EP0378666A4 - Interleukin ii analogs - Google Patents

Interleukin ii analogs

Info

Publication number
EP0378666A4
EP0378666A4 EP19890908361 EP89908361A EP0378666A4 EP 0378666 A4 EP0378666 A4 EP 0378666A4 EP 19890908361 EP19890908361 EP 19890908361 EP 89908361 A EP89908361 A EP 89908361A EP 0378666 A4 EP0378666 A4 EP 0378666A4
Authority
EP
European Patent Office
Prior art keywords
interleukin
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19890908361
Other versions
EP0378666A1 (en
Inventor
Bruce W. Altrock
Thomas C. Boone
Robert A. Goldman
William C. Kenny
Yitzhak Stabinsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of EP0378666A1 publication Critical patent/EP0378666A1/en
Publication of EP0378666A4 publication Critical patent/EP0378666A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EP19890908361 1988-07-05 1989-07-05 Interleukin ii analogs Withdrawn EP0378666A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US214998 1980-12-10
US21499888A 1988-07-05 1988-07-05

Publications (2)

Publication Number Publication Date
EP0378666A1 EP0378666A1 (en) 1990-07-25
EP0378666A4 true EP0378666A4 (en) 1992-01-22

Family

ID=22801232

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19890908361 Withdrawn EP0378666A4 (en) 1988-07-05 1989-07-05 Interleukin ii analogs

Country Status (4)

Country Link
EP (1) EP0378666A4 (en)
JP (1) JPH03500415A (en)
AU (1) AU627477B2 (en)
WO (1) WO1990000565A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5312903A (en) * 1990-06-01 1994-05-17 E. I. Du Pont De Nemours And Company Lysine-glycosylated recombinant interleukin-2
WO1992000762A1 (en) * 1990-07-05 1992-01-23 Akzo N.V. Receptor directed-toxin conjugates
DE69331319T2 (en) * 1992-06-09 2002-08-08 Neorx Corp Biotin-DOTA conjugates and their use in "pretargeting" processes
US5911969A (en) 1992-06-09 1999-06-15 Neorx Corporation Pretargeting protocols for enhanced localization of active agents to target sites
US6358490B2 (en) 1992-06-09 2002-03-19 Neorx Corporation Three-step pretargeting methods and compounds
US5696234A (en) * 1994-08-01 1997-12-09 Schering Corporation Muteins of mammalian cytokine interleukin-13
IL116436A (en) 1995-12-18 2006-12-31 Yissum Res Dev Co Fc?Á-PE CHIMERIC PROTEIN FOR TARGETED TREATMENT OF ALLERGY RESPONSES AND
US6168785B1 (en) * 1998-07-16 2001-01-02 Institut Pasteur Biological applications of new peptides of IL-2 and derivatives and use as therapeutic agents
WO2005091956A2 (en) * 2004-03-05 2005-10-06 Chiron Corporation In vitro test system for predicting patient tolerability of therapeutic agents
CA2749539C (en) 2009-01-21 2022-07-19 Amgen Inc. Compositions and methods comprising interleukin-2 mutants for treating inflammatory and autoimmune diseases
CN107106654B (en) * 2014-08-11 2021-06-11 德里尼亚公司 Modified IL-2 variants that selectively activate regulatory T cells for treatment of autoimmune diseases
US10851144B2 (en) 2015-04-10 2020-12-01 Amgen Inc. Interleukin-2 muteins for the expansion of T-regulatory cells
US20170204154A1 (en) 2016-01-20 2017-07-20 Delinia, Inc. Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
EA201991142A1 (en) 2016-11-08 2019-10-31 OPTIONS IL-2 FOR TREATMENT OF AUTOIMMUNE DISEASES

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4568640A (en) * 1981-05-11 1986-02-04 Harvey Rubin Method of inserting amino acid analogs into proteins
EP0108146B1 (en) * 1982-05-12 1987-01-28 The President And Fellows Of Harvard College Fused genes encoding hybrid proteins, cloning vectors containing them and the use thereof
WO1985000817A1 (en) * 1983-08-10 1985-02-28 Amgen Microbial expression of interleukin ii
US4636463A (en) * 1984-04-05 1987-01-13 Scripps Clinic And Research Foundation Antibodies to human interleukin-2 induced by synthetic polypeptides
US4761375A (en) * 1984-05-08 1988-08-02 Genetics Institute, Inc. Human interleukin-2 cDNA sequence
CA1340265C (en) * 1985-01-18 1998-12-15 Kirston E. Koths Oxidation resistant muteins
US5391485A (en) * 1985-08-06 1995-02-21 Immunex Corporation DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues
JPS62185098A (en) * 1986-02-10 1987-08-13 Otsuka Pharmaceut Co Ltd Polypeptide having interleukin ii activity

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIOLOGY CHEMISTRY HOPPE-SEYLER, vol. 368, no. 9, 1987, page 1060; R. H\FER et al.: "Modification and introduction of protein glycosylation sites by site-specific mutagenesis: Studies on human interleukin 2" *
JOURNAL OF CELLULAR BIOCHEMISTRY-UCLA SYMPOSIA ON MOLECULAR & CELLULAR BIOLOGY, 15th ANNUAL MEETINGS, Suppl. 10A, 20th January-15th February 1986, page 77, abstract no. B32, Alan R. Liss, Inc., New York, US; G. JU et al.: "Site-directed mutagenesis of the human interleukin-2 gene product: Identification of amino acid residues required for biological activity" *
See also references of WO9000565A1 *

Also Published As

Publication number Publication date
JPH03500415A (en) 1991-01-31
WO1990000565A1 (en) 1990-01-25
AU3877689A (en) 1990-02-05
EP0378666A1 (en) 1990-07-25
AU627477B2 (en) 1992-08-27

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Legal Events

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