AU6908398A - Fused 2,4-pyrimidinedione combinatorial libraries and biologically active fused 2,4-pyramidinediones - Google Patents

Fused 2,4-pyrimidinedione combinatorial libraries and biologically active fused 2,4-pyramidinediones

Info

Publication number
AU6908398A
AU6908398A AU69083/98A AU6908398A AU6908398A AU 6908398 A AU6908398 A AU 6908398A AU 69083/98 A AU69083/98 A AU 69083/98A AU 6908398 A AU6908398 A AU 6908398A AU 6908398 A AU6908398 A AU 6908398A
Authority
AU
Australia
Prior art keywords
fused
pyramidinediones
pyrimidinedione
biologically active
combinatorial libraries
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU69083/98A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vicuron Pharmaceuticals LLC
Original Assignee
Versicor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/740,103 external-priority patent/US6025371A/en
Priority claimed from US08/795,189 external-priority patent/US6413724B1/en
Application filed by Versicor Inc filed Critical Versicor Inc
Publication of AU6908398A publication Critical patent/AU6908398A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU69083/98A 1996-10-28 1997-10-27 Fused 2,4-pyrimidinedione combinatorial libraries and biologically active fused 2,4-pyramidinediones Abandoned AU6908398A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US08/740103 1996-10-28
US08/740,103 US6025371A (en) 1996-10-28 1996-10-28 Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones
US08/795189 1997-02-04
US08/795,189 US6413724B1 (en) 1996-10-28 1997-02-04 Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones
US81612097A 1997-03-11 1997-03-11
US08/816120 1997-03-11
PCT/US1997/019483 WO1998018781A2 (en) 1996-10-28 1997-10-27 Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents

Publications (1)

Publication Number Publication Date
AU6908398A true AU6908398A (en) 1998-05-22

Family

ID=27419256

Family Applications (1)

Application Number Title Priority Date Filing Date
AU69083/98A Abandoned AU6908398A (en) 1996-10-28 1997-10-27 Fused 2,4-pyrimidinedione combinatorial libraries and biologically active fused 2,4-pyramidinediones

Country Status (2)

Country Link
AU (1) AU6908398A (en)
WO (1) WO1998018781A2 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
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DE19724983A1 (en) * 1997-06-13 1998-12-17 Basf Ag Process for the preparation of quinazoline dions on solid phase and their use
FR2784379B1 (en) * 1998-10-07 2000-11-17 Synthelabo QUINAZOLINEDIONE DERIVATIVES, THEIR PREPARATIONS AND THERAPEUTIC APPLICATIONS
AR026748A1 (en) 1999-12-08 2003-02-26 Vertex Pharma A CASPASE INHIBITING COMPOUND, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, A METHOD FOR THE SYNTHESIS OF THE SAME AND AN INTERMEDIATE COMPOUND PARADICHA SYNTHESIS
WO2001044228A2 (en) * 1999-12-14 2001-06-21 Sanofi-Synthelabo Derivatives of quinazolinedione phthalimide, preparations thereof and their therapeutic uses
KR20020067701A (en) 2000-01-24 2002-08-23 워너-램버트 캄파니 3-aminoquinazolin-2,4-dione antibacterial agents
JP2004532876A (en) 2001-05-30 2004-10-28 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー Antibacterial agent
BR0210028A (en) * 2001-06-19 2004-06-22 Warner Lambert Co Antibacterial agents
JP4616643B2 (en) 2002-06-28 2011-01-19 バーテックス ファーマシューティカルズ インコーポレイテッド Caspase inhibitors and their uses
GB0223730D0 (en) * 2002-10-11 2002-11-20 Novartis Ag Organic compounds
US7612091B2 (en) 2002-12-20 2009-11-03 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
AU2003300114B9 (en) * 2002-12-31 2009-11-26 Vertex Pharmaceuticals Incorporated Inhibitors of phosphatases
US7439249B2 (en) 2002-12-31 2008-10-21 Vertex Pharmaceuticals Incorporated Inhibitors of phosphatases
PE20050159A1 (en) 2003-05-27 2005-04-19 Vertex Pharma DERIVATIVES OF 3- [2- (3-AMINO-2-OXO-2H-PYRIDIN-1-IL) -ACETILAMINO] -4-OXO-PENTANOICO AS CASPASE INHIBITORS
JP4533391B2 (en) 2004-01-16 2010-09-01 エフ．ホフマン−ラ ロシュ アーゲー 1-Benzyl-5-piperazin-1-yl-3,4-dihydro-1H-quinazolin-2-one derivatives as modulators of 5-hydroxytryptamine receptor (5-HT) for the treatment of central nervous system diseases And the respective 1H-benzo (1,2,6) thiadiazin-2,2-dioxide and 1,4-dihydrobenzo (D) (1,3) oxazin-2-one derivatives
GB0412769D0 (en) 2004-06-08 2004-07-07 Novartis Ag Organic compounds
US20090221056A1 (en) 2005-11-30 2009-09-03 Petrovick Martha S Pathogen-Detecting Cell Preservation Systems
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
CN107383009B (en) 2012-06-13 2020-06-09 因塞特控股公司 Substituted tricyclic compounds as FGFR inhibitors
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
SG11201508328PA (en) 2013-04-19 2015-11-27 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (en) 2015-02-20 2017-12-26 Incyte Corp BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS
CN107438607B (en) 2015-02-20 2021-02-05 因赛特公司 Bicyclic heterocycles as FGFR inhibitors
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
AR111960A1 (en) 2017-05-26 2019-09-04 Incyte Corp CRYSTALLINE FORMS OF A FGFR INHIBITOR AND PROCESSES FOR ITS PREPARATION
CA3099116A1 (en) 2018-05-04 2019-11-07 Incyte Corporation Salts of an fgfr inhibitor
AU2019262195B2 (en) 2018-05-04 2024-09-12 Incyte Corporation Solid forms of an FGFR inhibitor and processes for preparing the same
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
JP2022552324A (en) 2019-10-14 2022-12-15 インサイト・コーポレイション Bicyclic heterocycles as FGFR inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CA3163875A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
KR20220131900A (en) 2019-12-04 2022-09-29 인사이트 코포레이션 Derivatives of FGFR inhibitors
WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CN116783181A (en) * 2021-04-12 2023-09-19 上海瑛派药业有限公司 Substituted fused bicyclic compounds as PARP inhibitors and use thereof
US12065494B2 (en) 2021-04-12 2024-08-20 Incyte Corporation Combination therapy comprising an FGFR inhibitor and a Nectin-4 targeting agent
JP2024522189A (en) 2021-06-09 2024-06-11 インサイト・コーポレイション Tricyclic Heterocycles as FGFR Inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3228871A1 (en) * 1982-08-03 1984-02-09 Bayer Ag, 5090 Leverkusen OXOCHINAZOLIN-CARBAMINE ACID ESTER
JPH02225485A (en) * 1989-02-27 1990-09-07 Taiho Yakuhin Kogyo Kk Thienopyrimidine-3-acetic acid derivative
TW276256B (en) * 1993-08-26 1996-05-21 Takeda Pharm Industry Co Ltd
UY23948A1 (en) * 1995-02-08 2001-10-25 Takeda Chemical Industries Ltd DERIVATIVES FROM THYPHENE CONDENSED RINGS, THEIR PRODUCTION AND USE.

Also Published As

Publication number Publication date
WO1998018781A2 (en) 1998-05-07
WO1998018781A3 (en) 1998-06-11

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