US3854480A
(en)
|
1969-04-01 |
1974-12-17 |
Alza Corp |
Drug-delivery system
|
US4469863A
(en)
|
1980-11-12 |
1984-09-04 |
Ts O Paul O P |
Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
|
US4675189A
(en)
|
1980-11-18 |
1987-06-23 |
Syntex (U.S.A.) Inc. |
Microencapsulation of water soluble active polypeptides
|
DE3280400D1
(de)
|
1981-10-23 |
1992-06-04 |
Molecular Biosystems Inc |
Oligonukleotides heilmittel und dessen herstellungsverfahren.
|
US5023243A
(en)
|
1981-10-23 |
1991-06-11 |
Molecular Biosystems, Inc. |
Oligonucleotide therapeutic agent and method of making same
|
US4452775A
(en)
|
1982-12-03 |
1984-06-05 |
Syntex (U.S.A.) Inc. |
Cholesterol matrix delivery system for sustained release of macromolecules
|
US4806463A
(en)
*
|
1986-05-23 |
1989-02-21 |
Worcester Foundation For Experimental Biology |
Inhibition of HTLV-III by exogenous oligonucleotides
|
US5565354A
(en)
|
1986-09-05 |
1996-10-15 |
Sandoz Ltd. |
Production of human monoclonal antibodies specific for hepatitis B surface antigen
|
US5075109A
(en)
|
1986-10-24 |
1991-12-24 |
Southern Research Institute |
Method of potentiating an immune response
|
US5264423A
(en)
|
1987-03-25 |
1993-11-23 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibitors for replication of retroviruses and for the expression of oncogene products
|
US5276019A
(en)
*
|
1987-03-25 |
1994-01-04 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibitors for replication of retroviruses and for the expression of oncogene products
|
CA1339596C
(en)
|
1987-08-07 |
1997-12-23 |
New England Medical Center Hospitals, Inc. |
Viral expression inhibitors
|
US5004810A
(en)
*
|
1988-09-30 |
1991-04-02 |
Schering Corporation |
Antiviral oligomers
|
US5133974A
(en)
|
1989-05-05 |
1992-07-28 |
Kv Pharmaceutical Company |
Extended release pharmaceutical formulations
|
US5177198A
(en)
|
1989-11-30 |
1993-01-05 |
University Of N.C. At Chapel Hill |
Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates
|
US5457189A
(en)
|
1989-12-04 |
1995-10-10 |
Isis Pharmaceuticals |
Antisense oligonucleotide inhibition of papillomavirus
|
US5248670A
(en)
|
1990-02-26 |
1993-09-28 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotides for inhibiting herpesviruses
|
US5514577A
(en)
*
|
1990-02-26 |
1996-05-07 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide therapies for modulating the effects of herpes viruses
|
US5166195A
(en)
|
1990-05-11 |
1992-11-24 |
Isis Pharmaceuticals, Inc. |
Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides
|
EP0468520A3
(en)
|
1990-07-27 |
1992-07-01 |
Mitsui Toatsu Chemicals, Inc. |
Immunostimulatory remedies containing palindromic dna sequences
|
DK0544713T3
(da)
|
1990-08-16 |
1997-09-29 |
Isis Pharmaceuticals Inc |
Oligonukleutider til modulering af virkningerne af cytomegalovirusinfektioner
|
US5576302A
(en)
|
1991-10-15 |
1996-11-19 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating hepatitis C virus having phosphorothioate linkages of high chiral purity
|
US5407686A
(en)
|
1991-11-27 |
1995-04-18 |
Sidmak Laboratories, Inc. |
Sustained release composition for oral administration of active ingredient
|
AU3610293A
(en)
|
1992-02-04 |
1993-09-01 |
Chiron Viagene, Inc. |
Hepatitis therapeutics
|
US6498147B2
(en)
|
1992-05-22 |
2002-12-24 |
The Scripps Research Institute |
Suppression of nuclear factor-κb dependent processes using oligonucleotides
|
US6107062A
(en)
|
1992-07-30 |
2000-08-22 |
Inpax, Inc. |
Antisense viruses and antisense-ribozyme viruses
|
JPH08504570A
(ja)
|
1992-10-05 |
1996-05-21 |
ハイブライドン インコーポレイテッド |
治療用抗hivオリゴヌクレオチドと薬剤
|
DK0681483T3
(da)
|
1993-01-26 |
2005-11-21 |
Univ Pennsylvania |
Præparater og fremgangsmåder til administration af genetisk materiale
|
US5593972A
(en)
|
1993-01-26 |
1997-01-14 |
The Wistar Institute |
Genetic immunization
|
US5567604A
(en)
|
1993-04-23 |
1996-10-22 |
Aronex Pharmaceuticals, Inc. |
Anti-viral guanosine-rich oligonucleotides
|
JP2798305B2
(ja)
*
|
1993-06-23 |
1998-09-17 |
ジェネシス ファーマ インコーポレイテッド |
アンチセンスオリゴヌクレオチドおよびヒト免疫不全ウイルス感染におけるその使用
|
DE4321946A1
(de)
|
1993-07-01 |
1995-01-12 |
Hoechst Ag |
Methylphosphonsäureester, Verfahren zu deren Herstellung und deren Verwendung
|
AU688364B2
(en)
|
1993-07-19 |
1998-03-12 |
Gen-Probe Incorporated |
Oligonucleotides with activity against human immunodeficiency virus
|
US20030109469A1
(en)
|
1993-08-26 |
2003-06-12 |
Carson Dennis A. |
Recombinant gene expression vectors and methods for use of same to enhance the immune response of a host to an antigen
|
US5859231A
(en)
|
1993-09-03 |
1999-01-12 |
Duke University |
Synthesis of oligonucleotides with boranophosphonate linkages
|
US6133244A
(en)
|
1993-10-22 |
2000-10-17 |
Institut Pasteur |
Method for immunization against hepatitis B
|
FR2711670B1
(fr)
*
|
1993-10-22 |
1996-01-12 |
Pasteur Institut |
Vecteur nucléotidique, composition le contenant et vaccin pour l'immunisation à l'encontre d'une hépatite.
|
US5712384A
(en)
|
1994-01-05 |
1998-01-27 |
Gene Shears Pty Ltd. |
Ribozymes targeting retroviral packaging sequence expression constructs and recombinant retroviruses containing such constructs
|
US5728518A
(en)
*
|
1994-01-12 |
1998-03-17 |
The Immune Response Corporation |
Antiviral poly-and oligonucleotides
|
WO1995026204A1
(en)
|
1994-03-25 |
1995-10-05 |
Isis Pharmaceuticals, Inc. |
Immune stimulation by phosphorothioate oligonucleotide analogs
|
US6727230B1
(en)
*
|
1994-03-25 |
2004-04-27 |
Coley Pharmaceutical Group, Inc. |
Immune stimulation by phosphorothioate oligonucleotide analogs
|
US5658738A
(en)
|
1994-05-31 |
1997-08-19 |
Becton Dickinson And Company |
Bi-directional oligonucleotides that bind thrombin
|
US6239116B1
(en)
|
1994-07-15 |
2001-05-29 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
US6207646B1
(en)
*
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
US6429199B1
(en)
|
1994-07-15 |
2002-08-06 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules for activating dendritic cells
|
US20030026782A1
(en)
|
1995-02-07 |
2003-02-06 |
Arthur M. Krieg |
Immunomodulatory oligonucleotides
|
CA2194761C
(en)
|
1994-07-15 |
2006-12-19 |
Arthur M. Krieg |
Immunomodulatory oligonucleotides
|
US7935675B1
(en)
|
1994-07-15 |
2011-05-03 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
US20030050263A1
(en)
*
|
1994-07-15 |
2003-03-13 |
The University Of Iowa Research Foundation |
Methods and products for treating HIV infection
|
US5646262A
(en)
*
|
1994-07-28 |
1997-07-08 |
Georgetown University |
Antisense oligonucleotides against hepatitis B viral replication
|
US5858987A
(en)
*
|
1995-05-05 |
1999-01-12 |
Mitotix, Inc. |
E6AP antisense constructs and methods of use
|
US5856459A
(en)
*
|
1995-06-06 |
1999-01-05 |
Hybridon, Inc. |
Oligonucleotides specific for hepatitis B virus
|
US5985662A
(en)
|
1995-07-13 |
1999-11-16 |
Isis Pharmaceuticals Inc. |
Antisense inhibition of hepatitis B virus replication
|
US6160109A
(en)
|
1995-10-20 |
2000-12-12 |
Isis Pharmaceuticals, Inc. |
Preparation of phosphorothioate and boranophosphate oligomers
|
US5736152A
(en)
|
1995-10-27 |
1998-04-07 |
Atrix Laboratories, Inc. |
Non-polymeric sustained release delivery system
|
US5780448A
(en)
|
1995-11-07 |
1998-07-14 |
Ottawa Civic Hospital Loeb Research |
DNA-based vaccination of fish
|
EP0879284B1
(de)
|
1996-01-30 |
2009-07-29 |
The Regents of The University of California |
Expressionsvektoren, die eine antigen-spezifische immunantwort induzieren, und methoden für ihre verwendung.
|
US5843770A
(en)
|
1996-03-11 |
1998-12-01 |
The Immune Response Corporation |
Antisense constructs directed against viral post-transcriptional regulatory sequences
|
US6030955A
(en)
*
|
1996-03-21 |
2000-02-29 |
The Trustees Of Columbia University In The City Of New York And Imclone Systems, Inc. |
Methods of affecting intracellular phosphorylation of tyrosine using phosphorothioate oligonucleotides, and antiangiogenic and antiproliferative uses thereof
|
US6136316A
(en)
|
1996-04-17 |
2000-10-24 |
Dabur Research Foundation |
Hepatoprotective compositions and composition for treatment of conditions related to hepatitis B and E infection
|
US5854418A
(en)
|
1996-07-25 |
1998-12-29 |
The Trustees Of Columbia University In The City Of New York |
Kaposi's sarcoma-associated herpesvirus (KSHV) viral macrophage inflammatory protein-1α II (vMIP-1α II) and uses thereof
|
US5922757A
(en)
|
1996-09-30 |
1999-07-13 |
The Regents Of The University Of California |
Treatment and prevention of hepatic disorders
|
ATE292980T1
(de)
|
1996-10-11 |
2005-04-15 |
Univ California |
Immunostimulierende oligonucleotidekonjugate
|
PT1132393E
(pt)
|
1996-10-16 |
2003-08-29 |
Ribapharm Inc |
L-ribavirina e usos da mesma
|
EP0855184A1
(de)
*
|
1997-01-23 |
1998-07-29 |
Grayson B. Dr. Lipford |
Pharmazeutisches Präparat das ein Polynukleotid und ein Antigen enthält, insbesondere zur Impfung
|
WO1998037919A1
(en)
*
|
1997-02-28 |
1998-09-03 |
University Of Iowa Research Foundation |
USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS
|
US6406705B1
(en)
|
1997-03-10 |
2002-06-18 |
University Of Iowa Research Foundation |
Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
|
US6426334B1
(en)
|
1997-04-30 |
2002-07-30 |
Hybridon, Inc. |
Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal
|
US6835395B1
(en)
|
1997-05-14 |
2004-12-28 |
The University Of British Columbia |
Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles
|
EP1003531B1
(de)
*
|
1997-05-20 |
2007-08-22 |
Ottawa Health Research Institute |
Verfahren zur Herstellung von Nukleinsäurekonstrukten
|
CA2291483C
(en)
|
1997-06-06 |
2012-09-18 |
Dynavax Technologies Corporation |
Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
|
US20040006034A1
(en)
*
|
1998-06-05 |
2004-01-08 |
Eyal Raz |
Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
|
US6589940B1
(en)
|
1997-06-06 |
2003-07-08 |
Dynavax Technologies Corporation |
Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
|
ATE408422T1
(de)
*
|
1997-07-03 |
2008-10-15 |
Donald E Macfarlane |
Methode zur hemmung immunstimulatorischer mit dna assoziierter antworten
|
EP1007657B1
(de)
|
1997-08-19 |
2006-02-08 |
Idera Pharmaceuticals, Inc. |
Hiv-spezifische oligonukleotide und verfahren zu deren verwendung
|
US7393630B2
(en)
*
|
1997-12-16 |
2008-07-01 |
Novartis Vaccines And Diagnostics, Inc. |
Use of microparticles combined with submicron oil-in-water emulsions
|
US20050031638A1
(en)
*
|
1997-12-24 |
2005-02-10 |
Smithkline Beecham Biologicals S.A. |
Vaccine
|
GB9727262D0
(en)
|
1997-12-24 |
1998-02-25 |
Smithkline Beecham Biolog |
Vaccine
|
ES2284247T3
(es)
*
|
1998-04-03 |
2007-11-01 |
University Of Iowa Research Foundation |
Metodos y productos para estimular el sistema inmunitario usando oligonucleotidos y citoquinas inmunoterapeuticos.
|
WO1999052549A1
(en)
|
1998-04-09 |
1999-10-21 |
Smithkline Beecham Biologicals S.A. |
Adjuvant compositions
|
AU3884199A
(en)
|
1998-05-06 |
1999-11-23 |
Ottawa Health Research Institute |
Methods for the prevention and treatment of parasitic infections and related diseases using cpg oligonucleotides
|
IL139646A0
(en)
*
|
1998-05-14 |
2002-02-10 |
Coley Pharm Group Inc |
Methods for regulating hematopoiesis using cpg-oligonucleotides
|
EP1733735B1
(de)
|
1998-05-22 |
2017-03-22 |
Ottawa Hospital Research Institute |
Verfahren und Produkte zur Induktion von mukosaler Immunität
|
US6562798B1
(en)
|
1998-06-05 |
2003-05-13 |
Dynavax Technologies Corp. |
Immunostimulatory oligonucleotides with modified bases and methods of use thereof
|
US20040247662A1
(en)
|
1998-06-25 |
2004-12-09 |
Dow Steven W. |
Systemic immune activation method using nucleic acid-lipid complexes
|
WO2000006588A1
(en)
|
1998-07-27 |
2000-02-10 |
University Of Iowa Research Foundation |
STEREOISOMERS OF CpG OLIGONUCLEOTIDES AND RELATED METHODS
|
CA2341338A1
(en)
|
1998-09-03 |
2000-03-16 |
Coley Pharmaceutical Gmbh |
G-motif oligonucleotides and uses thereof
|
BR9913406A
(pt)
|
1998-09-04 |
2002-01-29 |
Viropharma Inc |
Processo de tratamento de infecção causada por pelo menos um vìrus da famìlia flaviviridae e de doença associada com a citada infecção em um hospedeiro vivo possuindo a citada infecção
|
US20020065236A1
(en)
|
1998-09-09 |
2002-05-30 |
Yew Nelson S. |
CpG reduced plasmids and viral vectors
|
FR2783170B1
(fr)
|
1998-09-11 |
2004-07-16 |
Pasteur Merieux Serums Vacc |
Emulsion immunostimulante
|
EP1119375A4
(de)
|
1998-10-05 |
2005-02-02 |
Regetns Of The University Of C |
Verfahren und adjuvantien für die stimulierung von mukosaler immunität
|
US6228642B1
(en)
*
|
1998-10-05 |
2001-05-08 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of tumor necrosis factor-(α) (TNF-α) expression
|
AU6425999A
(en)
|
1998-10-09 |
2000-05-01 |
Dynavax Technologies Corporation |
Anti hiv compositions comprising immunostimulatory polynucleotides and hiv antigens
|
CZ20012544A3
(cs)
|
1999-01-12 |
2002-01-16 |
Smithkline Beecham Biologicals S.A. |
Farmaceutické balení
|
US6207819B1
(en)
|
1999-02-12 |
2001-03-27 |
Isis Pharmaceuticals, Inc. |
Compounds, processes and intermediates for synthesis of mixed backbone oligomeric compounds
|
WO2000054803A2
(en)
|
1999-03-16 |
2000-09-21 |
Panacea Pharmaceuticals, Llc |
Immunostimulatory nucleic acids and antigens
|
FR2790955B1
(fr)
|
1999-03-19 |
2003-01-17 |
Assist Publ Hopitaux De Paris |
Utilisation d'oligonucleotides stabilises comme principe actif antitumoral
|
EP1176966B1
(de)
*
|
1999-04-12 |
2013-04-03 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Oligodeoxynukleotide und deren verwendung zur induktion einer immunreaktion
|
US6977245B2
(en)
|
1999-04-12 |
2005-12-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Oligodeoxynucleotide and its use to induce an immune response
|
AU4642600A
(en)
|
1999-04-15 |
2000-11-02 |
Regents Of The University Of California, The |
Methods and compositions for use in potentiating antigen presentation by antigenpresenting cells
|
US6558670B1
(en)
|
1999-04-19 |
2003-05-06 |
Smithkline Beechman Biologicals S.A. |
Vaccine adjuvants
|
EP1177439B1
(de)
|
1999-04-29 |
2004-09-08 |
Coley Pharmaceutical GmbH |
Screening nach modulatoren der funktion von immunstimulatorischer dna
|
CA2372960C
(en)
|
1999-05-06 |
2006-03-28 |
The Immune Response Corporation |
Hiv immunogenic compositions and methods
|
US6737066B1
(en)
|
1999-05-06 |
2004-05-18 |
The Immune Response Corporation |
HIV immunogenic compositions and methods
|
CA2412345A1
(en)
|
1999-06-16 |
2000-12-21 |
University Of Iowa Research Foundation |
Antagonism of immunostimulatory cpg-oligonucleotides by 4-aminoquinolines and other weak bases
|
DE60023300T2
(de)
|
1999-06-29 |
2006-07-06 |
Glaxosmithkline Biologicals S.A. |
Verwendung von cpg als adjuvans für hivimpstoff
|
US6514948B1
(en)
|
1999-07-02 |
2003-02-04 |
The Regents Of The University Of California |
Method for enhancing an immune response
|
DE19935756A1
(de)
|
1999-07-27 |
2001-02-08 |
Mologen Forschungs Entwicklung |
Kovalent geschlossenes Nukleinsäuremolekül zur Immunstimulation
|
ATE419869T1
(de)
|
1999-08-19 |
2009-01-15 |
Dynavax Tech Corp |
Methode zur modulierung eines immunantwortes mit immunstimulierenden sequencen und zusammensetzungen dafür
|
GB9921147D0
(en)
|
1999-09-07 |
1999-11-10 |
Smithkline Beecham Biolog |
Novel composition
|
GB9921146D0
(en)
|
1999-09-07 |
1999-11-10 |
Smithkline Beecham Biolog |
Novel composition
|
AP1775A
(en)
|
1999-09-25 |
2007-08-28 |
Univ Iowa Res Found |
Immunostimulatory nucleic acids.
|
US6949520B1
(en)
*
|
1999-09-27 |
2005-09-27 |
Coley Pharmaceutical Group, Inc. |
Methods related to immunostimulatory nucleic acid-induced interferon
|
MXPA02003059A
(es)
*
|
1999-09-27 |
2002-09-30 |
Univ Iowa Res Found |
Metodos relacionados con interferon inducido por acido nucleico inmunoestabilizador.
|
EP1222281B1
(de)
|
1999-09-30 |
2006-11-15 |
University of Washington |
Immunologisch relevante antigene aus herpes simplexvirus
|
US7223398B1
(en)
|
1999-11-15 |
2007-05-29 |
Dynavax Technologies Corporation |
Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof
|
AU2593701A
(en)
|
1999-12-21 |
2001-07-03 |
Regents Of The University Of California, The |
Method for preventing an anaphylactic reaction
|
KR100359753B1
(ko)
*
|
1999-12-21 |
2002-11-09 |
주식회사 제넥신 |
면역조절능력 및 안전성이 증가되고 dG 연속서열이결합된 포스포다이에스터 CpG올리고데옥시뉴클레오티드 변형체
|
AU3108001A
(en)
|
2000-01-20 |
2001-12-24 |
Coley Pharmaceutical Group, Inc. |
Immunostimulatory nucleic acids for inducing a th2 immune response
|
US6552006B2
(en)
|
2000-01-31 |
2003-04-22 |
The Regents Of The University Of California |
Immunomodulatory polynucleotides in treatment of an infection by an intracellular pathogen
|
KR100808348B1
(ko)
|
2000-01-31 |
2008-02-27 |
글락소스미스클라인 바이오로지칼즈 에스.에이. |
Hiv에 대한 예방 또는 치료용 면역화를 위한 백신
|
US7585847B2
(en)
*
|
2000-02-03 |
2009-09-08 |
Coley Pharmaceutical Group, Inc. |
Immunostimulatory nucleic acids for the treatment of asthma and allergy
|
EP1259264A4
(de)
|
2000-02-23 |
2005-08-31 |
Univ California |
VERFAHREN ZUR BEHANDLUNG VON ENTZüNDLICHEN DARMERKRANKUNGEN UND ANDEREN FORMEN VON GASTROINTESTINALEN ENTZüNDUNGEN
|
US20020156033A1
(en)
|
2000-03-03 |
2002-10-24 |
Bratzler Robert L. |
Immunostimulatory nucleic acids and cancer medicament combination therapy for the treatment of cancer
|
US20040131628A1
(en)
|
2000-03-08 |
2004-07-08 |
Bratzler Robert L. |
Nucleic acids for the treatment of disorders associated with microorganisms
|
US20010046967A1
(en)
|
2000-03-10 |
2001-11-29 |
Gary Van Nest |
Methods of preventing and treating respiratory viral infection using immunomodulatory polynucleotide
|
US20020028784A1
(en)
*
|
2000-03-10 |
2002-03-07 |
Nest Gary Van |
Methods of preventing and treating viral infections using immunomodulatory polynucleotide sequences
|
US7157437B2
(en)
|
2000-03-10 |
2007-01-02 |
Dynavax Technologies Corporation |
Methods of ameliorating symptoms of herpes infection using immunomodulatory polynucleotide sequences
|
US20020098199A1
(en)
|
2000-03-10 |
2002-07-25 |
Gary Van Nest |
Methods of suppressing hepatitis virus infection using immunomodulatory polynucleotide sequences
|
US20030129251A1
(en)
*
|
2000-03-10 |
2003-07-10 |
Gary Van Nest |
Biodegradable immunomodulatory formulations and methods for use thereof
|
US20020107212A1
(en)
|
2000-03-10 |
2002-08-08 |
Nest Gary Van |
Methods of reducing papillomavirus infection using immunomodulatory polynucleotide sequences
|
AU2001249609A1
(en)
|
2000-03-28 |
2001-10-08 |
Department Of Veterans Affairs |
Methods for increasing a cytotoxic T lymphocyte response in vivo
|
US6339630B1
(en)
*
|
2000-05-18 |
2002-01-15 |
The United States Of America As Represented By The United States Department Of Energy |
Sealed drive screw operator
|
WO2001097843A2
(en)
*
|
2000-06-22 |
2001-12-27 |
University Of Iowa Research Foundation |
Methods for enhancing antibody-induced cell lysis and treating cancer
|
US20020165178A1
(en)
|
2000-06-28 |
2002-11-07 |
Christian Schetter |
Immunostimulatory nucleic acids for the treatment of anemia, thrombocytopenia, and neutropenia
|
US20020198165A1
(en)
|
2000-08-01 |
2002-12-26 |
Bratzler Robert L. |
Nucleic acids for the prevention and treatment of gastric ulcers
|
JP2005512499A
(ja)
*
|
2000-09-01 |
2005-05-12 |
エピゲノミクス アーゲー |
進行中の疾病または特定の疾病の発病素質の診断
|
US20020091097A1
(en)
|
2000-09-07 |
2002-07-11 |
Bratzler Robert L. |
Nucleic acids for the prevention and treatment of sexually transmitted diseases
|
WO2002022809A2
(en)
|
2000-09-15 |
2002-03-21 |
Coley Pharmaceutical Gmbh |
PROCESS FOR HIGH THROUGHPUT SCREENING OF CpG-BASED IMMUNO-AGONIST/ANTAGONIST
|
FR2814958B1
(fr)
|
2000-10-06 |
2003-03-07 |
Aventis Pasteur |
Composition vaccinale
|
GB0025577D0
(en)
*
|
2000-10-18 |
2000-12-06 |
Smithkline Beecham Biolog |
Vaccine
|
EP1985702A3
(de)
|
2000-12-08 |
2010-08-18 |
Coley Pharmaceutical GmbH |
CPG-ähnliche Nukleinsäuren und Verwendungsverfahren dafür
|
AU2002248185A1
(en)
*
|
2000-12-14 |
2002-07-16 |
Coley Pharmaceutical Group, Inc. |
Inhibition of angiogenesis by nucleic acids
|
US20030050268A1
(en)
*
|
2001-03-29 |
2003-03-13 |
Krieg Arthur M. |
Immunostimulatory nucleic acid for treatment of non-allergic inflammatory diseases
|
KR20030022268A
(ko)
*
|
2001-05-30 |
2003-03-15 |
소니 가부시끼 가이샤 |
테이프 카세트의 릴 로크기구 및 테이프 카세트
|
EP2423335B1
(de)
*
|
2001-06-21 |
2014-05-14 |
Dynavax Technologies Corporation |
Chimäre immunmodulierende Verbindungen und Verwendungsverfahren dafür
|
JP4370161B2
(ja)
|
2001-06-29 |
2009-11-25 |
ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド |
Hcve1e2ワクチン組成物
|
US7666674B2
(en)
*
|
2001-07-27 |
2010-02-23 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo
|
AU2002318944A1
(en)
|
2001-08-01 |
2003-02-17 |
Coley Pharmaceutical Gmbh |
Methods and compositions relating to plasmacytoid dendritic cells
|
EP1501359A4
(de)
*
|
2001-08-03 |
2007-04-18 |
Celldex Therapeutics Inc |
Immunstimulierende oligonukleotide enthaltende zusammensetzungen sowie verwendungen davon zur verbesserung fc-rezeptor-vermittelter immuntherapien
|
SG177000A1
(en)
|
2001-08-17 |
2012-01-30 |
Coley Pharm Gmbh |
Combination motif immune stimulatory oligonucleotides with improved activity
|
JP2005501550A
(ja)
|
2001-08-30 |
2005-01-20 |
スリーエム イノベイティブ プロパティズ カンパニー |
免疫反応調整剤分子を用いた形質細胞様樹状細胞を成熟させる方法
|
DK1450856T3
(da)
|
2001-09-14 |
2010-05-31 |
Cytos Biotechnology Ag |
Pakning af immunstimulatorisk CpG i virus-lignende partilker, fremgangsmåde og anvendelse
|
US7514414B2
(en)
*
|
2001-09-24 |
2009-04-07 |
The United States Of America As Represented By The Department Of Health And Human Services |
Suppressors of CpG oligonucleotides and methods of use
|
BR0213097A
(pt)
|
2001-10-05 |
2005-02-01 |
Coley Pharm Gmbh |
Agonistas e antagonistas sinalizadores do receptor 3 similar a toll
|
AU2002346960A1
(en)
|
2001-10-06 |
2003-04-22 |
Merial Limited |
Methods and compositions for promoting growth and innate immunity in young animals
|
US20030139364A1
(en)
|
2001-10-12 |
2003-07-24 |
University Of Iowa Research Foundation |
Methods and products for enhancing immune responses using imidazoquinoline compounds
|
WO2003035836A2
(en)
|
2001-10-24 |
2003-05-01 |
Hybridon Inc. |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends
|
DE60230340D1
(de)
|
2001-11-16 |
2009-01-22 |
3M Innovative Properties Co |
N-Ä4-(4-Amino-2-ethyl-1H-imidazoÄ4,5-cÜchinolin-1-yl)butylÜmethanesulfonamide, diese enthaltende pharmazeutische Zusammensetzung und deren Verwendung
|
AU2002366710A1
(en)
*
|
2001-12-20 |
2003-07-09 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of |
USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS
|
EP3006043B1
(de)
|
2002-04-04 |
2019-05-29 |
Zoetis Belgium S.A. |
Immunostimulatorische g,u-haltige oligoribonucleotide
|
JP2005532315A
(ja)
|
2002-05-10 |
2005-10-27 |
イネックス ファーマシューティカルズ コーポレイション |
メチル化免疫刺激性オリゴヌクレオチド及びその使用方法
|
WO2003100040A1
(en)
|
2002-05-28 |
2003-12-04 |
Merck Patent Gmbh |
A method for generating antigen-presenting cells
|
US20040009949A1
(en)
*
|
2002-06-05 |
2004-01-15 |
Coley Pharmaceutical Group, Inc. |
Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory CpG nucleic acids
|
US7569553B2
(en)
*
|
2002-07-03 |
2009-08-04 |
Coley Pharmaceutical Group, Inc. |
Nucleic acid compositions for stimulating immune responses
|
US7605138B2
(en)
|
2002-07-03 |
2009-10-20 |
Coley Pharmaceutical Group, Inc. |
Nucleic acid compositions for stimulating immune responses
|
US7807803B2
(en)
|
2002-07-03 |
2010-10-05 |
Coley Pharmaceutical Group, Inc. |
Nucleic acid compositions for stimulating immune responses
|
US7576066B2
(en)
|
2002-07-03 |
2009-08-18 |
Coley Pharmaceutical Group, Inc. |
Nucleic acid compositions for stimulating immune responses
|
US20040053880A1
(en)
*
|
2002-07-03 |
2004-03-18 |
Coley Pharmaceutical Group, Inc. |
Nucleic acid compositions for stimulating immune responses
|
WO2004007743A2
(en)
|
2002-07-17 |
2004-01-22 |
Coley Pharmaceutical Gmbh |
Use of cpg nucleic acids in prion-disease
|
CN1468957A
(zh)
|
2002-07-19 |
2004-01-21 |
中国人民解放军第二军医大学 |
一种用作人用治疗性疫苗佐剂的质粒
|
AR040996A1
(es)
*
|
2002-08-19 |
2005-04-27 |
Coley Pharm Group Inc |
Acidos nucleicos inmunoestimuladores
|
US8263091B2
(en)
|
2002-09-18 |
2012-09-11 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides
|
WO2004026888A2
(en)
|
2002-09-19 |
2004-04-01 |
Coley Pharmaceutical Gmbh |
Toll-like receptor 9 (tlr9) from various mammalian species
|
JP2006500066A
(ja)
|
2002-09-25 |
2006-01-05 |
ファルマシア・コーポレーション |
ミクロソームのプロスタグランジンe2シンターゼ発現のアンチセンス調節
|
GB0222953D0
(en)
|
2002-10-03 |
2002-11-13 |
Glaxo Group Ltd |
Novel Compounds
|
US8043622B2
(en)
*
|
2002-10-08 |
2011-10-25 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Method of treating inflammatory lung disease with suppressors of CpG oligonucleotides
|
ZA200503511B
(en)
*
|
2002-10-29 |
2006-10-25 |
Coley Pharmaceutical Group Ltd |
Use of CPG oligonucleotides in the treatment of hepatitis C virus infection
|
US7758876B2
(en)
*
|
2002-11-01 |
2010-07-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method of preventing infections from bioterrorism agents with immunostimulatory CpG oligonucleotides
|
US7956043B2
(en)
|
2002-12-11 |
2011-06-07 |
Coley Pharmaceutical Group, Inc. |
5′ CpG nucleic acids and methods of use
|
KR100525321B1
(ko)
|
2002-12-13 |
2005-11-02 |
안웅식 |
파필로마바이러스 항원 단백질 및CpG-올리고데옥시뉴클레오타이드를 포함하는파필로마바이러스 유발 질환의 예방 또는 치료용 약제학적조성물
|
US8158768B2
(en)
*
|
2002-12-23 |
2012-04-17 |
Dynavax Technologies Corporation |
Immunostimulatory sequence oligonucleotides and methods of using the same
|
US7625872B2
(en)
|
2002-12-23 |
2009-12-01 |
Dynavax Technologies Corporation |
Branched immunomodulatory compounds and methods of using the same
|
WO2004087049A2
(en)
|
2003-03-25 |
2004-10-14 |
3M Innovative Properties Company |
Selective activation of cellular activities mediated through a common toll-like receptor
|
ZA200507562B
(en)
|
2003-03-26 |
2006-11-29 |
Cytos Biotechnology Ag |
HIV-peptide-carrier-conjugates
|
AU2004226605A1
(en)
|
2003-04-02 |
2004-10-14 |
Coley Pharmaceutical Group, Ltd. |
Immunostimulatory nucleic acid oil-in-water formulations for topical application
|
WO2005016235A2
(en)
|
2003-04-14 |
2005-02-24 |
The Regents Of The University Of California |
Combined use of impdh inhibitors with toll-like receptor agonists
|
WO2004094671A2
(en)
|
2003-04-22 |
2004-11-04 |
Coley Pharmaceutical Gmbh |
Methods and products for identification and assessment of tlr ligands
|
DE602004028468D1
(de)
*
|
2003-06-17 |
2010-09-16 |
Mannkind Corp |
Haltung von immunantworten gegen mhc-klasse-i-beschränkte epitope, für prophylaktische oder therapeutische zwecke
|
BRPI0411514A
(pt)
|
2003-06-20 |
2006-08-01 |
Coley Pharm Gmbh |
antagonistas de receptor toll-like de molécula pequena
|
AU2004255470B2
(en)
|
2003-07-10 |
2010-08-19 |
Cytos Biotechnology Ag |
Packaged virus-like particles
|
DE602004030343D1
(de)
|
2003-07-11 |
2011-01-13 |
Intercell Ag |
Hcv-vakzin
|
US20050013812A1
(en)
*
|
2003-07-14 |
2005-01-20 |
Dow Steven W. |
Vaccines using pattern recognition receptor-ligand:lipid complexes
|
US20050196411A1
(en)
|
2003-08-28 |
2005-09-08 |
Moss Ronald B. |
Immunogenic HIV compositions and related methods
|
NZ545536A
(en)
*
|
2003-09-05 |
2010-04-30 |
Anadys Pharmaceuticals Inc |
TLR7 ligands for the treatment of hepatitis C
|
US20070110714A1
(en)
|
2003-09-08 |
2007-05-17 |
Norio Hayashi |
Medicinal composition for treatment of chronic hepatitis c
|
AU2004275876B2
(en)
|
2003-09-25 |
2011-03-31 |
Coley Pharmaceutical Gmbh |
Nucleic acid-lipophilic conjugates
|
US20050215501A1
(en)
|
2003-10-24 |
2005-09-29 |
Coley Pharmaceutical Group, Inc. |
Methods and products for enhancing epitope spreading
|
CN101454451A
(zh)
|
2003-10-30 |
2009-06-10 |
科勒制药有限公司 |
具有增强免疫刺激能力的c类寡核苷酸类似物
|
US20050239733A1
(en)
|
2003-10-31 |
2005-10-27 |
Coley Pharmaceutical Gmbh |
Sequence requirements for inhibitory oligonucleotides
|
US20050100983A1
(en)
|
2003-11-06 |
2005-05-12 |
Coley Pharmaceutical Gmbh |
Cell-free methods for identifying compounds that affect toll-like receptor 9 (TLR9) signaling
|
WO2005079419A2
(en)
|
2004-02-17 |
2005-09-01 |
The Regents Of The University Of California |
Methods of treating immunopathological disorders
|
EP1720568A2
(de)
|
2004-02-19 |
2006-11-15 |
Coley Pharmaceutical Group, Inc. |
Immunstimulatorische virale rna-oligonucleotide
|
CA2557443A1
(en)
|
2004-03-12 |
2005-09-29 |
Hybridon, Inc. |
Enhanced activity of hiv vaccine using a second generation immunomodulatory oligonucleotide
|
AU2005243250A1
(en)
*
|
2004-04-02 |
2005-11-24 |
Coley Pharmaceutical Gmbh |
Immunostimulatory nucleic acids for inducing IL-10 responses
|
US7622125B2
(en)
|
2004-05-05 |
2009-11-24 |
Novartis Vaccines And Diagnostics, Inc. |
Polycistronic HIV vector constructs
|
CA2567789A1
(en)
|
2004-06-08 |
2006-08-03 |
Coley Pharmaceutical Gmbh |
Abasic oligonucleotide as carrier platform for antigen and immunostimulatory agonist and antagonist
|
CA2574090A1
(en)
*
|
2004-07-18 |
2006-12-21 |
Coley Pharmaceutical Group, Ltd. |
Methods and compositions for inducing innate immune responses
|
EP2484374A1
(de)
|
2004-07-18 |
2012-08-08 |
CSL Limited |
Immunstimulierender Komplex und Oligonucleotidformulierungen zur Induzierung verbesserter Interferon-Gamma-Antworten
|
NZ554387A
(en)
|
2004-09-21 |
2009-09-25 |
Cytos Biotechnology Ag |
Virus-like particles comprising a fusion protein of the coat protein of AP205 and an antigenic polypeptide
|
MY159370A
(en)
*
|
2004-10-20 |
2016-12-30 |
Coley Pharm Group Inc |
Semi-soft-class immunostimulatory oligonucleotides
|
JP2008531018A
(ja)
*
|
2005-02-24 |
2008-08-14 |
コーリー ファーマシューティカル グループ,インコーポレイテッド |
免疫刺激性オリゴヌクレオチド
|
JP2008535859A
(ja)
|
2005-04-08 |
2008-09-04 |
コーリー ファーマシューティカル グループ,インコーポレイテッド |
感染症によって悪化した喘息を治療するための方法
|
CN1847256B
(zh)
|
2005-04-13 |
2011-06-15 |
长春华普生物技术有限公司 |
含CpG单链脱氧寡核苷酸和利巴韦林联合应用产生的抗病毒作用
|
WO2006116458A2
(en)
|
2005-04-26 |
2006-11-02 |
Coley Pharmaceutical Gmbh |
Modified oligoribonucleotide analogs with enhances immunostimulatory activity
|
WO2007088423A2
(en)
|
2005-09-16 |
2007-08-09 |
Coley Pharmaceutical Gmbh |
Immunostimulatory single-stranded ribonucleic acid with phosphodiester backbone
|
US20090306177A1
(en)
|
2005-09-16 |
2009-12-10 |
Coley Pharmaceutical Gmbh |
Modulation of Immunostimulatory Properties of Short Interfering Ribonucleic Acid (Sirna) by Nucleotide Modification
|
EA200800943A1
(ru)
|
2005-09-27 |
2008-12-30 |
Коли Фармасьютикал Гмбх |
Модуляция tlr-опосредуемых иммунных ответов с использованием олигонуклеотидов-адаптеров
|
KR20080072934A
(ko)
|
2005-11-25 |
2008-08-07 |
콜리 파마슈티칼 게엠베하 |
면역자극성 올리고리보뉴클레오티드
|
AU2006325225B2
(en)
*
|
2005-12-14 |
2013-07-04 |
Cytos Biotechnology Ag |
Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity
|
EP1991678B2
(de)
*
|
2006-02-15 |
2020-07-15 |
Rechtsanwalt Thomas Beck |
Zusammensetzungen und verfahren für oligonukleotidformulierungen
|
US8027888B2
(en)
|
2006-08-31 |
2011-09-27 |
Experian Interactive Innovation Center, Llc |
Online credit card prescreen systems and methods
|
WO2008033432A2
(en)
|
2006-09-12 |
2008-03-20 |
Coley Pharmaceutical Group, Inc. |
Immune modulation by chemically modified ribonucleosides and oligoribonucleotides
|
CA2664156A1
(en)
|
2006-09-27 |
2008-04-03 |
Coley Pharmaceutical Group, Inc. |
Compositions of tlr ligands and antivirals
|
MX2009003398A
(es)
|
2006-09-27 |
2009-08-12 |
Coley Pharm Gmbh |
Analogos de oligonucleotidos cpg que contienen analogos t hidrofobos con actividad inmunoestimuladora mejorada.
|
BRPI0718182A2
(pt)
|
2006-10-26 |
2014-02-25 |
Coley Pharm Gmbh |
Oligorribonucleotídeos e seus usos.
|
US20090142362A1
(en)
|
2006-11-06 |
2009-06-04 |
Avant Immunotherapeutics, Inc. |
Peptide-based vaccine compositions to endogenous cholesteryl ester transfer protein (CETP)
|
MX2009005849A
(es)
*
|
2006-12-04 |
2009-08-12 |
Univ Illinois |
Composiciones y metodos para tratar cancer con adn rico en cpg y cupredoxinas.
|
CA2687441A1
(en)
|
2007-05-17 |
2008-11-27 |
Coley Pharmaceutical Group, Inc. |
Class a oligonucleotides with immunostimulatory potency
|
PT2170353E
(pt)
*
|
2007-05-18 |
2015-09-16 |
Adiutide Pharmaceuticals Gmbh |
Análogos de oligonucleotídeo modificados por fosfato com atividade imunoestimulante
|
WO2009143292A2
(en)
*
|
2008-05-21 |
2009-11-26 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Method of treating pneumoconiosis with oligodeoxynucleotides
|
US8053422B2
(en)
*
|
2008-12-04 |
2011-11-08 |
The United States Of America As Represented By The Department Of Health And Human Services |
Anti-cancer oligodeoxynucleotides
|
US9501570B2
(en)
|
2014-07-14 |
2016-11-22 |
Verizon Patent And Licensing Inc. |
Dynamic routing system
|
US9719791B2
(en)
|
2014-12-10 |
2017-08-01 |
Mapquest, Inc. |
Computerized systems and methods for providing travel information and/or content to users
|