BR9910187A - Processo e composição para induzir uma resposta anti-tumor em um paciente mamìfero sofrendo de um tumor - Google Patents
Processo e composição para induzir uma resposta anti-tumor em um paciente mamìfero sofrendo de um tumorInfo
- Publication number
- BR9910187A BR9910187A BR9910187-4A BR9910187A BR9910187A BR 9910187 A BR9910187 A BR 9910187A BR 9910187 A BR9910187 A BR 9910187A BR 9910187 A BR9910187 A BR 9910187A
- Authority
- BR
- Brazil
- Prior art keywords
- tumor
- response
- mammalian
- inducing
- patient suffering
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 10
- 239000000203 mixture Substances 0.000 title abstract 5
- 230000006023 anti-tumor response Effects 0.000 title abstract 3
- 230000001939 inductive effect Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 210000004881 tumor cell Anatomy 0.000 abstract 4
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 3
- 239000000284 extract Substances 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 2
- 208000027930 type IV hypersensitivity disease Diseases 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010054094 Tumour necrosis Diseases 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000008595 infiltration Effects 0.000 abstract 1
- 238000001764 infiltration Methods 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/46449—Melanoma antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6012—Haptens, e.g. di- or trinitrophenyl (DNP, TNP)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/57—Skin; melanoma
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
"PROCESSO E COMPOSIçãO PARA INDUZIR UMA RESPOSTA ANTI-TUMOR EM UM PACIENTE MAMìFERO SOFRENDO DE UM TUMOR". A presente invenção dirige-se a composições contendo células e extratos de tumor modificadas por hapteno, e processo para tratar câncer por administração de uma quantidade terapeuticamente efetiva de uma composição contendo uma célula de tumor ou extrato de célula de tumor a um indivíduo em necessidade deste tratamento. As células de tumor e extratos da invenção e composições dos mesmos são capazes de eliciar linfócitos T que tem a propriedade de infiltrar em um tumor de mamíferos, eliciar uma resposta imune inflamatória para um tumor de mamíferos, eliciar uma resposta de hipersensibilidade de tipo retardada a um tumor de mamífero e/ou estimular linfócitos T in vitro. A invenção também se refere a um esquema de vacinação efetivo utilizável para induzir uma resposta anti-tumor em um paciente mamífero sofrendo de câncer por indução de pelo menos um dos seguintes: necrose de tumor, regressão de tumor, inflamação de tumor, infiltração de tumor por linfócitos T ativados, resposta de hipersensibilidade de tipo retardado, e prolongamento da sobrevivência do paciente.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8408198P | 1998-05-04 | 1998-05-04 | |
| PCT/US1999/009826 WO1999056773A2 (en) | 1998-05-04 | 1999-05-04 | Composition comprising tumor cells and extracts and method of using thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9910187A true BR9910187A (pt) | 2002-01-29 |
Family
ID=22182777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9910187-4A BR9910187A (pt) | 1998-05-04 | 1999-05-04 | Processo e composição para induzir uma resposta anti-tumor em um paciente mamìfero sofrendo de um tumor |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6458369B1 (pt) |
| EP (1) | EP1082134B1 (pt) |
| JP (1) | JP2002513772A (pt) |
| KR (1) | KR20010043331A (pt) |
| CN (1) | CN1309569A (pt) |
| AR (1) | AR016254A1 (pt) |
| AT (1) | ATE401096T1 (pt) |
| AU (1) | AU3786999A (pt) |
| BR (1) | BR9910187A (pt) |
| CA (1) | CA2328507A1 (pt) |
| DE (1) | DE69939111D1 (pt) |
| ES (1) | ES2311303T3 (pt) |
| IL (1) | IL139442A0 (pt) |
| PL (1) | PL347981A1 (pt) |
| WO (1) | WO1999056773A2 (pt) |
| ZA (1) | ZA200006300B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1119365A4 (en) * | 1997-07-24 | 2003-08-13 | Univ Jefferson | COMPOSITIONS AND METHODS FOR USING TUMOR CELLS |
| ES2311303T3 (es) * | 1998-05-04 | 2009-02-01 | Thomas Jefferson University | Uso de celulas tumorales sometidas a hapteno y extractos de las mismas. |
| WO2000018435A1 (de) * | 1998-09-25 | 2000-04-06 | Horst Lindhofer | Verwendung von tumorzellen zeitversetzt in kombination mit intakten antikörpern zur immunisierung |
| US6248585B1 (en) | 1998-11-19 | 2001-06-19 | Thomas Jefferson University | Compositions for preserving haptenized tumor cells for use in vaccines |
| JP2004507446A (ja) * | 2000-02-04 | 2004-03-11 | トーマス・ジェファーソン・ユニバーシティ | 低用量ハプテン化腫瘍細胞および腫瘍細胞抽出物の免疫治療 |
| US7297330B2 (en) * | 2000-02-04 | 2007-11-20 | Thomas Jefferson University | Low dose haptenized tumor cell and tumor cell extract immunotherapy |
| US20030165518A1 (en) * | 2002-02-01 | 2003-09-04 | Thomas Jefferson University | Mixed haptenized tumor cells and extracts and methods of treating or screening for cancer |
| JP2005528901A (ja) * | 2002-06-10 | 2005-09-29 | アバクス・テクノロジーズ・インコーポレーテッド | ハプテン化腫瘍細胞の凍結保存 |
| JP2008526976A (ja) * | 2005-01-14 | 2008-07-24 | アバクス・テクノロジーズ・インコーポレーテッド | 癌治療用ワクチンの製造方法 |
| WO2010002983A2 (en) * | 2008-07-03 | 2010-01-07 | Duke University | Composition and methods for eliciting an immune response |
| TWI540816B (zh) | 2014-03-10 | 2016-07-01 | 新唐科技股份有限公司 | 切換電路及馬達能源回收系統 |
| JP6813258B2 (ja) * | 2014-12-11 | 2021-01-13 | リティックス バイオファーマ エイエス | 化学療法の組み合わせ |
| JP6767096B2 (ja) | 2014-12-11 | 2020-10-14 | リティックス バイオファーマ エイエス | 免疫チェックポイント阻害剤の組み合わせ |
| JP2022502493A (ja) * | 2018-09-24 | 2022-01-11 | バイオヴァクシーズ インコーポレイテッド | 二ハプテン化自己ワクチン及びその使用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5290551A (en) * | 1990-05-08 | 1994-03-01 | Thomas Jefferson University | Treatment of melanoma with a vaccine comprising irradiated autologous melanoma tumor cells conjugated to a hapten |
| US20020004052A1 (en) * | 1990-05-08 | 2002-01-10 | David Berd | Composition comprising a tumor cell extract and method of using the composition |
| US5478556A (en) * | 1994-02-28 | 1995-12-26 | Elliott; Robert L. | Vaccination of cancer patients using tumor-associated antigens mixed with interleukin-2 and granulocyte-macrophage colony stimulating factor |
| KR19990022592A (ko) * | 1995-06-07 | 1999-03-25 | 아브람 엠. 골드핑거 | 합텐으로 변형된 종양 세포 추출물과 암 치료 또는 스크리닝 방법 |
| IL125747A0 (en) * | 1996-10-04 | 1999-04-11 | Univ Jefferson | T cells mediating an immune response and methods of use |
| ES2311303T3 (es) * | 1998-05-04 | 2009-02-01 | Thomas Jefferson University | Uso de celulas tumorales sometidas a hapteno y extractos de las mismas. |
-
1999
- 1999-05-04 ES ES99920351T patent/ES2311303T3/es not_active Expired - Lifetime
- 1999-05-04 DE DE69939111T patent/DE69939111D1/de not_active Expired - Lifetime
- 1999-05-04 CN CN99807512A patent/CN1309569A/zh active Pending
- 1999-05-04 EP EP99920351A patent/EP1082134B1/en not_active Expired - Lifetime
- 1999-05-04 JP JP2000546797A patent/JP2002513772A/ja active Pending
- 1999-05-04 AT AT99920351T patent/ATE401096T1/de not_active IP Right Cessation
- 1999-05-04 AR ARP990102082A patent/AR016254A1/es unknown
- 1999-05-04 WO PCT/US1999/009826 patent/WO1999056773A2/en not_active Application Discontinuation
- 1999-05-04 KR KR1020007012301A patent/KR20010043331A/ko not_active Application Discontinuation
- 1999-05-04 CA CA002328507A patent/CA2328507A1/en not_active Abandoned
- 1999-05-04 BR BR9910187-4A patent/BR9910187A/pt not_active IP Right Cessation
- 1999-05-04 PL PL99347981A patent/PL347981A1/xx unknown
- 1999-05-04 AU AU37869/99A patent/AU3786999A/en not_active Abandoned
- 1999-05-04 US US09/304,859 patent/US6458369B1/en not_active Expired - Lifetime
- 1999-05-04 IL IL13944299A patent/IL139442A0/xx unknown
-
2000
- 2000-11-03 ZA ZA200006300A patent/ZA200006300B/xx unknown
-
2002
- 2002-09-27 US US10/260,119 patent/US20030068337A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999056773A9 (en) | 2000-03-23 |
| AU3786999A (en) | 1999-11-23 |
| US20030068337A1 (en) | 2003-04-10 |
| ZA200006300B (en) | 2001-06-07 |
| KR20010043331A (ko) | 2001-05-25 |
| AR016254A1 (es) | 2001-06-20 |
| WO1999056773A3 (en) | 2000-01-20 |
| DE69939111D1 (de) | 2008-08-28 |
| ES2311303T3 (es) | 2009-02-01 |
| PL347981A1 (en) | 2002-05-06 |
| IL139442A0 (en) | 2001-11-25 |
| JP2002513772A (ja) | 2002-05-14 |
| ATE401096T1 (de) | 2008-08-15 |
| CN1309569A (zh) | 2001-08-22 |
| US6458369B1 (en) | 2002-10-01 |
| EP1082134B1 (en) | 2008-07-16 |
| WO1999056773A2 (en) | 1999-11-11 |
| EP1082134A2 (en) | 2001-03-14 |
| CA2328507A1 (en) | 1999-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A, 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007. |