|
JP5138938B2
(ja)
|
2003-12-19 |
2013-02-06 |
プレキシコン インコーポレーテッド |
Ret調節剤の開発のための化合物および方法
|
|
ES2364340T3
(es)
|
2004-03-30 |
2011-08-31 |
Vertex Pharmaceuticals Incorporated |
Azaindoles útiles como inhibidores de jak y otras proteína quinasas.
|
|
US7498342B2
(en)
|
2004-06-17 |
2009-03-03 |
Plexxikon, Inc. |
Compounds modulating c-kit activity
|
|
US8969379B2
(en)
|
2004-09-17 |
2015-03-03 |
Eisai R&D Management Co., Ltd. |
Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide
|
|
AU2006272951A1
(en)
|
2005-05-17 |
2007-02-01 |
Plexxikon, Inc. |
Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
|
|
MY153898A
(en)
|
2005-06-22 |
2015-04-15 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
|
CN102127078A
(zh)
|
2005-07-14 |
2011-07-20 |
安斯泰来制药株式会社 |
Janus激酶3的杂环类抑制剂
|
|
JP5071374B2
(ja)
|
2005-07-14 |
2012-11-14 |
アステラス製薬株式会社 |
ヘテロ環ヤヌスキナーゼ3阻害剤
|
|
JP4989476B2
(ja)
|
2005-08-02 |
2012-08-01 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
血管新生阻害物質の効果を検定する方法
|
|
CN102716490A
(zh)
*
|
2005-09-01 |
2012-10-10 |
卫材R&D管理有限公司 |
药物组合物的崩解性的改善方法
|
|
HUE028588T2
(hu)
|
2005-12-13 |
2016-12-28 |
Incyte Holdings Corp |
Heteroaril-szubsztituált pirrolo[2,3-b]piridinek és pirrolo[2,3-b]pirimidinek mint Janus-kináz inhibitorok
|
|
NZ592968A
(en)
|
2006-01-17 |
2012-08-31 |
Vertex Pharma |
Azaindoles substituted with either triazine or pyrimidine useful as inhibitors of janus kinases consisting of JAK1, JAK2, JAK3, and TYK2
|
|
WO2007084667A2
(en)
*
|
2006-01-19 |
2007-07-26 |
Osi Pharmaceutical, Inc. |
Fused heterobicyclic kinase inhibitors
|
|
EP2003132B1
(en)
|
2006-04-03 |
2014-03-05 |
Astellas Pharma Inc. |
Oxadiazole derivatives as S1P1 agonists
|
|
CN104706637A
(zh)
|
2006-05-18 |
2015-06-17 |
卫材R&D管理有限公司 |
针对甲状腺癌的抗肿瘤剂
|
|
WO2007135398A1
(en)
*
|
2006-05-22 |
2007-11-29 |
Astrazeneca Ab |
Indole derivatives
|
|
US7964728B2
(en)
|
2006-07-06 |
2011-06-21 |
Solvay Pharmaceuticals B.V. |
Azaindole derivatives with a combination of partial nicotinic acetyl-choline receptor agonism and dopamine reuptake inhibition
|
|
ES2374581T3
(es)
*
|
2006-07-06 |
2012-02-20 |
Abbott Healthcare Products B.V. |
Derivados de azaindol con una combinación de agonismo parcial del receptor nicotínico de la acetilcolina e inhibición de la reabsorción de dopamina.
|
|
GB0617161D0
(en)
*
|
2006-08-31 |
2006-10-11 |
Vernalis R&D Ltd |
Enzyme inhibitors
|
|
EP2529621B1
(en)
|
2006-09-22 |
2016-10-05 |
Pharmacyclics LLC |
Inhibitors of bruton's tyrosine kinase
|
|
WO2008063888A2
(en)
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
|
PE20121126A1
(es)
*
|
2006-12-21 |
2012-08-24 |
Plexxikon Inc |
Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
|
|
WO2008079909A1
(en)
*
|
2006-12-21 |
2008-07-03 |
Plexxikon, Inc. |
Pyrrolo [2,3-b] pyridines as kinase modulators
|
|
RU2009122670A
(ru)
*
|
2006-12-21 |
2011-01-27 |
Плекссикон, Инк. (Us) |
Соединения и способы для модуляции киназ и показания к их применению
|
|
WO2008079346A1
(en)
|
2006-12-21 |
2008-07-03 |
Vertex Pharmaceuticals Incorporated |
5-cyan0-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
|
|
US8809273B2
(en)
|
2007-03-28 |
2014-08-19 |
Pharmacyclics, Inc. |
Inhibitors of Bruton's tyrosine kinase
|
|
EP2139487B1
(en)
*
|
2007-03-28 |
2015-11-11 |
Pharmacyclics LLC |
Inhibitors of bruton's tyrosine kinase
|
|
CA2683559C
(en)
|
2007-04-13 |
2019-09-24 |
Dana Farber Cancer Institute, Inc. |
Methods for treating cancer resistant to erbb therapeutics
|
|
GB0710528D0
(en)
*
|
2007-06-01 |
2007-07-11 |
Glaxo Group Ltd |
Novel compounds
|
|
EP2740731B1
(en)
|
2007-06-13 |
2016-03-23 |
Incyte Holdings Corporation |
Crystalline salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
|
|
JP2010533729A
(ja)
|
2007-07-17 |
2010-10-28 |
プレキシコン,インコーポレーテッド |
キナーゼ調節のための化合物と方法、及びそのための適応
|
|
MX2010001636A
(es)
*
|
2007-08-14 |
2010-03-15 |
Hoffmann La Roche |
Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.
|
|
WO2009026239A1
(en)
*
|
2007-08-17 |
2009-02-26 |
University Of Maryland, Baltimore |
Small molecule inhibitors of lck sh2 domain binding
|
|
JP2009077712A
(ja)
|
2007-09-11 |
2009-04-16 |
F Hoffmann La Roche Ag |
B−Rafキナーゼ阻害剤に対する感受性についての診断試験
|
|
DE102007045956A1
(de)
|
2007-09-26 |
2009-04-09 |
Bayer Cropscience Ag |
Wirkstoffkombination mit insektiziden und akariziden Eigenschaften
|
|
DE102007045919B4
(de)
|
2007-09-26 |
2018-07-05 |
Bayer Intellectual Property Gmbh |
Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften
|
|
JP2011500806A
(ja)
|
2007-10-25 |
2011-01-06 |
メルク・シャープ・エンド・ドーム・コーポレイション |
治療用化合物
|
|
WO2009089352A1
(en)
|
2008-01-08 |
2009-07-16 |
Array Biopharma Inc. |
Pyrrolopyridines as kinase inhibitors
|
|
US8426396B2
(en)
*
|
2008-01-08 |
2013-04-23 |
Shriners Hospitals For Children |
Treatment for achondroplasia
|
|
EP2242757B1
(en)
|
2008-01-09 |
2012-08-01 |
Array Biopharma, Inc. |
Pyrazolopyridines as kinase inhibitors
|
|
AU2009206775A1
(en)
*
|
2008-01-22 |
2009-07-30 |
Merck Patent Gmbh |
Protein kinase inhibitors and use thereof
|
|
ATE517107T1
(de)
*
|
2008-02-25 |
2011-08-15 |
Hoffmann La Roche |
Pyrrolopyrazinkinaseinhibitoren
|
|
WO2009111278A2
(en)
|
2008-02-29 |
2009-09-11 |
Array Biopharma Inc. |
Raf inhibitor compounds and methods of use thereof
|
|
AR072657A1
(es)
|
2008-02-29 |
2010-09-15 |
Genentech Inc |
Compuestos inhibidores de raf y metodos para su uso
|
|
US20110003859A1
(en)
|
2008-02-29 |
2011-01-06 |
Array Biopharma Inc. |
N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer
|
|
UA103319C2
(en)
|
2008-05-06 |
2013-10-10 |
Глаксосмитклайн Ллк |
Thiazole- and oxazole-benzene sulfonamide compounds
|
|
US8158636B2
(en)
|
2008-05-19 |
2012-04-17 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
PE20091846A1
(es)
|
2008-05-19 |
2009-12-16 |
Plexxikon Inc |
DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS
|
|
US20110065577A1
(en)
*
|
2008-05-21 |
2011-03-17 |
Basf Se |
Substituted pyridin-4-yl-methyl sulfonamides as fungicides
|
|
EP2300471A1
(en)
*
|
2008-05-28 |
2011-03-30 |
Basf Se |
Substituted pyridin-4-yl-methyl sulfonamidesas fungicides
|
|
CN104530052A
(zh)
*
|
2008-06-10 |
2015-04-22 |
普莱希科公司 |
用于激酶调节的5h-吡咯[2,3-b]吡嗪衍生物和其适应症
|
|
US8110576B2
(en)
|
2008-06-10 |
2012-02-07 |
Plexxikon Inc. |
Substituted pyrrolo[2,3b]pyrazines and methods for treatment of raf protein kinase-mediated indications
|
|
AR072008A1
(es)
*
|
2008-06-13 |
2010-07-28 |
Merck & Co Inc |
Compuestos heterobiciclicos como agentes de inhibicion de quinasa p38
|
|
US9447049B2
(en)
|
2010-03-01 |
2016-09-20 |
University Of Tennessee Research Foundation |
Compounds for treatment of cancer
|
|
EP2298731A4
(en)
|
2008-06-25 |
2011-09-21 |
Takeda Pharmaceutical |
AMIDE COMPOUND
|
|
CN102159214A
(zh)
|
2008-07-16 |
2011-08-17 |
药品循环公司 |
用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂
|
|
DE102008052943A1
(de)
|
2008-10-23 |
2010-04-29 |
Merck Patent Gmbh |
Azaindolderivate
|
|
EP2356116A1
(en)
*
|
2008-11-20 |
2011-08-17 |
OSI Pharmaceuticals, Inc. |
Substituted pyrroloý2,3-b¨-pyridines and-pyrazines
|
|
CN102264743B
(zh)
*
|
2008-11-25 |
2015-02-11 |
罗彻斯特大学 |
Mlk抑制剂及其使用方法
|
|
US8318446B2
(en)
*
|
2008-12-05 |
2012-11-27 |
California Institute Of Technology |
DNA-damage-induced proteolysis
|
|
HUE025314T2
(en)
*
|
2009-02-10 |
2016-02-29 |
Monsanto Technology Llc |
Preparations and procedures for controlling nematodes
|
|
AR075812A1
(es)
|
2009-03-11 |
2011-04-27 |
Plexxikon Inc |
Derivados de pirrol[2,3-b]piridina como inhibidores de raf quinasa
|
|
AR076105A1
(es)
*
|
2009-03-11 |
2011-05-18 |
Plexxikon Inc |
Derivados pirrol[2,3-b]piridina para inhibir la raf quinasa
|
|
WO2010111527A1
(en)
*
|
2009-03-26 |
2010-09-30 |
Plexxikon, Inc. |
Pyrazolo [ 3, 4 -b] pyridines as kinase inhibitors and their medical use
|
|
CA2738573C
(en)
*
|
2009-04-03 |
2013-02-19 |
F. Hoffmann-La Roche Ag |
Compositions of propane-1 sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide and uses thereof
|
|
TW201041888A
(en)
*
|
2009-05-06 |
2010-12-01 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
|
BRPI1012108B8
(pt)
|
2009-05-22 |
2021-05-25 |
Incyte Corp |
composto 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octa no- ou heptano-nitrila, sua composição, seus usos e processo para preparar um sal de ácido fosfórico
|
|
NZ596479A
(en)
|
2009-05-22 |
2014-01-31 |
Incyte Corp |
N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
US9034875B2
(en)
|
2009-05-26 |
2015-05-19 |
Abbvie Inc. |
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
US20220315555A1
(en)
|
2009-05-26 |
2022-10-06 |
Abbvie Inc. |
Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
ES2546294T7
(es)
*
|
2009-05-26 |
2024-06-06 |
Abbvie Ireland Unlimited Co |
Agentes inductores de la apoptosis para el tratamiento de cáncer y enfermedades inmunitarias y autoinmunitarias
|
|
US8546399B2
(en)
*
|
2009-05-26 |
2013-10-01 |
Abbvie Inc. |
Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
GEP20207129B
(en)
|
2009-06-17 |
2020-07-10 |
Vertex Pharma |
Inhibitors of influenza viruses replication
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
US8329724B2
(en)
|
2009-08-03 |
2012-12-11 |
Hoffmann-La Roche Inc. |
Process for the manufacture of pharmaceutically active compounds
|
|
CA2771403C
(en)
|
2009-08-19 |
2015-02-24 |
Eisai R&D Management Co. Ltd. |
Quinoline derivative-containing pharmaceutical composition
|
|
AU2010289143A1
(en)
|
2009-08-24 |
2012-02-16 |
Ascepion Pharmaceuticals, Inc. |
5,6-bicyclic heteroaryl-containing urea compounds as kinase inhibitors
|
|
SG178854A1
(en)
|
2009-08-28 |
2012-04-27 |
Array Biopharma Inc |
Raf inhibitor compounds and methods of use thereof
|
|
EP2470538A1
(en)
*
|
2009-08-28 |
2012-07-04 |
Array Biopharma, Inc. |
Raf inhibitor compounds and methods of use thereof
|
|
CN102858754A
(zh)
|
2009-08-28 |
2013-01-02 |
阵列生物制药公司 |
Raf抑制剂化合物及其使用方法
|
|
US20120157452A1
(en)
|
2009-08-28 |
2012-06-21 |
Genentech, Inc. |
1h-pyrazolo[3,4-b] pyridine compounds for inhibiting raf kinase
|
|
SG178853A1
(en)
|
2009-08-28 |
2012-04-27 |
Array Biopharma Inc |
Raf inhibitor compounds and methods of use thereof
|
|
WO2011025965A1
(en)
|
2009-08-28 |
2011-03-03 |
Genentech, Inc. |
Raf inhibitor compounds and methods of use thereof
|
|
TW201113285A
(en)
|
2009-09-01 |
2011-04-16 |
Incyte Corp |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
EP2490713A2
(en)
|
2009-10-23 |
2012-08-29 |
MannKind Corporation |
Cancer immunotherapy and method of treatment
|
|
JP2013510166A
(ja)
*
|
2009-11-06 |
2013-03-21 |
プレキシコン インコーポレーテッド |
キナーゼ調節のための化合物、方法およびその適用
|
|
WO2011060216A1
(en)
|
2009-11-12 |
2011-05-19 |
Concert Pharmaceuticals Inc. |
Substituted azaindoles
|
|
EP2501236B1
(en)
*
|
2009-11-18 |
2017-03-29 |
Plexxikon Inc. |
N-[2-fluoro-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-4-benzenesulfonamide derivatives as Raf protein kinase modulators for the treatment of cancer
|
|
DE102009058280A1
(de)
*
|
2009-12-14 |
2011-06-16 |
Merck Patent Gmbh |
Thiazolderivate
|
|
CA2784393A1
(en)
|
2009-12-23 |
2011-06-30 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
EP2937345B1
(en)
|
2009-12-29 |
2018-03-21 |
Dana-Farber Cancer Institute, Inc. |
Type ii raf kinase inhibitors
|
|
US8658170B2
(en)
|
2010-01-06 |
2014-02-25 |
Joseph P. Errico |
Combination therapy with MDM2 and EFGR inhibitors
|
|
KR20130027080A
(ko)
|
2010-01-06 |
2013-03-14 |
에리코, 조셉, 피. |
표적화된 약물 개발 방법 및 조성물
|
|
WO2011100607A1
(en)
|
2010-02-11 |
2011-08-18 |
Vanderbilt University |
Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as mglur4 allosteric potentiators, compounds, and methods of treating neurological dysfunction
|
|
US11084811B2
(en)
|
2010-03-01 |
2021-08-10 |
Oncternal Therapeutics, Inc. |
Compounds for treatment of cancer
|
|
CA2792508C
(en)
|
2010-03-10 |
2018-01-16 |
Incyte Corporation |
Piperidin-4-yl azetidine derivatives as jak1 inhibitors
|
|
EP2550361B1
(en)
|
2010-03-25 |
2017-02-08 |
The J. David Gladstone Institutes |
Compositions and methods for treating neurological disorders
|
|
ES2734552T3
(es)
|
2010-04-16 |
2019-12-10 |
Ac Immune Sa |
Compuestos novedosos para el tratamiento de enfermedades asociadas a proteínas amiloides o de tipo amiloide
|
|
TWI510487B
(zh)
|
2010-04-21 |
2015-12-01 |
Plexxikon Inc |
用於激酶調節的化合物和方法及其適應症
|
|
WO2011140164A1
(en)
*
|
2010-05-06 |
2011-11-10 |
Merck Sharp & Dohme Corp. |
Aza-indole derivatives useful as modulators of faah
|
|
US20130072495A1
(en)
|
2010-05-14 |
2013-03-21 |
OSI Pharmaceuticals, LLC |
Fused bicyclic kinase inhibitors
|
|
AR081039A1
(es)
|
2010-05-14 |
2012-05-30 |
Osi Pharmaceuticals Llc |
Inhibidores biciclicos fusionados de quinasa
|
|
BR122019024201B1
(pt)
|
2010-05-20 |
2021-08-03 |
Array Biopharma Inc |
Composto macrocíclico como inibidores de trk quinase, seu uso, e composição farmacêutica
|
|
EA202091303A3
(ru)
|
2010-05-21 |
2021-05-31 |
Инсайт Холдингс Корпорейшн |
Композиция ингибитора jak для местного применения
|
|
US8669256B2
(en)
|
2010-05-28 |
2014-03-11 |
Merck Sharp & Dohme B.V. |
Substituted thieno[2,3-b]pyrazine compounds as modulators of B-Raf kinase activity
|
|
MX380504B
(es)
|
2010-06-03 |
2025-03-12 |
Pharmacyclics Llc |
El uso de inhibidores de la tirosina quinasa de bruton (btk).
|
|
AU2011264074B2
(en)
|
2010-06-09 |
2015-01-22 |
Bayer Cropscience Nv |
Methods and means to modify a plant genome at a nucleotide sequence commonly used in plant genome engineering
|
|
US8779150B2
(en)
|
2010-07-21 |
2014-07-15 |
Hoffmann-La Roche Inc. |
Processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide
|
|
EP2598661B1
(en)
|
2010-07-26 |
2017-09-27 |
Biomatrica, INC. |
Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
|
|
US9376709B2
(en)
|
2010-07-26 |
2016-06-28 |
Biomatrica, Inc. |
Compositions for stabilizing DNA and RNA in blood and other biological samples during shipping and storage at ambient temperatures
|
|
US20120045433A1
(en)
|
2010-08-17 |
2012-02-23 |
Kapil Dhingra |
Combination therapy
|
|
US8709419B2
(en)
*
|
2010-08-17 |
2014-04-29 |
Hoffmann-La Roche, Inc. |
Combination therapy
|
|
EP2616467A1
(en)
|
2010-09-13 |
2013-07-24 |
Concert Pharmaceuticals Inc. |
Substituted azaindoles
|
|
KR20180059560A
(ko)
|
2010-10-29 |
2018-06-04 |
애브비 인코포레이티드 |
아폽토시스―유도제를 포함하는 고체 분산체
|
|
UA113500C2
(xx)
|
2010-10-29 |
2017-02-10 |
|
Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
|
|
KR101236731B1
(ko)
|
2010-11-02 |
2013-02-25 |
한국과학기술원 |
아자인돌 화합물, 이를 포함하는 pi3k 저해제용 약학 조성물 및 pi3k와 연관된 질환 치료용 약학 조성물
|
|
CA2818542A1
(en)
|
2010-11-19 |
2012-05-24 |
Incyte Corporation |
Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
|
|
ES2536415T3
(es)
|
2010-11-19 |
2015-05-25 |
Incyte Corporation |
Pirrolopiridinas y pirrolopirimidinas sustituidas heterocíclicas como inhibidores de JAK
|
|
WO2012071336A1
(en)
|
2010-11-23 |
2012-05-31 |
Abbott Laboratories |
Salts and crystalline forms of an apoptosis-inducing agent
|
|
RU2593231C2
(ru)
|
2010-11-23 |
2016-08-10 |
ЭббВи Айэленд Анлимитед Компани |
Способы лечения с использованием селективных ингибиторов bcl-2
|
|
WO2012075327A1
(en)
|
2010-12-02 |
2012-06-07 |
University Of Pittsburgh-Of The Commonwealth System Of Higher Education |
Methods for treating a tumor using an antibody that specifically binds grp94
|
|
US9295669B2
(en)
|
2010-12-14 |
2016-03-29 |
Hoffman La-Roche Inc. |
Combination therapy for proliferative disorders
|
|
RU2013132681A
(ru)
|
2010-12-16 |
2015-01-27 |
Вертекс Фармасьютикалз Инкорпорейтед |
Ингибиторы репликации вирусов гриппа
|
|
CA2824028A1
(en)
|
2011-01-06 |
2012-07-12 |
Beta Pharma Canada Inc. |
Novel ureas for the treatment and prevention of cancer
|
|
PE20141360A1
(es)
|
2011-02-07 |
2014-10-13 |
Plexxikon Inc |
Compuestos y metodos para la modulacion de quinasas e indicaciones para los mismos.
|
|
EP2672963A4
(en)
|
2011-02-08 |
2015-06-24 |
Childrens Medical Center |
METHOD FOR THE TREATMENT OF MELANOMA
|
|
WO2012112847A1
(en)
|
2011-02-18 |
2012-08-23 |
Novartis Pharma Ag |
mTOR/JAK INHIBITOR COMBINATION THERAPY
|
|
TWI558702B
(zh)
|
2011-02-21 |
2016-11-21 |
普雷辛肯公司 |
醫藥活性物質的固態形式
|
|
US20140199292A1
(en)
*
|
2011-03-15 |
2014-07-17 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Compositions and methods for inhibiting tumor development caused by chemotherapy induced senescence
|
|
FI2694072T4
(fi)
*
|
2011-04-01 |
2024-09-30 |
Genentech Inc |
Akt-inhibiittoriyhdisteen ja abirateronin yhdistelmä käytettäväksi terapeuttisissa hoidoissa
|
|
WO2012138809A1
(en)
*
|
2011-04-05 |
2012-10-11 |
Dawei Zhang |
Heterocyclic compounds as kinase inhibitors
|
|
AU2012246490B2
(en)
|
2011-04-18 |
2016-08-04 |
Eisai R&D Management Co., Ltd. |
Therapeutic agent for tumor
|
|
AU2012253525B2
(en)
*
|
2011-05-10 |
2016-09-22 |
Brunangelo Falini |
Hairy cell leukemia biomarkers and methods of using same
|
|
JP2014513724A
(ja)
|
2011-05-16 |
2014-06-05 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
融合二環キナーゼ阻害剤
|
|
CA2836474A1
(en)
|
2011-05-17 |
2012-11-22 |
Plexxikon Inc. |
Kinase modulation and indications therefor
|
|
JP2014515368A
(ja)
|
2011-05-26 |
2014-06-30 |
第一三共株式会社 |
プロテインキナーゼ阻害剤としての複素環化合物
|
|
JP6038128B2
(ja)
|
2011-06-03 |
2016-12-07 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
|
|
US8877742B2
(en)
|
2011-06-10 |
2014-11-04 |
Glaxosmithkline Intellectual Property Limited |
Compounds
|
|
US8691807B2
(en)
|
2011-06-20 |
2014-04-08 |
Incyte Corporation |
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
|
|
KR20140048968A
(ko)
|
2011-07-13 |
2014-04-24 |
파마시클릭스, 인코포레이티드 |
브루톤형 티로신 키나제의 억제제
|
|
BR112014002353B1
(pt)
|
2011-08-01 |
2022-09-27 |
Genentech, Inc |
Usos de antagonistas de ligação do eixo pd-1 e inibidores de mek, composições farmacêuticas, e kit
|
|
UA118010C2
(uk)
*
|
2011-08-01 |
2018-11-12 |
Вертекс Фармасьютікалз Інкорпорейтед |
Інгібітори реплікації вірусів грипу
|
|
WO2013023119A1
(en)
|
2011-08-10 |
2013-02-14 |
Novartis Pharma Ag |
JAK P13K/mTOR COMBINATION THERAPY
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為jak抑制劑之環己基氮雜環丁烷衍生物
|
|
WO2013029043A1
(en)
*
|
2011-08-25 |
2013-02-28 |
Reaction Biology Corp. |
Selective kinase inhibitors
|
|
WO2013032951A1
(en)
|
2011-08-26 |
2013-03-07 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
AU2012308238B2
(en)
*
|
2011-09-14 |
2017-05-25 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
|
EP2570127A1
(en)
|
2011-09-16 |
2013-03-20 |
Sanofi |
Compositions and methods for treating cancer using PI3KB beta inhibitor and MAPK pathway inhibitor, including MEK and RAF inhibitors
|
|
AU2012312515A1
(en)
|
2011-09-19 |
2014-03-13 |
Genentech, Inc. |
Combination treatments comprising c-met antagonists and B-raf antagonists
|
|
US9174984B2
(en)
*
|
2011-10-24 |
2015-11-03 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Chemical compounds
|
|
JP6106685B2
(ja)
|
2011-11-17 |
2017-04-05 |
ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド |
C−jun−n−末端キナーゼ(jnk)の阻害剤
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
DK2797888T3
(en)
|
2011-12-31 |
2016-09-19 |
Beigene Ltd |
Fused tricyclic compounds as RAF kinase inhibitors
|
|
WO2013109142A1
(en)
|
2012-01-16 |
2013-07-25 |
Stichting Het Nederlands Kanker Instituut |
Combined pdk and mapk/erk pathway inhibition in neoplasia
|
|
CN102603734A
(zh)
*
|
2012-01-19 |
2012-07-25 |
盛世泰科生物医药技术(苏州)有限公司 |
一种蛋白激酶抑制剂及其应用
|
|
EP2806874B1
(en)
|
2012-01-25 |
2017-11-15 |
Neupharma, Inc. |
Quinoxaline-oxy-phenyl derivatives as kinase inhibitors
|
|
US9358235B2
(en)
|
2012-03-19 |
2016-06-07 |
Plexxikon Inc. |
Kinase modulation, and indications therefor
|
|
US9216170B2
(en)
|
2012-03-19 |
2015-12-22 |
Hoffmann-La Roche Inc. |
Combination therapy for proliferative disorders
|
|
HK1202452A1
(en)
|
2012-03-28 |
2015-10-02 |
Neuropore Therapies, Inc. |
Phenyl-urea and phenyl-carbamate derivatives as inhibitors of protein aggregation
|
|
RU2635359C2
(ru)
*
|
2012-04-23 |
2017-11-13 |
Дженентек Инк. |
Промежуточные химические соединения и способы получения соединений
|
|
TW201406761A
(zh)
|
2012-05-18 |
2014-02-16 |
Incyte Corp |
做爲jak抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
|
|
WO2013176970A1
(en)
*
|
2012-05-22 |
2013-11-28 |
Merck Sharp & Dohme Corp. |
TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
|
|
US10077474B2
(en)
*
|
2012-05-29 |
2018-09-18 |
Abbott Molecular, Inc. |
Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits
|
|
US9150570B2
(en)
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
|
JP6231085B2
(ja)
|
2012-05-31 |
2017-11-15 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
アミノキナゾリン誘導体及びピリドピリミジン誘導体
|
|
MA37711A1
(fr)
|
2012-06-04 |
2017-05-31 |
Pharmacyclics Inc |
Formes cristallines d'un inhibiteur de tyrosine kinase de bruton
|
|
WO2014008270A1
(en)
|
2012-07-03 |
2014-01-09 |
Ratiopharm Gmbh |
Solid state form of vemurafenib choline salt
|
|
HK1206073A1
(en)
|
2012-07-24 |
2015-12-31 |
药品循环有限责任公司 |
Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk)
|
|
US20150183781A1
(en)
*
|
2012-08-07 |
2015-07-02 |
Um Pharmauji Sdn. Bhd. |
5-(1H-Pyrazol-4-yl)-1H-Pyrrolo[2,3-b]Pyridine Derivatives as Kinase Inhibitors
|
|
DK2884979T3
(da)
|
2012-08-17 |
2019-09-02 |
Hoffmann La Roche |
Kombinationsbehandlinger mod melanom omfattende indgivelse af cobimetinib og vemurafenib
|
|
CN103626765B
(zh)
*
|
2012-08-27 |
2016-08-10 |
广东东阳光药业有限公司 |
取代的氮杂吲哚化合物及其盐、组合物和用途
|
|
TWI601725B
(zh)
*
|
2012-08-27 |
2017-10-11 |
加拓科學公司 |
取代的氮雜吲哚化合物及其鹽、組合物和用途
|
|
JP6318156B2
(ja)
|
2012-09-06 |
2018-04-25 |
プレキシコン インコーポレーテッドPlexxikon Inc. |
キナーゼをモジュレートするための化合物および方法、ならびにその指標
|
|
CN104812389B
(zh)
|
2012-09-24 |
2020-07-17 |
润新生物公司 |
某些化学实体、组合物及方法
|
|
CN103613591B
(zh)
*
|
2012-09-29 |
2016-04-13 |
上海科州药物研发有限公司 |
作为cMet抑制剂的化合物及其制备方法和用途
|
|
CA2885259A1
(en)
|
2012-10-04 |
2014-04-10 |
Pfizer Limited |
Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors
|
|
CN109276716B
(zh)
*
|
2012-10-08 |
2021-06-08 |
归属疗法有限公司 |
用在病毒性疾病的治疗中的mek抑制剂
|
|
EP2909194A1
(en)
|
2012-10-18 |
2015-08-26 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
|
USRE48175E1
(en)
|
2012-10-19 |
2020-08-25 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
|
US10000483B2
(en)
|
2012-10-19 |
2018-06-19 |
Dana-Farber Cancer Institute, Inc. |
Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
|
|
US9725421B2
(en)
|
2012-11-12 |
2017-08-08 |
Neupharma, Inc. |
Substituted quinoxalines as B-raf kinase inhibitors
|
|
KR20150084923A
(ko)
|
2012-11-15 |
2015-07-22 |
파마시클릭스, 인코포레이티드 |
키나제 억제제로서의 피롤로피리미딘 화합물
|
|
KR102242077B1
(ko)
|
2012-11-15 |
2021-04-20 |
인사이트 홀딩스 코포레이션 |
룩솔리티니브의 서방성 제형
|
|
US9260426B2
(en)
|
2012-12-14 |
2016-02-16 |
Arrien Pharmaceuticals Llc |
Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
|
|
US9725703B2
(en)
|
2012-12-20 |
2017-08-08 |
Biomatrica, Inc. |
Formulations and methods for stabilizing PCR reagents
|
|
ME03000B
(me)
|
2012-12-21 |
2018-10-20 |
Plexxikon Inc |
Jedinjenja i metode modulacije kinaze i povezane indikacije
|
|
JPWO2014098176A1
(ja)
|
2012-12-21 |
2017-01-12 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
キノリン誘導体のアモルファス及びその製造方法
|
|
EP2943485B1
(en)
|
2013-01-14 |
2017-09-20 |
Incyte Holdings Corporation |
Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors
|
|
TWI662030B
(zh)
|
2013-01-15 |
2019-06-11 |
英塞特控股公司 |
適用作pim激酶抑制劑之噻唑甲醯胺及吡啶甲醯胺化合物
|
|
US20140357636A1
(en)
*
|
2013-02-21 |
2014-12-04 |
Wayne Rothbaum |
Treatment of Skeletal-Related Disorders
|
|
WO2014128235A1
(en)
|
2013-02-22 |
2014-08-28 |
F. Hoffmann-La Roche Ag |
Methods of treating cancer and preventing drug resistance
|
|
CN105163584B
(zh)
*
|
2013-03-05 |
2019-06-04 |
田纳西大学研究基金会 |
用于治疗癌症的化合物
|
|
EP3489239B1
(en)
|
2013-03-06 |
2021-09-15 |
Incyte Holdings Corporation |
Processes and intermediates for making a jak inhibitor
|
|
US20140275082A1
(en)
|
2013-03-14 |
2014-09-18 |
Abbvie Inc. |
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
EP2970270A1
(en)
|
2013-03-14 |
2016-01-20 |
ratiopharm GmbH |
Solid state forms of vemurafenib hydrochloride
|
|
US20160030438A1
(en)
|
2013-03-15 |
2016-02-04 |
Sanofi |
Anti-tumoral composition comprising a pi3kbeta inhibitor and a raf inhibitor, to overcome cancer cells resistance
|
|
US20140303121A1
(en)
|
2013-03-15 |
2014-10-09 |
Plexxikon Inc. |
Heterocyclic compounds and uses thereof
|
|
CN105073747B
(zh)
|
2013-03-15 |
2017-06-06 |
普莱希科公司 |
杂环化合物及其应用
|
|
HK1214533A1
(zh)
|
2013-03-15 |
2016-07-29 |
基因泰克公司 |
治疗癌症和预防癌症耐药性的方法
|
|
US9206188B2
(en)
*
|
2013-04-18 |
2015-12-08 |
Arrien Pharmaceuticals Llc |
Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors
|
|
CA2912219C
(en)
|
2013-05-14 |
2021-11-16 |
Eisai R&D Management Co., Ltd. |
Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
|
|
RU2015149937A
(ru)
|
2013-05-30 |
2017-07-06 |
Плексксикон Инк. |
Соединения для модулирования киназы и показания к их применению
|
|
US20160135446A1
(en)
|
2013-06-13 |
2016-05-19 |
Biomatrica, Inc. |
Cell stabilization
|
|
WO2014206344A1
(en)
|
2013-06-28 |
2014-12-31 |
Beigene, Ltd. |
Fused tricyclic amide compounds as multiple kinase inhibitors
|
|
TWI839690B
(zh)
|
2013-07-12 |
2024-04-21 |
印度商皮拉馬爾企業有限公司 |
治療黑色素瘤的藥物組合的用途
|
|
JP6800750B2
(ja)
|
2013-08-02 |
2020-12-16 |
ファーマサイクリックス エルエルシー |
固形腫瘍の処置方法
|
|
MX376856B
(es)
|
2013-08-07 |
2025-03-07 |
Incyte Holdings Corp |
Formas de dosificacion de liberacion prolongada para un inhibidor de jak 1 (cinasa de janus 1).
|
|
CA2920534A1
(en)
|
2013-08-12 |
2015-02-19 |
Pharmacyclics Llc |
Methods for the treatment of her2 amplified cancer
|
|
US9556197B2
(en)
|
2013-08-23 |
2017-01-31 |
Incyte Corporation |
Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
|
|
US9629851B2
(en)
|
2013-09-20 |
2017-04-25 |
Stitching Het Nederlands Kanker Institut—Antoni Van Leeuwenhoek Ziekenhuis |
ROCK in combination with MAPK pathway
|
|
WO2015041534A1
(en)
|
2013-09-20 |
2015-03-26 |
Stichting Het Nederlands Kanker Instituut |
P90rsk in combination with raf/erk/mek
|
|
CN105764896A
(zh)
|
2013-09-30 |
2016-07-13 |
药品循环有限责任公司 |
布鲁顿氏酪氨酸激酶的抑制剂
|
|
AU2014337044A1
(en)
|
2013-10-18 |
2016-05-05 |
Dana-Farber Cancer Institute, Inc. |
Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
|
|
WO2015058126A1
(en)
|
2013-10-18 |
2015-04-23 |
Syros Pharmaceuticals, Inc. |
Heteroaromatic compounds useful for the treatment of prolferative diseases
|
|
PT3068776T
(pt)
|
2013-11-13 |
2019-08-26 |
Vertex Pharma |
Inibidores da replicação de vírus da gripe
|
|
HUE038820T2
(hu)
|
2013-11-13 |
2018-11-28 |
Vertex Pharma |
Eljárás influenzavírusok replikációjának inhibitorai elõállítására
|
|
WO2015073864A1
(en)
|
2013-11-15 |
2015-05-21 |
The Wisar Institute Of Anatomy And Biology |
Ebna1 inhibitors and their method of use
|
|
WO2015075749A1
(en)
*
|
2013-11-22 |
2015-05-28 |
Laurus Labs Private Limited |
Novel processes for the preparation of vemurafenib
|
|
CZ2013943A3
(cs)
|
2013-11-27 |
2015-06-03 |
Zentiva, K.S. |
Krystalické formy vemurafenibu
|
|
CN104710417B
(zh)
*
|
2013-12-11 |
2020-09-08 |
上海科州药物研发有限公司 |
氮杂吲哚类衍生物及其合成方法
|
|
BR112016014481B1
(pt)
*
|
2013-12-20 |
2022-11-08 |
Biomed Valley Discoveries, Inc |
Uso de uma composição farmacêutica, método in vitro para efetuar a morte de células cancerosas, e kit
|
|
CN104739823A
(zh)
*
|
2013-12-28 |
2015-07-01 |
复旦大学附属华山医院 |
淫羊藿素在制备维罗非尼增敏剂中的用途
|
|
WO2015108907A2
(en)
|
2014-01-14 |
2015-07-23 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms
|
|
US9771369B2
(en)
|
2014-03-04 |
2017-09-26 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
US9885086B2
(en)
|
2014-03-20 |
2018-02-06 |
Pharmacyclics Llc |
Phospholipase C gamma 2 and resistance associated mutations
|
|
US20170027940A1
(en)
|
2014-04-10 |
2017-02-02 |
Stichting Het Nederlands Kanker Instituut |
Method for treating cancer
|
|
US20180228907A1
(en)
|
2014-04-14 |
2018-08-16 |
Arvinas, Inc. |
Cereblon ligands and bifunctional compounds comprising the same
|
|
WO2015164614A1
(en)
|
2014-04-23 |
2015-10-29 |
Dana-Farber Cancer Institute, Inc. |
Janus kinase inhibitors and uses thereof
|
|
US9862688B2
(en)
|
2014-04-23 |
2018-01-09 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged janus kinase inhibitors and uses thereof
|
|
CN106535900A
(zh)
*
|
2014-05-06 |
2017-03-22 |
加利福尼亚大学董事会 |
使用braf抑制剂的伤口愈合
|
|
WO2015178770A1
(en)
|
2014-05-19 |
2015-11-26 |
Stichting Het Nederlands Kanker Instituut |
Compositions for cancer treatment
|
|
WO2015181628A1
(en)
*
|
2014-05-27 |
2015-12-03 |
Eisai R&D Management Co., Ltd. |
Treatment of acute myeloid leukemia with an hck inhibitor
|
|
WO2015184305A1
(en)
|
2014-05-30 |
2015-12-03 |
Incyte Corporation |
TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
|
|
TW201613916A
(en)
|
2014-06-03 |
2016-04-16 |
Gilead Sciences Inc |
TANK-binding kinase inhibitor compounds
|
|
WO2015191632A1
(en)
|
2014-06-10 |
2015-12-17 |
Biomatrica, Inc. |
Stabilization of thrombocytes at ambient temperatures
|
|
EP3154588A1
(en)
*
|
2014-06-13 |
2017-04-19 |
Genentech, Inc. |
Methods of treating and preventing cancer drug resistance
|
|
WO2015191986A1
(en)
|
2014-06-13 |
2015-12-17 |
Genentech, Inc. |
Methods of treating and preventing cancer drug resistance
|
|
US20170114323A1
(en)
|
2014-06-19 |
2017-04-27 |
Whitehead Institute For Biomedical Research |
Uses of kinase inhibitors for inducing and maintaining pluripotency
|
|
WO2016004305A2
(en)
|
2014-07-02 |
2016-01-07 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
|
CN105777756B
(zh)
*
|
2014-07-02 |
2019-03-01 |
广东东阳光药业有限公司 |
杂芳化合物及其在药物中的应用
|
|
US9580418B2
(en)
|
2014-07-14 |
2017-02-28 |
Incyte Corporation |
Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
|
|
WO2016010897A1
(en)
|
2014-07-14 |
2016-01-21 |
Incyte Corporation |
Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors
|
|
BR112017000672A2
(pt)
|
2014-07-15 |
2017-11-14 |
Genentech Inc |
composições para tratamento de câncer utilizando antagonistas de ligação de eixo pd-1 e inibidores de mek
|
|
CA2959602A1
(en)
|
2014-08-01 |
2016-02-04 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
|
US9545407B2
(en)
|
2014-08-07 |
2017-01-17 |
Pharmacyclics Llc |
Formulations of a bruton's tyrosine kinase inhibitor
|
|
EP3187491A4
(en)
|
2014-08-28 |
2018-08-01 |
Eisai R&D Management Co., Ltd. |
High-purity quinoline derivative and method for manufacturing same
|
|
ES2774177T3
(es)
|
2014-09-15 |
2020-07-17 |
Plexxikon Inc |
Compuestos heterocíclicos y usos de estos
|
|
SG11201701724VA
(en)
|
2014-09-26 |
2017-04-27 |
Gilead Sciences Inc |
Aminotriazine derivatives useful as tank-binding kinase inhibitor compounds
|
|
US20170248603A1
(en)
|
2014-10-06 |
2017-08-31 |
Dana-Farber Cancer Institute, Inc. |
Angiopoiten-2 biomarkers predictive of anti-immune checkpoint response
|
|
US10611765B2
(en)
|
2014-11-06 |
2020-04-07 |
Ohio State Innovation Foundation |
Pyrrolopyrimidine derivatives as Mps1/TTK kinase inhibitors
|
|
EP3223817A4
(en)
|
2014-11-29 |
2018-05-30 |
Shilpa Medicare Limited |
Substantially pure vemurafenib and its salts
|
|
JP6815318B2
(ja)
|
2014-12-23 |
2021-01-20 |
ダナ−ファーバー キャンサー インスティテュート,インコーポレイテッド |
二官能性分子によって標的化タンパク質分解を誘導する方法
|
|
US10870651B2
(en)
|
2014-12-23 |
2020-12-22 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (CDK7)
|
|
US9694084B2
(en)
|
2014-12-23 |
2017-07-04 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
|
US20180028662A1
(en)
|
2015-02-25 |
2018-02-01 |
Eisai R&D Management Co., Ltd. |
Method for Suppressing Bitterness of Quinoline Derivative
|
|
IL315294A
(en)
|
2015-03-03 |
2024-10-01 |
Pharmacyclics Llc |
Pharmaceutical formulations of proton tyrosine kinase inhibitor
|
|
KR20240064733A
(ko)
|
2015-03-04 |
2024-05-13 |
머크 샤프 앤드 돔 코포레이션 |
암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
|
|
CN107427521B
(zh)
|
2015-03-27 |
2021-08-03 |
达纳-法伯癌症研究所股份有限公司 |
细胞周期蛋白依赖性激酶的抑制剂
|
|
US10160755B2
(en)
|
2015-04-08 |
2018-12-25 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
CZ2015250A3
(cs)
|
2015-04-14 |
2016-10-26 |
Zentiva, K.S. |
Amorfní formy vemurafenibu
|
|
CN112574196A
(zh)
|
2015-05-06 |
2021-03-30 |
普莱希科公司 |
调节激酶的1H-吡咯并[2,3-b]吡啶衍生物的合成
|
|
SMT202000535T1
(it)
|
2015-05-06 |
2020-11-10 |
Plexxikon Inc |
Forme solide di composto modulante chinasi
|
|
WO2016183120A1
(en)
|
2015-05-13 |
2016-11-17 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of influenza viruses replication
|
|
EP3294717B1
(en)
|
2015-05-13 |
2020-07-29 |
Vertex Pharmaceuticals Inc. |
Methods of preparing inhibitors of influenza viruses replication
|
|
KR102616818B1
(ko)
|
2015-05-14 |
2023-12-22 |
더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 |
Ebna1 억제제 및 그의 사용 방법
|
|
HUE050936T2
(hu)
|
2015-05-22 |
2021-01-28 |
Plexxikon Inc |
Heterociklusos vegyületek szintézise
|
|
BR112017025045A2
(pt)
|
2015-05-22 |
2018-08-07 |
Plexxikon Inc |
plx-8394 ou plx-7904 para uso no tratamento de doenças relacionadas a braf-v600
|
|
WO2016196244A1
(en)
|
2015-05-29 |
2016-12-08 |
Incyte Corporation |
Pyridineamine compounds useful as pim kinase inhibitors
|
|
JP6549735B2
(ja)
*
|
2015-06-09 |
2019-07-24 |
アッヴィ・インコーポレイテッド |
核内受容体調節剤
|
|
CA2986441A1
(en)
|
2015-06-12 |
2016-12-15 |
Dana-Farber Cancer Institute, Inc. |
Combination therapy of transcription inhibitors and kinase inhibitors
|
|
CA2988707C
(en)
|
2015-06-16 |
2023-10-10 |
Eisai R&D Management Co., Ltd. |
Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer
|
|
CA2992586A1
(en)
|
2015-07-16 |
2017-01-19 |
Array Biopharma, Inc. |
Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
|
|
CR20180109A
(es)
*
|
2015-07-20 |
2018-05-03 |
Genzyme Corp |
Inhibidores de receptor del factor estimulador de colonias 1 (csf-1r)
|
|
US10829484B2
(en)
|
2015-07-28 |
2020-11-10 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
US10729669B2
(en)
*
|
2015-07-28 |
2020-08-04 |
University Of Iowa Research Foundation |
Compositions and methods for treating cancer
|
|
CN108135894B
(zh)
|
2015-08-20 |
2021-02-19 |
卫材R&D管理有限公司 |
肿瘤治疗剂
|
|
WO2017044858A2
(en)
|
2015-09-09 |
2017-03-16 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
|
AR105967A1
(es)
|
2015-09-09 |
2017-11-29 |
Incyte Corp |
Sales de un inhibidor de pim quinasa
|
|
HK1255102A1
(zh)
|
2015-09-21 |
2019-08-02 |
Plexxikon Inc. |
杂环化合物及其应用
|
|
WO2017059251A1
(en)
|
2015-10-02 |
2017-04-06 |
Incyte Corporation |
Heterocyclic compounds useful as pim kinase inhibitors
|
|
WO2017066193A1
(en)
*
|
2015-10-15 |
2017-04-20 |
Princeton Drug Discovery, Llc |
Novel inhibitors of protein kinases
|
|
EP3368039A1
(en)
|
2015-10-26 |
2018-09-05 |
The Regents of The University of Colorado, A Body Corporate |
Point mutations in trk inhibitor-resistant cancer and methods relating to the same
|
|
WO2017087851A1
(en)
|
2015-11-19 |
2017-05-26 |
Genentech, Inc. |
Methods of treating cancer using b-raf inhibitors and immune checkpoint inhibitors
|
|
US9938273B2
(en)
|
2015-12-07 |
2018-04-10 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
ES2946184T3
(es)
|
2015-12-08 |
2023-07-13 |
Biomatrica Inc |
Reducción de la velocidad de eritrosedimentación
|
|
CN108605084B
(zh)
|
2015-12-14 |
2019-09-13 |
Red.Com有限责任公司 |
模块化的数码相机以及移动电话
|
|
BR112017002594A2
(pt)
|
2015-12-17 |
2017-12-19 |
Gilead Sciences Inc |
compostos inibidores de cinase de ligação de tank
|
|
WO2017147316A1
(en)
*
|
2016-02-25 |
2017-08-31 |
Taxis Pharmaceuticals, Inc. |
Synthetic processes and intermediates
|
|
US10160747B2
(en)
|
2016-03-16 |
2018-12-25 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
UA125026C2
(uk)
|
2016-04-04 |
2021-12-29 |
Локсо Онколоджі, Інк. |
РІДКІ КОМПОЗИЦІЇ (S)-N-(5-((R)-2-(2,5-ДИФТОРФЕНІЛ)ПІРОЛІДИН-1-ІЛ)ПІРАЗОЛО[1,5-a]ПІРИМІДИН-3-ІЛ)-3-ГІДРОКСИПІРОЛІДИН-1-КАРБОКСАМІДУ
|
|
UA125025C2
(uk)
|
2016-04-04 |
2021-12-29 |
Локсо Онколоджі, Інк. |
Способи лікування дитячих ракових захворювань
|
|
AU2017249229A1
(en)
|
2016-04-15 |
2018-10-04 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
|
MX392604B
(es)
|
2016-05-18 |
2025-03-24 |
Array Biopharma Inc |
Procesos para la preparacion de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidin-1-carboxamida y sales del mismo.
|
|
RU2768479C2
(ru)
*
|
2016-06-13 |
2022-03-24 |
Хемоцентрикс, Инк. |
Способы лечения рака поджелудочной железы
|
|
AU2017281940C1
(en)
|
2016-06-24 |
2024-11-07 |
University Of Iowa Research Foundation |
Compositions and methods of treating melanoma
|
|
JP6911062B2
(ja)
|
2016-07-01 |
2021-07-28 |
フェルミオン オサケ ユキチュア |
ベムラフェニブの新規な製造方法
|
|
IL311645B2
(en)
|
2016-07-12 |
2025-11-01 |
Revolution Medicines Inc |
2,5- disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines asallosteric shp2 inhibitors
|
|
CA3032210A1
(en)
|
2016-09-16 |
2018-03-22 |
Helmholtz Zentrum Muenchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) |
Traf 6 inhibitors
|
|
TW201815766A
(zh)
|
2016-09-22 |
2018-05-01 |
美商普雷辛肯公司 |
用於ido及tdo調節之化合物及方法以及其適應症
|
|
TWI704148B
(zh)
|
2016-10-10 |
2020-09-11 |
美商亞雷生物製藥股份有限公司 |
作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
|
|
TWI752098B
(zh)
|
2016-10-10 |
2022-01-11 |
美商亞雷生物製藥股份有限公司 |
作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
|
|
EP3308773A1
(en)
|
2016-10-11 |
2018-04-18 |
Recordati Industria Chimica E Farmaceutica SPA |
Formulations of cysteamine and cysteamine derivatives
|
|
CA3040348A1
(en)
|
2016-10-19 |
2018-04-26 |
United States Government As Represented By The Department Of Veterans Affairs |
Compositions and methods for treating cancer
|
|
JOP20190092A1
(ar)
|
2016-10-26 |
2019-04-25 |
Array Biopharma Inc |
عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
|
|
IL294410B2
(en)
|
2016-11-23 |
2024-02-01 |
Chemocentryx Inc |
A method for the treatment of focal segmental tuberous sclerosis
|
|
ES2954279T3
(es)
|
2016-12-15 |
2023-11-21 |
Nestle Sa |
Composiciones y métodos que modulan el fósforo o las enzimas en un animal de compañía
|
|
US11173211B2
(en)
|
2016-12-23 |
2021-11-16 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides
|
|
IL325835A
(en)
*
|
2016-12-23 |
2026-03-01 |
Univ Yale |
Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides
|
|
JP7193460B2
(ja)
|
2016-12-23 |
2022-12-20 |
プレキシコン インコーポレーテッド |
Cdk8調節およびその適応症のための化合物および方法
|
|
US11040027B2
(en)
|
2017-01-17 |
2021-06-22 |
Heparegenix Gmbh |
Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
|
|
WO2018136663A1
(en)
|
2017-01-18 |
2018-07-26 |
Array Biopharma, Inc. |
Ret inhibitors
|
|
JP6888101B2
(ja)
|
2017-01-18 |
2021-06-16 |
アレイ バイオファーマ インコーポレイテッド |
RETキナーゼ阻害剤としての置換ピラゾロ[1,5−a]ピラジン化合物
|
|
CN110446709B
(zh)
|
2017-01-23 |
2023-09-12 |
锐新医药公司 |
作为变构shp2抑制剂的二环化合物
|
|
CA3051054A1
(en)
|
2017-01-23 |
2018-07-26 |
Revolution Medicines, Inc. |
Pyridine compounds as allosteric shp2 inhibitors
|
|
IL319363A
(en)
|
2017-01-31 |
2025-05-01 |
Arvinas Operations Inc |
Cervalon ligands and bifunctional compounds containing them
|
|
CN110072528B
(zh)
|
2017-02-08 |
2022-04-26 |
卫材R&D管理有限公司 |
治疗肿瘤的药物组合物
|
|
EP3579872A1
(en)
|
2017-02-10 |
2019-12-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway
|
|
JOP20190213A1
(ar)
|
2017-03-16 |
2019-09-16 |
Array Biopharma Inc |
مركبات حلقية ضخمة كمثبطات لكيناز ros1
|
|
WO2018175311A1
(en)
|
2017-03-20 |
2018-09-27 |
Plexxikon Inc. |
Crystalline forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1h- pyrrolo[3,2-b]pyridin-3-yl)benzoic acid that inhibits bromodomain
|
|
EP3601326A4
(en)
*
|
2017-03-20 |
2020-12-16 |
The Broad Institute, Inc. |
COMPOUNDS AND METHODS OF REGULATING INSULIN SECRETION
|
|
WO2018183762A1
(en)
|
2017-03-29 |
2018-10-04 |
United States Government As Represented By The Department Of Veterans Affairs |
Methods and compositions for treating cancer
|
|
CN110891566B
(zh)
|
2017-03-30 |
2023-12-19 |
塔克西斯医药股份有限公司 |
合成方法和合成中间体
|
|
WO2018200981A1
(en)
*
|
2017-04-28 |
2018-11-01 |
Quartz Therapeutics, Inc. |
Raf-degrading conjugate compounds
|
|
WO2018210661A1
(en)
*
|
2017-05-15 |
2018-11-22 |
Basf Se |
Heteroaryl compounds as agrochemical fungicides
|
|
WO2018212202A1
(en)
|
2017-05-16 |
2018-11-22 |
Eisai R&D Management Co., Ltd. |
Treatment of hepatocellular carcinoma
|
|
ES2913213T3
(es)
|
2017-05-19 |
2022-06-01 |
Nflection Therapeutics Inc |
Compuestos heteroaromáticos de anilina condensados para el tratamiento de trastornos dérmicos
|
|
JP7212956B2
(ja)
|
2017-05-19 |
2023-01-26 |
エヌフレクション セラピューティクス インコーポレイテッド |
皮膚障害の処置用のピロロピリジン-アニリン化合物
|
|
WO2018226846A1
(en)
|
2017-06-07 |
2018-12-13 |
Plexxikon Inc. |
Compounds and methods for kinase modulation
|
|
IL321754A
(en)
|
2017-06-30 |
2025-08-01 |
Univ California |
Compositions and methods for modulating hair growth
|
|
BR112019028235B1
(pt)
|
2017-07-25 |
2024-04-30 |
Plexxikon, Inc. |
Composições e seus métodos de preparação
|
|
CN109384785B
(zh)
*
|
2017-08-10 |
2021-09-28 |
浙江海正药业股份有限公司 |
吡咯并吡啶酮类衍生物、其制备方法及其在医药上的用途
|
|
KR102811888B1
(ko)
|
2017-09-08 |
2025-05-27 |
에프. 호프만-라 로슈 아게 |
암의 진단 및 치료 방법
|
|
TWI791053B
(zh)
|
2017-10-10 |
2023-02-01 |
美商亞雷生物製藥股份有限公司 |
6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
|
|
TWI876442B
(zh)
|
2017-10-10 |
2025-03-11 |
美商絡速藥業公司 |
6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
|
|
MX386699B
(es)
|
2017-10-11 |
2025-03-19 |
Chemocentryx Inc |
Tratamiento de glomerulosclerosis segmentaria focal con antagonistas ccr2
|
|
BR112020007058A2
(pt)
|
2017-10-12 |
2020-10-06 |
Revolution Medicines, Inc. |
compostos de piridina, pirazina, e triazina como inibidores de shp2 alostéricos
|
|
US10717735B2
(en)
|
2017-10-13 |
2020-07-21 |
Plexxikon Inc. |
Solid forms of a compound for modulating kinases
|
|
ES2947411T3
(es)
|
2017-10-26 |
2023-08-08 |
Xynomic Pharmaceuticals Inc |
Sales cristalinas de un campo inhibidor de quinasa B-RAF
|
|
CA3080197C
(en)
|
2017-10-27 |
2023-12-19 |
Plexxikon Inc. |
Formulations of a compound modulating kinases
|
|
TW201924683A
(zh)
|
2017-12-08 |
2019-07-01 |
美商英塞特公司 |
用於治療骨髓增生性贅瘤的低劑量組合療法
|
|
BR112020009757A2
(pt)
|
2017-12-15 |
2020-11-03 |
Revolution Medicines, Inc. |
compostos policíclicos como inibidores alostéricos de shp2
|
|
CA3086765A1
(en)
|
2017-12-28 |
2019-07-04 |
Tract Pharmaceuticals, Inc. |
Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
|
|
CN111630054B
(zh)
|
2018-01-18 |
2023-05-09 |
奥瑞生物药品公司 |
作为RET激酶抑制剂的取代的吡唑并[3,4-d]嘧啶化合物
|
|
EP3740491A1
(en)
|
2018-01-18 |
2020-11-25 |
Array Biopharma, Inc. |
Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
|
|
EP3740486A1
(en)
|
2018-01-18 |
2020-11-25 |
Array Biopharma, Inc. |
Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
|
|
MD3746429T2
(ro)
|
2018-01-30 |
2022-08-31 |
Incyte Corp |
Procedee pentru prepararea de (1-(3-fluoro-2-(trifluorometil)izonicotinil)piperidin-4-onă)
|
|
AU2019216264B2
(en)
|
2018-01-31 |
2023-08-31 |
Heparegenix Gmbh |
Protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
|
|
US20210008047A1
(en)
|
2018-02-13 |
2021-01-14 |
Vib Vzw |
Targeting minimal residual disease in cancer with rxr antagonists
|
|
US11149011B2
(en)
|
2018-03-20 |
2021-10-19 |
Plexxikon Inc. |
Compounds and methods for IDO and TDO modulation, and indications therefor
|
|
KR20260080448A
(ko)
|
2018-03-30 |
2026-06-02 |
인사이트 코포레이션 |
Jak 억제제를 사용하는 화농성 한선염의 치료
|
|
EP3774767B1
(en)
|
2018-04-05 |
2025-10-29 |
Beth Israel Deaconess Medical Center, Inc. |
Aryl hydrocarbon receptor modulators and uses thereof
|
|
EP3560516A1
(en)
*
|
2018-04-27 |
2019-10-30 |
Bergen Teknologioverforing AS |
Combination therapy including beta-sitosterol in combination with at least one of a braf inhibitor, a mek inhibitor or an erk inhibitor and methods and use thereof
|
|
EP3793546B1
(en)
|
2018-05-17 |
2025-11-19 |
The Wistar Institute |
Ebna1 inhibitor crystalline forms, and methods of preparing and using same
|
|
GB201808321D0
(en)
*
|
2018-05-21 |
2018-07-11 |
Univ College Dublin Nat Univ Ireland Dublin |
Compositions and uses thereof
|
|
RU2687107C1
(ru)
*
|
2018-06-18 |
2019-05-07 |
федеральное государственное автономное образовательное учреждение высшего образования "Московский физико-технический институт (государственный университет)" |
Ингибитор braf киназы n-(3-(5-(4-хлорофенил)-1h-пиразоло[3,4-b]пиридин-3-карбонил)-2,4-дифторофенил) пропан-1-сульфонамид
|
|
WO2019243315A1
(en)
|
2018-06-21 |
2019-12-26 |
Heparegenix Gmbh |
Tricyclic protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
|
|
EP3810132A4
(en)
|
2018-06-25 |
2022-06-22 |
Dana-Farber Cancer Institute, Inc. |
TAIRE FAMILY KINASE INHIBITORS AND RELATED USES
|
|
GB2612522B
(en)
|
2018-07-06 |
2023-08-02 |
The Regents Of The Univ Of Colorado A Body Corporate Existing Under The Laws Of The State Of Colorad |
Genetically encoded system for constructing and detecting biologically active agents
|
|
SG11202012732UA
(en)
*
|
2018-07-16 |
2021-02-25 |
Heparegenix Gmbh |
Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
|
|
CN112469718B
(zh)
*
|
2018-07-19 |
2022-08-30 |
深圳市瓴方生物医药科技有限公司 |
氮杂吲哚衍生物及其作为FGFR和C-Met抑制剂的应用
|
|
CA3108065C
(en)
|
2018-07-31 |
2025-10-07 |
Loxo Oncology, Inc. |
SPRAY-DRIED DISPERSIONS, FORMULATIONS AND POLYMORPHIES OF (S)-5-AMINO-3-(4-((5-FLUORO-2-METHOXYBENZAMIDO)METHYL)PHENYL)(1,1,1-TRIFLUOROPROPANE-2-YL)-1H-PYRAZOLE-4-CARBOXAMIDE
|
|
ES2922314T3
(es)
|
2018-09-10 |
2022-09-13 |
Array Biopharma Inc |
Compuestos heterocíclicos condensados como inhibidores de cinasa RET
|
|
WO2020070390A1
(en)
|
2018-10-03 |
2020-04-09 |
Jyväskylän Yliopisto |
Vemurafenib and salts thereof for use in the treatment of enteroviral infections
|
|
US11066404B2
(en)
|
2018-10-11 |
2021-07-20 |
Incyte Corporation |
Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
|
|
CN112867803A
(zh)
|
2018-10-16 |
2021-05-28 |
诺华股份有限公司 |
单独的或与免疫标志物组合的肿瘤突变负荷作为生物标志物用于预测对靶向疗法的应答
|
|
CN113423707A
(zh)
*
|
2018-11-16 |
2021-09-21 |
加利福尼亚技术学院 |
Erk抑制剂及其用途
|
|
CN113473986B
(zh)
|
2018-11-20 |
2024-10-11 |
恩福莱克逊治疗有限公司 |
用于治疗皮肤疾病萘啶酮苯胺化合物
|
|
EP3883552B1
(en)
|
2018-11-20 |
2025-04-09 |
NFlection Therapeutics, Inc. |
Cyanoaryl-aniline compounds for treatment of dermal disorders
|
|
WO2020106305A1
(en)
|
2018-11-20 |
2020-05-28 |
Nflection Therapeutics, Inc. |
Thienyl-aniline compounds for treatment of dermal disorders
|
|
JP2022510368A
(ja)
*
|
2018-12-03 |
2022-01-26 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
タンキラーゼのインヒビターとしての4-ヘテロアリールカルボニル-n-(フェニルまたはヘテロアリール)ピペリジン-1-カルボキサミド
|
|
CN113164477A
(zh)
|
2018-12-14 |
2021-07-23 |
达纳-法伯癌症研究所股份有限公司 |
C-jun-n-末端激酶的吡唑并吡啶抑制剂及其用途
|
|
WO2020131627A1
(en)
|
2018-12-19 |
2020-06-25 |
Array Biopharma Inc. |
Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases
|
|
US12351571B2
(en)
|
2018-12-19 |
2025-07-08 |
Array Biopharma Inc. |
Substituted quinoxaline compounds as inhibitors of FGFR tyrosine kinases
|
|
EP3902542A4
(en)
|
2018-12-28 |
2022-09-07 |
Dana-Farber Cancer Institute, Inc. |
CYCLIN DEPENDENT KINASE 7 INHIBITORS AND USES THEREOF
|
|
AR118043A1
(es)
*
|
2019-02-11 |
2021-09-15 |
Merck Patent Gmbh |
DERIVADOS DE INDAZOLIL-ISOXAZOL COMO INHIBIDORES DE c-KIT QUINASA
|
|
WO2020168197A1
(en)
|
2019-02-15 |
2020-08-20 |
Incyte Corporation |
Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
|
|
TW202100520A
(zh)
|
2019-03-05 |
2021-01-01 |
美商英塞特公司 |
作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
|
|
US11919904B2
(en)
|
2019-03-29 |
2024-03-05 |
Incyte Corporation |
Sulfonylamide compounds as CDK2 inhibitors
|
|
JP7636646B2
(ja)
|
2019-04-09 |
2025-02-27 |
オプナ バイオ ソシエテ アノニム |
Ep300またはcbpの調節のための縮合アジンおよびその適応
|
|
WO2020223558A1
(en)
|
2019-05-01 |
2020-11-05 |
Incyte Corporation |
Tricyclic amine compounds as cdk2 inhibitors
|
|
WO2020223469A1
(en)
|
2019-05-01 |
2020-11-05 |
Incyte Corporation |
N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer
|
|
US20220227760A1
(en)
*
|
2019-05-29 |
2022-07-21 |
Ifm Due, Inc. |
Compounds and compositions for treating conditions associated with sting activity
|
|
MX2021014674A
(es)
*
|
2019-05-31 |
2022-01-11 |
Fochon Biosciences Ltd |
Pirrolo [2,3-b] piridina sustituida y derivados de pirazolo [3,4-b] piridina como inhibidores de proteinas quinasas.
|
|
WO2021000935A1
(en)
|
2019-07-04 |
2021-01-07 |
Qilu Regor Therapeutics Inc. |
Hpk1 inhibitors and uses thereof
|
|
JP7629442B2
(ja)
|
2019-07-29 |
2025-02-13 |
ヘパリジェニックス ゲーエムベーハー |
肝臓再生を促進または肝細胞死を縮減もしくは防止するためのヘテロアリール置換ピラゾロ-ピリジンタンパク質キナーゼ阻害剤
|
|
WO2021030537A1
(en)
|
2019-08-14 |
2021-02-18 |
Incyte Corporation |
Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors
|
|
WO2021067749A2
(en)
*
|
2019-10-02 |
2021-04-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for the treatment of osteoarthritis
|
|
CR20220170A
(es)
|
2019-10-11 |
2022-10-10 |
Incyte Corp |
Aminas bicíclicas como inhibidoras de la cdk2
|
|
CN111004210A
(zh)
*
|
2019-10-23 |
2020-04-14 |
中山大学 |
化合物单晶及其制备方法
|
|
US20230101747A1
(en)
|
2019-12-06 |
2023-03-30 |
Schrödinger, Inc. |
Cyclic compounds and methods of using same
|
|
WO2021113625A1
(en)
|
2019-12-06 |
2021-06-10 |
Plexxikon Inc. |
Compounds and methods for cd73 modulation and indications therefor
|
|
WO2021127443A1
(en)
|
2019-12-19 |
2021-06-24 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of androgen receptor
|
|
US12649736B2
(en)
|
2019-12-20 |
2026-06-09 |
The Regents Of The University Of California |
Synthesis of compounds to promote hair growth
|
|
IL294214B2
(en)
|
2019-12-27 |
2026-04-01 |
Schrodinger Inc |
Cyclic compounds and methods of using same
|
|
CN115052663B
(zh)
|
2020-01-08 |
2026-06-09 |
辛瑟斯治疗股份有限公司 |
Alk5抑制剂缀合物及其用途
|
|
CA3164361A1
(en)
|
2020-01-15 |
2021-07-22 |
Heparegenix Gmbh |
3-benzoyl-1h-pyrrolo[2,3-b]pyridine derivatives as mkk4 inhibitors for treating liver diseases
|
|
US12583818B2
(en)
|
2020-01-17 |
2026-03-24 |
Daegu-Gyeongbuk Medical Innovation Foundation |
Compound, preparation method thereof, and use thereof
|
|
US20230090446A1
(en)
|
2020-01-28 |
2023-03-23 |
Universite De Strasbourg |
Antisense oligonucleotide targeting linc00518 for treating melanoma
|
|
IL296921B1
(en)
*
|
2020-04-15 |
2026-08-01 |
Pyramid Biosciences Inc |
Methods for preparing receptor tyrosine kinase inhibitors
|
|
JP7842698B2
(ja)
|
2020-04-23 |
2026-04-08 |
オプナ バイオ ソシエテ アノニム |
Cd73調節のための化合物及び方法並びにそれらの表示
|
|
AU2021263383A1
(en)
|
2020-04-29 |
2022-11-24 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
|
KR102841083B1
(ko)
|
2020-05-04 |
2025-07-31 |
아주대학교산학협력단 |
톨-유사 수용체 7/9 억제 기능이 있는 길항성 소분자 화합물
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
WO2021255212A1
(en)
|
2020-06-19 |
2021-12-23 |
F. Hoffmann-La Roche Ag |
Braf degraders
|
|
EP4172159A4
(en)
|
2020-06-30 |
2024-01-10 |
The Regents of the University of California |
Compositions and methods for modulating hair growth
|
|
US11529335B2
(en)
|
2020-07-31 |
2022-12-20 |
University Of Iowa Research Foundation |
Compositions and methods for treating cancer
|
|
AU2021327375A1
(en)
|
2020-08-21 |
2023-03-16 |
Opna Bio SA |
Combinational drug anticancer therapies
|
|
WO2022047145A1
(en)
|
2020-08-28 |
2022-03-03 |
Arvinas Operations, Inc. |
Rapidly accelerating fibrosarcoma protein degrading compounds and associated methods of use
|
|
CN116490507A
(zh)
|
2020-09-10 |
2023-07-25 |
薛定谔公司 |
用于治疗癌症的杂环包缩合cdc7激酶抑制剂
|
|
US12692275B2
(en)
*
|
2020-09-23 |
2026-07-28 |
Genfleet Therapeutics (Shanghai) Inc. |
Aroyl substituted tricyclic compound, preparation method therefor and use thereof
|
|
CN114478528A
(zh)
*
|
2020-10-28 |
2022-05-13 |
劲方医药科技(上海)有限公司 |
芳甲酰取代的三环化合物及其制法和用途
|
|
JP2023549273A
(ja)
*
|
2020-11-17 |
2023-11-22 |
フォチョン・バイオサイエンシーズ・リミテッド |
プロテインキナ-ゼ阻害剤としての置換されたピロロ[2,3-b]ピリジン及びピラゾロ[3,4-b]ピリジン誘導体
|
|
EP4234558A4
(en)
*
|
2020-12-07 |
2024-10-23 |
Zhejiang Longcharm Bio-Tech Pharma. Co., Ltd. |
PYRROLOPYRIDINE COMPOUND AND APPLICATION THEREOF
|
|
US20250197396A1
(en)
*
|
2020-12-07 |
2025-06-19 |
Lieber Institute, Inc. |
Compounds for inhibiting inositol hexakisphosphate kinase (ip6k) and methods of use thereof
|
|
US11530216B2
(en)
|
2020-12-23 |
2022-12-20 |
Genzyme Corporation |
Deuterated colony stimulating factor-1 receptor (CSF-1R) inhibitors
|
|
CN117157065A
(zh)
|
2021-01-21 |
2023-12-01 |
恩福莱克逊治疗有限公司 |
吡咯并吡啶-苯胺化合物的晶型
|
|
EP4284804A1
(en)
|
2021-01-26 |
2023-12-06 |
Schrödinger, Inc. |
Tricyclic compounds useful in the treatment of cancer, autoimmune and inflammatory disorders
|
|
CN112574200B
(zh)
*
|
2021-02-26 |
2021-06-11 |
安润医药科技(苏州)有限公司 |
Btk和/或btk的突变体c481s的小分子抑制剂
|
|
CN115073469B
(zh)
*
|
2021-03-15 |
2023-12-22 |
药雅科技(上海)有限公司 |
吡咯并嘧啶类化合物作为激酶抑制剂的制备及其应用
|
|
TW202300150A
(zh)
|
2021-03-18 |
2023-01-01 |
美商薛定諤公司 |
環狀化合物及其使用方法
|
|
EP4308935A1
(en)
|
2021-03-18 |
2024-01-24 |
Novartis AG |
Biomarkers for cancer and methods of use thereof
|
|
TW202304890A
(zh)
*
|
2021-04-14 |
2023-02-01 |
美商百歐克斯製藥公司 |
Klk5雙環雜芳香族抑制劑
|
|
US12371667B2
(en)
|
2021-05-13 |
2025-07-29 |
Washington University |
Enhanced methods for inducing and maintaining naive human pluripotent stem cells
|
|
KR102635126B1
(ko)
|
2021-05-27 |
2024-02-13 |
한국과학기술연구원 |
엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 피롤로피리미딘 유도체 및 이들의 용도
|
|
US11981671B2
(en)
|
2021-06-21 |
2024-05-14 |
Incyte Corporation |
Bicyclic pyrazolyl amines as CDK2 inhibitors
|
|
WO2023059786A1
(en)
*
|
2021-10-06 |
2023-04-13 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Inhibitors of ulk1 and methods of use
|
|
KR20240125577A
(ko)
|
2021-11-23 |
2024-08-19 |
엔플렉션 테라퓨틱스, 인코포레이티드 |
피롤로피리딘-아닐린 화합물의 제형
|
|
US11976073B2
(en)
|
2021-12-10 |
2024-05-07 |
Incyte Corporation |
Bicyclic amines as CDK2 inhibitors
|
|
WO2023174300A1
(zh)
*
|
2022-03-15 |
2023-09-21 |
劲方医药科技(上海)有限公司 |
Btk抑制剂的晶型及其酸式盐和其酸式盐的晶型
|
|
US20250186439A1
(en)
*
|
2022-03-16 |
2025-06-12 |
The Children's Medical Center Corporation |
Pyk2 inhibition modulates immune cell function
|
|
WO2023191425A1
(ko)
*
|
2022-03-28 |
2023-10-05 |
주식회사 비엔에이치리서치 |
약물의 전기생리학적 스크리닝 방법
|
|
WO2024003350A1
(en)
|
2022-06-30 |
2024-01-04 |
Universite De Strasbourg |
Combination therapy for melanoma
|
|
CN115141197B
(zh)
*
|
2022-07-27 |
2024-03-26 |
安徽医科大学 |
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|
|
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|
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|
|
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(en)
|
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|
|
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(zh)
*
|
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|
|
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(zh)
*
|
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|
|
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*
|
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|
|
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(ko)
|
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|
|
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(en)
|
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|
|
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(zh)
*
|
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|
|
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(zh)
|
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|
|
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(en)
*
|
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|
|
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(en)
|
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|
|
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(en)
|
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|