WO1998018781A3 - Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents - Google Patents

Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents Download PDF

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Publication number
WO1998018781A3
WO1998018781A3 PCT/US1997/019483 US9719483W WO9818781A3 WO 1998018781 A3 WO1998018781 A3 WO 1998018781A3 US 9719483 W US9719483 W US 9719483W WO 9818781 A3 WO9818781 A3 WO 9818781A3
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WO
WIPO (PCT)
Prior art keywords
fused
pyrimidinediones
pyrimidinedione
derivatives
preparation
Prior art date
Application number
PCT/US1997/019483
Other languages
French (fr)
Other versions
WO1998018781A2 (en
WO1998018781A9 (en
Inventor
Mikhail Gordeev
Dinesh Patesh
Original Assignee
Versicor Inc
Mikhail Gordeev
Patel Dinesh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/740,103 external-priority patent/US6025371A/en
Priority claimed from US08/795,189 external-priority patent/US6413724B1/en
Application filed by Versicor Inc, Mikhail Gordeev, Patel Dinesh filed Critical Versicor Inc
Priority to AU69083/98A priority Critical patent/AU6908398A/en
Publication of WO1998018781A2 publication Critical patent/WO1998018781A2/en
Publication of WO1998018781A3 publication Critical patent/WO1998018781A3/en
Publication of WO1998018781A9 publication Critical patent/WO1998018781A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The invention provides chemistry libraries containing fused 2,4-pyrimidinediones. The invention also provides methods for the construction of fused 2,4-pyrimidinedione containing libraries. The invention further provides methods for the identification of bioactive, fused 2,4-pyrimidinediones from those libraries. The invention is still further directed to bioactive fused 2,4-pyrimidinediones.
PCT/US1997/019483 1996-10-28 1997-10-27 Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents WO1998018781A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU69083/98A AU6908398A (en) 1996-10-28 1997-10-27 Fused 2,4-pyrimidinedione combinatorial libraries and biologically active fused 2,4-pyramidinediones

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US08/740,103 US6025371A (en) 1996-10-28 1996-10-28 Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones
US08/740,103 1996-10-28
US08/795,189 1997-02-04
US08/795,189 US6413724B1 (en) 1996-10-28 1997-02-04 Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones
US81612097A 1997-03-11 1997-03-11
US08/816,120 1997-03-11

Publications (3)

Publication Number Publication Date
WO1998018781A2 WO1998018781A2 (en) 1998-05-07
WO1998018781A3 true WO1998018781A3 (en) 1998-06-11
WO1998018781A9 WO1998018781A9 (en) 1998-08-20

Family

ID=27419256

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/019483 WO1998018781A2 (en) 1996-10-28 1997-10-27 Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents

Country Status (2)

Country Link
AU (1) AU6908398A (en)
WO (1) WO1998018781A2 (en)

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US9533984B2 (en) 2013-04-19 2017-01-03 Incyte Holdings Corporation Bicyclic heterocycles as FGFR inhibitors
US9533954B2 (en) 2010-12-22 2017-01-03 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors

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DE19724983A1 (en) * 1997-06-13 1998-12-17 Basf Ag Process for the preparation of quinazoline dions on solid phase and their use
FR2784379B1 (en) * 1998-10-07 2000-11-17 Synthelabo QUINAZOLINEDIONE DERIVATIVES, THEIR PREPARATIONS AND THERAPEUTIC APPLICATIONS
AR026748A1 (en) 1999-12-08 2003-02-26 Vertex Pharma A CASPASE INHIBITING COMPOUND, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, A METHOD FOR THE SYNTHESIS OF THE SAME AND AN INTERMEDIATE COMPOUND PARADICHA SYNTHESIS
WO2001044228A2 (en) * 1999-12-14 2001-06-21 Sanofi-Synthelabo Derivatives of quinazolinedione phthalimide, preparations thereof and their therapeutic uses
US7094780B1 (en) 2000-01-24 2006-08-22 Warner Lambert Company Llc 3-aminoquinazolin-2,4-dione antibacterial agents
DE60208541D1 (en) 2001-05-30 2006-03-30 Warner Lambert Co ANTIBACTERIAL AGENTS
BR0210028A (en) * 2001-06-19 2004-06-22 Warner Lambert Co Antibacterial agents
JP4616643B2 (en) 2002-06-28 2011-01-19 バーテックス ファーマシューティカルズ インコーポレイテッド Caspase inhibitors and their uses
GB0223730D0 (en) * 2002-10-11 2002-11-20 Novartis Ag Organic compounds
AU2003303345A1 (en) 2002-12-20 2004-07-22 Vertex Pharmaceuticals, Inc. 4-oxo-3-(1-oxo-1h-isoquinolin-2-ylacetylamino)-pentanoic acid ester and amide derivatives and their use as caspase inhibitors
AU2003300114B9 (en) * 2002-12-31 2009-11-26 Vertex Pharmaceuticals Incorporated Inhibitors of phosphatases
US7439249B2 (en) 2002-12-31 2008-10-21 Vertex Pharmaceuticals Incorporated Inhibitors of phosphatases
PE20050159A1 (en) 2003-05-27 2005-04-19 Vertex Pharma DERIVATIVES OF 3- [2- (3-AMINO-2-OXO-2H-PYRIDIN-1-IL) -ACETILAMINO] -4-OXO-PENTANOICO AS CASPASE INHIBITORS
JP4533391B2 (en) 2004-01-16 2010-09-01 エフ．ホフマン−ラ ロシュ アーゲー 1-Benzyl-5-piperazin-1-yl-3,4-dihydro-1H-quinazolin-2-one derivatives as modulators of 5-hydroxytryptamine receptor (5-HT) for the treatment of central nervous system diseases And the respective 1H-benzo (1,2,6) thiadiazin-2,2-dioxide and 1,4-dihydrobenzo (D) (1,3) oxazin-2-one derivatives
GB0412769D0 (en) 2004-06-08 2004-07-07 Novartis Ag Organic compounds
BRPI0619235A2 (en) 2005-11-30 2011-09-20 Massachusetts Inst Technology methods for cell preservation and emitting cell
KR102406771B1 (en) 2012-06-13 2022-06-13 인사이트 홀딩스 코포레이션 Substituted tricyclic compounds as fgfr inhibitors
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (en) 2015-02-20 2017-12-26 Incyte Corp BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS
ES2751669T3 (en) 2015-02-20 2020-04-01 Incyte Corp Bicyclic heterocycles as FGFR inhibitors
AR111960A1 (en) 2017-05-26 2019-09-04 Incyte Corp CRYSTALLINE FORMS OF A FGFR INHIBITOR AND PROCESSES FOR ITS PREPARATION
MA52493A (en) 2018-05-04 2021-03-10 Incyte Corp FGFR INHIBITOR SALTS
DK3788047T3 (en) 2018-05-04 2024-09-16 Incyte Corp Solid forms of an FGFR inhibitor and methods of making the same
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
WO2021076602A1 (en) 2019-10-14 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CN115151539A (en) 2019-12-04 2022-10-04 因赛特公司 Derivatives of FGFR inhibitors
CA3163875A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
JP2024513575A (en) 2021-04-12 2024-03-26 インサイト・コーポレイション Combination therapy including FGFR inhibitor and Nectin-4 targeting agent
EP4326713A1 (en) * 2021-04-12 2024-02-28 Impact Therapeutics (Shanghai), Inc. Substituted fused bicyclic compounds as parp inhibitors and the use thereof
CA3220274A1 (en) 2021-06-09 2022-12-15 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors

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JPH02225485A (en) * 1989-02-27 1990-09-07 Taiho Yakuhin Kogyo Kk Thienopyrimidine-3-acetic acid derivative
EP0640606A1 (en) * 1993-08-26 1995-03-01 Takeda Chemical Industries, Ltd. Thienopyrimidine derivatives, their production and use
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US4521420A (en) * 1982-08-03 1985-06-04 Bayer Aktiengesellschaft Oxoquinazoline carbamates
JPH02225485A (en) * 1989-02-27 1990-09-07 Taiho Yakuhin Kogyo Kk Thienopyrimidine-3-acetic acid derivative
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9533954B2 (en) 2010-12-22 2017-01-03 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
US9533984B2 (en) 2013-04-19 2017-01-03 Incyte Holdings Corporation Bicyclic heterocycles as FGFR inhibitors
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors

Also Published As

Publication number Publication date
WO1998018781A2 (en) 1998-05-07
AU6908398A (en) 1998-05-22

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