AU2015209145B2 - Antibody molecules to PD-1 and uses thereof - Google Patents

Antibody molecules to PD-1 and uses thereof Download PDF

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Publication number
AU2015209145B2
AU2015209145B2 AU2015209145A AU2015209145A AU2015209145B2 AU 2015209145 B2 AU2015209145 B2 AU 2015209145B2 AU 2015209145 A AU2015209145 A AU 2015209145A AU 2015209145 A AU2015209145 A AU 2015209145A AU 2015209145 B2 AU2015209145 B2 AU 2015209145B2
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seq
amino acid
acid sequence
cancer
antibody molecule
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AU2015209145A1 (en
Inventor
Walter A. Blattler
Hwai Wen Chang
Gordon James Freeman
Gerhard Johann Frey
Jennifer Marie Mataraza
Catherine Anne SABATOS-PEYTON
Arlene Helen Sharpe
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Novartis AG
Dana Farber Cancer Institute Inc
Harvard University
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Novartis AG
Dana Farber Cancer Institute Inc
Harvard University
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Application filed by Novartis AG, Dana Farber Cancer Institute Inc, Harvard University filed Critical Novartis AG
Publication of AU2015209145A1 publication Critical patent/AU2015209145A1/en
Priority to AU2020204366A priority Critical patent/AU2020204366A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Proteomics, Peptides & Aminoacids (AREA)
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AU2015209145A 2014-01-24 2015-01-23 Antibody molecules to PD-1 and uses thereof Active AU2015209145B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020204366A AU2020204366A1 (en) 2014-01-24 2020-06-30 Antibody molecules to PD-1 and uses thereof

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461931512P 2014-01-24 2014-01-24
US61/931,512 2014-01-24
US201462059676P 2014-10-03 2014-10-03
US62/059,676 2014-10-03
US201462094834P 2014-12-19 2014-12-19
US62/094,834 2014-12-19
PCT/US2015/012754 WO2015112900A1 (en) 2014-01-24 2015-01-23 Antibody molecules to pd-1 and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020204366A Division AU2020204366A1 (en) 2014-01-24 2020-06-30 Antibody molecules to PD-1 and uses thereof

Publications (2)

Publication Number Publication Date
AU2015209145A1 AU2015209145A1 (en) 2016-07-07
AU2015209145B2 true AU2015209145B2 (en) 2020-08-13

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AU2015209145A Active AU2015209145B2 (en) 2014-01-24 2015-01-23 Antibody molecules to PD-1 and uses thereof
AU2020204366A Abandoned AU2020204366A1 (en) 2014-01-24 2020-06-30 Antibody molecules to PD-1 and uses thereof

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AU2020204366A Abandoned AU2020204366A1 (en) 2014-01-24 2020-06-30 Antibody molecules to PD-1 and uses thereof

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US (5) US9683048B2 (enExample)
EP (2) EP3514179B1 (enExample)
JP (3) JP6521986B2 (enExample)
KR (1) KR102357621B1 (enExample)
CN (3) CN111909270A (enExample)
AU (2) AU2015209145B2 (enExample)
CA (1) CA2935423C (enExample)
CL (1) CL2016001723A1 (enExample)
CY (1) CY1121542T1 (enExample)
DK (1) DK3097121T3 (enExample)
EA (1) EA201691488A1 (enExample)
EC (1) ECSP16068976A (enExample)
ES (1) ES2716685T3 (enExample)
HK (1) HK1225747B (enExample)
HR (1) HRP20190516T1 (enExample)
HU (1) HUE043363T2 (enExample)
IL (2) IL246382A0 (enExample)
JO (2) JO3560B1 (enExample)
LT (1) LT3097121T (enExample)
ME (1) ME03366B (enExample)
MX (2) MX375683B (enExample)
MY (1) MY184757A (enExample)
NZ (1) NZ721678A (enExample)
PE (1) PE20170255A1 (enExample)
PH (1) PH12016501456A1 (enExample)
PL (1) PL3097121T3 (enExample)
PT (1) PT3097121T (enExample)
RS (1) RS58535B1 (enExample)
SG (2) SG11201604939SA (enExample)
SI (1) SI3097121T1 (enExample)
TN (1) TN2016000272A1 (enExample)
TW (3) TW202045549A (enExample)
UA (1) UA122479C2 (enExample)
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