CN104661664B - 手性控制 - Google Patents

手性控制 Download PDF

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Publication number
CN104661664B
CN104661664B CN201380047876.5A CN201380047876A CN104661664B CN 104661664 B CN104661664 B CN 104661664B CN 201380047876 A CN201380047876 A CN 201380047876A CN 104661664 B CN104661664 B CN 104661664B
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optionally substituted
oligonucleotides
oligonucleotide
linkage
phosphorothioate diester
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Chinese (zh)
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CN104661664A (zh
Inventor
大卫·巴特勒
岩本直树
米纳
内纳德·斯夫尔齐卡帕
格雷戈里·L·韦尔迪
伊万·兹洛泰夫
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Wave Life Sciences Pte Ltd
Wave Life Sciences USA Inc
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Wave Life Sciences Pte Ltd
Ontorii Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C07C317/00—Sulfones; Sulfoxides
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    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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  • General Engineering & Computer Science (AREA)
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  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Massaging Devices (AREA)
  • Paper (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
CN201380047876.5A 2012-07-13 2013-07-12 手性控制 Active CN104661664B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010516947.3A CN112007045B (zh) 2012-07-13 2013-07-12 手性控制

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201261671656P 2012-07-13 2012-07-13
US201261671655P 2012-07-13 2012-07-13
US61/671,655 2012-07-13
US61/671,656 2012-07-13
US201261671724P 2012-07-14 2012-07-14
US201261671722P 2012-07-14 2012-07-14
US61/671,722 2012-07-14
US61/671,724 2012-07-14
PCT/US2013/050407 WO2014012081A2 (en) 2012-07-13 2013-07-12 Chiral control

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CN104661664B true CN104661664B (zh) 2020-07-03

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EP (2) EP2872147B1 (cg-RX-API-DMAC7.html)
JP (4) JP6453212B2 (cg-RX-API-DMAC7.html)
KR (4) KR20240148947A (cg-RX-API-DMAC7.html)
CN (1) CN104661664B (cg-RX-API-DMAC7.html)
AU (5) AU2013289880B2 (cg-RX-API-DMAC7.html)
CA (1) CA2878945A1 (cg-RX-API-DMAC7.html)
CL (1) CL2015000092A1 (cg-RX-API-DMAC7.html)
DK (1) DK2872147T3 (cg-RX-API-DMAC7.html)
ES (1) ES2940887T3 (cg-RX-API-DMAC7.html)
IL (1) IL236621B (cg-RX-API-DMAC7.html)
MX (1) MX2015000577A (cg-RX-API-DMAC7.html)
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RU (1) RU2015104762A (cg-RX-API-DMAC7.html)
SG (3) SG10201912895PA (cg-RX-API-DMAC7.html)
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