CN102206216B - 作为蛋白质激酶抑制剂的吡咯并[2,3-b]吡啶衍生物 - Google Patents
作为蛋白质激酶抑制剂的吡咯并[2,3-b]吡啶衍生物 Download PDFInfo
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- CN102206216B CN102206216B CN201110084299.XA CN201110084299A CN102206216B CN 102206216 B CN102206216 B CN 102206216B CN 201110084299 A CN201110084299 A CN 201110084299A CN 102206216 B CN102206216 B CN 102206216B
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- phenyl
- fluoro
- pyrrolo
- pyridine
- carbonyl
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- 0 C*=C(*=C(*)*c1c[n]c2ncc(*)cc12)N(*)C(N(C)*)=* Chemical compound C*=C(*=C(*)*c1c[n]c2ncc(*)cc12)N(*)C(N(C)*)=* 0.000 description 8
- JGBIBMXDDURRQW-UHFFFAOYSA-N c1c[nH]c(nc2)c1cc2-c1cccnc1 Chemical compound c1c[nH]c(nc2)c1cc2-c1cccnc1 JGBIBMXDDURRQW-UHFFFAOYSA-N 0.000 description 2
- RBZMSGOBSOCYHR-UHFFFAOYSA-N BrCc1ccc(CBr)cc1 Chemical compound BrCc1ccc(CBr)cc1 RBZMSGOBSOCYHR-UHFFFAOYSA-N 0.000 description 1
- LPTVWZSQAIDCEB-UHFFFAOYSA-N Brc1cnc2[nH]ccc2c1 Chemical compound Brc1cnc2[nH]ccc2c1 LPTVWZSQAIDCEB-UHFFFAOYSA-N 0.000 description 1
- AQSMNULTDSMPFG-UHFFFAOYSA-N CC(C)(C)OC(Oc(c(F)c1C=O)ccc1F)=O Chemical compound CC(C)(C)OC(Oc(c(F)c1C=O)ccc1F)=O AQSMNULTDSMPFG-UHFFFAOYSA-N 0.000 description 1
- XKUKTAOPIRCSNW-UHFFFAOYSA-N CC(C)(C)[Si](C)(C)[n]1c2ncccc2c(I)c1 Chemical compound CC(C)(C)[Si](C)(C)[n]1c2ncccc2c(I)c1 XKUKTAOPIRCSNW-UHFFFAOYSA-N 0.000 description 1
- ADTDLVKTUGQOCC-UHFFFAOYSA-N CC(C)c1cnc2[nH]ccc2c1 Chemical compound CC(C)c1cnc2[nH]ccc2c1 ADTDLVKTUGQOCC-UHFFFAOYSA-N 0.000 description 1
- KELCKSADPTZELD-UHFFFAOYSA-N CC(c1cnc2[nH]ccc2c1)=C Chemical compound CC(c1cnc2[nH]ccc2c1)=C KELCKSADPTZELD-UHFFFAOYSA-N 0.000 description 1
- YDFICAXFOZNUIU-UHFFFAOYSA-N CCCCCN(CCCC)C([n](cc1)c2c1c(C(O)=O)ccc2)=O Chemical compound CCCCCN(CCCC)C([n](cc1)c2c1c(C(O)=O)ccc2)=O YDFICAXFOZNUIU-UHFFFAOYSA-N 0.000 description 1
- QCYQDZWTDOKTGG-UHFFFAOYSA-N CCCS(Nc1cccc(C(c2c[nH]c(nc3)c2cc3OC)=O)c1F)(=O)=O Chemical compound CCCS(Nc1cccc(C(c2c[nH]c(nc3)c2cc3OC)=O)c1F)(=O)=O QCYQDZWTDOKTGG-UHFFFAOYSA-N 0.000 description 1
- AGGJEGDAUHUUCY-UHFFFAOYSA-N CN1CCN(Cc2ccc(COc(ccc(C=O)c3)c3OC)cc2)CC1 Chemical compound CN1CCN(Cc2ccc(COc(ccc(C=O)c3)c3OC)cc2)CC1 AGGJEGDAUHUUCY-UHFFFAOYSA-N 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N COc1cc(C=O)ccc1O Chemical compound COc1cc(C=O)ccc1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- AMCJPMDOXRAQCK-UHFFFAOYSA-N Fc(c(OCc1ccccc1)c1)cc(Br)c1F Chemical compound Fc(c(OCc1ccccc1)c1)cc(Br)c1F AMCJPMDOXRAQCK-UHFFFAOYSA-N 0.000 description 1
- ZTGVOWIFSNTQKH-UHFFFAOYSA-N Fc(cc1OCc2ccccc2)c(Cc2c[nH]c3ncccc23)cc1F Chemical compound Fc(cc1OCc2ccccc2)c(Cc2c[nH]c3ncccc23)cc1F ZTGVOWIFSNTQKH-UHFFFAOYSA-N 0.000 description 1
- BTIANIFSBYIGPA-UHFFFAOYSA-N Ic1c[nH]c2ncccc12 Chemical compound Ic1c[nH]c2ncccc12 BTIANIFSBYIGPA-UHFFFAOYSA-N 0.000 description 1
- CYOWYQXXRVNVOG-UHFFFAOYSA-N O=C(NC1CCCC1)Nc1cc(Cc2c[nH]c(nc3)c2cc3-c2cnccc2)ccc1 Chemical compound O=C(NC1CCCC1)Nc1cc(Cc2c[nH]c(nc3)c2cc3-c2cnccc2)ccc1 CYOWYQXXRVNVOG-UHFFFAOYSA-N 0.000 description 1
- PEDPXKZHFMJANG-UHFFFAOYSA-N OC(c1c[nH]c2ncccc12)c(cc(c(OCc1ccccc1)c1)F)c1F Chemical compound OC(c1c[nH]c2ncccc12)c(cc(c(OCc1ccccc1)c1)F)c1F PEDPXKZHFMJANG-UHFFFAOYSA-N 0.000 description 1
- ROGHUJUFCRFUSO-UHFFFAOYSA-N OC(c1cccc2c1cc[nH]2)=O Chemical compound OC(c1cccc2c1cc[nH]2)=O ROGHUJUFCRFUSO-UHFFFAOYSA-N 0.000 description 1
- BYZMZJIWCQTYSR-UHFFFAOYSA-N Oc(cc(c(Br)c1)F)c1F Chemical compound Oc(cc(c(Br)c1)F)c1F BYZMZJIWCQTYSR-UHFFFAOYSA-N 0.000 description 1
- GUEZVCXGPDMWBU-UHFFFAOYSA-N Oc(ccc(F)c1Cc(c2c3)c[nH]c2ncc3-c2cnccc2)c1F Chemical compound Oc(ccc(F)c1Cc(c2c3)c[nH]c2ncc3-c2cnccc2)c1F GUEZVCXGPDMWBU-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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| US69296005P | 2005-06-22 | 2005-06-22 | |
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| US73152805P | 2005-10-28 | 2005-10-28 | |
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| CN2006800303262A Active CN101243084B (zh) | 2005-06-22 | 2006-06-21 | 作为蛋白质激酶抑制剂的吡咯并[2,3-b]吡啶衍生物 |
| CN201110084299.XA Active CN102206216B (zh) | 2005-06-22 | 2006-06-21 | 作为蛋白质激酶抑制剂的吡咯并[2,3-b]吡啶衍生物 |
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| CN2006800303262A Active CN101243084B (zh) | 2005-06-22 | 2006-06-21 | 作为蛋白质激酶抑制剂的吡咯并[2,3-b]吡啶衍生物 |
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