CN101517082B - 具有增强的免疫刺激活性的含疏水性T类似物的CpG寡聚核苷酸类似物 - Google Patents
具有增强的免疫刺激活性的含疏水性T类似物的CpG寡聚核苷酸类似物 Download PDFInfo
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- CN101517082B CN101517082B CN200780035967.1A CN200780035967A CN101517082B CN 101517082 B CN101517082 B CN 101517082B CN 200780035967 A CN200780035967 A CN 200780035967A CN 101517082 B CN101517082 B CN 101517082B
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Abstract
Description
Seq ID No# | 寡聚核苷酸序列 | 描述/类别衍生自 |
1 | T*G*T*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:2的1×PO |
2 | T*G*T*C*G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | |
3 | T*G*FF*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的5′FF衍生物 |
4 | T*G*T*C-G*FF*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的3′FF衍生物 |
5 | T*G*FF*C-G*FF*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的3′和5′FF衍生物 |
6 | T*G*T*FF-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | C->FF |
7 | T*G*T*C-FF*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | G->FF |
8 | T*FF*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | GT->FF |
9 | T*G*T*C-G*T*FF*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的3′FF衍生物 |
10 | T*G*BU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的5′BU衍生物 |
11 | T*G*T*C-G*BU*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的3′BU衍生物 |
12 | T*G*BU*C-G*BU*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的3′和5′BU衍生物 |
13 | T*G*JU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的5′JU衍生物 |
14 | T*G*T*C-G*JU*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的3′JU衍生物 |
15 | T*G*JU*C-G*JU*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的3′和5′JU衍生物 |
16 | T*G*U*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的5′U衍生物 |
17 | T*G*T*C-G*U*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的3′U衍生物 |
Seq ID No# | 寡聚核苷酸序列 | 描述/类别衍生自 |
18 | T*G*U*C-G*U*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的3′和5′U衍生物 |
Seq ID编号 | 寡聚核苷酸序列 | 描述/类别衍生自 |
1 | T*G*T*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | 未经修饰 |
41 | T*G*CU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的Cl衍生物 |
10 | T*G*BU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的5′BU衍生物 |
13 | T*G*JU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的5′JU衍生物 |
16 | T*G*U*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的U衍生物 |
41 | T*G*CU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的CU衍生物 |
Seq ID编号 | 寡聚核苷酸序列 | 描述/类别衍生自 |
42 | T*G*EU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的EU衍生物 |
29 | T*G*T*C-G*EU*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的3′EU衍生物 |
30 | T*G*EU*C-G*EU*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的5′3′EU衍生物 |
Seq ID编号 | 修饰寡聚核苷酸 | 寡聚体类别 |
16 | T*G*U*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | B |
17 | T*G*T*C-G*U*T*T*T*T*T*T*T*T*T*T*T*T*T*T | B |
18 | T*G*U*C-G*U*T*T*T*T*T*T*T*T*T*T*T*T*T*T | B |
19 | JU*C*G*T*C*G*T*T*T*T*T*C*G*G*T*C*G*T*T*T*T | B |
20 | T*C*G*JU*C*G*T*T*T*T*T*C*G*G*T*C*G*T*T*T*T | B |
21 | T*C*G*T*C*G*T*T*T*T*T*C*G*G*JU*C*G*T*T*T*T | B |
22 | JU*C*G*JU*C*G*T*T*T*T*T*C*G*G*T*C*G*T*T*T*T | B |
23 | T*C*G*JU*C*G*JU*T*T*T*T*C*G*G*T*C*G*T*T*T*T | B |
24 | T*C*G*T*C*G*T*T*T*T*T*C*G*G*JU*C*G*JU*T*T*T | B |
25 | T*C*T*T*T*T*T*T*G*T*C-G*T*T*T*T*T*T*T*T*T*T | T |
26 | T*G*C*T*G*C*T*T*T*T*G*T*G*C*T*T*T*T*G*T*G*C*T*T | 非CpG ODN |
27 | JU*C-G*T*C*G*T*T*T*T*A*C*G*G*C*G*C*C*G*T*G*C*C*G | C |
28 | T*C*G*JU*C-G*T*T*T*T*A*C*G*G*C*G*C*C*G*T*G*C*C*G | C |
31 | JU*C-G*T*C*G*A*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G | P |
32 | T*C*G*JU*C-G*A*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G | P |
33 | JU*C-G*JU*C*G*A*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G | P |
34 | JU*C-G-A-C-G-T-C-G-T-G-G*G*G*G | A |
35 | T*C-G-A-C-G-JU-C-G-T-G-G*G*G*G | A |
36 | T*C-G-A-C-G-JU-C-G-JU-G-G*G*G*G | A |
37 | T*C*G*T*C*G*T*T*T*T*T*C*G*G*T*C*G*T*T*T*T | B |
43 | T*C-G-A-C-G-T-C-G-T-G-G*G*G*G | A |
44 | JU*C-G*JU*C*G*T*T*T*T*A*C*G*G*C*G*C*C*G*T*G*C*C*G | P |
45 | T*C*G*JU*C-G*JU*T*T*T*A*C*G*G*C*G*C*C*G*T*G*C*C*G | P |
46 | T*C*G*T*C-G*T*T*T*T*A*C*G*G*C*G*C*C*G*T*G*C*C*G | P |
47 | T*C*T*T*T*T*T*T*G*JU*C-G*T*T*T*T*T*T*T*T*T*T | T |
48 | T*C*T*T*T*T*T*T*G*JU*C-G*JU*T*T*T*T*T*T*T*T*T | T |
49 | JU*C*T*T*T*T*T*T*G*T*C-G*T*T*T*T*T*T*T*T*T*T | T |
50 | JU*C-T*T*T*T*T*T*G*T*C-G*T*T*T*T*T*T*T*T*T*T | T |
51 | T*C*T*T*T*T*T*T*G*U*C-G*T*T*T*T*T*T*T*T*T*T | T |
52 | T*C-G*T*C*G*A*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G | P |
Seq ID编号 | 短聚体序列 | 修饰 |
38 | G*T*C-G*T*T | 未经修饰 |
39 | G*JU*C-G*T*T | 5′JU |
40 | G*JU*C-G*JU*T | 5′和3′JU |
37 | T*C*G*T*C*G*T*T*T*T*T*C*G*G*T*C*G*T*T*T*T | 未经修饰的B类 |
Seq ID编号 | 序列 | 修饰 |
13 | T*G*JU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | SEQ ID NO:1的5′JU衍生物 |
37 | T*C*G*T*C*G*T*T*T*T*T*C*G*G*T*C*G*T*T*T*T | 未经修饰的B类 |
26 | T*G*C*T*G*C*T*T*T*T*G*T*G*C*T*T*T*T*G*T*G*C*T*T | 非CpG对照 |
Seq ID 编号 | 序列 | 类型和修饰 |
1 | T*G*T*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | 未经修饰的B类 |
13 | T*G*JU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | B类:SEQ ID NO:1的5′JU衍生物 |
38 | G*T*C-G*T*T | 未经修饰的B类 |
96 | (T*G*JU*C-G*T*T*L*)2doub-3mG | 3′3′-分枝 |
97 | (JU*C*G*T*T*C*G*L*)2doub-3mG | 3′3′-分枝 |
Seq ID 编号 | 序列 | 类型和修饰 |
101 | (T*G*JU*C-G*T*T*L*)2doub-teg | 3′3′-分枝 |
102 | (JU*C*G*T*T*C*G*L*)2doub-teg | 3′3′-分枝 |
111 | T*mG*JU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | 2′-O-甲基修饰的B类 |
112 | T*G*JU*C-mG*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | 2′-O-甲基修饰的B类 |
113 | T*mG*JU*C-mG*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | 2′-O-甲基修饰的B类 |
116 | T*G*PU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | 具有5-丙炔基-dU(PU)的B类 |
117 | T*G*T*C-G*PU*T*T*T*T*T*T*T*T*T*T*T*T*T*T | 具有5-丙炔基-dU(PU)的B类 |
126 | G*JU*C-G*JU*T-hex | 具有JU和十六烷基甘油基3′标签的 38的B类衍生物 |
132 | JU*C*T*T*T*T*T*T*T*T*C*G*T*T*T*T*T*T*T*T*T*T | T-类 |
133 | T*C*T*T*T*T*T*T*T*JU*C*G*T*T*T*T*T*T*T*T*T*T | T-类 |
134 | JU*C*T*T*T*T*T*T*T*JU*C*G*T*T*T*T*T*T*T*T*T*T | T-类 |
138 | T*G*JU*C-E*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | 具有7-脱氮-dG(E)的B类 |
139 | T*G*JU*C-I*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | 具有肌苷(I)的B类 |
140 | T*G*JU*Z-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | 具有5-甲基-dC(Z)的B类 |
153 | T*G*BVU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | 具有5-(2-溴-乙烯基)-尿苷(BVU)的B 类 |
154 | T*G*T*C-G*BVU*T*T*T*T*T*T*T*T*T*T*T*T*T*T | 具有5-(2-溴-乙烯基)-尿苷(BVU)的B 类 |
178 | T*G*6NB*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T | 具有6-硝基-苯并咪唑(6NB)的B类 |
198 | C*G*G*C*G*C*C*T*C*G | C类 |
Seq ID 编号 | 序列 | 类型和修饰 |
53 | T*C*C*A*G*G*A*C*T*T*C*T*C*T*C*A*G*G*T*T | 负对照 |
54 | T*C*G*T*C*G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*G | C类 |
55 | T*C*G*T*C*G*T*T*T*T*G*T*C*G*T*T*T*T*G*T*C*G*T*T | B类 |
56 | T*C-G*A*C*G*T*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G | P类T->A,5′CpG PO |
57 | T*C-G*T*C*G*A*C*G*A*T*C*G*G*C*G*G*C*C*G*C*C*G | P类3′回文,5′CpG PO |
58 | JU*C-G*A*C*G*T*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G | P类 |
59 | JU*C*G*A*C*G*T*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G | P类 |
60 | JU*C-G*A*C*G*T*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G*T | P类 |
61 | JU*C*G*A*C*G*T*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G*T | P类 |
62 | EU*C-G*A*C*G*T*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G | P类 |
63 | EU*C-G*A*C*G*T*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G | P类 |
64 | EU*C-G*A*C*G*T*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G | P类 |
65 | EU*C*G*A*C*G*T*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G | P类 |
66 | JU*C-G*T*C*G*A*C*G*A*T*C*G*G*C*G*G*C*C*G*C*C*G*T | P类 |
67 | JU*C*G*T*C*G*A*C*G*A*T*C*G*G*C*G*G*C*C*G*C*C*G*T | P类 |
68 | T*C_G*C_G*T*C_G*T*T*C_G*G*C*G*C_G*C*G*C*C*G | C类 |
Seq ID编号 | 寡聚核苷酸序列 |
3 | T*G*FF*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
4 | T*G*T*C-G*FF*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
5 | T*G*FF*C-G*FF*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
6 | T*G*T*FF-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
7 | T*G*T*C-FF*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
8 | T*FF*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
9 | T*G*T*C-G*T*FF*T*T*T*T*T*T*T*T*T*T*T*T*T |
10 | T*G*BU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
11 | T*G*T*C-G*BU*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
12 | T*G*BU*C-G*BU*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
13 | T*G*JU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
14 | T*G*T*C-G*JU*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
15 | T*G*JU*C-G*JU*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
16 | T*G*U*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
17 | T*G*T*C-G*U*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
18 | T*G*U*C-G*U*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
19 | JU*C*G*T*C*G*T*T*T*T*T*C*G*G*T*C*G*T*T*T*T |
20 | T*C*G*JU*C*G*T*T*T*T*T*C*G*G*T*C*G*T*T*T*T |
21 | T*C*G*T*C*G*T*T*T*T*T*C*G*G*JU*C*G*T*T*T*T |
22 | JU*C*G*JU*C*G*T*T*T*T*T*C*G*G*T*C*G*T*T*T*T |
23 | T*C*G*JU*C*G*JU*T*T*T*T*C*G*G*T*C*G*T*T*T*T |
24 | T*C*G*T*C*G*T*T*T*T*T*C*G*G*JU*C*G*JU*T*T*T |
27 | JU*C-G*T*C*G*T*T*T*T*A*C*G*G*C*G*C*C*G*T*G*C*C*G |
28 | T*C*G*JU*C-G*T*T*T*T*A*C*G*G*C*G*C*C*G*T*G*C*C*G |
29 | T*G*T*C-G*EU*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
30 | T*G*EU*C-G*EU*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
31 | JU*C-G*T*C*G*A*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G |
32 | T*C*G*JU*C-G*A*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G |
33 | JU*C-G*JU*C*G*A*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G |
34 | JU*C-G-A-C-G-T-C-G-T-G-G*G*G*G |
35 | T*C-G-A-C-G-JU-C-G-T-G-G*G*G*G |
36 | T*C-G-A-C-G-JU-C-G-JU-G-G*G*G*G |
39 | G*JU*C-G*T*T |
40 | G*JU*C-G*JU*T |
41 | T*G*CU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
42 | T*G*EU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
44 | JU*C-G*JU*C*G*T*T*T*T*A*C*G*G*C*G*C*C*G*T*G*C*C*G |
45 | T*C-G*JU*C*G*JU*T*T*T*A*C*G*G*C*G*C*C*G*T*G*C*C*G |
47 | T*C*T*T*T*T*T*T*G*JU*C-G*T*T*T*T*T*T*T*T*T*T |
48 | T*C*T*T*T*T*T*T*G*JU*C-G*JU*T*T*T*T*T*T*T*T*T |
49 | JU*C*T*T*T*T*T*T*G*T*C-G*T*T*T*T*T*T*T*T*T*T |
50 | JU*C-T*T*T*T*T*T*G*T*C-G*T*T*T*T*T*T*T*T*T*T |
51 | T*C*T*T*T*T*T*T*G*U*C-G*T*T*T*T*T*T*T*T*T*T |
58 | JU*C-G*A*C*G*T*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G |
59 | JU*C*G*A*C*G*T*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G |
60 | JU*C-G*A*C*G*T*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G*T |
61 | JU*C*G*A*C*G*T*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G*T |
SeqID编号 | 寡聚核苷酸序列 |
62 | EU*C-G*A*C*G*T*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G |
63 | EU*C*G*A*C*G*T*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G |
66 | JU*C-G*T*C*G*A*C*G*A*T*C*G*G*C*G*G*C*C*G*C*C*G*T |
67 | JU*C*G*T*C*G*A*C*G*A*T*C*G*G*C*G*G*C*C*G*C*C*G*T |
64 | EU*C-G*T*C*G*A*C*G*A*T*C*G*G*C*G*G*C*C*G*C*C*G |
65 | JU*C-G*T*C*G*A*C*G*A*T*C*G*G*C*G*G*C*C*G*C*C*G |
78 | T*G*T*C-G*FU*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
79 | T*G*FU*C-G*FU*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
80 | T*G*U*C-G*U*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
81 | T*G*T*C-6NB*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
82 | T*G*T*6NB-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
83 | T*G*T*6NB-G-T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
84 | JU*G*T*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
85 | JU*G*JU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
86 | T*G*T*C-G*T*JU*T*T*T*T*T*T*T*T*T*T*T*T*T |
87 | T*G*FT*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
88 | T*G*T*C-G*FT*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
89 | T*G*FT*C-G*FT*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
90 | T*G*CU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
91 | T*G*T*C-G*CU*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
92 | T*G*CU*C-G*CU*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
93 | T*JU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
94 | T*G*JU*C-G*T*T*T*T |
95 | T*G*JU*C-G*T*T*T*T*G*T*C-G*T*T |
96 | (T*G*JU*C-G*T*T*L*)2doub-3mG |
97 | (JU*C*G*T*T*C*G*L*)2doub-3mG |
98 | T*T*JU*C-G*T*C-G*T*T*T*C-G*T*C-G*T*T |
99 | BU*C-G-A-C-G-T-C-G-T-G-G-G*G*G |
100 | T*G*JU*G-C*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
101 | (T*G*JU*C-G*T*T*L*)2doub-teg |
102 | (JU*C*G*T*T*C*G*L*)2doub-teg |
103 | JU*C-G*T*C*G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*G |
104 | T*C*G*JU*C-G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*G |
105 | T*C*G*T*C*G*T*T*T*JU*C-G*G*C*G*C*G*C*G*C*C*G |
106 | JU*C*G*T*C*G*T*T*T*T*T*C*G*G*JU*C*G*T*T*T*T |
107 | T*C*G*JU*C*G*T*T*T*T*T*C*G*G*JU*C*G*T*T*T*T |
108 | T*G*JU*C-G*T*T*T*T*T*T*T*T*T*G*JU*C-G*T*T |
109 | T*G*JU*C*G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
110 | JU*C-G-A-C-G-T-C-G-T-G-G*E*G*G |
111 | T*mG*JU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
112 | T*G*JU*C-mG*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
113 | T*mG*JU*C-mG*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
114 | JU*C-G*JU*C*G*T*T*T*T*T*C*G*G*T*C*G*T*T*T*T |
115 | JU*C*G*JU*C-G*T*T*T*T*T*C*G*G*T*C*G*T*T*T*T |
116 | T*G*PU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
117 | T*G*T*C-G*PU*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
118 | BU*C-G-A-C-G-T-C-G-T-G-G*G*G*G |
119 | T*G*JU*C-G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*G |
120 | T*JU*C-G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*G*T |
121 | T*EU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
122 | T*G*EU*G-C*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
Seq ID编号 | 寡聚核苷酸序列 |
123 | JU*C-G*T*C*G*T*T*T*T*T*C*G*G*T*C*G*T*T*T*T |
124 | EU*C-G*T*C*G*T*T*T*T*T*C*G*G*T*C*G*T*T*T*T |
125 | G*JU*C-G*T*T-hex |
126 | G*JU*C-G*JU*T-hex |
127 | G*EU*C-G*EU*T-hex |
128 | EU*C-G*T*C*G*T*T*T*T*A*C*G*G*C*G*C*C*G*T*G*C*C*G |
129 | T*C*G*EU*C-G*T*T*T*T*A*C*G*G*C*G*C*C*G*T*G*C*C*G |
130 | EU*C-G*T*C*G*A*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G |
131 | JU*C*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
132 | JU*C*T*T*T*T*T*T*T*T*C*G*T*T*T*T*T*T*T*T*T*T |
133 | T*C*T*T*T*T*T*T*T*JU*C*G*T*T*T*T*T*T*T*T*T*T |
134 | JU*C*T*T*T*T*T*T*T*JU*C*G*T*T*T*T*T*T*T*T*T*T |
135 | JU*C-G*T*C*G*T*T*T*C*G*T*C*G*T*T*T*T*G*T*C*G*T*T |
136 | T*C*G*T*C*G*T*T*T*C*G*T*C*G*T*T*T*T*G*JU*C-G*T*T |
137 | JU*C-G*T*C*G*T*T*T*C*G*T*C*G*T*T*T*T*G*JU*C-G*T*T |
138 | T*G*JU*C-E*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
139 | T*G*JU*C-I*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
140 | T*G*JU*Z-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
141 | T*G*T*C-G*T*T*JU*T*T*T*T*T*T*T*T*T*T*T*T |
142 | T*G*T*C-G*T*T*T*JU*T*T*T*T*T*T*T*T*T*T*T |
143 | JU*C-G*T*C*G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*G*T |
144 | EU*C-G*T*C*G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*G*T |
145 | T*C-G*EU*C*G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*G*T |
146 | T*C-G*T*C*G*T*T*T*JU*C*G*G*C*G*C*G*C*G*C*C*G*T |
147 | T*C-G*T*C*G*T*T*T*EU*C*G*G*C*G*C*G*C*G*C*C*G*T |
148 | EU*C-G*T*C*G*T*T*T*EU*C*G*G*C*G*C*G*C*G*C*C*G*T |
149 | EU*C-G*EU*C*G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*G*T |
150 | JU*C-G*EU*C*G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*G*T |
151 | JU*C-G*T*C*G*T*T*T*T*G*T*C*G*T*T*T*T*G*T*C*G*T*T |
152 | EU*C-G*T*C*G*T*T*T*T*G*T*C*G*T*T*T*T*G*T*C*G*T*T |
153 | T*G*BVU*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
154 | T*G*T*C-G*BVU*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
155 | JU*C*G*G*C*G*G*C*C*G*C*C*G |
156 | JU*C*G*T*C*G*T*T*T*T*A*C*G*G*C*G*C*C*G*T*G*C*C*3mG |
157 | EU*C*G*T*C*G*T*T*T*T*A*C*G*G*C*G*C*C*G*T*G*C*C*3mG |
158 | EU*C*G*EU*C*G*T*T*T*T*A*C*G*G*C*G*C*C*G*T*G*C*C*3mG |
159 | EU*C-G*EU*C*G*T*T*T*T*A*C*G*G*C*G*C*C*G*T*G*C*C*3mG |
160 | EU*C*G*T*C*G*T*T*T*T*A*C*G*G*C*G*C*C*G*T*G*C*C*G*iT |
161 | JU*C*G*T*C*G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*3mG |
162 | EU*C*G*T*C*G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*3mG |
163 | EU*C-G*T*C*G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*3mG |
164 | EU*C*G*EU*C*G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*3mG |
165 | EU*C-G*EU*C*G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*3mG |
166 | EU*C*G*T*C*G*T*T*T*EU*C*G*G*C*G*C*G*C*G*C*C*3mG |
167 | JU*C*G*T*C*G*T*T*T*JU*C*G*G*C*G*C*G*C*G*C*C*3mG |
168 | EU*C*G*T*C*G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*G*iT |
169 | JU*C*G*T*C*G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*G*iT |
170 | EU*C*G*T*C*G*A*C*G*T*T*C*G*G*C*G*C*C*G*T*G*C*C*3mG |
171 | JU*C*G*T*C*G*A*C*G*T*T*C*G*G*C*G*C*C*G*T*G*C*C*3mG |
172 | JU*C*G*T*C*G*A*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*3mG |
173 | EU*C*G*T*C*G*A*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*3mG |
Seq ID编号 | 寡聚核苷酸序列 |
174 | EU*C*G*T*C*G*A*C*G*T*T*C*G*G*C*G*C*C*G*T*G*C*C*G*iT |
175 | EU*C*G*T*C*G*A*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G*iT |
176 | T*G*NI*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
177 | T*G*NP*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
178 | T*G*6NB*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
179 | EU*C*G*T*C*G*T*T*T*T*T*C*G*G*T*C*G*T*T*T*T |
180 | JU*C*G*T*C*G*A*C*G*A*T*G*G*C*G*G*C*G*C*C*G*C*C |
181 | EU*C*G*T*C*G*A*C*G*A*T*G*G*C*G*G*C*G*C*C*G*C*C |
182 | T*T*C-G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*G*T |
183 | T*EU*C-G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*G*T |
184 | JU*C-G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*G*T |
185 | JU*JU*C-G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*G*T |
186 | T*JU*C*G*T*T*T*T*C*G*G*C*G*C*G*C*G*C*C*G*T |
187 | EU*C*G*T*C*G*T*T*T*T*A*C*G*G*C*G*C*C*G*T*G*C*C*G*T |
188 | T*EU*C*G*T*T*T*T*A*C*G*G*C*G*C*C*G*T*G*C*C*G*T |
189 | T*JU*C*G*T*T*T*T*A*C*G*G*C*G*C*C*G*T*G*C*C*G*T |
190 | JU*C*G*T*C*G*T*T*T*T*rG*rU*rU*rG*rU*rG*rU |
191 | EU*C-G*T*C*G*A*C*G*A*T*C*G*G*C*G*G*C*C*G*C*C*G*T |
192 | EU*C*G*T*C*G*A*C*G*A*T*C*G*G*C*G*G*C*C*G*C*C*G*T |
193 | EU-C-G*A*C*G*T*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G |
194 | EU-C*G*A*C*G*T*C*G*A*T*C*G*G*C*G*C*G*C*G*C*C*G |
195 | T*G*U*C-G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
196 | T*G*T*C-G*U*T*T*T*T*T*T*T*T*T*T*T*T*T*T |
* | 硫代磷酸酯核苷酸间键 |
- | 磷酸二酯核苷酸间键 |
teg | 间隔子9(三乙二醇磷酸酯) |
hex | 十六烷基甘油基 |
3mG | 3′-O-甲基-rG |
iT | 逆向核苷酸(3′和5′交换) |
2doub | 二倍子2(Chemgenes) |
FF | 2,4-二氟甲苯 |
BU | 5-溴-2′-脱氧尿苷 |
JU | 5-碘-2′-脱氧尿苷 |
U | 尿苷 |
CU | 5-氯-2′-脱氧尿苷 |
FU | 5-氟-dU |
EU | 5-乙基-2′-脱氧尿苷 |
6NB | 6-硝基-苯并咪唑 |
PU | 5-丙炔基-dU |
I | 肌苷 |
Z | 5-甲基-dC |
E | 7-脱氮-dG |
FT | a,a,a-三氟-dT |
BVU | 5-(d-溴-乙烯基)-尿苷 |
NI | 硝基吲哚 |
NP | 硝基吡咯 |
F | 5-氟-dU |
L | 间隔子18(六乙二醇磷酸酯) |
Claims (7)
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US84781106P | 2006-09-27 | 2006-09-27 | |
US60/847,811 | 2006-09-27 | ||
PCT/IB2007/004389 WO2008068638A2 (en) | 2006-09-27 | 2007-09-27 | Cpg oligonucleotide analogs containing hydrophobic t analogs with enhanced immunostimulatory activity |
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CN101517082A CN101517082A (zh) | 2009-08-26 |
CN101517082B true CN101517082B (zh) | 2014-01-22 |
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EP (2) | EP2078080B1 (zh) |
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CN (1) | CN101517082B (zh) |
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ES (1) | ES2544958T3 (zh) |
HK (1) | HK1133440A1 (zh) |
HU (1) | HUE027064T2 (zh) |
IL (1) | IL197549A (zh) |
MX (1) | MX2009003398A (zh) |
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