ATE311402T1 - Peptidnukleinsäuren mit erhöhter bindungsaffinität, sequenzspezifität und löslichkeit - Google Patents

Peptidnukleinsäuren mit erhöhter bindungsaffinität, sequenzspezifität und löslichkeit

Info

Publication number
ATE311402T1
ATE311402T1 AT97935053T AT97935053T ATE311402T1 AT E311402 T1 ATE311402 T1 AT E311402T1 AT 97935053 T AT97935053 T AT 97935053T AT 97935053 T AT97935053 T AT 97935053T AT E311402 T1 ATE311402 T1 AT E311402T1
Authority
AT
Austria
Prior art keywords
solubility
nucleic acids
peptide nucleic
sequence specificity
binding affinity
Prior art date
Application number
AT97935053T
Other languages
English (en)
Inventor
Peter E Nielsen
Michael Egholm
Rolf H Berg
Ole Buchardt
Original Assignee
Buchardt Dorte
Nielsen Peter Eigil Prof Dr
Michael Egholm
Berg Rolf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/686,114 external-priority patent/US6414112B1/en
Priority claimed from US08/686,116 external-priority patent/US5714331A/en
Priority claimed from US08/685,484 external-priority patent/US5719262A/en
Priority claimed from US08/686,113 external-priority patent/US5766855A/en
Application filed by Buchardt Dorte, Nielsen Peter Eigil Prof Dr, Michael Egholm, Berg Rolf filed Critical Buchardt Dorte
Application granted granted Critical
Publication of ATE311402T1 publication Critical patent/ATE311402T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT97935053T 1996-07-24 1997-07-24 Peptidnukleinsäuren mit erhöhter bindungsaffinität, sequenzspezifität und löslichkeit ATE311402T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US08/686,114 US6414112B1 (en) 1991-05-24 1996-07-24 Peptide nucleic acids having 2,6-diaminopurine nucleobases
US08/686,116 US5714331A (en) 1991-05-24 1996-07-24 Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US08/685,484 US5719262A (en) 1993-11-22 1996-07-24 Peptide nucleic acids having amino acid side chains
US08/686,113 US5766855A (en) 1991-05-24 1996-07-24 Peptide nucleic acids having enhanced binding affinity and sequence specificity
US5100297P 1997-05-29 1997-05-29
PCT/US1997/012811 WO1998003542A1 (en) 1996-07-24 1997-07-24 Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility

Publications (1)

Publication Number Publication Date
ATE311402T1 true ATE311402T1 (de) 2005-12-15

Family

ID=27535143

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97935053T ATE311402T1 (de) 1996-07-24 1997-07-24 Peptidnukleinsäuren mit erhöhter bindungsaffinität, sequenzspezifität und löslichkeit

Country Status (7)

Country Link
EP (1) EP0960121B1 (de)
JP (2) JP3306073B2 (de)
AT (1) ATE311402T1 (de)
AU (1) AU717387B2 (de)
CA (1) CA2261566A1 (de)
DE (1) DE69734783T2 (de)
WO (1) WO1998003542A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985558A (en) * 1997-04-14 1999-11-16 Isis Pharmaceuticals Inc. Antisense oligonucleotide compositions and methods for the inibition of c-Jun and c-Fos
DE19653646A1 (de) * 1996-12-20 1998-06-25 Hoechst Ag Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung
US6326479B1 (en) 1998-01-27 2001-12-04 Boston Probes, Inc. Synthetic polymers and methods, kits or compositions for modulating the solubility of same
US7892737B2 (en) 2005-06-30 2011-02-22 Life Technologies Corporation Compositions, kits and methods pertaining to stability modulation of PNA oligomer/nucleic acid complexes
EP1954838B1 (de) 2005-11-14 2014-02-26 Life Technologies Corporation Kodierte moleküle zur erkennung von zielanalyten
US20080050752A1 (en) 2006-06-30 2008-02-28 Applera Corporation Methods of analyzing binding interactions
DE102006034319A1 (de) * 2006-07-21 2008-01-31 Ugichem Gmbh Chirale mit Phosponsäurester- oder Phosphonsäure- substituierte Verbindungen
US20100284959A1 (en) * 2008-01-23 2010-11-11 Gene Arrest Ltd. Sequence specific double-stranded dna/rna binding compounds and uses thereof
CN102282155B (zh) 2008-12-02 2017-06-09 日本波涛生命科学公司 磷原子修饰的核酸的合成方法
KR101885383B1 (ko) 2009-07-06 2018-08-03 웨이브 라이프 사이언시스 리미티드 신규한 핵산 프로드러그 및 그의 사용 방법
WO2012039448A1 (ja) 2010-09-24 2012-03-29 株式会社キラルジェン 不斉補助基
US9605019B2 (en) 2011-07-19 2017-03-28 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
SG10201912895PA (en) 2012-07-13 2020-02-27 Wave Life Sciences Ltd Chiral control
KR101835401B1 (ko) 2012-07-13 2018-03-08 신 니뽄 바이오메디칼 라보라토리즈, 엘티디. 키랄 핵산 어쥬번트
AU2013288048A1 (en) 2012-07-13 2015-01-22 Wave Life Sciences Ltd. Asymmetric auxiliary group
KR101830700B1 (ko) * 2013-11-11 2018-02-21 주식회사 파나진 클램핑 프로브 및 검출 프로브를 이용한 다중 표적핵산 검출방법
EP3095459A4 (de) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chirales nukleinsäureadjuvans mit antitumorwirkung und antitumormittel
JPWO2015108046A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
WO2015108047A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
JP6382344B2 (ja) 2014-01-16 2018-08-29 ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． キラルデザイン
DE102014007158A1 (de) * 2014-05-16 2015-11-19 Ugichem Gmbh Neue Peptid-Nukleinsäuren-Monomere und -Oligomere
WO2018030789A1 (ko) 2016-08-09 2018-02-15 주식회사 시선바이오머티리얼스 세포투과성이 향상된 펩티드 핵산 복합체 및 이를 포함하는 약학적 조성물
KR102262260B1 (ko) * 2018-02-08 2021-06-09 주식회사 시선테라퓨틱스 엔도좀 탈출능을 갖는 펩티드 핵산 복합체 및 이의 용도
KR102484332B1 (ko) * 2018-02-08 2023-01-04 주식회사 시선테라퓨틱스 핵산 복합체를 함유하는 피부 투과성 전달체 및 이의 용도

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS200063B1 (cs) * 1978-08-24 1980-08-29 Milan Strasak Způsob přípravy alkylen-Ν,Ν '-bis-histidinů
JPS6163661A (ja) * 1984-09-05 1986-04-01 Microbial Chem Res Found ヒスタジン関連化合物
AU5410786A (en) * 1985-03-04 1986-09-11 Fujisawa Pharmaceutical Co., Ltd. Amino acid derivatives and processes for preparation thereof
US5166315A (en) * 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
CA1268404A (en) * 1985-03-15 1990-05-01 Antivirals Inc. Polynucleotide assay reagent and method
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
DE4408528A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung
DE19532553A1 (de) * 1995-09-04 1997-03-06 Hoechst Ag Verfahren zur Herstellung substituierter N-Ethyl-Glycinderivate

Also Published As

Publication number Publication date
JP2002105059A (ja) 2002-04-10
CA2261566A1 (en) 1998-01-29
JP3306073B2 (ja) 2002-07-24
EP0960121A1 (de) 1999-12-01
WO1998003542A1 (en) 1998-01-29
AU3808197A (en) 1998-02-10
JP2000503671A (ja) 2000-03-28
EP0960121A4 (de) 2003-05-28
DE69734783T2 (de) 2006-08-17
DE69734783D1 (de) 2006-01-05
AU717387B2 (en) 2000-03-23
EP0960121B1 (de) 2005-11-30

Similar Documents

Publication Publication Date Title
ATE311402T1 (de) Peptidnukleinsäuren mit erhöhter bindungsaffinität, sequenzspezifität und löslichkeit
KR0133131B1 (en) Peptide nucleic acids
WO1994025477A3 (en) Novel peptide nucleic acids
ZA971208B (en) Sugar-modified gapped oligonucleotides.
WO1996032496A3 (en) Covalently linked oligonucleotide minor groove binder conjugates
EP1762619A3 (de) Multi-tumor abweichende wachstumsgene
DE69527857D1 (de) Peptid-nukleinsäure-konjugate
CA2320100A1 (en) High affinity nucleic acid ligands of complement system proteins
PT1210357E (pt) Oligonucleótido-tiofosforamidatos n3'→p5': sua síntese e utilização
ATE370960T1 (de) Verknüpfte peptid-nukleinsäuren
EP1975172A3 (de) Hochaffine TGFß-Nukleinsäureliganden und -inhibitoren
ATE217906T1 (de) Methoden zur zielrichtung von dna
EP0828849A4 (de) Oligonukleotidliganden mit hoher affinität für wachstumsfaktoren
ATE419262T1 (de) 2'-o-acetamido-modifizierte monomere und oligomere
JP2003522514A5 (de)
ATE239090T1 (de) Methode zum generieren von einzelsträngigen dna molekülen
ATE283353T1 (de) Kovalente bindung von dna zu rna strängen katalysiert durch vaccinia topoisomerase
EP1147123A4 (de) Neuartige geruchsrezeptoren in drosophila
WO2001023426A3 (en) Hypoxia-related human genes, proteins, and uses thereof
WO2001079216A3 (de) Polyamidnukleinsäure-derivate, mittel und verfahren zur ihrer herstellung
WO1996012397A3 (en) Recombinant antibody capable of binding to pna/nucleic acid complexes

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties