BRPI0717510B8 - análogos de oligonucleotídeo cpg contendo análogos t hidrofóbicos com atividade imunoestimulatória intensificada e composição farmacêutica que os compreende - Google Patents

análogos de oligonucleotídeo cpg contendo análogos t hidrofóbicos com atividade imunoestimulatória intensificada e composição farmacêutica que os compreende

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Publication number
BRPI0717510B8
BRPI0717510B8 BRPI0717510A BRPI0717510A BRPI0717510B8 BR PI0717510 B8 BRPI0717510 B8 BR PI0717510B8 BR PI0717510 A BRPI0717510 A BR PI0717510A BR PI0717510 A BRPI0717510 A BR PI0717510A BR PI0717510 B8 BRPI0717510 B8 BR PI0717510B8
Authority
BR
Brazil
Prior art keywords
analogues
cpg oligonucleotide
immunostimulatory activity
containing hydrophobic
pharmaceutical composition
Prior art date
Application number
BRPI0717510A
Other languages
English (en)
Inventor
Eugen Uhlmann
Harald Debelak
Marion Jurk
Original Assignee
Coley Pharm Gmbh
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coley Pharm Gmbh, Pfizer filed Critical Coley Pharm Gmbh
Publication of BRPI0717510A2 publication Critical patent/BRPI0717510A2/pt
Publication of BRPI0717510B1 publication Critical patent/BRPI0717510B1/pt
Publication of BRPI0717510B8 publication Critical patent/BRPI0717510B8/pt

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Abstract

análogos de oligonucleotídeo cpg contendo análogos t hidrofóbicos com atividade imunoestimulatória intensificada. a presente invenção refere-se a oligonucleotídeos incluindo pelo menos um análogo de nucleotídeo substituído lipofílico e dinucleotídeo de pirimidina-purina. a invenção também refere-se a composições farmacêuticas e a métodos de uso das mesmas.
BRPI0717510A 2006-09-27 2007-09-27 análogos de oligonucleotídeo cpg contendo análogos t hidrofóbicos com atividade imunoestimulatória intensificada e composição farmacêutica que os compreende BRPI0717510B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84781106P 2006-09-27 2006-09-27
US60/847,811 2006-09-27
PCT/IB2007/004389 WO2008068638A2 (en) 2006-09-27 2007-09-27 Cpg oligonucleotide analogs containing hydrophobic t analogs with enhanced immunostimulatory activity

Publications (3)

Publication Number Publication Date
BRPI0717510A2 BRPI0717510A2 (pt) 2013-11-19
BRPI0717510B1 BRPI0717510B1 (pt) 2021-01-12
BRPI0717510B8 true BRPI0717510B8 (pt) 2021-09-14

Family

ID=39492695

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BRPI0717510A BRPI0717510B8 (pt) 2006-09-27 2007-09-27 análogos de oligonucleotídeo cpg contendo análogos t hidrofóbicos com atividade imunoestimulatória intensificada e composição farmacêutica que os compreende

Country Status (22)

Country Link
US (3) US8580268B2 (pt)
EP (2) EP2078080B1 (pt)
JP (2) JP5455629B2 (pt)
KR (2) KR101251707B1 (pt)
CN (1) CN101517082B (pt)
AU (1) AU2007330410B2 (pt)
BR (1) BRPI0717510B8 (pt)
CA (1) CA2664219C (pt)
DK (1) DK2078080T3 (pt)
ES (1) ES2544958T3 (pt)
HK (1) HK1133440A1 (pt)
HU (1) HUE027064T2 (pt)
IL (1) IL197549A (pt)
MX (1) MX2009003398A (pt)
NO (1) NO342465B1 (pt)
NZ (1) NZ575437A (pt)
PL (1) PL2078080T3 (pt)
PT (1) PT2078080E (pt)
RU (1) RU2477315C2 (pt)
SI (1) SI2078080T1 (pt)
WO (1) WO2008068638A2 (pt)
ZA (1) ZA200901735B (pt)

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JP2014036652A (ja) 2014-02-27
RU2009109098A (ru) 2010-11-10
KR101251707B1 (ko) 2013-04-11
NO342465B1 (no) 2018-05-28
IL197549A (en) 2016-04-21
AU2007330410B2 (en) 2012-07-26
PL2078080T3 (pl) 2015-12-31
CA2664219A1 (en) 2008-06-12
JP5455629B2 (ja) 2014-03-26
WO2008068638A2 (en) 2008-06-12
US9382545B2 (en) 2016-07-05
EP2078080A2 (en) 2009-07-15
BRPI0717510B1 (pt) 2021-01-12
NO20091218L (no) 2009-04-21
HUE027064T2 (hu) 2016-09-28
EP2960332A1 (en) 2015-12-30
MX2009003398A (es) 2009-08-12
JP2010504750A (ja) 2010-02-18
AU2007330410A1 (en) 2008-06-12
KR20090058581A (ko) 2009-06-09
JP6006183B2 (ja) 2016-10-12
US20140163213A1 (en) 2014-06-12
US20160348115A1 (en) 2016-12-01
CA2664219C (en) 2013-12-17
US10260071B2 (en) 2019-04-16
RU2477315C2 (ru) 2013-03-10
SI2078080T1 (sl) 2015-09-30
HK1133440A1 (en) 2010-03-26
BRPI0717510A2 (pt) 2013-11-19
AU2007330410A8 (en) 2012-05-03
KR20130014620A (ko) 2013-02-07
US8580268B2 (en) 2013-11-12
US20100166780A1 (en) 2010-07-01
ZA200901735B (en) 2010-05-26
PT2078080E (pt) 2015-09-18
WO2008068638A3 (en) 2008-11-13

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