BRPI0508424A - muteìnas de interleucina-2 melhoradas - Google Patents
muteìnas de interleucina-2 melhoradasInfo
- Publication number
- BRPI0508424A BRPI0508424A BRPI0508424-5A BRPI0508424A BRPI0508424A BR PI0508424 A BRPI0508424 A BR PI0508424A BR PI0508424 A BRPI0508424 A BR PI0508424A BR PI0508424 A BRPI0508424 A BR PI0508424A
- Authority
- BR
- Brazil
- Prior art keywords
- muteins
- interleukin
- mutein
- variants
- nucleic acid
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5064—Endothelial cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/55—IL-2
Abstract
muteínas de interleucina-2 melhoradas novas muteínas de interleucina-2 (IL-2) humana ou variantes destas, e moléculas de ácido nucléico e variantes destes são fornecidas. Métodos para produção destas muteínas, assim como métodos para estimular o sistema imunológico de um animal são também divulgadas. adicionalmente, a invenção fornece vetores de expressão recombinantes compreemdendo moléculas de ácido nucléico desta invenção e células hospedeiras na quais os vetores de expressão foram introduzidos. Composções farmacêuticas são incluídas compreendendo uma quantidade terapeuticamente efetiva de uma muteína de lL-2 humana da invenção e um veículo farmaceuticamente aceitável. A muteína de lL-2 possui menor toxicidade que a lL-2 nativa ou proleucina® a lL-2, enquanto mantém ou melhora os efeitos mediados por célula NK, e pode ser utilizada em composiçoes farmacêuticasnpara uso em tratamento de câncer e para estimular a resposta imune.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55086804P | 2004-03-05 | 2004-03-05 | |
US58598004P | 2004-07-07 | 2004-07-07 | |
US64609505P | 2005-01-21 | 2005-01-21 | |
PCT/US2005/007517 WO2005086798A2 (en) | 2004-03-05 | 2005-03-04 | Improved interleukin-2 muteins |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0508424A true BRPI0508424A (pt) | 2007-07-24 |
Family
ID=34976126
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0508470-9A BRPI0508470A (pt) | 2004-03-05 | 2005-03-03 | sistema de teste in vitro para prever toleráncia do paciente aos agentes terapêuticos |
BRPI0508424-5A BRPI0508424A (pt) | 2004-03-05 | 2005-03-04 | muteìnas de interleucina-2 melhoradas |
BRPI0508455-5A BRPI0508455A (pt) | 2004-03-05 | 2005-03-07 | muteìnas de interleucina-2 combinatórias |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0508470-9A BRPI0508470A (pt) | 2004-03-05 | 2005-03-03 | sistema de teste in vitro para prever toleráncia do paciente aos agentes terapêuticos |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0508455-5A BRPI0508455A (pt) | 2004-03-05 | 2005-03-07 | muteìnas de interleucina-2 combinatórias |
Country Status (11)
Country | Link |
---|---|
US (3) | US20060234205A1 (pt) |
EP (3) | EP1723251A4 (pt) |
JP (3) | JP2007527242A (pt) |
KR (1) | KR20070003934A (pt) |
AU (3) | AU2005227263A1 (pt) |
BR (3) | BRPI0508470A (pt) |
CA (3) | CA2557677A1 (pt) |
IL (1) | IL177876A0 (pt) |
MX (2) | MXPA06010017A (pt) |
RU (3) | RU2006135112A (pt) |
WO (3) | WO2005091956A2 (pt) |
Families Citing this family (80)
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EP4161956A1 (en) | 2020-06-03 | 2023-04-12 | Ascendis Pharma Oncology Division A/S | Il-2 sequences and uses thereof |
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JP2023540701A (ja) * | 2020-08-28 | 2023-09-26 | アセンディス ファーマ オンコロジー ディヴィジョン エー/エス | グリコシル化il-2タンパク質及びその使用 |
KR20230060514A (ko) * | 2020-09-01 | 2023-05-04 | 다케다 야쿠힌 고교 가부시키가이샤 | 인터루킨-2 뮤테인 및 이의 용도 |
TWI815194B (zh) | 2020-10-22 | 2023-09-11 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
KR20230097094A (ko) | 2020-10-29 | 2023-06-30 | 브리스톨-마이어스 스큅 컴퍼니 | 질환의 치료를 위한 융합 단백질 |
EP4255923A2 (en) * | 2020-12-04 | 2023-10-11 | F. Hoffmann-La Roche AG | Ph-dependent mutant interleukin-2 polypeptides |
WO2023180527A1 (en) | 2022-03-25 | 2023-09-28 | Universität Zürich | Adenoviral mediated targeting of activated immune cells |
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FI82266C (fi) * | 1982-10-19 | 1991-02-11 | Cetus Corp | Foerfarande foer framstaellning av il-2 -mutein. |
US4518584A (en) * | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
US4604377A (en) * | 1984-03-28 | 1986-08-05 | Cetus Corporation | Pharmaceutical compositions of microbially produced interleukin-2 |
CA1297003C (en) * | 1985-09-20 | 1992-03-10 | Jack H. Nunberg | Composition and method for treating animals |
US5643565A (en) * | 1985-09-20 | 1997-07-01 | Chiron Corporation | Human IL-2 as a vaccine adjuvant |
US5683864A (en) * | 1987-11-18 | 1997-11-04 | Chiron Corporation | Combinations of hepatitis C virus (HCV) antigens for use in immunoassays for anti-HCV antibodies |
EP0378666A4 (en) * | 1988-07-05 | 1992-01-22 | Amgen Inc. | Interleukin ii analogs |
AU5355790A (en) * | 1989-04-19 | 1990-11-16 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
US5229109A (en) * | 1992-04-14 | 1993-07-20 | Board Of Regents, The University Of Texas System | Low toxicity interleukin-2 analogues for use in immunotherapy |
US5593671A (en) * | 1994-07-01 | 1997-01-14 | American Cyanamid Company | Method of attenuating lung capillary leak in a mammal |
US5696234A (en) * | 1994-08-01 | 1997-12-09 | Schering Corporation | Muteins of mammalian cytokine interleukin-13 |
JP2003250820A (ja) * | 2002-03-06 | 2003-09-09 | Toyoaki Murohara | 血管の再生方法、そのための細胞の分離回収方法及び装置 |
CA2303431A1 (en) * | 1997-09-10 | 1999-03-18 | Junichi Masuyama | Monoclonal antibody against human monocytes |
DZ2788A1 (fr) * | 1998-05-15 | 2003-12-01 | Bayer Ag | Agonistes et antagonistes selectifs à IL-2. |
AU772316B2 (en) * | 1999-01-29 | 2004-04-22 | Millennium Pharmaceuticals, Inc. | Anti-CCR1 antibodies and methods of use therefor |
US6960652B2 (en) * | 1999-03-30 | 2005-11-01 | Board Of Regents, The University Of Texas System | Compositions and methods for modifying toxic effects of proteinaceous compounds |
US20020041865A1 (en) * | 2000-01-20 | 2002-04-11 | Richard Austin | Methods for treating tumors |
US20030185796A1 (en) * | 2000-03-24 | 2003-10-02 | Chiron Corporation | Methods of therapy for non-hodgkin's lymphoma |
JP2005507870A (ja) * | 2001-08-13 | 2005-03-24 | ユニバーシティ・オブ・サザン・カリフォルニア | 低毒性のインターロイキン−2突然変異体 |
WO2003061571A2 (en) * | 2002-01-18 | 2003-07-31 | Chiron Corporation | Combination il-2/anti-herz antibody therapy for cancers characterized by overexpression of the her2 receptor protein |
BRPI0417990A (pt) * | 2003-12-22 | 2007-04-27 | Chiron Corp | uso de polimorfismos de receptor fc como diagnósticos para estratégias de tratamento para distúrbios de resposta imune |
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2005
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- 2005-03-03 EP EP05724480A patent/EP1723251A4/en not_active Withdrawn
- 2005-03-03 JP JP2007501987A patent/JP2007527242A/ja active Pending
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- 2005-03-03 CA CA002557677A patent/CA2557677A1/en not_active Abandoned
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- 2005-03-03 US US11/073,374 patent/US20060234205A1/en not_active Abandoned
- 2005-03-03 BR BRPI0508470-9A patent/BRPI0508470A/pt not_active IP Right Cessation
- 2005-03-04 WO PCT/US2005/007517 patent/WO2005086798A2/en active Application Filing
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WO2005086798A2 (en) | 2005-09-22 |
WO2005091956A2 (en) | 2005-10-06 |
CA2557677A1 (en) | 2005-10-06 |
EP1817332A2 (en) | 2007-08-15 |
JP2007527242A (ja) | 2007-09-27 |
IL177876A0 (en) | 2006-12-31 |
EP1817332A4 (en) | 2009-12-02 |
WO2005086798A3 (en) | 2009-02-12 |
JP2007528728A (ja) | 2007-10-18 |
CA2558632A1 (en) | 2005-09-22 |
WO2005086751A3 (en) | 2007-12-13 |
US20060269515A1 (en) | 2006-11-30 |
JP2008509651A (ja) | 2008-04-03 |
AU2005220872A1 (en) | 2005-09-22 |
BRPI0508455A (pt) | 2007-07-24 |
RU2006135112A (ru) | 2008-04-10 |
EP1723251A2 (en) | 2006-11-22 |
AU2005227263A1 (en) | 2005-10-06 |
RU2006135129A (ru) | 2008-04-10 |
RU2006135131A (ru) | 2008-04-10 |
KR20070003934A (ko) | 2007-01-05 |
EP1730184A2 (en) | 2006-12-13 |
AU2005220822A1 (en) | 2005-09-22 |
WO2005091956A3 (en) | 2005-12-08 |
EP1723251A4 (en) | 2008-04-23 |
US20060234205A1 (en) | 2006-10-19 |
US20060160187A1 (en) | 2006-07-20 |
CA2564614A1 (en) | 2005-09-22 |
MXPA06010021A (es) | 2008-03-07 |
BRPI0508470A (pt) | 2007-07-31 |
WO2005086751A2 (en) | 2005-09-22 |
MXPA06010017A (es) | 2007-03-29 |
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