JP7091247B2 - 適応開口 - Google Patents
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- JP7091247B2 JP7091247B2 JP2018544022A JP2018544022A JP7091247B2 JP 7091247 B2 JP7091247 B2 JP 7091247B2 JP 2018544022 A JP2018544022 A JP 2018544022A JP 2018544022 A JP2018544022 A JP 2018544022A JP 7091247 B2 JP7091247 B2 JP 7091247B2
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- A61N5/00—Radiation therapy
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- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
- A61N5/1043—Scanning the radiation beam, e.g. spot scanning or raster scanning
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
- A61N5/1045—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head using a multi-leaf collimator, e.g. for intensity modulated radiation therapy or IMRT
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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- A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
- A61N5/1045—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head using a multi-leaf collimator, e.g. for intensity modulated radiation therapy or IMRT
- A61N5/1047—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head using a multi-leaf collimator, e.g. for intensity modulated radiation therapy or IMRT with movement of the radiation head during application of radiation, e.g. for intensity modulated arc therapy or IMAT
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- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
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- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
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- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
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- A61N5/00—Radiation therapy
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- A61N2005/1092—Details
- A61N2005/1095—Elements inserted into the radiation path within the system, e.g. filters or wedges
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Description
40 リーフ
40a、40b、42a、42b コイルセット
50 高さ
55 舌および溝特徴部
56 湾曲した端部
100 磁石ヨーク
102 引き出しチャネル
105 粒子加速器
106 走査システム
108 走査磁石
109 電離箱
110 エネルギーデグレーダ
115 飛程変調装置
116 プレート
116a プレート
117 矢印
118 電流センサ
122 磁石システム
138 引き出しチャネル
140 環状超電導コイル
142 環状超電導コイル
144 磁極面
146 磁極面
170 低温保持槽
171 支持点
173 支持点
181、183 半分
184 帰還磁束
186 容積部
190 粒子源
191 高周波駆動システム
192 幾何学的中心
200 プロセス
230 ビーム移動
233 層
390 陰極
392 陰極
393 ガス管路
394 管
399 水素の供給部
400 荷電粒子線治療システム
402、404、406 高温-低温支持ストラップ
402 ビーム発生粒子加速器
404 回転式ガントリー
406 患者
408 S2ガラス繊維リンク
408、410 脚部
412、414 軸受
416 鉄骨トラス、トラス構造体
418 治療領域
420 回転範囲
422 床
424 ボールト
432 水平回転軸線
442 垂直軸線
480、482 略平行なスパン
500 ディープレート
502 ダミーディー
503、505 半円形表面
507 空間
507、509 ビーム成形要素
509 ダクト
514 磁気シールド
516 空間
517 強磁性体(例えば、鋼または鉄)の層
525 ビーム形成システム
602 システム
604 シンクロサイクロトロン
605 回転式ガントリー
606 患者支持体
622、624 釣合いおもり
700 適応開口
701 リーフ
704 治療領域
706 配置
707 配置
708 円
711 ビームスポット
713、714、715 キャリッジ
720 トラック
722 ロッド
723 ロッド
725 モータ
726 モータ
730 モータ
731 送りネジ
732 ハウジング
735、736 リーフ
735a リーフ
735b リーフスティック
735c 送りネジナット
735d 送りネジ
735e スラスト軸受アセンブリ
735f 継手
735g モータ
735h 軸受ブロック
735i スリーブ軸受ピン
735j スリーブ軸受
735k モータマウントブロック
750 リーフ
751 シャフト
770 実施例
771 患者
771a ビーム
910 治療システム
912 加速器
914 粒子(例えば、陽子)ビーム
916 走査ユニット
916 散乱ユニット
918 監視ユニット
920 エネルギーデグレーダ
922 身体
922' 身体または身体部分
924 ターゲット容積部
926a~926i 層
928 照射方向
930 ターゲット容積部
932 制御装置
1012 磁石システム
1035、1037 曲線
1300 内部導体
1302 外部導体
1304 電力結合デバイス
1306、1308 可変リアクタンス素子
1310 ブレード
1312 プレート
1314 方向
1316 表面
1400 リーフ
1401 放射線スポット
1402 配置
1420 湾曲したトラック
1421 粒子ビーム
1422 発生源
1422 粒子ビーム
1423 場
1425 配置
1426 配置
1428、1429 リーフ
1431 真っ直ぐな端部(または「前部」)
Claims (34)
- 粒子ビームを出力するための粒子加速器と、
前記粒子加速器のための走査システムであって、前記走査システムが、ビーム場の領域内において粒子ビームを前記走査システムと照射ターゲットとの間で移動させるための磁石を備えており、前記ビーム場が、前記磁石の変更範囲によって定義されている、前記走査システムと、
前記走査システムと前記照射ターゲットとの間に設けられている適応開口であって、前記適応開口が、前記照射ターゲットの治療領域の一部分の形状に近似的な形状を形成するために前記照射ターゲットに対して移動可能とされる構造体を備えており、前記治療領域の一部分が、前記粒子ビームのスポットサイズの領域に基づくサイズを有している、前記適応開口と、
を備えている粒子線治療システムにおいて、
前記適応開口が、
少なくとも1つの二次キャリッジに結合されている一次キャリッジであって、第1の方向に移動可能とされる前記一次キャリッジと、
前記第1の方向とは異なる第2の方向に移動可能とされる二次キャリッジであって、前記二次キャリッジそれぞれが、前記粒子ビームが前記照射ターゲットに到達する前に前記粒子ビームの少なくとも一部分をトリミングするための形状を生成するために、前記粒子ビームが前記ビーム場の領域内において移動する際に前記ビーム場の領域内において移動可能とされる、前記二次キャリッジと、
を備えており、
前記一次キャリッジと前記二次キャリッジとが、前記ビーム場の領域内に前記構造体を位置決めするために前記粒子ビームの移動を辿るように制御可能とされ、
前記構造体が、前記第1の方向及び前記第2の方向それぞれから成る前記ビーム場の全体より小さい領域において前記粒子ビームをブロックしていることを特徴とする粒子線治療システム。 - 前記構造体が、少なくとも部分的に湾曲している形状に近似的な形状を形成するように移動可能である、請求項1に記載の粒子線治療システム。
- 前記適応開口が、前記一次キャリッジの移動を制御するための一次モータを備えていることを特徴とする請求項1に記載の粒子線治療システム。
- 前記適応開口が、前記第2の方向における前記構造体の移動を制御するための1つ以上の二次モータを備えていることを特徴とする請求項3に記載の粒子線治療システム。
- 前記第2の方向における移動が、前記粒子ビームによって治療されるべき領域をブロック又は露出させるための移動とされることを特徴とする請求項1に記載の粒子線治療システム。
- 前記二次キャリッジが、
前記ビーム場の領域内において少なくとも幾つかの前記構造体を移動させるように、前記一次キャリッジに結合されている第1の二次キャリッジと、
前記ビーム場の領域内において少なくとも幾つかの構造体を移動させるように、前記一次キャリッジに結合されている第2の二次キャリッジと、
を備えていることを特徴とする請求項1に記載の粒子線治療システム。 - 少なくとも1つの前記二次キャリッジが、前記一次キャリッジに対して回転可能とされることを特徴とする請求項1に記載の粒子線治療システム。
- 前記適応開口が、前記照射ターゲットに対して回転可能とされることを特徴とする請求項1に記載の粒子線治療システム。
- 少なくとも幾つかの前記構造体が、平坦な縁部を有しており、
前記二次キャリッジが、湾曲しているトラックに取り付けられており、且つ、前記トラックに沿って移動可能とされることを特徴とする請求項1に記載の粒子線治療システム。 - 前記構造体が、リーフを備えており、
少なくとも幾つかの前記リーフが、他の前記リーフの幅とは相違する幅を有していることを特徴とする請求項1に記載の粒子線治療システム。 - 少なくとも幾つかの前記リーフが、他の前記リーフの幅の3倍以上の幅を有していることを特徴とする請求項10に記載の粒子線治療システム。
- 前記リーフが、金属を含んでいることを特徴とする請求項10に記載の粒子線治療システム。
- 前記金属が、ニッケルを含んでいることを特徴とする請求項12に記載の粒子線治療システム。
- 前記リーフが、タングステンを含んでいることを特徴とする請求項10に記載の粒子線治療システム。
- 実行可能な命令を記憶するためのメモリと、
前記構造体の移動を制御することによって前記適応開口を構成するために前記命令を実行するための1つ以上の処理デバイスと、
を備えていることを特徴とする請求項1に記載の粒子線治療システム。 - 前記構造体の前記移動が、前記走査システムの動作に基づいて制御可能とされることを特徴とする請求項15に記載の粒子線治療システム。
- 前記走査システムが、前記照射ターゲットの前記治療領域に亘って前記粒子ビームを複数回移動させるように制御可能とされ、
前記構造体の移動が、前記治療領域の少なくとも一部分に亘る前記粒子ビームの走査それぞれについて、前記構造体によって生成される形状が変化するように制御可能とされることを特徴とする請求項16に記載の粒子線治療システム。 - 前記治療領域に亘る前記粒子ビームの走査それぞれについて、前記構造体が、前記ビーム場の領域内において前記第2の方向に移動可能とされることを特徴とする請求項17に記載の粒子線治療システム。
- 前記治療領域に亘る前記粒子ビームの走査それぞれについて、少なくとも幾つかの前記構造体が、前記ビーム場の領域内において前記第1の方向に移動可能とされることを特徴とする請求項17に記載の粒子線治療システム。
- 前記構造体が、5枚~15枚のリーフを備えていることを特徴とする請求項1に記載の粒子線治療システム。
- 前記粒子加速器が、シンクロサイクロトロンとされ、
前記粒子線治療システムが、前記粒子ビームを位置決めするために少なくとも前記シンクロサイクロトロンを搭載しているガントリーを備えていることを特徴とする請求項1に記載の粒子線治療システム。 - 前記シンクロサイクロトロンが、
粒子源からの粒子を加速するために高周波(RF)電圧を空洞に印加するための電圧源であって、RF電圧を所定の周波数範囲に亘って周期的に掃引するように構成されている前記電圧源と、
複数の値のうち一の値を有している電流を通過させ、前記電流に対応する磁場を発生させるためのコイルであって、前記磁場が、前記電流に対応するエネルギーで前記粒子を前記空洞の内部において軌道に沿って移動させるようになっている、前記コイルと、
前記粒子を前記空洞から受け取り、前記空洞から受け取った前記粒子を前記走査システムに出力するための引き出しチャネルであって、前記粒子が、前記電流に対応するエネルギーを有している、前記空洞からの出力である、前記引き出しチャネルと、
を備えており、
前記シンクロサイクロトロンが、前記電流を前記複数の値のうち一の値に設定することができるように構成されており、前記複数の値それぞれが、異なるエネルギーに対応しており、前記粒子が、前記異なるエネルギーで前記空洞から出力され、
前記電圧源が、異なる周波数範囲に亘って前記RF電圧を掃引するように構成されており、異なる周波数範囲それぞれが、異なるエネルギーに対応しており、前記粒子が、前記異なるエネルギーで前記空洞から出力されることを特徴とする請求項21に記載の粒子線治療システム。 - 前記シンクロサイクロトロンが、
電離プラズマを保持するための粒子源であって、空洞の内部に配設されており、加速領域で分離されている2つの部分を備えている前記粒子源と、
加速領域で前記電離プラズマからの粒子を加速させるために、高周波(RF)電圧を前記空洞に印加するための電圧源であって、RF電圧を所定の周波数範囲に亘って周期的に掃引するように構成されている前記電圧源と、
所定の電流に対応する磁場を発生させるために前記電流を通過させるためのコイルであって、前記磁場が、前記電流に対応するエネルギーで前記粒子を前記空洞の内部において軌道に沿って移動させるようになっており、前記磁場が、前記空洞の中央において少なくとも4テスラである、前記コイルと、
前記空洞に隣接する強磁性体を含んでいる少なくとも1つの磁極片と、
前記空洞から前記粒子を受け取るための、及び、受け取った前記粒子を前記走査システムに出力するための引き出しチャネルと、
を備えており、
前記空洞から出力される前記粒子のエネルギーが、約100MeV~約300MeVの範囲とされることを特徴とする請求項21に記載の粒子線治療システム。 - 前記走査システムが、
走査磁石であって、前記粒子ビームの方向に影響を及ぼすことによって少なくとも2つの方向において前記粒子ビームを移動させるために、前記走査磁石を通過する電流に基づいて制御可能とされる前記走査磁石と、
前記粒子ビームのエネルギーを変化させるためのデグレーダであって、前記粒子加速器に対して前記走査磁石のビーム下流側に位置している前記デグレーダと、
(i)照射ターゲットの少なくとも一部分に亘って前記粒子ビームの途切れのない移動を実現するために、前記走査磁石を通過する電流を制御するための、(ii)前記粒子ビームが前記粒子ビームからの放射線量を送達する位置について、送達された放射線量及び前記位置を識別するための情報を記憶するための、(iii)前記位置に送達された累積放射線量をターゲット累積線量と比較するための、並びに、(iv)前記累積放射線量が特定位置における前記ターゲット累積線量と一致しない場合に、追加の放射線量を前記特定位置に送達するために前記電流を制御するための、制御システムと、
を備えていることを特徴とする請求項1に記載の粒子線治療システム。 - 前記適応開口が、患者特有の開口を模倣するように構成されていることを特徴とする請求項1に記載の粒子線治療システム。
- 前記構造体が、リーフを備えており、
少なくとも幾つかの前記リーフが、他の前記リーフとは異なる形状を有しており、
少なくとも幾つかの前記リーフが、湾曲した形状を有していることを特徴とする請求項1に記載の粒子線治療システム。 - 前記構造体が、平坦な縁部を有しているリーフを備えていることを特徴とする請求項1に記載の粒子線治療システム。
- 前記粒子線治療システムが、前記二次キャリッジの移動経路であるトラックを備えており、
前記トラックが、湾曲していることを特徴とする請求項27に記載の粒子線治療システム。 - 生成可能とされる前記形状が、前記粒子ビームのスポットそれぞれの一部分をトリミングするための形状、又は前記粒子ビームの複数のスポットから成る領域をトリミングするための形状とされることを特徴とする請求項1に記載の粒子線治療システム。
- 前記治療領域の一部分のサイズが、2つのスポットサイズの領域と略同一であることを特徴とする請求項29に記載の粒子線治療システム。
- 前記治療領域の一部分のサイズが、3つのスポットサイズの領域と略同一であることを特徴とする請求項29に記載の粒子線治療システム。
- 前記治療領域の一部分のサイズが、4つのスポットサイズの領域と略同一であることを特徴とする請求項29に記載の粒子線治療システム。
- 前記治療領域の一部分のサイズが、5つのスポットサイズの領域と略同一であることを特徴とする請求項29に記載の粒子線治療システム。
- 前記治療領域の一部分が、前記治療領域の全体未満であることを特徴とする請求項29に記載の粒子線治療システム。
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JP2022118114A (ja) | 2022-08-12 |
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CN108883295A (zh) | 2018-11-23 |
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