|
WO1990006952A1
(fr)
*
|
1988-12-22 |
1990-06-28 |
Kirin-Amgen, Inc. |
Facteur de stimulation de colonies de granulocytes modifies chimiquement
|
|
US20020177688A1
(en)
*
|
1988-12-22 |
2002-11-28 |
Kirin-Amgen, Inc., |
Chemically-modified G-CSF
|
|
US5581476A
(en)
*
|
1993-01-28 |
1996-12-03 |
Amgen Inc. |
Computer-based methods and articles of manufacture for preparing G-CSF analogs
|
|
US5951974A
(en)
*
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
WO1995021629A1
(en)
*
|
1994-02-08 |
1995-08-17 |
Amgen Inc. |
Oral delivery of chemically modified proteins
|
|
US6429290B1
(en)
|
1994-08-17 |
2002-08-06 |
The Rockefeller University |
OB polypeptides, modified forms and derivatives
|
|
US6001968A
(en)
|
1994-08-17 |
1999-12-14 |
The Rockefeller University |
OB polypeptides, modified forms and compositions
|
|
US20030053982A1
(en)
*
|
1994-09-26 |
2003-03-20 |
Kinstler Olaf B. |
N-terminally chemically modified protein compositions and methods
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
WO1996041813A2
(en)
*
|
1994-11-09 |
1996-12-27 |
Offord Robin E |
Functionalized polymers for site-specific attachment
|
|
US6008202A
(en)
*
|
1995-01-23 |
1999-12-28 |
University Of Pittsburgh |
Stable lipid-comprising drug delivery complexes and methods for their production
|
|
US5795587A
(en)
|
1995-01-23 |
1998-08-18 |
University Of Pittsburgh |
Stable lipid-comprising drug delivery complexes and methods for their production
|
|
US5908621A
(en)
*
|
1995-11-02 |
1999-06-01 |
Schering Corporation |
Polyethylene glycol modified interferon therapy
|
|
ATE262920T1
(de)
|
1995-11-02 |
2004-04-15 |
Schering Corp |
Kontinuierliche, niedrigdosierte zytokine- infusionstherapie
|
|
TW517067B
(en)
*
|
1996-05-31 |
2003-01-11 |
Hoffmann La Roche |
Interferon conjugates
|
|
WO1998024477A1
(en)
|
1996-12-06 |
1998-06-11 |
Amgen Inc. |
Combination therapy using an il-1 inhibitor for treating il-1 mediated diseases
|
|
ATE200030T1
(de)
*
|
1997-01-29 |
2001-04-15 |
Polymasc Pharmaceuticals Plc |
Pegylationsverfahren
|
|
NZ334068A
(en)
|
1997-06-06 |
2000-07-28 |
Kyowa Hakko Kogyo Kk |
Polypeptides chemically modified with polyalkylene glycol derivatives
|
|
US20080076706A1
(en)
|
1997-07-14 |
2008-03-27 |
Bolder Biotechnology, Inc. |
Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
|
|
US6753165B1
(en)
*
|
1999-01-14 |
2004-06-22 |
Bolder Biotechnology, Inc. |
Methods for making proteins containing free cysteine residues
|
|
DE69838552T2
(de)
*
|
1997-07-14 |
2008-05-21 |
Bolder Biotechnology, Inc., Louisville |
Derivate des wachstumshormons und verwandte proteine
|
|
US6017876A
(en)
*
|
1997-08-15 |
2000-01-25 |
Amgen Inc. |
Chemical modification of granulocyte-colony stimulating factor (G-CSF) bioactivity
|
|
US5985263A
(en)
*
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
US5981709A
(en)
*
|
1997-12-19 |
1999-11-09 |
Enzon, Inc. |
α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
|
|
WO1999055377A2
(en)
*
|
1998-04-28 |
1999-11-04 |
Applied Research Systems Ars Holding N.V. |
Polyol-ifn-beta conjugates
|
|
EP1213029A1
(en)
*
|
1998-05-15 |
2002-06-12 |
Schering Corporation |
Combination therapy for eradicating detectable HCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection
|
|
NL1009601C2
(nl)
*
|
1998-07-09 |
2000-01-11 |
Univ Utrecht |
Verbinding welke de binding van een eiwit aan mestcellen kan remmen, toepassing van de verbinding voor de bereiding van een geneesmiddel, een farmaceutisch preparaat, een werkwijze voor het diagnostiseren van een ziekte en een selectiewerkwijze.
|
|
EP1133563A2
(en)
*
|
1998-07-16 |
2001-09-19 |
Hyseq, Inc. |
Methods and molecules relating to cd39-like polypeptides
|
|
PT1588716E
(pt)
|
1998-08-06 |
2011-05-25 |
Mountain View Pharmaceuticals |
Conjugados de peg-urato oxidase e sua utiliza??o
|
|
US6783965B1
(en)
*
|
2000-02-10 |
2004-08-31 |
Mountain View Pharmaceuticals, Inc. |
Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
|
|
US6420339B1
(en)
*
|
1998-10-14 |
2002-07-16 |
Amgen Inc. |
Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
|
|
TR200101087T2
(tr)
*
|
1998-10-16 |
2001-09-21 |
Biogen, Inc. |
İnterferon beta-füzyon proteinleri ve kullanımları
|
|
CN101062419B
(zh)
*
|
1998-10-16 |
2016-06-29 |
生物基因Ma公司 |
干扰素-β-1a的聚合物缀合物及其使用
|
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
CZ302155B6
(cs)
|
1998-10-23 |
2010-11-18 |
Kirin-Amgen Inc. |
Sloucenina, která se váže na mpl receptor, zpusob její výroby, farmaceutická kompozice s jejím obsahem, polynukleotid, vektor a hostitelská bunka
|
|
US7488590B2
(en)
|
1998-10-23 |
2009-02-10 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
EP1135493A2
(en)
*
|
1998-11-30 |
2001-09-26 |
Eli Lilly And Company |
Erythropoietic compounds
|
|
AU775937B2
(en)
|
1999-01-14 |
2004-08-19 |
Bolder Biotechnology, Inc. |
Methods for making proteins containing free cysteine residues
|
|
US8288126B2
(en)
|
1999-01-14 |
2012-10-16 |
Bolder Biotechnology, Inc. |
Methods for making proteins containing free cysteine residues
|
|
EA004685B1
(ru)
*
|
1999-01-29 |
2004-06-24 |
Эмджен Инк. |
Конъюгаты гксф
|
|
SI1157037T1
(en)
*
|
1999-01-29 |
2003-12-31 |
F. Hoffmann-La Roche Ag |
Gcsf conjugates
|
|
AU2824700A
(en)
*
|
1999-03-01 |
2000-09-21 |
Kyowa Hakko Kogyo Co. Ltd. |
Chemically modified g-csf preparations
|
|
US6485718B1
(en)
|
1999-04-13 |
2002-11-26 |
Pharmacia Corporation |
Site specific ligation of proteins to synthetic particles
|
|
US6924264B1
(en)
*
|
1999-04-30 |
2005-08-02 |
Amylin Pharmaceuticals, Inc. |
Modified exendins and exendin agonists
|
|
US8106098B2
(en)
*
|
1999-08-09 |
2012-01-31 |
The General Hospital Corporation |
Protein conjugates with a water-soluble biocompatible, biodegradable polymer
|
|
US7459540B1
(en)
|
1999-09-07 |
2008-12-02 |
Amgen Inc. |
Fibroblast growth factor-like polypeptides
|
|
US7074878B1
(en)
*
|
1999-12-10 |
2006-07-11 |
Harris J Milton |
Hydrolytically degradable polymers and hydrogels made therefrom
|
|
US6348558B1
(en)
|
1999-12-10 |
2002-02-19 |
Shearwater Corporation |
Hydrolytically degradable polymers and hydrogels made therefrom
|
|
US6831158B2
(en)
*
|
2000-01-10 |
2004-12-14 |
Maxygen Holdings Ltd. |
G-CSF conjugates
|
|
MXPA02006795A
(es)
|
2000-01-10 |
2005-04-19 |
Maxygen Holdings Ltd |
Conjugados g-csf.
|
|
US6555660B2
(en)
*
|
2000-01-10 |
2003-04-29 |
Maxygen Holdings Ltd. |
G-CSF conjugates
|
|
US6646110B2
(en)
*
|
2000-01-10 |
2003-11-11 |
Maxygen Holdings Ltd. |
G-CSF polypeptides and conjugates
|
|
WO2001058935A2
(en)
|
2000-02-11 |
2001-08-16 |
Maxygen Aps |
FACTOR VII OR VIIa-LIKE MOLECULES
|
|
US7049761B2
(en)
*
|
2000-02-11 |
2006-05-23 |
Altair Engineering, Inc. |
Light tube and power supply circuit
|
|
ATE269716T1
(de)
|
2000-02-29 |
2004-07-15 |
Pfizer Prod Inc |
Stabilisierter granulozyten-kolonie- stimulierender faktor
|
|
US20020064820A1
(en)
*
|
2000-03-13 |
2002-05-30 |
Jean-Michel Dayer |
Apo-A-I regulation of T-cell signaling
|
|
WO2001076639A2
(en)
*
|
2000-04-06 |
2001-10-18 |
Pharmacia Corporation |
Chemically-modified myelopoietin conjugates
|
|
US6586398B1
(en)
*
|
2000-04-07 |
2003-07-01 |
Amgen, Inc. |
Chemically modified novel erythropoietin stimulating protein compositions and methods
|
|
EP1280924A2
(en)
*
|
2000-04-14 |
2003-02-05 |
University of South Carolina Research Foundation |
Cloning of corynebacteriaceae histidine ammonia lyase and therapeutic uses
|
|
CA2407083A1
(en)
|
2000-04-21 |
2001-11-01 |
Amgen Inc. |
Apo-ai/aii peptide derivatives
|
|
US6677136B2
(en)
|
2000-05-03 |
2004-01-13 |
Amgen Inc. |
Glucagon antagonists
|
|
US20030211094A1
(en)
*
|
2001-06-26 |
2003-11-13 |
Nelsestuen Gary L. |
High molecular weight derivatives of vitamin k-dependent polypeptides
|
|
US20050089970A1
(en)
*
|
2000-07-12 |
2005-04-28 |
Bradburne James A. |
Polymer-modified bioactive synthetic chemokines, and methods for their manufacture and use
|
|
US7118737B2
(en)
*
|
2000-09-08 |
2006-10-10 |
Amylin Pharmaceuticals, Inc. |
Polymer-modified synthetic proteins
|
|
AU2001273388B2
(en)
*
|
2000-09-08 |
2005-01-13 |
Gryphon Therapeutics, Inc. |
"Pseudo"-native chemical ligation
|
|
EP1324779B1
(en)
*
|
2000-09-29 |
2011-07-20 |
Schering Corporation |
Pegylated interleukin-10
|
|
JP5170931B2
(ja)
*
|
2000-10-16 |
2013-03-27 |
中外製薬株式会社 |
Peg修飾エリスロポエチン
|
|
ATE537845T1
(de)
*
|
2000-10-31 |
2012-01-15 |
Pr Pharmaceuticals Inc |
Verfahren zur herstellung von formulierungen zur verbesserten abgabe von bioaktiven molekülen
|
|
AU2002212108A1
(en)
*
|
2000-11-02 |
2002-05-15 |
Maxygen Aps |
Single-chain multimeric polypeptides
|
|
CN1321134C
(zh)
*
|
2000-11-23 |
2007-06-13 |
赵剑 |
一种生物活性蛋白质的非均一制品及其制备方法
|
|
US8273713B2
(en)
*
|
2000-12-14 |
2012-09-25 |
Amylin Pharmaceuticals, Llc |
Methods of treating obesity using PYY[3-36]
|
|
TW593427B
(en)
*
|
2000-12-18 |
2004-06-21 |
Nektar Therapeutics Al Corp |
Synthesis of high molecular weight non-peptidic polymer derivatives
|
|
US7053150B2
(en)
|
2000-12-18 |
2006-05-30 |
Nektar Therapeutics Al, Corporation |
Segmented polymers and their conjugates
|
|
AU3323002A
(en)
*
|
2000-12-20 |
2002-07-01 |
Hoffmann La Roche |
Erythropoietin conjugates
|
|
US7442370B2
(en)
|
2001-02-01 |
2008-10-28 |
Biogen Idec Ma Inc. |
Polymer conjugates of mutated neublastin
|
|
EP1392731B1
(en)
*
|
2001-02-06 |
2008-07-02 |
Merk Patent Gmbh |
Modified granulocyte colony stimulating factor (g-csf) with reduced immunogenicity
|
|
EP1234583A1
(en)
*
|
2001-02-23 |
2002-08-28 |
F. Hoffmann-La Roche Ag |
PEG-conjugates of HGF-NK4
|
|
CZ20032526A3
(cs)
|
2001-02-27 |
2003-12-17 |
Maxygen Aps |
Nové molekuly podobné interferonu beta
|
|
US7276580B2
(en)
|
2001-03-12 |
2007-10-02 |
Biogen Idec Ma Inc. |
Neurotrophic factors
|
|
CA2445947A1
(en)
*
|
2001-04-30 |
2002-11-07 |
Targeted Genetics Corporation |
Lipid-comprising drug delivery complexes and methods for their production
|
|
US7247618B2
(en)
*
|
2001-04-30 |
2007-07-24 |
Tripathi Rajavashisth |
Methods for inhibiting macrophage colony stimulating factor and c-FMS-dependent cell signaling
|
|
NZ542878A
(en)
|
2001-05-11 |
2007-06-29 |
Amgen Inc |
Peptides and related molecules that bind to tall-1 in particular SEQ ID NO:104
|
|
DE60229958D1
(de)
*
|
2001-06-28 |
2009-01-02 |
Mountain View Pharmaceuticals |
Polymerstabilisierte proteinasen
|
|
NZ530545A
(en)
*
|
2001-07-11 |
2006-10-27 |
Maxygen Holdings Ltd |
Specific conjugates comprising a polypeptide exhibiting G-CSF activity and a non-polypeptide moiety
|
|
US20040077835A1
(en)
*
|
2001-07-12 |
2004-04-22 |
Robin Offord |
Chemokine receptor modulators, production and use
|
|
BR0213103A
(pt)
*
|
2001-10-05 |
2004-09-21 |
Intermune Inc |
Método para tratamento de infecção pelo vìrus da hepatite com um perfil de liberação de interferon multifásico
|
|
US7084257B2
(en)
|
2001-10-05 |
2006-08-01 |
Amgen Inc. |
Fully human antibody Fab fragments with human interferon-gamma neutralizing activity
|
|
US6908963B2
(en)
*
|
2001-10-09 |
2005-06-21 |
Nektar Therapeutics Al, Corporation |
Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
|
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
|
US7214660B2
(en)
*
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
US7157277B2
(en)
|
2001-11-28 |
2007-01-02 |
Neose Technologies, Inc. |
Factor VIII remodeling and glycoconjugation of Factor VIII
|
|
US7138370B2
(en)
|
2001-10-11 |
2006-11-21 |
Amgen Inc. |
Specific binding agents of human angiopoietin-2
|
|
JP4814488B2
(ja)
|
2001-10-18 |
2011-11-16 |
ネクター セラピューティックス |
重合体共役物オピオイドアンタゴニスト
|
|
CN100484569C
(zh)
*
|
2001-11-19 |
2009-05-06 |
协和发酵工业株式会社 |
将多潜能干细胞从组织中流通到外周血的药物
|
|
EA200700431A1
(ru)
*
|
2001-11-20 |
2008-02-28 |
Фармация Корпорейшн |
Конъюгаты химически модифицированного гормона роста человека
|
|
US20030171285A1
(en)
*
|
2001-11-20 |
2003-09-11 |
Finn Rory F. |
Chemically-modified human growth hormone conjugates
|
|
KR100480432B1
(ko)
*
|
2001-12-04 |
2005-04-06 |
선바이오(주) |
G-csf와 폴리에틸렌글리콜 유도체의 배합체
|
|
WO2003049760A1
(en)
*
|
2001-12-07 |
2003-06-19 |
Intermune, Inc. |
Compositions and method for treating hepatitis virus infection
|
|
AU2003209227A1
(en)
|
2002-01-14 |
2003-07-30 |
The General Hospital Corporation |
Biodegradable polyketal polymers and methods for their formation and use
|
|
GEP20074024B
(en)
*
|
2002-01-18 |
2007-01-10 |
Biogen Idec Inc |
Polyalkylene glycol comprising a radical for conjugation of biologically active compound
|
|
DE10209821A1
(de)
|
2002-03-06 |
2003-09-25 |
Biotechnologie Ges Mittelhesse |
Kopplung von Proteinen an ein modifiziertes Polysaccharid
|
|
US20030191056A1
(en)
*
|
2002-04-04 |
2003-10-09 |
Kenneth Walker |
Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
|
|
US20030199464A1
(en)
*
|
2002-04-23 |
2003-10-23 |
Silviu Itescu |
Regeneration of endogenous myocardial tissue by induction of neovascularization
|
|
WO2003105763A2
(en)
*
|
2002-06-14 |
2003-12-24 |
Amylin Pharmaceuticals, Inc. |
Prevention and/or treatment of inflammatory bowel disease using pyy or agonists thereof
|
|
US20040002451A1
(en)
*
|
2002-06-20 |
2004-01-01 |
Bruce Kerwin |
Compositions of pegylated soluble tumor necrosis factor receptors and methods of preparing
|
|
AU2003256613A1
(en)
*
|
2002-07-19 |
2004-02-09 |
Amgen Inc. |
Protein conjugates with a water-soluble biocompatible, biogradable polymer
|
|
EP1534269B1
(en)
|
2002-07-19 |
2013-10-30 |
The General Hospital Corporation |
Oxime conjugates and methods for their formation and use
|
|
JP2006508056A
(ja)
|
2002-08-28 |
2006-03-09 |
イミュネックス・コーポレーション |
心臓血管疾患を治療するための組成物および方法
|
|
PL375883A1
(en)
|
2002-09-09 |
2005-12-12 |
Nektar Therapeutics Al, Corporation |
Water-soluble polymer alkanals
|
|
US8129330B2
(en)
|
2002-09-30 |
2012-03-06 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
|
ES2314238T3
(es)
|
2002-10-08 |
2009-03-16 |
Fresenius Kabi Deutschland Gmbh |
Conjugados de oligosacaridos farmaceuticamente activos.
|
|
JP2004196770A
(ja)
*
|
2002-10-24 |
2004-07-15 |
Effector Cell Institute Inc |
樹状細胞前駆体の血中レベル上昇剤
|
|
US20050075279A1
(en)
*
|
2002-10-25 |
2005-04-07 |
Boehringer Ingelheim International Gmbh |
Macrocyclic peptides active against the hepatitis C virus
|
|
US7314613B2
(en)
|
2002-11-18 |
2008-01-01 |
Maxygen, Inc. |
Interferon-alpha polypeptides and conjugates
|
|
PA8588901A1
(es)
*
|
2002-11-20 |
2005-02-04 |
Pharmacia Corp |
Conjugados de hormona de crecimiento humana pegilados n-terminales y proceso para su preparacion
|
|
EA008866B1
(ru)
*
|
2002-12-26 |
2007-08-31 |
Маунтин Вью Фамэсьютикэлс, Инк. |
ПОЛИМЕРНЫЙ КОНЪЮГАТ МОДИФИКАЦИЙ ИНТЕРФЕРОНА-β, ФАРМАЦЕВТИЧЕСКИЕ ПРОДУКТЫ НА ЕГО ОСНОВЕ И СПОСОБ ИХ ПОЛУЧЕНИЯ
|
|
BR0317752A
(pt)
*
|
2002-12-26 |
2005-11-22 |
Mountain View Pharmaceuticals |
Conjugados poliméricos de citocinas, quimiocinas, fatores do crescimento, hormÈnios polipeptìdicos e seus antagonistas com atividade de ligação a receptores conservada
|
|
KR20050090420A
(ko)
|
2002-12-26 |
2005-09-13 |
다케다 야쿠힌 고교 가부시키가이샤 |
메타스틴 유도체 및 이의 용도
|
|
WO2004061094A1
(en)
|
2002-12-30 |
2004-07-22 |
Gryphon Therapeutics, Inc. |
Water-soluble thioester and selenoester compounds and methods for making and using the same
|
|
US7803362B2
(en)
*
|
2003-01-24 |
2010-09-28 |
Synageva Biopharma Corp. |
Glycosylated interferon alpha
|
|
WO2004076474A2
(en)
*
|
2003-02-26 |
2004-09-10 |
Intermune, Inc. |
Polyethylene glycol modified interferon compositions and methods of use thereof
|
|
US20070077225A1
(en)
*
|
2003-02-28 |
2007-04-05 |
Blatt Lawrence M |
Continuous delivery methods for treating hepatitis virus infection
|
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
|
US7871607B2
(en)
|
2003-03-05 |
2011-01-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
|
|
EP2177620B1
(en)
|
2003-03-05 |
2014-11-19 |
Halozyme, Inc. |
Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof
|
|
CN102212019B
(zh)
|
2003-03-14 |
2015-05-27 |
蔚所番有限公司 |
支化水溶性聚合物及其缀合物
|
|
WO2004084948A1
(en)
*
|
2003-03-28 |
2004-10-07 |
Biopolymed Inc. |
Biologically active material conjugated with biocompatible polymer with 1:1 complex, preparation method thereof and pharmaceutical composition comprising the same
|
|
US20060134736A1
(en)
*
|
2003-03-28 |
2006-06-22 |
Jacobs John W |
Human growth hormone conjugated with biocompatible polymer
|
|
US7642340B2
(en)
|
2003-03-31 |
2010-01-05 |
Xencor, Inc. |
PEGylated TNF-α variant proteins
|
|
CA2520875A1
(en)
|
2003-03-31 |
2004-10-21 |
Xencor, Inc. |
Methods for rational pegylation of proteins
|
|
US7610156B2
(en)
|
2003-03-31 |
2009-10-27 |
Xencor, Inc. |
Methods for rational pegylation of proteins
|
|
MXPA05010773A
(es)
|
2003-04-09 |
2005-12-12 |
Neose Technologies Inc |
Metodos de glicopegilacion y proteinas/peptidos producidos por los metodos.
|
|
US8791070B2
(en)
|
2003-04-09 |
2014-07-29 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
|
WO2004091494A2
(en)
*
|
2003-04-11 |
2004-10-28 |
Pr Pharmaceuticals Inc. |
Method for preparation of site-specific protein conjugates
|
|
JP4753867B2
(ja)
|
2003-04-15 |
2011-08-24 |
グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー |
ヒトil−18を含むコンジュゲートおよびその置換変異体
|
|
WO2004094592A2
(en)
|
2003-04-18 |
2004-11-04 |
Biogen Idec Ma Inc. |
Polymer-conjugated glycosylated neublastin
|
|
EP1633317A4
(en)
|
2003-05-16 |
2008-08-20 |
Intermune Inc |
Synthetic chemokine receptor ligands and methods of use therefor
|
|
AU2004259327B2
(en)
*
|
2003-07-22 |
2009-12-17 |
Nektar Therapeutics |
Method for preparing functionalized polymers from polymer alcohols
|
|
EP2133362B1
(en)
|
2003-07-25 |
2012-04-18 |
Amgen, Inc |
Methods relating to LDCAM and CRTAM
|
|
WO2005012484A2
(en)
|
2003-07-25 |
2005-02-10 |
Neose Technologies, Inc. |
Antibody-toxin conjugates
|
|
WO2005014655A2
(en)
|
2003-08-08 |
2005-02-17 |
Fresenius Kabi Deutschland Gmbh |
Conjugates of hydroxyalkyl starch and a protein
|
|
CN100519581C
(zh)
*
|
2003-08-25 |
2009-07-29 |
东丽株式会社 |
干扰素-β复合物
|
|
GB0320638D0
(en)
|
2003-09-03 |
2003-10-01 |
Novartis Ag |
Organic compounds
|
|
KR20120073370A
(ko)
|
2003-09-17 |
2012-07-04 |
넥타르 테라퓨틱스 |
다분지형 고분자 전구약물
|
|
ATE500264T1
(de)
*
|
2003-09-22 |
2011-03-15 |
Boehringer Ingelheim Int |
Makrozyklische peptide mit wirkung gegen das hepatitis-c-virus
|
|
SG143252A1
(en)
|
2003-10-09 |
2008-06-27 |
Ambrx Inc |
Polymer derivatives
|
|
EP1675871A2
(en)
|
2003-10-10 |
2006-07-05 |
Xencor Inc. |
Protein based tnf-alpha variants for the treatment of tnf-alpha related disorders
|
|
JP2007533298A
(ja)
|
2003-10-10 |
2007-11-22 |
ノボ ノルディスク アクティーゼルスカブ |
Il−21の誘導体
|
|
CN103145715B
(zh)
|
2003-10-14 |
2016-08-03 |
F·霍夫曼-罗须公司 |
作为hcv复制抑制剂的巨环羧酸和酰基磺酰胺
|
|
ES2428358T3
(es)
|
2003-10-17 |
2013-11-07 |
Novo Nordisk A/S |
Terapia de combinación
|
|
US7407973B2
(en)
*
|
2003-10-24 |
2008-08-05 |
Intermune, Inc. |
Use of pirfenidone in therapeutic regimens
|
|
US7220407B2
(en)
*
|
2003-10-27 |
2007-05-22 |
Amgen Inc. |
G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction
|
|
EP1725572B1
(de)
|
2003-11-05 |
2017-05-31 |
AGCT GmbH |
Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
|
|
US20080305992A1
(en)
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
|
US8633157B2
(en)
|
2003-11-24 |
2014-01-21 |
Novo Nordisk A/S |
Glycopegylated erythropoietin
|
|
US20060040856A1
(en)
|
2003-12-03 |
2006-02-23 |
Neose Technologies, Inc. |
Glycopegylated factor IX
|
|
WO2005053730A1
(ja)
*
|
2003-12-05 |
2005-06-16 |
Kirin Beer Kabushiki Kaisha |
末期心不全治療剤
|
|
WO2005067963A1
(en)
*
|
2003-12-23 |
2005-07-28 |
Intermune, Inc. |
Use of polyethylene glycol-modified interferon-alpha in therapeutic dosing regimens
|
|
GB0500020D0
(en)
|
2005-01-04 |
2005-02-09 |
Novartis Ag |
Organic compounds
|
|
US8361961B2
(en)
|
2004-01-08 |
2013-01-29 |
Biogenerix Ag |
O-linked glycosylation of peptides
|
|
ES2358333T3
(es)
*
|
2004-01-21 |
2011-05-09 |
Boehringer Ingelheim International Gmbh |
Péptidos macrocíclicos con acción contra el virus de la hepatitis c.
|
|
GB2429207A
(en)
|
2004-02-02 |
2007-02-21 |
Ambrx Inc |
Modified human interferon polypeptides and their uses
|
|
US8076288B2
(en)
*
|
2004-02-11 |
2011-12-13 |
Amylin Pharmaceuticals, Inc. |
Hybrid polypeptides having glucose lowering activity
|
|
EP2335715A3
(en)
*
|
2004-02-11 |
2013-12-18 |
Amylin Pharmaceuticals, LLC |
Pancreatic polypeptide family motifs and polypeptides comprising the same
|
|
AU2005211755B2
(en)
|
2004-02-11 |
2012-03-15 |
Amylin Pharmaceuticals, Llc |
Hybrid polypeptides with selectable properties
|
|
EP1734988A4
(en)
*
|
2004-03-01 |
2009-08-05 |
Enzon Pharmaceuticals Inc |
INTERFERON BETA-polymer
|
|
US20050215710A1
(en)
*
|
2004-03-23 |
2005-09-29 |
Gegg Colin V Jr |
Chemically modified protein compositions and methods
|
|
JP2008505853A
(ja)
|
2004-04-13 |
2008-02-28 |
クインテセンス バイオサイエンシーズ インコーポレーティッド |
細胞傷害性薬剤としての非天然のリボヌクレアーゼ複合体
|
|
EP1586334A1
(en)
*
|
2004-04-15 |
2005-10-19 |
TRASTEC scpa |
G-CSF conjugates with peg
|
|
US7318918B2
(en)
|
2004-05-19 |
2008-01-15 |
Maxygen, Inc. |
Interferon-alpha polypeptides and conjugates
|
|
US20060018875A1
(en)
*
|
2004-06-14 |
2006-01-26 |
Blatt Lawrence M |
Interferon compositions and methods of use thereof
|
|
NZ551335A
(en)
|
2004-06-18 |
2010-03-26 |
Ambrx Inc |
Antibodies and fragments thereof comprising an non naturally encoded amino acid coupled to a linker
|
|
AR049938A1
(es)
|
2004-06-25 |
2006-09-13 |
Takeda Pharmaceutical |
Derivados de metastina y utilizacion de los mismos
|
|
JP2008509889A
(ja)
*
|
2004-06-30 |
2008-04-03 |
イージェン コーポレーション |
ペグ化インターフェロンα−1b
|
|
EP1773400A2
(en)
*
|
2004-07-08 |
2007-04-18 |
Amgen Inc. |
Therapeutic peptides
|
|
EP1771066A2
(en)
|
2004-07-13 |
2007-04-11 |
Neose Technologies, Inc. |
Branched peg remodeling and glycosylation of glucagon-like peptide-1 glp-1
|
|
JP2008507280A
(ja)
|
2004-07-21 |
2008-03-13 |
アンブレツクス・インコーポレイテツド |
非天然コードアミノ酸を用いた生合成ポリペプチド
|
|
US7597884B2
(en)
|
2004-08-09 |
2009-10-06 |
Alios Biopharma, Inc. |
Hyperglycosylated polypeptide variants and methods of use
|
|
NZ553420A
(en)
|
2004-08-19 |
2010-02-26 |
Biogen Idec Inc |
Refolding transforming growth factor beta family proteins
|
|
BRPI0514534A
(pt)
|
2004-08-19 |
2008-06-17 |
Biogen Idec Inc |
variantes de neublastina
|
|
EP1799249A2
(en)
|
2004-09-10 |
2007-06-27 |
Neose Technologies, Inc. |
Glycopegylated interferon alpha
|
|
WO2006034455A2
(en)
|
2004-09-23 |
2006-03-30 |
Vasgene Therapeutics, Inc. |
Polipeptide compounds for inhibiting angiogenesis and tumor growth
|
|
MX2007003320A
(es)
|
2004-09-24 |
2007-05-18 |
Amgen Inc |
Moleculas fc modificadas.
|
|
EP1814573B1
(en)
|
2004-10-29 |
2016-03-09 |
ratiopharm GmbH |
Remodeling and glycopegylation of fibroblast growth factor (fgf)
|
|
US20060153799A1
(en)
*
|
2004-11-05 |
2006-07-13 |
Northwestern University |
Use of SCF and G-CSF in the treatment of cerebral ischemia and neurological disorders
|
|
EP3000826A1
(en)
|
2004-12-13 |
2016-03-30 |
Amylin Pharmaceuticals, LLC |
Pancreatic polypeptide family motifs, polypeptides and methods comprising the same
|
|
BRPI0519170A8
(pt)
*
|
2004-12-22 |
2018-05-08 |
Ambrx Inc |
formulações de hormônio de crescimento humano que compreendem um aminoácido não naturalmente codificado
|
|
CA3005835C
(en)
|
2004-12-22 |
2023-01-31 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
|
|
EP1836314B1
(en)
|
2004-12-22 |
2012-01-25 |
Ambrx, Inc. |
Modified human growth hormone
|
|
ZA200704927B
(en)
*
|
2004-12-22 |
2009-09-30 |
Ambrx Inc |
Compositions of aminoacyl-tRNA synthetase and uses thereof
|
|
EP1674113A1
(en)
|
2004-12-22 |
2006-06-28 |
F. Hoffmann-La Roche Ag |
Conjugates of insulin-like growth factor-1 (IGF-1) and poly(ethylene glycol)
|
|
BRPI0518661A2
(pt)
*
|
2004-12-22 |
2008-12-02 |
Ambrx Inc |
mÉtodos para expressço e purificaÇço do hormânio do crescimento humano recombinante
|
|
JP4951527B2
(ja)
|
2005-01-10 |
2012-06-13 |
バイオジェネリックス アーゲー |
糖peg化顆粒球コロニー刺激因子
|
|
AU2006208199B2
(en)
|
2005-01-25 |
2012-06-07 |
Cell Therapeutics, Inc. |
Conjugates of biologically active proteins having a modified in vivo half-life
|
|
US7662781B2
(en)
*
|
2005-01-31 |
2010-02-16 |
Eci, Inc. |
Immunopotentiating agent
|
|
US7402730B1
(en)
|
2005-02-03 |
2008-07-22 |
Lexicon Pharmaceuticals, Inc. |
Knockout animals manifesting hyperlipidemia
|
|
MX2007009760A
(es)
|
2005-02-11 |
2007-11-07 |
Amylin Pharmaceuticals Inc |
Polipeptidos del analogo e hibrido del peptido inhibidor gastrico con propiedades seleccionables.
|
|
US8263545B2
(en)
*
|
2005-02-11 |
2012-09-11 |
Amylin Pharmaceuticals, Inc. |
GIP analog and hybrid polypeptides with selectable properties
|
|
WO2006094530A1
(en)
*
|
2005-03-11 |
2006-09-14 |
Siegfried Ltd. |
Di-polymer protein conjugates and processes for their preparation
|
|
WO2007010552A2
(en)
*
|
2005-03-17 |
2007-01-25 |
Serum Institute Of India Limited |
N- terminal peg conjugate of erythropoietin
|
|
DE602006008456D1
(de)
|
2005-03-31 |
2009-09-24 |
Amylin Pharmaceuticals Inc |
Amylin und amylinagonisten für die behandlung von psychiatrischen erkrankungen und störungen
|
|
EP2314320A2
(en)
|
2005-04-05 |
2011-04-27 |
Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. |
Method for shielding functional sites or epitopes on proteins
|
|
WO2006121569A2
(en)
|
2005-04-08 |
2006-11-16 |
Neose Technologies, Inc. |
Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
|
|
LT3321359T
(lt)
|
2005-04-11 |
2021-05-10 |
Horizon Pharma Rheumatology Llc |
Urato oksidazės variantinės formos ir jų panaudojimas
|
|
US7833979B2
(en)
|
2005-04-22 |
2010-11-16 |
Amgen Inc. |
Toxin peptide therapeutic agents
|
|
KR20080019619A
(ko)
|
2005-05-18 |
2008-03-04 |
맥시겐, 인크. |
개량된 인터페론-알파 폴리펩티드
|
|
EP2975135A1
(en)
|
2005-05-25 |
2016-01-20 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
|
CA2607844C
(en)
*
|
2005-06-01 |
2012-07-10 |
Maxygen Holdings Ltd. |
Pegylated g-csf polypeptides and methods of producing same
|
|
JP2008545754A
(ja)
*
|
2005-06-01 |
2008-12-18 |
アルザ・コーポレーシヨン |
ポリエチレングリコール試薬をアシル化するためのバイオコンジュゲーション反応
|
|
WO2007009208A1
(en)
*
|
2005-06-02 |
2007-01-25 |
Cangene Corporation |
Poly(ethylene glocol) modified human gm-csf with increased biological activity
|
|
US20100135959A1
(en)
*
|
2005-06-03 |
2010-06-03 |
Ambrx, Inc. |
Human Interferon Molecules and Their Uses
|
|
KR100694994B1
(ko)
*
|
2005-06-13 |
2007-03-14 |
씨제이 주식회사 |
사람 과립구 콜로니 형성인자 동종체
|
|
EP1893240A2
(en)
*
|
2005-06-13 |
2008-03-05 |
Nastech Pharmaceutical Company Inc. |
Transmucosal delivery of peptide derivatives
|
|
ES2553160T3
(es)
|
2005-06-17 |
2015-12-04 |
Novo Nordisk Health Care Ag |
Reducción y derivatización selectivas de proteínas Factor VII transformadas por ingeniería que comprenden al menos una cisteína no nativa
|
|
WO2006138507A1
(en)
|
2005-06-17 |
2006-12-28 |
Novartis Ag |
Use of sanglifehrin in hcv
|
|
US7695710B2
(en)
*
|
2005-06-20 |
2010-04-13 |
Pepgen Corporation |
Antitumor and antiviral combination therapies using low-toxicity, long-circulating human interferon-alpha analogs
|
|
WO2007002233A2
(en)
*
|
2005-06-20 |
2007-01-04 |
Pepgen Corporation |
Low-toxicity, long-circulating chimeras of human interferon- alpha analogs and interferon tau
|
|
US8568705B2
(en)
|
2005-07-18 |
2013-10-29 |
Nektar Therapeutics |
Method for preparing branched functionalized polymers using branched polyol cores
|
|
KR100735784B1
(ko)
|
2005-07-20 |
2007-07-06 |
재단법인 목암생명공학연구소 |
인간 과립구콜로니자극인자 변이체 및 이의 화학적 접합물
|
|
CA2615666C
(en)
|
2005-07-25 |
2014-08-26 |
Intermune, Inc. |
Novel macrocyclic inhibitors of hepatitis c virus replication
|
|
WO2007015591A1
(en)
*
|
2005-08-02 |
2007-02-08 |
Cheil Industries Inc. |
Epoxy resin composition for packaging semiconductor device
|
|
KR20080033439A
(ko)
*
|
2005-08-04 |
2008-04-16 |
넥타르 테라퓨틱스 에이엘, 코포레이션 |
G-csf 부분 및 중합체의 컨주게이트
|
|
EP2330124B1
(en)
|
2005-08-11 |
2015-02-25 |
Amylin Pharmaceuticals, LLC |
Hybrid polypeptides with selectable properties
|
|
EP2330125A3
(en)
|
2005-08-11 |
2012-12-12 |
Amylin Pharmaceuticals, Inc. |
Hybrid polypeptides with selectable properties
|
|
US8008453B2
(en)
|
2005-08-12 |
2011-08-30 |
Amgen Inc. |
Modified Fc molecules
|
|
MX2008002149A
(es)
|
2005-08-18 |
2008-04-22 |
Ambrx Inc |
Composiciones de arnt y sus usos.
|
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
|
SI3524261T1
(sl)
|
2005-08-19 |
2024-02-29 |
Amylin Pharmaceuticals, Llc |
Exendin za uporabo pri zdravljenju sladkorne bolezni in zmanjševanju telesne teže
|
|
CA2624333A1
(en)
|
2005-10-11 |
2007-04-19 |
Intermune, Inc. |
Compounds and methods for inhibiting hepatitis c viral replication
|
|
WO2007047303A2
(en)
*
|
2005-10-12 |
2007-04-26 |
Alvine Pharmaceuticals, Inc. |
Pegylated glutenase polypeptides
|
|
KR20140077946A
(ko)
|
2005-10-13 |
2014-06-24 |
휴먼 게놈 사이언시즈, 인코포레이티드 |
자가항체 양성 질환 환자의 치료에 유용한 방법 및 조성물
|
|
US8168592B2
(en)
*
|
2005-10-21 |
2012-05-01 |
Amgen Inc. |
CGRP peptide antagonists and conjugates
|
|
US20080171696A1
(en)
*
|
2005-10-21 |
2008-07-17 |
Avigenics, Inc. |
Pharmacodynamically enhanced therapeutic proteins
|
|
EP1937294A4
(en)
*
|
2005-10-21 |
2009-11-04 |
Synageva Biopharma Corp |
GLYCOLIC AND GLYCOSYLATED THERAPEUTIC PROTEINS DERIVED FROM POULTRY
|
|
WO2007056191A2
(en)
|
2005-11-03 |
2007-05-18 |
Neose Technologies, Inc. |
Nucleotide sugar purification using membranes
|
|
NZ567234A
(en)
*
|
2005-11-08 |
2011-09-30 |
Ambrx Inc |
Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides
|
|
PE20070684A1
(es)
|
2005-11-14 |
2007-08-06 |
Amgen Inc |
MOLECULAS QUIMERICAS DE ANTICUERPO RANKL-PTH/PTHrP
|
|
CN106443006A
(zh)
*
|
2005-11-16 |
2017-02-22 |
Ambrx公司 |
包括非天然氨基酸的方法和组合物
|
|
DK1968635T3
(en)
*
|
2005-12-14 |
2014-12-15 |
Ambrx Inc |
Compositions and Methods of, and uses of non-natural amino acids and polypeptides
|
|
US8404643B2
(en)
|
2005-12-22 |
2013-03-26 |
Takeda Pharmaceutical Company Limited |
Metastin derivatives and use thereof
|
|
ES2664086T3
(es)
|
2005-12-30 |
2018-04-18 |
Zensun (Shanghai) Science & Technology, Co., Ltd. |
Liberación extendida de neurregulina para mejorar la función cardíaca
|
|
EP1985303B1
(en)
|
2006-01-12 |
2012-11-21 |
Kitasato Daiichi Sankyo Vaccine Co., Ltd. |
Oral composition containing Interferon-alpha
|
|
CN100475270C
(zh)
*
|
2006-01-20 |
2009-04-08 |
清华大学 |
一种治疗肿瘤的药物及其应用
|
|
EP1991577A2
(en)
|
2006-01-31 |
2008-11-19 |
Parkinson, John F. |
Modulation of mdl-1 activity for treatment of inflammatory disease
|
|
CA2642905C
(en)
|
2006-02-21 |
2015-04-28 |
Nektar Therapeutics Al, Corporation |
Segmented degradable polymers and conjugates made therefrom
|
|
TWI501774B
(zh)
|
2006-02-27 |
2015-10-01 |
Biogen Idec Inc |
神經性病症之治療
|
|
EP2010569A4
(en)
|
2006-03-20 |
2009-09-09 |
Xoma Technology Ltd |
HUMAN ANTIBODIES SPECIFIC TO GASTRINE MATERIALS AND METHODS
|
|
EP2007538A4
(en)
*
|
2006-03-31 |
2011-04-20 |
Centocor Ortho Biotech Inc |
BINDING PARTNER WITH MODIFIED IMMUNOGLOBULINDOMAS FOR EXTENDED SEMI-VALUE TIME
|
|
WO2007133865A2
(en)
|
2006-04-11 |
2007-11-22 |
Novartis Ag |
Hcv/hiv inhibitors an their uses
|
|
US9283260B2
(en)
|
2006-04-21 |
2016-03-15 |
Amgen Inc. |
Lyophilized therapeutic peptibody formulations
|
|
US8299024B2
(en)
*
|
2006-05-12 |
2012-10-30 |
Amylin Pharmaceuticals, Llc |
Methods to restore glycemic control
|
|
KR20090016596A
(ko)
|
2006-05-19 |
2009-02-16 |
글리코파이, 인크. |
에리트로포이에틴 조성물
|
|
US20090252720A1
(en)
|
2006-05-24 |
2009-10-08 |
Novo Nordisk Health Care Ag |
Prolonged FIX Analogues and Derivatives
|
|
US7981425B2
(en)
|
2006-06-19 |
2011-07-19 |
Amgen Inc. |
Thrombopoietic compounds
|
|
EP2044097A4
(en)
*
|
2006-06-23 |
2010-10-06 |
Quintessence Biosciences Inc |
Modified ribonucleases
|
|
US20080096900A1
(en)
|
2006-06-26 |
2008-04-24 |
Amgen Inc. |
Methods for treating atherosclerosis
|
|
EP2049151A4
(en)
|
2006-07-17 |
2010-03-24 |
Quintessence Biosciences Inc |
METHOD AND COMPOSITIONS FOR THE TREATMENT OF CANCER
|
|
WO2008011633A2
(en)
|
2006-07-21 |
2008-01-24 |
Neose Technologies, Inc. |
Glycosylation of peptides via o-linked glycosylation sequences
|
|
ES2344670T3
(es)
|
2006-07-25 |
2010-09-02 |
Lipoxen Technologies Limited |
Derivatizacion del factor estimulante de colonias granulociticas (gcsf).
|
|
GB0615067D0
(en)
*
|
2006-07-28 |
2006-09-06 |
Ttp Communications Ltd |
Reconfigurable signal processing scheme
|
|
WO2008019214A1
(en)
|
2006-08-04 |
2008-02-14 |
Prolong Pharmaceuticals, Inc. |
Modified erythropoietin
|
|
ITMI20061624A1
(it)
*
|
2006-08-11 |
2008-02-12 |
Bioker Srl |
Mono-coniugati sito-specifici di g-csf
|
|
US8497240B2
(en)
|
2006-08-17 |
2013-07-30 |
Amylin Pharmaceuticals, Llc |
DPP-IV resistant GIP hybrid polypeptides with selectable properties
|
|
EP2059530B1
(en)
*
|
2006-08-31 |
2012-08-29 |
F.Hoffmann-La Roche Ag |
Method for the production of insulin-like growth factor-i
|
|
CL2007002502A1
(es)
|
2006-08-31 |
2008-05-30 |
Hoffmann La Roche |
Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer.
|
|
WO2008030614A2
(en)
*
|
2006-09-08 |
2008-03-13 |
Ambrx, Inc. |
Suppressor trna transcription in vertebrate cells
|
|
PT2061878E
(pt)
*
|
2006-09-08 |
2014-04-22 |
Ambrx Inc |
Supressor híbrido arnt para células de vertebrados
|
|
EP2615108B1
(en)
*
|
2006-09-08 |
2016-10-26 |
Ambrx, Inc. |
Modified human plasma polypeptide or fc scaffolds and thier uses
|
|
US7985783B2
(en)
|
2006-09-21 |
2011-07-26 |
The Regents Of The University Of California |
Aldehyde tags, uses thereof in site-specific protein modification
|
|
AU2007314501B2
(en)
|
2006-09-28 |
2013-05-23 |
Merck Sharp & Dohme Corp. |
Use of pegylated IL-10 to treat cancer
|
|
JP2010505874A
(ja)
|
2006-10-03 |
2010-02-25 |
ノヴォ ノルディスク アー/エス |
ポリペプチドコンジュゲートの精製方法
|
|
ES2655734T3
(es)
*
|
2006-10-04 |
2018-02-21 |
Novo Nordisk A/S |
Glicopéptidos y azúcares pegilados unidos a glicerol
|
|
US20090252703A1
(en)
*
|
2006-10-19 |
2009-10-08 |
Gegg Jr Colin V |
Use of alcohol co-solvents to improve pegylation reaction yields
|
|
EP2081602A2
(en)
|
2006-10-25 |
2009-07-29 |
Amgen Inc. |
Toxin peptide therapeutic agents
|
|
TWI404726B
(zh)
|
2006-10-25 |
2013-08-11 |
Takeda Pharmaceutical |
腫瘤轉移抑制素衍生物及其用途
|
|
KR101079993B1
(ko)
*
|
2006-11-17 |
2011-11-04 |
동아제약주식회사 |
폴리에틸렌글리콜 과립구 콜로니 자극인자 접합체
|
|
AU2007325838B2
(en)
|
2006-11-22 |
2013-09-19 |
Bristol-Myers Squibb Company |
Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR
|
|
CN101855241B
(zh)
|
2006-12-08 |
2013-11-06 |
莱克康制药公司 |
针对angptl3的单克隆抗体
|
|
ATE516814T1
(de)
|
2007-02-02 |
2011-08-15 |
Bristol Myers Squibb Co |
10fn3 domain zur behandlung von krankheiten begleitet von unerwünschter angiogenese
|
|
CN101245109B
(zh)
*
|
2007-02-12 |
2011-12-14 |
杭州九源基因工程有限公司 |
一种聚乙二醇单修饰的重组人粒细胞集落刺激因子突变体及其制备方法
|
|
DK2068909T3
(da)
|
2007-03-30 |
2012-08-06 |
Ambrx Inc |
Modificerede FGF-21-polypeptider og anvendelse heraf
|
|
PT2144923E
(pt)
|
2007-04-03 |
2013-05-15 |
Biogenerix Ag |
Métodos de tratamento com g-csf glicopeguilado
|
|
JP2008266219A
(ja)
*
|
2007-04-20 |
2008-11-06 |
National Institute Of Advanced Industrial & Technology |
リジン及びシステイン残基を含まないタンパク質
|
|
ES2476253T3
(es)
|
2007-05-01 |
2014-07-14 |
Biogen Idec Ma Inc. |
P�ptidos de neublastina para su uso en el aumento de la vascularizaci�n en tejido con flujo sanguíneo deteriorado
|
|
CA2685596A1
(en)
|
2007-05-02 |
2008-11-13 |
Ambrx, Inc. |
Modified interferon beta polypeptides and their uses
|
|
US8420779B2
(en)
|
2007-05-22 |
2013-04-16 |
Amgen Inc. |
Compositions and methods for producing bioactive fusion proteins
|
|
CN101778937A
(zh)
*
|
2007-06-04 |
2010-07-14 |
诺和诺德公司 |
使用n-乙酰葡糖胺转移酶的o-联糖基化
|
|
US9493499B2
(en)
|
2007-06-12 |
2016-11-15 |
Novo Nordisk A/S |
Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography
|
|
US20110159523A1
(en)
*
|
2007-06-27 |
2011-06-30 |
Cedars-Sinai Medical Center |
N-terminal specific chemical labeling for proteomics applications
|
|
PT2489731E
(pt)
|
2007-07-26 |
2014-09-15 |
Amgen Inc |
Enzimas aciltransferase de lecitina-colesterol modificadas
|
|
CN101352573B
(zh)
*
|
2007-07-27 |
2011-02-09 |
杭州九源基因工程有限公司 |
聚乙二醇单修饰的重组人集落细胞刺激因子赖氨酸缺陷体
|
|
US20090324609A1
(en)
|
2007-08-09 |
2009-12-31 |
Genzyme Corporation |
Method of treating autoimmune disease with mesenchymal stem cells
|
|
CL2008002399A1
(es)
*
|
2007-08-16 |
2009-01-02 |
Pharmaessentia Corp |
Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c.
|
|
HRP20140590T1
(hr)
|
2007-08-27 |
2014-08-15 |
Ratiopharm Gmbh |
Tekuä†i oblik g-csf konjugata
|
|
US8207112B2
(en)
|
2007-08-29 |
2012-06-26 |
Biogenerix Ag |
Liquid formulation of G-CSF conjugate
|
|
US8758761B2
(en)
*
|
2007-09-30 |
2014-06-24 |
University Of Florida Research Foundation, Inc. |
Combination therapies for treating type 1 diabetes
|
|
US8697062B2
(en)
*
|
2007-10-08 |
2014-04-15 |
Quintessence Biosciences, Inc. |
Compositions and methods for ribonuclease-based therapeutics
|
|
EP2214716B1
(en)
|
2007-10-23 |
2021-11-17 |
Nektar Therapeutics |
Hydroxyapatite-targeting multiarm polymers and conjugates made therefrom
|
|
AU2008326324B9
(en)
*
|
2007-11-20 |
2012-11-15 |
Ambrx, Inc. |
Modified insulin polypeptides and their uses
|
|
WO2009073977A1
(en)
*
|
2007-12-13 |
2009-06-18 |
Biovectra Inc. |
Polypeptides modified by protein trans-splicing technology
|
|
DK2416157T3
(da)
|
2007-12-27 |
2014-08-18 |
Baxter Int |
Fremgangsmåde og sammensætninger til specifik påvisning af fysiologisk acceptable polymermolekyler
|
|
US20100316702A1
(en)
*
|
2008-01-08 |
2010-12-16 |
The Regents Of The University Of California |
Compositions and methods for regulating erythropoeitin expression and ameliorating anemia and stimulating erythropoiesis
|
|
CN102037004A
(zh)
*
|
2008-01-08 |
2011-04-27 |
生物种属学股份公司 |
使用寡糖基转移酶的多肽的糖缀合
|
|
US20090183503A1
(en)
*
|
2008-01-18 |
2009-07-23 |
Alberto Verdesi |
Exhaust apparatus
|
|
EP3219795B1
(en)
|
2008-01-18 |
2024-03-13 |
BioMarin Pharmaceutical Inc. |
Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof
|
|
US9938333B2
(en)
|
2008-02-08 |
2018-04-10 |
Ambrx, Inc. |
Modified leptin polypeptides and their uses
|
|
JP5225393B2
(ja)
*
|
2008-02-18 |
2013-07-03 |
ジエンス ヘンルイ メデイシンカンパニー リミテッド |
水溶性高分子修飾g−csf複合体
|
|
CN101965200B
(zh)
|
2008-02-27 |
2013-06-19 |
诺沃-诺迪斯克有限公司 |
缀合的因子ⅷ分子
|
|
TWI395593B
(zh)
|
2008-03-06 |
2013-05-11 |
Halozyme Inc |
可活化的基質降解酵素之活體內暫時性控制
|
|
ES2453946T3
(es)
*
|
2008-04-03 |
2014-04-09 |
Biosteed Gene Expression Tech. Co., Ltd. |
Hormona del crecimiento modificada con polietilenglicol bicatenario, método de preparación y aplicación de esta
|
|
WO2009121551A1
(en)
*
|
2008-04-03 |
2009-10-08 |
F. Hoffmann-La Roche Ag |
Pegylated insulin-like-growth-factor assay
|
|
CN103381267A
(zh)
|
2008-04-14 |
2013-11-06 |
哈洛齐梅公司 |
修饰的透明质酸酶及其在治疗透明质酸相关疾病和病症中的应用
|
|
TWI394580B
(zh)
|
2008-04-28 |
2013-05-01 |
Halozyme Inc |
超快起作用胰島素組成物
|
|
EP2303313B1
(en)
|
2008-05-21 |
2015-10-28 |
Amylin Pharmaceuticals, LLC |
Exendins to lower cholestrol and triglycerides
|
|
EP2799448A1
(en)
|
2008-05-22 |
2014-11-05 |
Bristol-Myers Squibb Company |
Multivalent fibronectin based scaffold domain proteins
|
|
JOP20190083A1
(ar)
|
2008-06-04 |
2017-06-16 |
Amgen Inc |
بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها
|
|
GB0811743D0
(en)
|
2008-06-26 |
2008-07-30 |
Hemosol Biopharma Inc |
Composition
|
|
AU2009262199B2
(en)
|
2008-06-27 |
2012-08-09 |
Amgen Inc. |
Ang-2 inhibition to treat multiple sclerosis
|
|
PT2318029T
(pt)
|
2008-07-23 |
2018-01-10 |
Ambrx Inc |
Polipéptidos de g-csf bovino modificados e suas utilizações
|
|
LT2314609T
(lt)
*
|
2008-07-30 |
2017-04-10 |
Takeda Pharmaceutical Company Limited |
Metastino darinys ir jo panaudojimas
|
|
CN102131844B
(zh)
*
|
2008-07-31 |
2016-03-02 |
药华医药股份有限公司 |
肽-聚合物缀合物
|
|
EP2331140B1
(en)
|
2008-08-11 |
2018-07-04 |
Nektar Therapeutics |
Multi-arm polymeric alkanoate conjugates
|
|
JP5766118B2
(ja)
|
2008-09-11 |
2015-08-19 |
ウェルズ ファーゴ バンク ナショナル アソシエイション |
ポリマー性アルファ−ヒドロキシアルデヒドおよびケトン反応剤ならびに抱合方法
|
|
DK2342223T3
(en)
|
2008-09-26 |
2017-07-24 |
Ambrx Inc |
Modified animal erythropoietin polypeptides and their uses
|
|
EA201170493A1
(ru)
|
2008-09-26 |
2011-10-31 |
Амбркс, Инк. |
Микроорганизмы и вакцины, зависимые от репликации неприродных аминокислот
|
|
CN102227443B
(zh)
|
2008-10-01 |
2014-05-14 |
昆特森斯生物科学公司 |
治疗性核糖核酸酶
|
|
CA2739615C
(en)
|
2008-10-10 |
2017-12-05 |
Amgen Inc. |
Fgf21 mutants comprising polyethylene glycol and uses thereof
|
|
AU2009303368B2
(en)
|
2008-10-15 |
2012-04-05 |
Takeda Pharmaceutical Company Limited |
Pegylation of recombinant blood coagulation factors in the presence of bound antibodies
|
|
KR101929641B1
(ko)
|
2008-10-17 |
2018-12-14 |
박스알타 인코퍼레이티드 |
낮은 수준의 수용성 중합체를 포함하는 개질된 혈액 인자
|
|
BRPI0919827B8
(pt)
*
|
2008-10-20 |
2021-05-25 |
Usv Ltd |
processos para aumentar o rendimento de uma reação de peguilação de r-methug-csf processo para a produção em escala grama de peg- r-methug-csf
|
|
DK2431741T3
(da)
|
2008-10-21 |
2013-10-21 |
Baxter Int |
Fremgangsmåde til bestemmelse af virksomme bestanddele i profarmaka-PEG-proteinkonjugat
|
|
EP2344527A4
(en)
*
|
2008-10-31 |
2012-04-04 |
Amgen Inc |
MATERIALS AND METHODS FOR STEM CELL MOBILIZATION THROUGH A MULTIPLE PEGYLATED GRANULOCYTE COLONY STIMULATING FACTOR
|
|
IT1392655B1
(it)
|
2008-11-20 |
2012-03-16 |
Bio Ker S R L |
Site-specific monoconjugated insulinotropic glp-1 peptides.
|
|
TWI496582B
(zh)
|
2008-11-24 |
2015-08-21 |
必治妥美雅史谷比公司 |
雙重專一性之egfr/igfir結合分子
|
|
US8927249B2
(en)
|
2008-12-09 |
2015-01-06 |
Halozyme, Inc. |
Extended soluble PH20 polypeptides and uses thereof
|
|
CA2746125C
(en)
*
|
2008-12-11 |
2017-07-11 |
Baxter International Inc. |
Detection of physiologically acceptable polymer molecules using near infrared spectroscopy
|
|
EP2379115B1
(en)
|
2008-12-17 |
2017-10-25 |
Merck Sharp & Dohme Corp. |
Mono- and di-peg il-10 production; and uses
|
|
US9636384B2
(en)
|
2009-04-06 |
2017-05-02 |
Mayo Foundation For Medical Education And Research |
Methods for making polymeric nanoparticle-polypeptide complex
|
|
US8512690B2
(en)
|
2009-04-10 |
2013-08-20 |
Novartis Ag |
Derivatised proline containing peptide compounds as protease inhibitors
|
|
US20110182850A1
(en)
|
2009-04-10 |
2011-07-28 |
Trixi Brandl |
Organic compounds and their uses
|
|
DK3248610T5
(da)
|
2009-05-05 |
2024-10-07 |
Amgen Inc |
Fgf21-mutanter og anvendelser deraf
|
|
JP2012525847A
(ja)
|
2009-05-05 |
2012-10-25 |
アムジエン・インコーポレーテツド |
Fgf21変異体およびその使用
|
|
DK2432489T3
(en)
|
2009-05-20 |
2017-01-16 |
Biomarin Pharm Inc |
VARIETIES OF C-TYPE NATRIURETIC PEPTID
|
|
AU2010262927A1
(en)
|
2009-06-17 |
2012-01-19 |
Amgen Inc. |
Chimeric FGF19 polypeptides and uses thereof
|
|
KR20120112350A
(ko)
|
2009-06-19 |
2012-10-11 |
메디뮨 엘엘씨 |
프로테아제 변이체
|
|
PL398781A1
(pl)
|
2009-06-25 |
2012-11-19 |
Savient Pharmaceuticals, Inc. |
Sposoby i zestawy do prognozowania ryzyka wystapienia reakcji na wlew oraz zaniku odpowiedzi której posrednicza przeciwciala poprzez monitorowanie kwasu moczowego w surowicy podczas terapii z zastosowaniem pegylowanej urykazy
|
|
US20110027229A1
(en)
|
2009-07-31 |
2011-02-03 |
Medtronic, Inc. |
Continuous subcutaneous administration of interferon-alpha to hepatitis c infected patients
|
|
PT2477603E
(pt)
|
2009-09-17 |
2016-06-16 |
Baxalta Inc |
Co-formulação estável de hialuronidase e imunoglobulina e métodos para a sua utilização
|
|
EP2480578A4
(en)
*
|
2009-09-25 |
2013-04-17 |
Vybion Inc |
MODIFICATION OF POLYPEPTIDE
|
|
CA2772945A1
(en)
|
2009-09-25 |
2011-03-31 |
Xoma Technology Ltd. |
Screening methods
|
|
US8926976B2
(en)
|
2009-09-25 |
2015-01-06 |
Xoma Technology Ltd. |
Modulators
|
|
WO2011050938A1
(de)
|
2009-10-26 |
2011-05-05 |
Genovoxx Gmbh |
Konjugate von nukleotiden und methoden zu deren anwendung
|
|
PH12012500827A1
(en)
|
2009-10-30 |
2013-01-07 |
Boehringer Ingelheim Int |
Dosage regimens for hcv combination therapy comprising bi201335, interferon alpha and ribavirin
|
|
EP2774935B8
(en)
|
2009-10-30 |
2017-06-21 |
NTF Therapeutics, Inc. |
Improved neurturin molecules
|
|
EP2504021A4
(en)
|
2009-11-23 |
2013-05-15 |
Amylin Pharmaceuticals Llc |
Polypeptide conjugate
|
|
CN107337734A
(zh)
|
2009-12-04 |
2017-11-10 |
弗·哈夫曼-拉罗切有限公司 |
多特异性抗体、抗体类似物、组合物和方法
|
|
UA109888C2
(uk)
|
2009-12-07 |
2015-10-26 |
|
ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
|
|
BR112012015461A2
(pt)
|
2009-12-21 |
2017-01-10 |
Ambrx Inc |
polipeptídeos de somatotropina boviina modificados e seus usos
|
|
SG181769A1
(en)
|
2009-12-21 |
2012-07-30 |
Ambrx Inc |
Modified porcine somatotropin polypeptides and their uses
|
|
US20110152188A1
(en)
*
|
2009-12-23 |
2011-06-23 |
Hanns-Christian Mahler |
Pharmaceutical compositions of igf/i proteins
|
|
US20130040888A1
(en)
|
2010-02-16 |
2013-02-14 |
Novo Nordisk A/S |
Factor VIII Molecules With Reduced VWF Binding
|
|
KR101857825B1
(ko)
*
|
2010-03-04 |
2018-05-14 |
피페넥스 인크. |
변성 없이 가용성 재조합 인터페론 단백질을 제조하는 방법
|
|
US8455218B2
(en)
|
2010-04-01 |
2013-06-04 |
Pfenex, Inc. |
Methods for G-CSF production in a Pseudomonas host cell
|
|
EP2558497A2
(en)
|
2010-04-15 |
2013-02-20 |
Amgen Inc. |
Human fgf receptor and beta-klotho binding proteins
|
|
CN103118692A
(zh)
|
2010-04-26 |
2013-05-22 |
Atyr医药公司 |
与半胱氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
|
|
US8961960B2
(en)
|
2010-04-27 |
2015-02-24 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases
|
|
US8993723B2
(en)
|
2010-04-28 |
2015-03-31 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl-tRNA synthetases
|
|
US9068177B2
(en)
|
2010-04-29 |
2015-06-30 |
Atyr Pharma, Inc |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases
|
|
WO2011139907A2
(en)
|
2010-04-29 |
2011-11-10 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases
|
|
CN103097523B
(zh)
|
2010-04-29 |
2016-09-28 |
Atyr医药公司 |
与天冬酰胺酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
|
|
CN102234310B
(zh)
*
|
2010-04-30 |
2017-02-08 |
杭州九源基因工程有限公司 |
一种聚乙二醇修饰蛋白的分离纯化方法
|
|
JP6008841B2
(ja)
|
2010-05-03 |
2016-10-19 |
エータイアー ファーマ, インコーポレイテッド |
メチオニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
|
|
AU2011248227B2
(en)
|
2010-05-03 |
2016-12-01 |
Pangu Biopharma Limited |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases
|
|
CN103096925A
(zh)
|
2010-05-03 |
2013-05-08 |
Atyr医药公司 |
与精氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
|
|
US9062302B2
(en)
|
2010-05-04 |
2015-06-23 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-tRNA synthetase complex
|
|
JP2013528374A
(ja)
|
2010-05-10 |
2013-07-11 |
パーシード セラピューティクス リミテッド ライアビリティ カンパニー |
Vla4のポリペプチド阻害剤
|
|
EP2568996B1
(en)
|
2010-05-14 |
2017-10-04 |
aTyr Pharma, Inc. |
Therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-trna synthetases
|
|
WO2011146410A2
(en)
|
2010-05-17 |
2011-11-24 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-trna synthetases
|
|
US8927488B2
(en)
|
2010-05-17 |
2015-01-06 |
Cebix, Inc. |
Pegylated C-peptide
|
|
WO2011150133A2
(en)
|
2010-05-26 |
2011-12-01 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold proteins having improved stability
|
|
AU2011261486B2
(en)
|
2010-06-01 |
2017-02-23 |
Pangu Biopharma Limited |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-tRNA synthetases
|
|
US20120123338A1
(en)
|
2010-06-16 |
2012-05-17 |
Medtronic, Inc. |
Damping systems for stabilizing medications in drug delivery devices
|
|
MX2013000242A
(es)
|
2010-06-24 |
2014-04-14 |
Panmed Ltd |
Tratamiento de enfermedades relacionadas con el virus de hepatitis c que usa hidroxicloroquina o una combinacion de hidroxicloroquina y un agente antiviral.
|
|
CA2804416C
(en)
|
2010-07-12 |
2020-04-28 |
Atyr Pharma, Inc. |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases
|
|
EP2593130A2
(en)
|
2010-07-15 |
2013-05-22 |
Novo Nordisk A/S |
Stabilized factor viii variants
|
|
EP2595624B1
(en)
|
2010-07-20 |
2018-01-31 |
Halozyme, Inc. |
Methods of treatment or prevention of the adverse side-effects associated with administration of an anti-hyaluronan agent
|
|
AR082319A1
(es)
|
2010-07-22 |
2012-11-28 |
Biomarin Pharm Inc |
Produccion de una n-acetilgalactosamina-6-sulfatasa humana activa altamente fosforilada y sus usos
|
|
CA2807552A1
(en)
|
2010-08-06 |
2012-02-09 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
RU2446173C1
(ru)
*
|
2010-08-13 |
2012-03-27 |
Зао "Биокад" |
Новый функционально активный, высокоочищенный стабильный конъюгат гранулоцитарного колониестимулирующего фактора (г-ксф) с полиэтиленгликолем с пролонгированным биологическим действием, пригодный для медицинского применения, и иммунобиологическое средство на его основе
|
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
|
HUE045845T2
(hu)
|
2010-08-17 |
2021-12-28 |
Ambrx Inc |
Módosított relaxin polipeptidek és felhasználásuk
|
|
EP2608801B1
(en)
|
2010-08-25 |
2019-08-21 |
aTyr Pharma, Inc. |
INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF TYROSYL-tRNA SYNTHETASES
|
|
EP2616486B1
(en)
|
2010-09-15 |
2019-01-02 |
Stichting Sanquin Bloedvoorziening |
Factor viii variants having a decreased cellular uptake
|
|
AR083006A1
(es)
|
2010-09-23 |
2013-01-23 |
Lilly Co Eli |
Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas
|
|
CA2813087C
(en)
|
2010-09-28 |
2020-07-21 |
Amylin Pharmaceuticals, Llc |
Engineered polypeptides having enhanced duration of action
|
|
AU2011311706B2
(en)
|
2010-10-05 |
2015-11-12 |
Debiopharm S.A. |
New treatments of Hepatitis C virus infection
|
|
CA2811799A1
(en)
|
2010-10-08 |
2012-04-12 |
Novartis Ag |
Vitamin e formulations of sulfamide ns3 inhibitors
|
|
CN102453089B
(zh)
*
|
2010-10-25 |
2014-06-04 |
北京凯因科技股份有限公司 |
重组集成干扰素变异体聚乙二醇偶联物的制备和应用
|
|
CN103933577B
(zh)
*
|
2010-10-25 |
2014-12-10 |
北京凯因科技股份有限公司 |
重组集成干扰素变异体聚乙二醇偶联物的制备和应用
|
|
US9023791B2
(en)
|
2010-11-19 |
2015-05-05 |
Novartis Ag |
Fibroblast growth factor 21 mutations
|
|
PT2643019T
(pt)
|
2010-11-24 |
2019-04-23 |
Lexicon Pharmaceuticals Inc |
Anticorpos para notum pectinacetilesterase
|
|
KR20140001966A
(ko)
|
2010-11-30 |
2014-01-07 |
노파르티스 아게 |
C형 간염 바이러스 감염의 새로운 치료법
|
|
CN102485742A
(zh)
*
|
2010-12-02 |
2012-06-06 |
山东新时代药业有限公司 |
一种聚乙二醇单修饰的重组人粒细胞集落刺激因子的制备及分离纯化方法
|
|
WO2012083197A1
(en)
|
2010-12-17 |
2012-06-21 |
Nektar Therapeutics |
Water-soluble polymer conjugates of topotecan
|
|
WO2012088282A1
(en)
|
2010-12-21 |
2012-06-28 |
Nektar Therapeutics |
Multi-arm polymeric prodrug conjugates of pemetrexed-based compounds
|
|
WO2012088422A1
(en)
|
2010-12-22 |
2012-06-28 |
Nektar Therapeutics |
Multi-arm polymeric prodrug conjugates of taxane-based compounds
|
|
US10894087B2
(en)
|
2010-12-22 |
2021-01-19 |
Nektar Therapeutics |
Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
|
|
JP2014510045A
(ja)
|
2011-02-08 |
2014-04-24 |
ハロザイム インコーポレイテッド |
ヒアルロナン分解酵素の組成物および脂質製剤ならびに良性前立腺肥大症の治療のためのその使用
|
|
KR20140145947A
(ko)
|
2011-03-16 |
2014-12-24 |
암젠 인크 |
Nav1.3과 nav1.7의 유효한 선별적 저해제
|
|
US20140171365A1
(en)
*
|
2011-03-25 |
2014-06-19 |
The Trustees Of Columbia University In The City Of New York |
Pegylated human hdl particle and process for production thereof
|
|
MX2013011256A
(es)
|
2011-03-31 |
2013-10-17 |
Novartis Ag |
Alisporivir para el tratamiento de la infeccion por el virus de hepatitis c.
|
|
DK2694087T3
(en)
|
2011-04-01 |
2015-04-13 |
Novartis Ag |
The treatment of infection with Hepatitis B virus alone or in combination with hepatitis delta virus, and in connection with liver diseases
|
|
PH12013502047A1
(en)
|
2011-04-13 |
2019-03-22 |
Debiopharm Int Sa |
Treatment of hepatitis c virus infection with alisporivir
|
|
WO2012158678A1
(en)
|
2011-05-17 |
2012-11-22 |
Bristol-Myers Squibb Company |
Methods for maintaining pegylation of polypeptides
|
|
CN116333113A
(zh)
|
2011-06-03 |
2023-06-27 |
佐马技术有限公司 |
对TGF-β具有特异性的抗体
|
|
CA2839512C
(en)
|
2011-06-17 |
2018-01-02 |
Halozyme, Inc. |
Continuous subcutaneous insulin infusion methods with a hyaluronan-degrading enzyme
|
|
US9993529B2
(en)
|
2011-06-17 |
2018-06-12 |
Halozyme, Inc. |
Stable formulations of a hyaluronan-degrading enzyme
|
|
WO2013003593A1
(en)
|
2011-06-28 |
2013-01-03 |
Alternative Innovative Technologies Llc |
Methods of use of hsp70 for increased performance or hsp70 related disorders
|
|
JP2014522641A
(ja)
|
2011-07-01 |
2014-09-08 |
バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング |
リラキシン融合ポリペプチドおよびその使用
|
|
PT2717917T
(pt)
|
2011-07-05 |
2016-07-27 |
Bioasis Technologies Inc |
Conjugados de anticorpos p97
|
|
CN103957926B
(zh)
|
2011-07-08 |
2018-07-03 |
安米林药品有限责任公司 |
具有增强的作用持续时间和降低的免疫原性的工程改造的多肽
|
|
CN102952067A
(zh)
*
|
2011-08-30 |
2013-03-06 |
苏州欣诺科生物科技有限公司 |
用于蛋白质n端聚乙二醇修饰的吡哆醛衍生物、制备方法及其应用
|
|
JP2014526441A
(ja)
|
2011-08-31 |
2014-10-06 |
アムジエン・インコーポレーテツド |
1型糖尿病の治療における使用のためのfgf21
|
|
US20130071394A1
(en)
|
2011-09-16 |
2013-03-21 |
John K. Troyer |
Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and methods of use
|
|
UY34346A
(es)
|
2011-09-26 |
2013-04-30 |
Novartis Ag |
Proteínas de fusión para tratar trastornos metabólicos
|
|
TW201315742A
(zh)
|
2011-09-26 |
2013-04-16 |
Novartis Ag |
治療代謝病症之雙功能蛋白質
|
|
CA2850052A1
(en)
|
2011-09-27 |
2013-04-04 |
Novartis Ag |
Alisporivr for treatment of hepatis c virus infection
|
|
RU2014114849A
(ru)
|
2011-10-14 |
2015-11-20 |
Алтернатив Инновейтив Текнолоджиз Ллц |
Устойчивые к деградации производные белков теплового шока-70 (бтш70) и способы их применения (варианты)
|
|
WO2013063155A2
(en)
|
2011-10-24 |
2013-05-02 |
Halozyme, Inc. |
Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof
|
|
US10350139B2
(en)
|
2011-10-25 |
2019-07-16 |
Corning Incorporated |
Pharmaceutical glass packaging assuring pharmaceutical sterility
|
|
EP2771298B1
(en)
|
2011-10-25 |
2017-12-13 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
|
CN104053670A
(zh)
|
2011-10-31 |
2014-09-17 |
百时美施贵宝公司 |
具有降低的免疫原性的纤连蛋白结合域
|
|
EP2780030A4
(en)
|
2011-11-17 |
2015-11-18 |
Cebix Ab |
PEGYLATED C-PEPTIDE
|
|
WO2013101509A2
(en)
|
2011-12-15 |
2013-07-04 |
Alternative Innovative Technologies Llc |
Hsp70 fusion protein conjugates and uses thereof
|
|
LT3130347T
(lt)
|
2011-12-30 |
2019-10-25 |
Halozyme Inc |
Ph20 polipeptido variantai, kompozicijos ir jų panaudojimas
|
|
WO2013114112A2
(en)
|
2012-01-30 |
2013-08-08 |
Arecor Limited |
Stabilized aqueous antibody compositions
|
|
JP6170077B2
(ja)
|
2012-02-16 |
2017-07-26 |
エータイアー ファーマ, インコーポレイテッド |
自己免疫および炎症疾患を処置するためのヒスチジルtRNA合成酵素
|
|
WO2013130683A2
(en)
|
2012-02-27 |
2013-09-06 |
Amunix Operating Inc. |
Xten conjugate compositions and methods of making same
|
|
AU2013226944B2
(en)
|
2012-02-29 |
2017-03-23 |
Toray Industries, Inc. |
Inhibitory agent for body cavity fluid accumulation
|
|
DK2822575T3
(da)
|
2012-03-03 |
2020-06-15 |
Immungene Inc |
Manipulerede, muterede antistof-interferon-fusionsmolekyler
|
|
JP2015509980A
(ja)
|
2012-03-14 |
2015-04-02 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Hcv−hiv同時感染患者集団のhcv感染症を治療するための併用療法
|
|
WO2013143581A1
(en)
|
2012-03-28 |
2013-10-03 |
Boehringer Ingelheim International Gmbh |
Combination therapy for treating hcv infection in specific patient subgenotype sub-population
|
|
EP2830663B1
(en)
|
2012-03-30 |
2019-02-06 |
Sorrento Therapeutics Inc. |
Fully human antibodies that bind to vegfr2
|
|
DK2833905T3
(en)
|
2012-04-04 |
2018-07-30 |
Halozyme Inc |
Combination therapy with hyaluronidase and a tumor-targeted taxane
|
|
AU2013267161A1
(en)
|
2012-05-31 |
2014-11-20 |
Sorrento Therapeutics, Inc. |
Antigen binding proteins that bind PD-L1
|
|
HUE043552T2
(hu)
|
2012-06-08 |
2019-09-30 |
Sutro Biopharma Inc |
Antitestek, amelyek tartalmaznak helyspecifikus nem természetes aminosav maradékokat, eljárások elõállításukra és eljárások használatukra
|
|
US9315579B2
(en)
|
2012-06-22 |
2016-04-19 |
Sorrento Therapeutics, Inc. |
Antigen binding proteins that bind CCR2
|
|
WO2014004639A1
(en)
|
2012-06-26 |
2014-01-03 |
Sutro Biopharma, Inc. |
Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
|
|
AU2013296557B2
(en)
|
2012-07-31 |
2019-04-18 |
Bioasis Technologies Inc. |
Dephosphorylated lysosomal storage disease proteins and methods of use thereof
|
|
HRP20220455T1
(hr)
|
2012-08-31 |
2022-05-27 |
Sutro Biopharma, Inc. |
Modificirane aminokiseline koje sadrže azid grupu
|
|
WO2014062856A1
(en)
|
2012-10-16 |
2014-04-24 |
Halozyme, Inc. |
Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
|
|
EP2916835A4
(en)
|
2012-11-12 |
2016-07-27 |
Redwood Bioscience Inc |
COMPOUNDS AND METHOD FOR PRODUCING A CONJUGATE
|
|
US9310374B2
(en)
|
2012-11-16 |
2016-04-12 |
Redwood Bioscience, Inc. |
Hydrazinyl-indole compounds and methods for producing a conjugate
|
|
US9605078B2
(en)
|
2012-11-16 |
2017-03-28 |
The Regents Of The University Of California |
Pictet-Spengler ligation for protein chemical modification
|
|
US20140205566A1
(en)
|
2012-11-30 |
2014-07-24 |
Novartis Ag |
Cyclic nucleuoside derivatives and uses thereof
|
|
US9383357B2
(en)
|
2012-12-07 |
2016-07-05 |
Northwestern University |
Biomarker for replicative senescence
|
|
EP3907237A1
(en)
|
2012-12-20 |
2021-11-10 |
Amgen Inc. |
Apj receptor agonists and uses thereof
|
|
CN103908660B
(zh)
*
|
2013-01-05 |
2015-02-04 |
石药集团百克(山东)生物制药有限公司 |
一种聚乙二醇修饰的rhG-CSF药物组合物及其制备方法
|
|
EP2951206A2
(en)
|
2013-02-01 |
2015-12-09 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold proteins
|
|
CN103113466B
(zh)
*
|
2013-03-01 |
2015-06-03 |
中国科学院过程工程研究所 |
聚乙二醇修饰的重组人干扰素β-1b及制备方法
|
|
WO2014165277A2
(en)
|
2013-03-12 |
2014-10-09 |
Amgen Inc. |
POTENT AND SELECTIVE INHIBITORS OF Nav1.7
|
|
CN105263958B
(zh)
|
2013-03-13 |
2019-09-27 |
比奥阿赛斯技术有限公司 |
p97片段及其应用
|
|
RU2535002C2
(ru)
*
|
2013-04-04 |
2014-12-10 |
Федеральное государственное бюджетное учреждение "Научно-исследовательский институт фармакологии" Сибирского отделения Российской академии медицинских наук |
Средство коррекции отдаленных последствий нарушений сперматогенеза, вызванных цитостатическим воздействием
|
|
HK1215681A1
(zh)
|
2013-04-18 |
2016-09-09 |
Armo Biosciences, Inc. |
使用白细胞介素-10治疗疾病和病症的方法
|
|
US9700486B2
(en)
|
2013-04-24 |
2017-07-11 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
|
US9849066B2
(en)
|
2013-04-24 |
2017-12-26 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
|
US9707154B2
(en)
|
2013-04-24 |
2017-07-18 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
|
US9717649B2
(en)
|
2013-04-24 |
2017-08-01 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
|
US9603775B2
(en)
|
2013-04-24 |
2017-03-28 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
|
US9700485B2
(en)
|
2013-04-24 |
2017-07-11 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
|
US9713572B2
(en)
|
2013-04-24 |
2017-07-25 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
|
US9717648B2
(en)
|
2013-04-24 |
2017-08-01 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
|
US9839579B2
(en)
|
2013-04-24 |
2017-12-12 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
|
US9707153B2
(en)
|
2013-04-24 |
2017-07-18 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
|
US9707155B2
(en)
|
2013-04-24 |
2017-07-18 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
|
ES2688206T3
(es)
|
2013-06-17 |
2018-10-31 |
Armo Biosciences, Inc. |
Procedimiento de evaluación de la identidad y la estabilidad de proteínas
|
|
TW201534726A
(zh)
|
2013-07-03 |
2015-09-16 |
Halozyme Inc |
熱穩定ph20玻尿酸酶變異體及其用途
|
|
ES2658039T3
(es)
|
2013-07-10 |
2018-03-08 |
Sutro Biopharma, Inc. |
Anticuerpos que comprenden múltiples residuos de aminoácidos no naturales sitio-específicos, métodos para su preparación y métodos de uso
|
|
AU2014312190A1
(en)
|
2013-08-28 |
2016-02-18 |
Bioasis Technologies Inc. |
CNS-targeted conjugates of antibodies
|
|
CN105658232A
(zh)
|
2013-08-30 |
2016-06-08 |
阿尔莫生物科技股份有限公司 |
使用白细胞介素-10治疗疾病和病症的方法
|
|
JP2016535080A
(ja)
|
2013-10-02 |
2016-11-10 |
ノバルティス アーゲー |
療法における使用のためのインスリン様成長因子模倣物
|
|
WO2015054658A1
(en)
|
2013-10-11 |
2015-04-16 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
|
US20160235810A1
(en)
|
2013-10-18 |
2016-08-18 |
Novartis Ag |
Methods of treating diabetes and related disorders
|
|
ES2862139T3
(es)
|
2013-11-11 |
2021-10-07 |
Armo Biosciences Inc |
Procedimientos de uso de Interleucina 10 para el tratamiento de enfermedades y trastornos
|
|
US20160296632A1
(en)
|
2013-11-13 |
2016-10-13 |
Aequus Biopharma, Inc. |
Engineered glycoproteins and uses thereof
|
|
CA3178867A1
(en)
|
2013-11-27 |
2015-06-04 |
Redwood Bioscience, Inc. |
Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
|
|
UY35874A
(es)
|
2013-12-12 |
2015-07-31 |
Novartis Ag |
Un proceso para la preparación de una composición de proteínas pegiladas
|
|
US10188739B2
(en)
|
2014-02-27 |
2019-01-29 |
Xenetic Biosciences, Inc. |
Compositions and methods for administering insulin or insulin-like protein to the brain
|
|
US10293043B2
(en)
|
2014-06-02 |
2019-05-21 |
Armo Biosciences, Inc. |
Methods of lowering serum cholesterol
|
|
US10941182B2
(en)
|
2014-06-10 |
2021-03-09 |
Amgen Inc. |
Apelin polypeptides
|
|
JP6432954B2
(ja)
|
2014-06-12 |
2018-12-05 |
ラ ファーマシューティカルズ インコーポレイテッドRa Pharmaceuticals,Inc. |
補体活性の変調
|
|
EP3183000A4
(en)
|
2014-08-22 |
2018-04-25 |
Sorrento Therapeutics, Inc. |
Antigen binding proteins that bind cxcr3
|
|
WO2016033555A1
(en)
|
2014-08-28 |
2016-03-03 |
Halozyme, Inc. |
Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor
|
|
KR20170068553A
(ko)
|
2014-10-14 |
2017-06-19 |
아르모 바이오사이언시스 인코포레이티드 |
인터류킨-15 조성물 및 이의 용도
|
|
EA201700181A1
(ru)
|
2014-10-14 |
2017-09-29 |
Галозим, Инк. |
Композиции аденозиндеаминазы-2 (ада-2), их варианты и способы использования
|
|
MX2017004983A
(es)
|
2014-10-22 |
2017-11-13 |
Armo Biosciences Inc |
Metodos para usar interleucina 10 para tratar enfermedades y trastornos.
|
|
BR112017008157A2
(pt)
|
2014-10-24 |
2017-12-19 |
Bristol Myers Squibb Co |
polipeptídeos de fgf-21 modificados e usos dos mesmos
|
|
SI3215193T1
(sl)
|
2014-11-06 |
2024-02-29 |
Pharmaessentia Corporation |
Dozirna shema za pegiliran interferon
|
|
US20160151511A1
(en)
*
|
2014-12-02 |
2016-06-02 |
Antriabio, Inc. |
Proteins and protein conjugates with increased hydrophobicity
|
|
CN104491843B
(zh)
*
|
2015-01-23 |
2017-09-12 |
石药集团百克(山东)生物制药有限公司 |
一种聚乙二醇修饰的rhG‑CSF活性药物组合物
|
|
SI3250230T1
(sl)
|
2015-01-28 |
2022-01-31 |
Ra Pharmaceuticals, Inc. |
Modulatorji aktivnosti komplementa
|
|
US10618970B2
(en)
|
2015-02-03 |
2020-04-14 |
Armo Biosciences, Inc. |
Method of treating cancer with IL-10 and antibodies that induce ADCC
|
|
US10335492B2
(en)
*
|
2015-03-03 |
2019-07-02 |
Nansha Biologics (Hong Kong) Limited |
Increasing serum half-life of human IL-11 variants by N-terminal branched PEGylation
|
|
US10711067B2
(en)
|
2015-03-03 |
2020-07-14 |
Xoma (Us) Llc |
Treatment of post-prandial hyperinsulinemia and hypoglycemia after bariatric surgery
|
|
WO2016161410A2
(en)
|
2015-04-03 |
2016-10-06 |
Xoma Technology Ltd. |
Treatment of cancer using inhibitors of tgf-beta and pd-1
|
|
WO2016167291A1
(ja)
|
2015-04-13 |
2016-10-20 |
国立研究開発法人産業技術総合研究所 |
環状化サイトカイン及びその製法
|
|
CA2981822C
(en)
|
2015-05-01 |
2023-04-11 |
Allysta Pharmaceuticals, Inc. |
Adiponectin peptidomimetics for treating ocular disorders
|
|
US10676723B2
(en)
|
2015-05-11 |
2020-06-09 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
|
HK1248137A1
(zh)
|
2015-05-28 |
2018-10-12 |
阿尔莫生物科技股份有限公司 |
用於治疗癌症的聚乙二醇化白细胞介素-10
|
|
WO2017024285A2
(en)
|
2015-08-06 |
2017-02-09 |
Xoma (Us) Llc |
Antibody fragments against the insulin receptor and uses thereof to treat hypoglycemia
|
|
MX2018002298A
(es)
|
2015-08-25 |
2018-07-06 |
Armo Biosciences Inc |
Metodos de uso de interleucina 10 para el tratamiento de enfermedades y trastornos.
|
|
EP3351561A4
(en)
|
2015-09-18 |
2019-05-15 |
University of Miyazaki |
ADRENOMEDULLINE DERIVATIVES WITH LONG-TERM EFFECT
|
|
MX2018004041A
(es)
|
2015-10-01 |
2018-11-09 |
Amgen Inc |
Tratamiento de trastornos de acidos biliares.
|
|
US10935276B2
(en)
|
2015-10-20 |
2021-03-02 |
Steven Michalski |
Air mixing device
|
|
US12102689B2
(en)
|
2015-11-09 |
2024-10-01 |
R.P. Scherer Technologies, Llc |
Anti-CD22 antibody-maytansine conjugates and methods of use thereof
|
|
KR20180088459A
(ko)
|
2015-12-08 |
2018-08-03 |
바이오마린 파머수티컬 인크. |
골관절염을 치료하기 위한 c-형 나트륨이뇨 펩타이드 변이체의 용도
|
|
AU2016370210A1
(en)
|
2015-12-16 |
2018-06-21 |
Ra Pharmaceuticals, Inc. |
Modulators of complement activity
|
|
US10118963B2
(en)
|
2016-01-29 |
2018-11-06 |
Sorrento Therapeutics, Inc. |
Antigen binding proteins that bind PD-L1
|
|
AU2017250778B2
(en)
|
2016-04-15 |
2021-09-23 |
Beckman Coulter, Inc. |
Photoactive macromolecules and uses thereof
|
|
WO2018026748A1
(en)
|
2016-08-01 |
2018-02-08 |
Xoma (Us) Llc |
Parathyroid hormone receptor 1 (pth1r) antibodies and uses thereof
|
|
KR20190057113A
(ko)
|
2016-09-28 |
2019-05-27 |
조마 (유에스) 엘엘씨 |
인터루킨-2에 결합하는 항체 및 그 용도
|
|
US20200237881A1
(en)
|
2019-01-30 |
2020-07-30 |
Horizon Pharma Rheumatology Llc |
Reducing immunogenicity to pegloticase
|
|
JP7301741B2
(ja)
|
2016-12-07 |
2023-07-03 |
ラ ファーマシューティカルズ インコーポレイテッド |
補体活性のモジュレータ
|
|
US11129906B1
(en)
|
2016-12-07 |
2021-09-28 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
|
AU2018219283B2
(en)
|
2017-02-08 |
2022-05-19 |
Bristol-Myers Squibb Company |
Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
|
|
SG10202110500TA
(en)
|
2017-06-22 |
2021-11-29 |
Catalyst Biosciences Inc |
Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use
|
|
KR102020995B1
(ko)
|
2017-10-30 |
2019-09-16 |
한국코러스 주식회사 |
콜로니자극인자와 폴리올이 접합된 접합물을 고수율로 제조하는 방법
|
|
CN119286279A
(zh)
|
2017-12-26 |
2025-01-10 |
贝克顿·迪金森公司 |
深紫外线可激发的水溶剂化聚合物染料
|
|
WO2019130344A1
(en)
|
2017-12-27 |
2019-07-04 |
Council Of Scientific And Industrial Research |
A polypeptide exhibiting granulocyte-colony stimulating factor activity
|
|
JP2021517143A
(ja)
*
|
2018-03-14 |
2021-07-15 |
バ、ヨン |
Peg化不凍タンパク質およびそれを作製する方法およびそれを使用する方法
|
|
US10844228B2
(en)
|
2018-03-30 |
2020-11-24 |
Becton, Dickinson And Company |
Water-soluble polymeric dyes having pendant chromophores
|
|
CN112105344B
(zh)
|
2018-04-24 |
2024-10-15 |
安进公司 |
用于制备可注射药物组合物的方法
|
|
US20190351031A1
(en)
|
2018-05-16 |
2019-11-21 |
Halozyme, Inc. |
Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
|
|
KR102167755B1
(ko)
|
2018-05-23 |
2020-10-19 |
주식회사 큐어바이오 |
단편화된 grs 폴리펩타이드, 이의 변이체 및 이들의 용도
|
|
WO2020023300A1
(en)
|
2018-07-22 |
2020-01-30 |
Bioasis Technologies, Inc. |
Treatment of lymmphatic metastases
|
|
ES2972137T3
(es)
|
2018-09-11 |
2024-06-11 |
Ambrx Inc |
Conjugados de polipéptidos de interleucina-2 y sus usos
|
|
AU2019361206A1
(en)
|
2018-10-19 |
2021-06-03 |
Ambrx, Inc. |
Interleukin-10 polypeptide conjugates, dimers thereof, and their uses
|
|
US11613744B2
(en)
|
2018-12-28 |
2023-03-28 |
Vertex Pharmaceuticals Incorporated |
Modified urokinase-type plasminogen activator polypeptides and methods of use
|
|
WO2020140101A1
(en)
|
2018-12-28 |
2020-07-02 |
Catalyst Biosciences, Inc. |
Modified urokinase-type plasminogen activator polypeptides and methods of use
|
|
WO2020160322A1
(en)
|
2019-01-30 |
2020-08-06 |
Horizon Pharma Rheumatology Llc |
Tolerization reduces intolerance to pegloticase and prolongs the urate lowering effect (triple)
|
|
WO2020168017A1
(en)
|
2019-02-12 |
2020-08-20 |
Ambrx, Inc. |
Compositions containing, methods and uses of antibody-tlr agonist conjugates
|
|
US10882954B2
(en)
|
2019-04-11 |
2021-01-05 |
Sunbio Inc. |
Tertiary alkoxy polyethylene glycol and derivatives thereof
|
|
US12448488B2
(en)
|
2019-04-15 |
2025-10-21 |
Nof Corporation |
Conjugate of bio-related substance and block polymer, and block polymer derivative for obtaining said conjugate
|
|
AU2020258384A1
(en)
|
2019-04-15 |
2021-11-04 |
Qwixel Therapeutics Llc |
Fusion protein composition(s) comprising targeted masked type I interferons (IFNA and IFNB) and an antibody against tumor antigen, for use in the treatment of cancer
|
|
CN120682337A
(zh)
|
2020-03-11 |
2025-09-23 |
北京泰德制药股份有限公司 |
白介素-2多肽偶联物及其使用方法
|
|
CA3171491A1
(en)
|
2020-03-20 |
2021-09-23 |
Amgen, Inc. |
Determination of free n-terminus of pegfilgrastim using an acid protease
|
|
US20210355468A1
(en)
|
2020-05-18 |
2021-11-18 |
Bioasis Technologies, Inc. |
Compositions and methods for treating lewy body dementia
|
|
US20210393787A1
(en)
|
2020-06-17 |
2021-12-23 |
Bioasis Technologies, Inc. |
Compositions and methods for treating frontotemporal dementia
|
|
EP4199968A1
(en)
|
2020-08-20 |
2023-06-28 |
Ambrx, Inc. |
Antibody-tlr agonist conjugates, methods and uses thereof
|
|
US11602598B1
(en)
*
|
2020-08-27 |
2023-03-14 |
Fresenius Kabi Deutschland Gmbh |
Prefilled syringe with pegfilgrastim having optimized dose and methods related thereto
|
|
CN112710826A
(zh)
*
|
2020-11-17 |
2021-04-27 |
北京九强生物技术股份有限公司 |
一种提高试剂稳定性的包被和封闭方法
|
|
US11952461B2
(en)
|
2021-03-22 |
2024-04-09 |
Sunbio, Inc. |
Siloxy polyethylene glycol and derivatives thereof
|
|
CA3213805A1
(en)
|
2021-04-03 |
2022-10-06 |
Feng Tian |
Anti-her2 antibody-drug conjugates and uses thereof
|
|
CN113214328B
(zh)
*
|
2021-05-08 |
2022-06-28 |
宁波经济技术开发区弘翔生化科技有限公司 |
一种双水相体系以及基于双水相体系的单糖分离方法
|
|
EP4155349A1
(en)
|
2021-09-24 |
2023-03-29 |
Becton, Dickinson and Company |
Water-soluble yellow green absorbing dyes
|
|
CA3260702A1
(en)
|
2022-07-01 |
2024-01-04 |
Beckman Coulter Inc |
NEW FLUORESCENT DYES AND POLYMERS DERIVED FROM DIHYDROPHENANTHREN DERIVATIVES
|
|
WO2024044327A1
(en)
|
2022-08-26 |
2024-02-29 |
Beckman Coulter, Inc. |
Dhnt monomers and polymer dyes with modified photophysical properties
|
|
CN120936679A
(zh)
|
2023-03-17 |
2025-11-11 |
贝克曼库尔特有限公司 |
苯并噻吩并吡咯花菁染料
|
|
US12269875B2
(en)
|
2023-08-03 |
2025-04-08 |
Jeff R. Peterson |
Gout flare prevention methods using IL-1BETA blockers
|
|
WO2025064842A1
(en)
|
2023-09-21 |
2025-03-27 |
Beckman Coulter, Inc. |
Dihydrophenanthrene (dhp) bridged dyes for use in flow cytometry
|
|
WO2025227129A2
(en)
|
2024-04-25 |
2025-10-30 |
Starrock Pharma Llc |
Delivery vehicles comprising proglucagon derived polypeptides and anabolic polypeptides and uses thereof
|
|
WO2025230756A1
(en)
|
2024-05-01 |
2025-11-06 |
BioLegend, Inc. |
Compositions for use with multiple fluorophores and methods of using
|