PL2456444T3 - Pochodne adeniny jako inhibitory PI3K - Google Patents

Pochodne adeniny jako inhibitory PI3K

Info

Publication number
PL2456444T3
PL2456444T3 PL10800175T PL10800175T PL2456444T3 PL 2456444 T3 PL2456444 T3 PL 2456444T3 PL 10800175 T PL10800175 T PL 10800175T PL 10800175 T PL10800175 T PL 10800175T PL 2456444 T3 PL2456444 T3 PL 2456444T3
Authority
PL
Poland
Prior art keywords
pi3k inhibitor
adenine derivative
adenine
derivative
pi3k
Prior art date
Application number
PL10800175T
Other languages
English (en)
Inventor
Pingda Ren
Yi Liu
Troy Edward Wilson
Liansheng Li
Katrina Chan
Christian Rommel
Original Assignee
Intellikine Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intellikine Llc filed Critical Intellikine Llc
Publication of PL2456444T3 publication Critical patent/PL2456444T3/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
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    • A61K31/13—Amines
    • A61K31/131—Amines acyclic
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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  • Pharmacology & Pharmacy (AREA)
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PL10800175T 2009-07-15 2010-07-15 Pochodne adeniny jako inhibitory PI3K PL2456444T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/503,776 US8193182B2 (en) 2008-01-04 2009-07-15 Substituted isoquinolin-1(2H)-ones, and methods of use thereof
EP10800175.1A EP2456444B1 (en) 2009-07-15 2010-07-15 Adenine derivative as pi3k inhibitor
PCT/US2010/002020 WO2011008302A1 (en) 2009-07-15 2010-07-15 Certain chemical entities, compositions and methods

Publications (1)

Publication Number Publication Date
PL2456444T3 true PL2456444T3 (pl) 2015-08-31

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Application Number Title Priority Date Filing Date
PL10800175T PL2456444T3 (pl) 2009-07-15 2010-07-15 Pochodne adeniny jako inhibitory PI3K

Country Status (31)

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US (12) US8193182B2 (pl)
EP (4) EP3150609B1 (pl)
JP (2) JP5944313B2 (pl)
KR (1) KR101680406B1 (pl)
CN (3) CN109912599B (pl)
AU (1) AU2010274075B2 (pl)
BR (1) BR112012000968B8 (pl)
CA (1) CA2768307C (pl)
CY (1) CY1116424T1 (pl)
DK (1) DK2456444T3 (pl)
ES (1) ES2538853T3 (pl)
HK (2) HK1170491A1 (pl)
HR (1) HRP20150586T1 (pl)
HU (1) HUS2100048I1 (pl)
IL (2) IL217181A (pl)
IN (1) IN2012DN00943A (pl)
LT (1) LTPA2021526I1 (pl)
MX (2) MX2012000626A (pl)
MY (2) MY168762A (pl)
NL (1) NL301140I2 (pl)
NZ (3) NZ597595A (pl)
PH (2) PH12015502432A1 (pl)
PL (1) PL2456444T3 (pl)
PT (1) PT2456444E (pl)
RU (2) RU2746319C2 (pl)
SG (2) SG10201503886WA (pl)
SI (1) SI2456444T1 (pl)
SM (1) SMT201500141B (pl)
UA (2) UA109878C2 (pl)
WO (1) WO2011008302A1 (pl)
ZA (1) ZA201200254B (pl)

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Publication number Priority date Publication date Assignee Title
EP1583562B1 (en) * 2003-01-06 2011-06-15 Angiochem Inc. Angiopep-1, related compounds, and uses thereof
WO2006068760A2 (en) 2004-11-19 2006-06-29 The Regents Of The University Of California Anti-inflammatory pyrazolopyrimidines
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