BRPI0618857A8 - Oligonucleotídeo de rna isolado, e método para regular negativamente células reguladoras cd4+ imunossupressoras - Google Patents
Oligonucleotídeo de rna isolado, e método para regular negativamente células reguladoras cd4+ imunossupressorasInfo
- Publication number
- BRPI0618857A8 BRPI0618857A8 BRPI0618857A BRPI0618857A BRPI0618857A8 BR PI0618857 A8 BRPI0618857 A8 BR PI0618857A8 BR PI0618857 A BRPI0618857 A BR PI0618857A BR PI0618857 A BRPI0618857 A BR PI0618857A BR PI0618857 A8 BRPI0618857 A8 BR PI0618857A8
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- compositions
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- rna oligonucleotide
- regulatory cells
- immunosuppressant
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- Health & Medical Sciences (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract
MÉTODO PARA ESTIMULAR A PRODUÇÃO DE UMA CITOCINA PRÓ-INFLAMATÓRIA, RNA OLIGONUCLEOTÍDEO (ORN), USO DO MESMO E MÉTODO PARA INFRA-REGULAR CÉLULAS REGULADORAS. A invenção fornece composições imunoestimuladoras e o uso desses compostos na preparação de medicamentos para o tratamento de doenças assim como para usos in vitro. Em particular, as composições da invenção incluem oligorribonucleotídeos imunoestimuladores que incorporam um motivo de sequência imunoestimulador dependente da sequência. São fornecidas modificações específicas envolvendo ligações fosfato, análogos de nucleotídeos, adutos, e combinações dos mesmos. As composições da invenção, que opcionalmente podem incluir um antígeno, podem ser usadas isoladas ou junto com outros tratamentos para estimular ou intensificar uma resposta imune. Também são fornecidas composições e métodos úteis para tratar um indivíduo que tem uma infecção, um câncer, uma condição alérgica, asma, remodelagem das vias aéreas, ou imunodeficiência. Acredita-se que os oligorribonucleotídeos da invenção estimular o receptor 8 semelhante a um "tolI" (TLR8).
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73952905P | 2005-11-25 | 2005-11-25 | |
US60/739,529 | 2005-11-25 | ||
US77898906P | 2006-03-03 | 2006-03-03 | |
US60/778,989 | 2006-03-03 | ||
PCT/US2006/045183 WO2007062107A2 (en) | 2005-11-25 | 2006-11-22 | Immunostimulatory oligoribonucleotides |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0618857A2 BRPI0618857A2 (pt) | 2011-09-13 |
BRPI0618857A8 true BRPI0618857A8 (pt) | 2016-04-05 |
BRPI0618857B1 BRPI0618857B1 (pt) | 2022-07-19 |
Family
ID=37946151
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0622298A BRPI0622298A8 (pt) | 2005-11-25 | 2006-11-22 | Oligorribonucleotídeo para estimular a produção de uma citocina pró-inflamatória, uso do mesmo e composição contendo tal oligorribonucleotídeo |
BRPI0618857-5A BRPI0618857B1 (pt) | 2005-11-25 | 2006-11-22 | Oligonucleotídeo de rna isolado, e método para regular negativamente células reguladoras cd4+ imunossupressoras |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0622298A BRPI0622298A8 (pt) | 2005-11-25 | 2006-11-22 | Oligorribonucleotídeo para estimular a produção de uma citocina pró-inflamatória, uso do mesmo e composição contendo tal oligorribonucleotídeo |
Country Status (16)
Country | Link |
---|---|
US (3) | US7662949B2 (pt) |
EP (2) | EP2883957A1 (pt) |
JP (1) | JP4538522B2 (pt) |
KR (1) | KR20080072934A (pt) |
CN (1) | CN102517292B (pt) |
AU (2) | AU2006318464B2 (pt) |
BR (2) | BRPI0622298A8 (pt) |
CA (1) | CA2630738C (pt) |
DK (1) | DK1957647T3 (pt) |
ES (1) | ES2536103T3 (pt) |
HK (1) | HK1210212A1 (pt) |
PL (1) | PL1957647T3 (pt) |
PT (1) | PT1957647E (pt) |
SI (1) | SI1957647T1 (pt) |
TW (1) | TW200738877A (pt) |
WO (1) | WO2007062107A2 (pt) |
Families Citing this family (78)
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EP1957647A2 (en) | 2008-08-20 |
ES2536103T3 (es) | 2015-05-20 |
CA2630738C (en) | 2013-09-03 |
US20110206719A1 (en) | 2011-08-25 |
BRPI0622298A2 (pt) | 2012-12-11 |
JP4538522B2 (ja) | 2010-09-08 |
BRPI0622298A8 (pt) | 2016-04-05 |
WO2007062107A3 (en) | 2007-07-12 |
KR20080072934A (ko) | 2008-08-07 |
US8354522B2 (en) | 2013-01-15 |
PL1957647T3 (pl) | 2015-07-31 |
EP1957647B1 (en) | 2015-03-04 |
AU2011202189A1 (en) | 2011-06-02 |
AU2011202189B2 (en) | 2012-05-17 |
CA2630738A1 (en) | 2007-05-31 |
JP2009517048A (ja) | 2009-04-30 |
DK1957647T3 (en) | 2015-04-07 |
EP2883957A1 (en) | 2015-06-17 |
CN102517292A (zh) | 2012-06-27 |
TW200738877A (en) | 2007-10-16 |
US7662949B2 (en) | 2010-02-16 |
BRPI0618857A2 (pt) | 2011-09-13 |
WO2007062107A2 (en) | 2007-05-31 |
US20100316659A1 (en) | 2010-12-16 |
AU2006318464B2 (en) | 2011-02-17 |
CN102517292B (zh) | 2014-12-24 |
SI1957647T1 (sl) | 2015-04-30 |
HK1210212A1 (en) | 2016-04-15 |
BRPI0618857B1 (pt) | 2022-07-19 |
AU2006318464A1 (en) | 2007-05-31 |
PT1957647E (pt) | 2015-06-01 |
US20070142315A1 (en) | 2007-06-21 |
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