ−３）へ結合するヒト抗体およびその使用 |
| JP2018177601A Pending JP2019030307A (ja) | 2008-08-11 | 2018-09-21 | リンパ球活性化遺伝子−３（ｌａｇ−３）へ結合するヒト抗体およびその使用 |
| JP2021027012A Active JP7286692B2 (ja) | 2008-08-11 | 2021-02-24 | リンパ球活性化遺伝子－３（ｌａｇ－３）へ結合するヒト抗体およびその使用 |
| JP2023085261A Pending JP2023113722A (ja) | 2008-08-11 | 2023-05-24 | リンパ球活性化遺伝子－３（ｌａｇ－３）へ結合するヒト抗体およびその使用 |
| JP2025049302A Pending JP2025094193A (ja) | 2008-08-11 | 2025-03-25 | リンパ球活性化遺伝子－３（ｌａｇ－３）へ結合するヒト抗体およびその使用 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014227725A Pending JP2015096503A (ja) | 2008-08-11 | 2014-11-10 | リンパ球活性化遺伝子−３（ｌａｇ−３）へ結合するヒト抗体およびその使用 |
| JP2016203692A Pending JP2017052765A (ja) | 2008-08-11 | 2016-10-17 | リンパ球活性化遺伝子−３（ｌａｇ−３）へ結合するヒト抗体およびその使用 |
| JP2018177601A Pending JP2019030307A (ja) | 2008-08-11 | 2018-09-21 | リンパ球活性化遺伝子−３（ｌａｇ−３）へ結合するヒト抗体およびその使用 |
| JP2021027012A Active JP7286692B2 (ja) | 2008-08-11 | 2021-02-24 | リンパ球活性化遺伝子－３（ｌａｇ－３）へ結合するヒト抗体およびその使用 |
| JP2023085261A Pending JP2023113722A (ja) | 2008-08-11 | 2023-05-24 | リンパ球活性化遺伝子－３（ｌａｇ－３）へ結合するヒト抗体およびその使用 |
| JP2025049302A Pending JP2025094193A (ja) | 2008-08-11 | 2025-03-25 | リンパ球活性化遺伝子－３（ｌａｇ－３）へ結合するヒト抗体およびその使用 |
Country Status (31)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015096503A (ja) * | 2008-08-11 | 2015-05-21 | メダレックス・リミテッド・ライアビリティ・カンパニーＭｅｄａｒｅｘ， Ｌ．Ｌ．Ｃ． | リンパ球活性化遺伝子−３（ｌａｇ−３）へ結合するヒト抗体およびその使用 |
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| TR201815863T4 (tr) | 2010-11-30 | 2018-11-21 | Chugai Pharmaceutical Co Ltd | Sitotoksisiteyi indükleyen terapötik madde. |
| CA2820134A1 (en) * | 2010-12-06 | 2012-06-14 | Dainippon Sumitomo Pharma Co., Ltd. | Human monoclonal antibody |
| US8440797B2 (en) | 2010-12-06 | 2013-05-14 | Dainippon Sumitomo Pharma Co., Ltd. | Human monoclonal antibody |
| EP2655409A4 (en) | 2010-12-22 | 2015-07-01 | Univ Leland Stanford Junior | SUPERAGONISTS AND ANTAGONISTS OF INTERLEUKIN-2 |
| PT3357511T (pt) * | 2011-06-30 | 2020-07-23 | Genzyme Corp | Inibidores da ativação de células t |
| PT3409278T (pt) | 2011-07-21 | 2020-12-18 | Sumitomo Dainippon Pharma Oncology Inc | Inibidores de proteína cinase heterocíclicos |
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| US10081681B2 (en) * | 2013-09-20 | 2018-09-25 | Bristol-Myers Squibb Company | Combination of anti-LAG-3 antibodies and anti-PD-1 antibodies to treat tumors |
| CN105722860A (zh) | 2013-09-24 | 2016-06-29 | 梅迪塞纳医疗股份有限公司 | 白介素-2融合蛋白及其应用 |
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| WO2015066413A1 (en) | 2013-11-01 | 2015-05-07 | Novartis Ag | Oxazolidinone hydroxamic acid compounds for the treatment of bacterial infections |
| SG10201808519VA (en) * | 2013-12-17 | 2018-10-30 | Genentech Inc | Methods of treating her2-positive cancers using pd-1 axis binding antagonists and anti-her2 antibodies |
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| KR102248804B1 (ko) | 2014-03-12 | 2021-05-11 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | Cns의 질환 및 손상을 치료하기 위한 전신적 조절 t 세포 수준 또는 활성의 감소 |
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| CN106659757B (zh) | 2014-04-24 | 2022-01-28 | 利兰斯坦福初级大学董事会 | 白介素2的超级激动剂、部分激动剂和拮抗剂 |
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|---|---|---|---|---|
| JP2015096503A (ja) * | 2008-08-11 | 2015-05-21 | メダレックス・リミテッド・ライアビリティ・カンパニーＭｅｄａｒｅｘ， Ｌ．Ｌ．Ｃ． | リンパ球活性化遺伝子−３（ｌａｇ−３）へ結合するヒト抗体およびその使用 |
| JP2017052765A (ja) * | 2008-08-11 | 2017-03-16 | メダレックス・リミテッド・ライアビリティ・カンパニーＭｅｄａｒｅｘ， Ｌ．Ｌ．Ｃ． | リンパ球活性化遺伝子−３（ｌａｇ−３）へ結合するヒト抗体およびその使用 |
| JP2019030307A (ja) * | 2008-08-11 | 2019-02-28 | イー・アール・スクイブ・アンド・サンズ・リミテッド・ライアビリティ・カンパニーＥ．Ｒ． Ｓｑｕｉｂｂ ＆ Ｓｏｎｓ， Ｌ．Ｌ．Ｃ． | リンパ球活性化遺伝子−３（ｌａｇ−３）へ結合するヒト抗体およびその使用 |
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