HK1133440A1 - 具有增強的免疫刺激活性的含疏水性 類似物的 寡聚核苷酸類似物 - Google Patents

具有增強的免疫刺激活性的含疏水性 類似物的 寡聚核苷酸類似物

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Publication number
HK1133440A1
HK1133440A1 HK09109331.0A HK09109331A HK1133440A1 HK 1133440 A1 HK1133440 A1 HK 1133440A1 HK 09109331 A HK09109331 A HK 09109331A HK 1133440 A1 HK1133440 A1 HK 1133440A1
Authority
HK
Hong Kong
Prior art keywords
cpg
analogs
immunostimulatory activity
containing hydrophobic
enhanced immunostimulatory
Prior art date
Application number
HK09109331.0A
Other languages
English (en)
Inventor
Harald Debelak
Eugen Uhlmann
Marion Jurk
Original Assignee
科勒製藥有限責任公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 科勒製藥有限責任公司 filed Critical 科勒製藥有限責任公司
Publication of HK1133440A1 publication Critical patent/HK1133440A1/zh

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/33—Chemical structure of the base
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/332—Abasic residue
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/335—Modified T or U
HK09109331.0A 2006-09-27 2009-10-08 具有增強的免疫刺激活性的含疏水性 類似物的 寡聚核苷酸類似物 HK1133440A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84781106P 2006-09-27 2006-09-27
PCT/IB2007/004389 WO2008068638A2 (en) 2006-09-27 2007-09-27 Cpg oligonucleotide analogs containing hydrophobic t analogs with enhanced immunostimulatory activity

Publications (1)

Publication Number Publication Date
HK1133440A1 true HK1133440A1 (zh) 2010-03-26

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HK09109331.0A HK1133440A1 (zh) 2006-09-27 2009-10-08 具有增強的免疫刺激活性的含疏水性 類似物的 寡聚核苷酸類似物

Country Status (22)

Country Link
US (3) US8580268B2 (zh)
EP (2) EP2960332A1 (zh)
JP (2) JP5455629B2 (zh)
KR (2) KR101251707B1 (zh)
CN (1) CN101517082B (zh)
AU (1) AU2007330410B2 (zh)
BR (1) BRPI0717510B8 (zh)
CA (1) CA2664219C (zh)
DK (1) DK2078080T3 (zh)
ES (1) ES2544958T3 (zh)
HK (1) HK1133440A1 (zh)
HU (1) HUE027064T2 (zh)
IL (1) IL197549A (zh)
MX (1) MX2009003398A (zh)
NO (1) NO342465B1 (zh)
NZ (1) NZ575437A (zh)
PL (1) PL2078080T3 (zh)
PT (1) PT2078080E (zh)
RU (1) RU2477315C2 (zh)
SI (1) SI2078080T1 (zh)
WO (1) WO2008068638A2 (zh)
ZA (1) ZA200901735B (zh)

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