ATE526019T1 - Verfahren zur behandlung von zellproliferationen störungen und virusinfektionen - Google Patents
Verfahren zur behandlung von zellproliferationen störungen und virusinfektionenInfo
- Publication number
- ATE526019T1 ATE526019T1 AT01972917T AT01972917T ATE526019T1 AT E526019 T1 ATE526019 T1 AT E526019T1 AT 01972917 T AT01972917 T AT 01972917T AT 01972917 T AT01972917 T AT 01972917T AT E526019 T1 ATE526019 T1 AT E526019T1
- Authority
- AT
- Austria
- Prior art keywords
- treating cell
- cell proliferation
- virus infections
- proliferation disorders
- viral infections
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 230000004663 cell proliferation Effects 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 title 1
- 208000036142 Viral infection Diseases 0.000 abstract 2
- 230000009385 viral infection Effects 0.000 abstract 2
- 230000004668 G2/M phase Effects 0.000 abstract 1
- 101710113864 Heat shock protein 90 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000022131 cell cycle Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22141500P | 2000-07-28 | 2000-07-28 | |
| US24526400P | 2000-11-02 | 2000-11-02 | |
| PCT/US2001/023640 WO2002009696A1 (en) | 2000-07-28 | 2001-07-27 | Methods for treating cell proliferative disorders and viral infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE526019T1 true ATE526019T1 (de) | 2011-10-15 |
Family
ID=26915764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01972917T ATE526019T1 (de) | 2000-07-28 | 2001-07-27 | Verfahren zur behandlung von zellproliferationen störungen und virusinfektionen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6946456B2 (de) |
| EP (1) | EP1322307B1 (de) |
| JP (1) | JP2004505044A (de) |
| KR (1) | KR20030046397A (de) |
| AT (1) | ATE526019T1 (de) |
| AU (2) | AU2001292548B2 (de) |
| CA (1) | CA2417495C (de) |
| WO (1) | WO2002009696A1 (de) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002228771B2 (en) * | 2000-11-02 | 2007-10-25 | Sloan-Kettering Institute For Cancer Research | Small molecule compositions for binding to HSP90 |
| US6872715B2 (en) | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| US20090197852A9 (en) * | 2001-08-06 | 2009-08-06 | Johnson Robert G Jr | Method of treating breast cancer using 17-AAG or 17-AG or a prodrug of either in combination with a HER2 inhibitor |
| EP1440072A4 (de) | 2001-10-30 | 2005-02-02 | Conforma Therapeutic Corp | Purinanaloga mit hsp90-inhibierender wirkung |
| EP1472230B1 (de) | 2002-02-08 | 2009-06-17 | Conforma Therapeutic Corporation | Ansamycine mit verbesserten pharmakologischen und biologischen eigenschaften |
| JP2006507021A (ja) * | 2002-03-18 | 2006-03-02 | メドトロニック・エイヴイイー・インコーポレーテッド | 再狭窄の危険のある解剖学的部位へ抗増殖性組成物を送付するための医療用具 |
| JP2005528390A (ja) * | 2002-04-10 | 2005-09-22 | コンフォーマ・セラピューティクス・コーポレイション | アンサマイシン製剤およびその製造ならびに使用方法 |
| US20060148776A1 (en) * | 2003-03-13 | 2006-07-06 | Conforma Therapeutics Corporation | Drug formulations having long and medium chain triglycerides |
| US7691838B2 (en) | 2003-05-30 | 2010-04-06 | Kosan Biosciences Incorporated | Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics |
| NZ546611A (en) | 2003-09-18 | 2010-02-26 | Conforma Therapeutics Corp | Novel heterocyclic compounds as HSP90-inhibitors |
| WO2005031002A2 (en) * | 2003-09-22 | 2005-04-07 | Rosetta Inpharmatics Llc | Synthetic lethal screen using rna interference |
| BRPI0418147A (pt) | 2003-12-23 | 2007-04-17 | Infinity Pharmaceuticals Inc | análogos de ansamicinas contendo benzoquinona e seus métodos de uso |
| US20050256097A1 (en) * | 2004-05-11 | 2005-11-17 | Kosan Biosciences, Inc. | Pharmaceutical solution formulations containing 17-AAG |
| US20060067953A1 (en) * | 2004-09-29 | 2006-03-30 | Conforma Therapeutics Corporation | Oral pharmaceutical formulations and methods for producing and using same |
| DE102004049078A1 (de) | 2004-10-08 | 2006-04-13 | Merck Patent Gmbh | Phenylpyrazole |
| EP2298748B1 (de) * | 2004-11-18 | 2016-07-20 | Synta Pharmaceuticals Corp. | HSP90-Aktivität modulierende Triazolverbindungen |
| US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| WO2006089290A1 (en) * | 2005-02-18 | 2006-08-24 | Abraxis Bioscience Inc.. | Combinations and modes of administration of therapeutic agents and combination therapy |
| DE102005009440A1 (de) | 2005-03-02 | 2006-09-07 | Merck Patent Gmbh | Thienopyridinderivate |
| BRPI0609509A2 (pt) | 2005-03-30 | 2010-04-13 | Conforma Therapeutics Corp | composto ou um polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto, polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável |
| JP2008535844A (ja) * | 2005-04-07 | 2008-09-04 | コンフォーマ・セラピューティクス・コーポレイション | リン脂質をベースとする医薬製剤およびその製造および使用方法 |
| JP5221131B2 (ja) * | 2005-06-29 | 2013-06-26 | 協和発酵キリン株式会社 | ベンゼノイドアンサマイシン誘導体 |
| EP1928846B1 (de) | 2005-08-18 | 2014-06-04 | Synta Pharmaceuticals Corp. | Hsp90-aktivität modulierende triazolverbindungen |
| AU2006320435A1 (en) * | 2005-12-01 | 2007-06-07 | Conforma Therapeutics Corporation | Compositions containing ansamycin |
| DE602006020621D1 (de) * | 2005-12-22 | 2011-04-21 | Astrazeneca Ab | Kombination von zd6474 und pemetrexed |
| US20070167422A1 (en) * | 2006-01-18 | 2007-07-19 | Yu Kwok S | Pharmaceutical compositions comprising 17-allylamino-17-demethoxygeldanamycin |
| WO2007131034A1 (en) * | 2006-05-03 | 2007-11-15 | The Regents Of The University Of Michigan | Pyrimidone derivatives which are modulators of heat shock protein (hsp) 70 |
| US20080027047A1 (en) * | 2006-05-25 | 2008-01-31 | Weiwen Ying | Compounds that modulate HSP90 activity and methods for identifying same |
| AR061185A1 (es) | 2006-05-26 | 2008-08-13 | Chugai Pharmaceutical Co Ltd | Compuestos heterociclicos como inhibidores de hsp90. composiciones farmaceuticas. |
| EP2136799B1 (de) * | 2006-08-11 | 2017-10-04 | Universite De Strasbourg | Makrocyclische verbindungen als hemmer von kinase und hsp90 |
| DE102007002715A1 (de) | 2007-01-18 | 2008-07-24 | Merck Patent Gmbh | Triazolderivat |
| CL2008000629A1 (es) | 2007-03-01 | 2008-08-29 | Chugai Pharmaceutical Co Ltd | Compuestos macrociclicos derivados de 6-aril-4-mercapto-[1.3.5]triazina/[1.3]pirimidin-2-amina; composicion farmaceutica, utiles en el tratamiento del cancer. |
| DE102007028521A1 (de) | 2007-06-21 | 2008-12-24 | Merck Patent Gmbh | Indazolamidderivate |
| DE102007032739A1 (de) | 2007-07-13 | 2009-01-15 | Merck Patent Gmbh | Chinazolinamidderivate |
| DE102007041116A1 (de) | 2007-08-30 | 2009-03-05 | Merck Patent Gmbh | 1,3-Dihydro-isoindolderivate |
| US20110190237A1 (en) * | 2008-01-15 | 2011-08-04 | Nexgenix Pharmaceuticals | Macrocyclic Prodrug Compounds Useful as Therapeutics |
| US8071766B2 (en) | 2008-02-01 | 2011-12-06 | Takeda Pharmaceutical Company Limited | HSP90 inhibitors |
| MX2011005664A (es) * | 2008-11-28 | 2011-06-16 | Novartis Ag | Inhibidores de hsp90 para tratamiento terapeutico. |
| DE102008061214A1 (de) | 2008-12-09 | 2010-06-10 | Merck Patent Gmbh | Chinazolinamidderivate |
| DE102009054302A1 (de) | 2009-11-23 | 2011-05-26 | Merck Patent Gmbh | Chinazolinderivate |
| WO2011123393A1 (en) | 2010-03-29 | 2011-10-06 | Abraxis Bioscience, Llc | Methods of enhancing drug delivery and effectiveness of therapeutic agents |
| NZ602385A (en) | 2010-03-29 | 2014-08-29 | Abraxis Bioscience Llc | Methods of treating cancer |
| EP2560640A1 (de) | 2010-04-19 | 2013-02-27 | Synta Pharmaceuticals Corp. | Krebstherapie mit einer kombination aus hsp90-inhibitorverbindungen und einem egfr-hemmer |
| KR20130088116A (ko) | 2010-06-04 | 2013-08-07 | 아브락시스 바이오사이언스, 엘엘씨 | 췌장암의 치료 방법 |
| DE102010046837A1 (de) | 2010-09-29 | 2012-03-29 | Merck Patent Gmbh | Phenylchinazolinderivate |
| WO2013067162A1 (en) | 2011-11-02 | 2013-05-10 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors |
| JP2014534228A (ja) | 2011-11-02 | 2014-12-18 | シンタ ファーマシューティカルズ コーポレーション | 白金含有剤とhsp90阻害剤の組合せ療法 |
| EP2780010A1 (de) | 2011-11-14 | 2014-09-24 | Synta Pharmaceuticals Corp. | Kombinationstherapie aus hsp90-inhibitoren mit braf-inhibitoren |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3595955A (en) | 1969-03-26 | 1971-07-27 | Upjohn Co | Geldanamycin and process for producing same |
| US4261989A (en) | 1979-02-19 | 1981-04-14 | Kaken Chemical Co. Ltd. | Geldanamycin derivatives and antitumor drug |
| US5650430A (en) * | 1990-06-06 | 1997-07-22 | Sankyo Company, Limited | Radicicol derivatives, their preparation and their anti-tumor activity |
| IE911915A1 (en) * | 1990-06-06 | 1991-12-18 | Sankyo Co | Radicicol derivatives, their preparation and their¹anti-tumor activity |
| US5387584A (en) | 1993-04-07 | 1995-02-07 | Pfizer Inc. | Bicyclic ansamycins |
| US5932566A (en) | 1994-06-16 | 1999-08-03 | Pfizer Inc. | Ansamycin derivatives as antioncogene and anticancer agents |
| US5731343A (en) * | 1995-02-24 | 1998-03-24 | The Scripps Research Institute | Method of use of radicicol for treatment of immunopathological disorders |
| ATE266017T1 (de) * | 1996-10-25 | 2004-05-15 | Kyowa Hakko Kogyo Kk | Radicicolderivate |
| WO1998051702A1 (en) * | 1997-05-14 | 1998-11-19 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for destruction of selected proteins |
| US5968921A (en) | 1997-10-24 | 1999-10-19 | Orgegon Health Sciences University | Compositions and methods for promoting nerve regeneration |
| CA2367143A1 (en) | 1999-04-02 | 2000-10-12 | Euro-Celtique S.A. | Purine derivatives having phosphodiesterase iv inhibition activity |
| AU769235B2 (en) | 1999-04-09 | 2004-01-22 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for degradation and/or inhibition of her-family tyrosine kinases |
| US6335157B1 (en) | 1999-05-07 | 2002-01-01 | The European Molecular Biology Laboratory | Method based on localization of Hsp90 to the centrosome |
| GB9924020D0 (en) | 1999-10-11 | 1999-12-15 | Pfizer Ltd | Pharmaceutically active compounds |
| EP1322325A4 (de) * | 2000-07-20 | 2004-09-15 | Merck & Co Inc | Inhibition der prozessierung und replikation des hepatitis c virus |
| EP1337275A4 (de) * | 2000-11-02 | 2007-05-09 | Sloan Kettering Inst Cancer | Verfahren zur verbesserung der wirksamkeit von zytotoxischen mitteln durch verwendung von hsp90-hemmern |
-
2001
- 2001-07-27 AT AT01972917T patent/ATE526019T1/de not_active IP Right Cessation
- 2001-07-27 WO PCT/US2001/023640 patent/WO2002009696A1/en not_active Ceased
- 2001-07-27 AU AU2001292548A patent/AU2001292548B2/en not_active Expired
- 2001-07-27 US US10/343,246 patent/US6946456B2/en not_active Expired - Lifetime
- 2001-07-27 CA CA2417495A patent/CA2417495C/en not_active Expired - Lifetime
- 2001-07-27 EP EP01972917A patent/EP1322307B1/de not_active Revoked
- 2001-07-27 AU AU9254801A patent/AU9254801A/xx active Pending
- 2001-07-27 JP JP2002515249A patent/JP2004505044A/ja active Pending
- 2001-07-27 KR KR10-2003-7001269A patent/KR20030046397A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2417495C (en) | 2013-04-30 |
| AU2001292548B2 (en) | 2005-06-16 |
| EP1322307A1 (de) | 2003-07-02 |
| CA2417495A1 (en) | 2002-02-07 |
| EP1322307A4 (de) | 2008-08-13 |
| EP1322307B1 (de) | 2011-09-28 |
| US20030216369A1 (en) | 2003-11-20 |
| US6946456B2 (en) | 2005-09-20 |
| KR20030046397A (ko) | 2003-06-12 |
| AU9254801A (en) | 2002-02-13 |
| WO2002009696A1 (en) | 2002-02-07 |
| JP2004505044A (ja) | 2004-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |