MX2019010709A - BICYCLE HETEROCYCLES AS INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTORS (FGFR). - Google Patents

BICYCLE HETEROCYCLES AS INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTORS (FGFR).

Info

Publication number
MX2019010709A
MX2019010709A MX2019010709A MX2019010709A MX2019010709A MX 2019010709 A MX2019010709 A MX 2019010709A MX 2019010709 A MX2019010709 A MX 2019010709A MX 2019010709 A MX2019010709 A MX 2019010709A MX 2019010709 A MX2019010709 A MX 2019010709A
Authority
MX
Mexico
Prior art keywords
bicyclic heterocycles
fgfr inhibitors
fgfr
inhibitors
heterocycles
Prior art date
Application number
MX2019010709A
Other languages
English (en)
Inventor
Zhuo Jincong
He Chunhong
Sun Yaping
Lu Liang
Qian Ding-Quan
Xu Meizhong
Zhang Fenglei
Wu Liangxing
Yao Wenqing
Original Assignee
Incyte Holdings Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201361813782P priority Critical
Application filed by Incyte Holdings Corp filed Critical Incyte Holdings Corp
Publication of MX2019010709A publication Critical patent/MX2019010709A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Abstract

La presente invención se refiere a heterociclos bicíclicos y composiciones farmacéuticas de estos, que son inhibidores de una o más enzimas del FGFR y son útiles en el tratamiento de enfermedades relacionadas con el FGFR, como el cáncer.The present invention relates to bicyclic heterocycles and pharmaceutical compositions thereof, which are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-related diseases, such as cancer.
MX2019010709A 2013-04-19 2015-10-19 BICYCLE HETEROCYCLES AS INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTORS (FGFR). MX2019010709A (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US201361813782P true 2013-04-19 2013-04-19

Publications (1)

Publication Number Publication Date
MX2019010709A true MX2019010709A (es) 2019-10-21

Family

ID=50983108

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015014683A MX367878B (es) 2013-04-19 2014-04-18 BICYCLIC HETEROCYCLES AS INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTORS (FGFR).
MX2019010709A MX2019010709A (es) 2013-04-19 2015-10-19 BICYCLE HETEROCYCLES AS INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTORS (FGFR).

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015014683A MX367878B (es) 2013-04-19 2014-04-18 BICYCLIC HETEROCYCLES AS INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTORS (FGFR).

Country Status (35)

Country Link
US (4) US9533984B2 (es)
EP (2) EP2986610B9 (es)
JP (3) JP6449244B2 (es)
KR (1) KR20150143707A (es)
CN (3) CN105263931B (es)
AR (1) AR096097A1 (es)
AU (3) AU2014253798C1 (es)
BR (1) BR112015026307A2 (es)
CA (1) CA2909207A1 (es)
CL (1) CL2015003089A1 (es)
CR (1) CR20150578A (es)
CY (1) CY1120556T1 (es)
DK (1) DK2986610T5 (es)
EA (2) EA035095B1 (es)
EC (1) ECSP15048555A (es)
ES (1) ES2657451T3 (es)
HK (2) HK1255159A1 (es)
HR (1) HRP20180365T2 (es)
HU (1) HUE036571T2 (es)
IL (1) IL262038D0 (es)
LT (1) LT2986610T (es)
ME (1) ME03015B (es)
MX (2) MX367878B (es)
NO (1) NO3087075T3 (es)
NZ (2) NZ752422A (es)
PE (1) PE20152033A1 (es)
PH (1) PH12015502383A1 (es)
PL (1) PL2986610T4 (es)
PT (1) PT2986610T (es)
RS (1) RS56924B9 (es)
SG (2) SG10201708520YA (es)
SI (1) SI2986610T1 (es)
TW (2) TWI649318B (es)
UA (1) UA120087C2 (es)
WO (1) WO2014172644A2 (es)

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