PT1957647E - Oligorribonucleótidos imunoestimulantes - Google Patents
Oligorribonucleótidos imunoestimulantes Download PDFInfo
- Publication number
- PT1957647E PT1957647E PT68382571T PT06838257T PT1957647E PT 1957647 E PT1957647 E PT 1957647E PT 68382571 T PT68382571 T PT 68382571T PT 06838257 T PT06838257 T PT 06838257T PT 1957647 E PT1957647 E PT 1957647E
- Authority
- PT
- Portugal
- Prior art keywords
- immunostimulatory oligoribonucleotides
- oligoribonucleotides
- immunostimulatory
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Transplantation (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73952905P | 2005-11-25 | 2005-11-25 | |
US77898906P | 2006-03-03 | 2006-03-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1957647E true PT1957647E (pt) | 2015-06-01 |
Family
ID=37946151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT68382571T PT1957647E (pt) | 2005-11-25 | 2006-11-22 | Oligorribonucleótidos imunoestimulantes |
Country Status (16)
Country | Link |
---|---|
US (3) | US7662949B2 (pt) |
EP (2) | EP1957647B1 (pt) |
JP (1) | JP4538522B2 (pt) |
KR (1) | KR20080072934A (pt) |
CN (1) | CN102517292B (pt) |
AU (2) | AU2006318464B2 (pt) |
BR (2) | BRPI0622298A8 (pt) |
CA (1) | CA2630738C (pt) |
DK (1) | DK1957647T3 (pt) |
ES (1) | ES2536103T3 (pt) |
HK (1) | HK1210212A1 (pt) |
PL (1) | PL1957647T3 (pt) |
PT (1) | PT1957647E (pt) |
SI (1) | SI1957647T1 (pt) |
TW (1) | TW200738877A (pt) |
WO (1) | WO2007062107A2 (pt) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
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US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US7935675B1 (en) * | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US20030026782A1 (en) * | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
DE69927495T2 (de) * | 1998-05-14 | 2006-07-06 | Coley Pharmaceutical Group, Inc., Wellesley | Verfahren zur regulieren der hämatopoese mit hilfe von cpg-oligonukleotiden |
IL139813A0 (en) * | 1998-05-22 | 2002-02-10 | Loeb Health Res Inst At The Ot | Methods and products for inducing mucosal immunity |
US6949520B1 (en) * | 1999-09-27 | 2005-09-27 | Coley Pharmaceutical Group, Inc. | Methods related to immunostimulatory nucleic acid-induced interferon |
US7585847B2 (en) * | 2000-02-03 | 2009-09-08 | Coley Pharmaceutical Group, Inc. | Immunostimulatory nucleic acids for the treatment of asthma and allergy |
US20030129251A1 (en) * | 2000-03-10 | 2003-07-10 | Gary Van Nest | Biodegradable immunomodulatory formulations and methods for use thereof |
AU7013401A (en) * | 2000-06-22 | 2002-01-02 | Univ Iowa Res Found | Methods for enhancing antibody-induced cell lysis and treating cancer |
ATE411054T1 (de) | 2001-08-17 | 2008-10-15 | Coley Pharm Gmbh | Kombinations-motif-immunstimulierende oligonukleotide mit verbesserter wirkung |
NZ535952A (en) | 2002-04-04 | 2009-01-31 | Coley Pharm Gmbh | Immunostimulatory G,U-containing oligoribonucleotides |
US7576066B2 (en) * | 2002-07-03 | 2009-08-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
US20040053880A1 (en) | 2002-07-03 | 2004-03-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
US7807803B2 (en) | 2002-07-03 | 2010-10-05 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
AR040996A1 (es) | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
NZ540098A (en) | 2002-10-29 | 2008-09-26 | Coley Pharmaceutical Group Ltd | Use of CPG oligonucleotides in the treatment of hepatitis C virus infection |
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JP2007524615A (ja) * | 2003-06-20 | 2007-08-30 | コーリー ファーマシューティカル ゲーエムベーハー | 低分子トール様レセプター(tlr)アンタゴニスト |
JP4989225B2 (ja) * | 2003-09-25 | 2012-08-01 | コーリー ファーマシューティカル グループ,インコーポレイテッド | 核酸親油性接合体 |
AU2004285561C1 (en) | 2003-10-30 | 2012-06-21 | Coley Pharmaceutical Gmbh | C-class oligonucleotide analogs with enhanced immunostimulatory potency |
US20050239733A1 (en) * | 2003-10-31 | 2005-10-27 | Coley Pharmaceutical Gmbh | Sequence requirements for inhibitory oligonucleotides |
EP1720568A2 (en) * | 2004-02-19 | 2006-11-15 | Coley Pharmaceutical Group, Inc. | Immunostimulatory viral rna oligonucleotides |
EP1716234B1 (de) * | 2004-02-20 | 2013-10-02 | Mologen AG | Substituiertes, nicht-kodierendes nukleinsäuremolekül zur therapeutischen und prophylaktischen immunstimulation in menschen und höheren tieren |
EP2484374A1 (en) * | 2004-07-18 | 2012-08-08 | CSL Limited | Immuno stimulating complex and oligonucleotide formulations for inducing enhanced interferon-gamma responses |
MY159370A (en) | 2004-10-20 | 2016-12-30 | Coley Pharm Group Inc | Semi-soft-class immunostimulatory oligonucleotides |
MEP44608A (en) * | 2005-04-08 | 2011-02-10 | Coley Pharm Group Inc | Methods for treating infectious disease exacerbated asthma |
AU2006269555A1 (en) * | 2005-07-07 | 2007-01-18 | Coley Pharmaceutical Group, Inc. | Anti-CTLA-4 antibody and CpG-motif-containing synthetic oligodeoxynucleotide combination therapy for cancer treatment |
CA2622679A1 (en) * | 2005-09-16 | 2007-08-09 | Coley Pharmaceutical Gmbh | Immunostimulatory single-stranded ribonucleic acid with phosphodiester backbone |
CN101321868A (zh) * | 2005-09-16 | 2008-12-10 | 科利制药公司 | 通过核苷酸修饰调节短干扰核糖核酸(siRNA)的免疫刺激特性 |
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KR101251707B1 (ko) | 2006-09-27 | 2013-04-11 | 콜리 파마슈티칼 게엠베하 | 면역 자극 활성이 증강된 소수성 T 유사체를 함유하는 CpG 올리고뉴클레오티드 유사체 |
JP2010504982A (ja) * | 2006-09-27 | 2010-02-18 | コーリー ファーマシューティカル グループ,インコーポレイテッド | Tlrのリガンドと抗ウイルス剤との組成物 |
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KR101023194B1 (ko) * | 2009-02-25 | 2011-03-18 | 사회복지법인 삼성생명공익재단 | 아토피 피부염 진단용 마커 및 그의 용도 |
EP3263707A1 (en) * | 2009-03-17 | 2018-01-03 | Rheinische Friedrich-Wilhelms-Universität Bonn | Tlr8 ligand and uses thereof |
AU2010229835B2 (en) | 2009-03-25 | 2015-01-15 | The Board Of Regents Of The University Of Texas System | Compositions for stimulation of mammalian innate immune resistance to pathogens |
EA028288B1 (ru) | 2009-05-27 | 2017-10-31 | Селекта Байосайенсиз, Инк. | Наноносители, имеющие компоненты с различными скоростями высвобождения |
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EA023897B1 (ru) | 2009-08-26 | 2016-07-29 | Селекта Байосайенсиз, Инк. | Композиции, которые индуцируют хелперное действие т-клеток |
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US10286065B2 (en) | 2014-09-19 | 2019-05-14 | Board Of Regents, The University Of Texas System | Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds |
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- 2006-11-22 US US11/603,978 patent/US7662949B2/en active Active
- 2006-11-22 DK DK06838257T patent/DK1957647T3/en active
- 2006-11-22 CN CN201110430925.6A patent/CN102517292B/zh active Active
- 2006-11-22 ES ES06838257.1T patent/ES2536103T3/es active Active
- 2006-11-22 KR KR1020087015356A patent/KR20080072934A/ko not_active Application Discontinuation
- 2006-11-22 SI SI200631904T patent/SI1957647T1/sl unknown
- 2006-11-22 WO PCT/US2006/045183 patent/WO2007062107A2/en active Application Filing
- 2006-11-22 EP EP06838257.1A patent/EP1957647B1/en active Active
- 2006-11-22 JP JP2008542433A patent/JP4538522B2/ja active Active
- 2006-11-22 CA CA2630738A patent/CA2630738C/en active Active
- 2006-11-22 AU AU2006318464A patent/AU2006318464B2/en active Active
- 2006-11-22 EP EP15150854.6A patent/EP2883957A1/en not_active Withdrawn
- 2006-11-22 PL PL06838257T patent/PL1957647T3/pl unknown
- 2006-11-22 BR BRPI0622298A patent/BRPI0622298A8/pt not_active Application Discontinuation
- 2006-11-22 PT PT68382571T patent/PT1957647E/pt unknown
- 2006-11-22 BR BRPI0618857-5A patent/BRPI0618857B1/pt active IP Right Grant
- 2006-11-23 TW TW095143354A patent/TW200738877A/zh unknown
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Also Published As
Publication number | Publication date |
---|---|
EP1957647A2 (en) | 2008-08-20 |
SI1957647T1 (sl) | 2015-04-30 |
HK1210212A1 (en) | 2016-04-15 |
US8354522B2 (en) | 2013-01-15 |
JP2009517048A (ja) | 2009-04-30 |
US20070142315A1 (en) | 2007-06-21 |
EP2883957A1 (en) | 2015-06-17 |
EP1957647B1 (en) | 2015-03-04 |
BRPI0622298A2 (pt) | 2012-12-11 |
AU2011202189A1 (en) | 2011-06-02 |
JP4538522B2 (ja) | 2010-09-08 |
AU2006318464B2 (en) | 2011-02-17 |
BRPI0618857A2 (pt) | 2011-09-13 |
CA2630738A1 (en) | 2007-05-31 |
AU2006318464A1 (en) | 2007-05-31 |
BRPI0618857B1 (pt) | 2022-07-19 |
BRPI0622298A8 (pt) | 2016-04-05 |
CN102517292B (zh) | 2014-12-24 |
PL1957647T3 (pl) | 2015-07-31 |
AU2011202189B2 (en) | 2012-05-17 |
WO2007062107A2 (en) | 2007-05-31 |
TW200738877A (en) | 2007-10-16 |
US20110206719A1 (en) | 2011-08-25 |
CN102517292A (zh) | 2012-06-27 |
US20100316659A1 (en) | 2010-12-16 |
KR20080072934A (ko) | 2008-08-07 |
CA2630738C (en) | 2013-09-03 |
BRPI0618857A8 (pt) | 2016-04-05 |
WO2007062107A3 (en) | 2007-07-12 |
DK1957647T3 (en) | 2015-04-07 |
US7662949B2 (en) | 2010-02-16 |
ES2536103T3 (es) | 2015-05-20 |
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