ES2569780T3 - Células posparto derivadas de tejido placentario y métodos de preparación y uso de las mismas - Google Patents
Células posparto derivadas de tejido placentario y métodos de preparación y uso de las mismas Download PDFInfo
- Publication number
- ES2569780T3 ES2569780T3 ES10184796.0T ES10184796T ES2569780T3 ES 2569780 T3 ES2569780 T3 ES 2569780T3 ES 10184796 T ES10184796 T ES 10184796T ES 2569780 T3 ES2569780 T3 ES 2569780T3
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- Prior art keywords
- cells
- cells derived
- preparation
- methods
- placental tissue
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 210000005059 placental tissue Anatomy 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 4
- 238000000684 flow cytometry Methods 0.000 abstract 2
- 210000002826 placenta Anatomy 0.000 abstract 2
- 102100022464 5'-nucleotidase Human genes 0.000 abstract 1
- 102100022749 Aminopeptidase N Human genes 0.000 abstract 1
- 108090000145 Bacillolysin Proteins 0.000 abstract 1
- 102100032912 CD44 antigen Human genes 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 abstract 1
- 108010075704 HLA-A Antigens Proteins 0.000 abstract 1
- 102000006354 HLA-DR Antigens Human genes 0.000 abstract 1
- 108010058597 HLA-DR Antigens Proteins 0.000 abstract 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 abstract 1
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 abstract 1
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 abstract 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 abstract 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 abstract 1
- 101001008874 Homo sapiens Mast/stem cell growth factor receptor Kit Proteins 0.000 abstract 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 abstract 1
- 101000763314 Homo sapiens Thrombomodulin Proteins 0.000 abstract 1
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 abstract 1
- 102000009571 Macrophage Inflammatory Proteins Human genes 0.000 abstract 1
- 108010009474 Macrophage Inflammatory Proteins Proteins 0.000 abstract 1
- 102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 108090000028 Neprilysin Proteins 0.000 abstract 1
- 102000003729 Neprilysin Human genes 0.000 abstract 1
- 102000035092 Neutral proteases Human genes 0.000 abstract 1
- 108091005507 Neutral proteases Proteins 0.000 abstract 1
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 abstract 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 abstract 1
- 102100026966 Thrombomodulin Human genes 0.000 abstract 1
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 abstract 1
- 230000006862 enzymatic digestion Effects 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 230000000510 mucolytic effect Effects 0.000 abstract 1
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Abstract
Población homogénea aislada de células derivadas de la placenta humana que pueden obtenerse mediante digestión enzimática con una metaloproteasa de matriz, una proteasa neutra y una enzima mucolítica de placenta humana exenta de sangre, y en la que dicha población de células es capaz de autorrenovación y expansión en cultivo, tiene el potencial de diferenciarse a células de otros fenotipos, y en la que las células: (a) producen cada uno de CD10, CD13, CD44, CD73, CD90, PDGFr-alfa y HLA-A,B,C, detectado mediante citometría de flujo; (b) no producen CD31, CD34, CD45, CD117, CD141 ni HLA-DR,DP,DQ, detectado mediante citometría de flujo; y (c) secretan la proteína inflamatoria de macrófagos 1 alfa (MIP1a).
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ES10184221.9T Expired - Lifetime ES2541604T3 (es) | 2003-06-27 | 2004-06-25 | Reparación y regeneración de tejido ocular usando células derivadas del cordón umbilical post parto |
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ES04809466.8T Expired - Lifetime ES2565582T3 (es) | 2003-06-27 | 2004-06-25 | Reparación y regeneración de cartílago y hueso utilizando células derivadas posparto |
ES10184137.7T Expired - Lifetime ES2542069T3 (es) | 2003-06-27 | 2004-06-25 | Regeneración y reparación de tejido neural usando células del postparto derivadas del cordón umbilical |
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ES04777287.6T Expired - Lifetime ES2564045T3 (es) | 2003-06-27 | 2004-06-25 | Células derivadas del post-parto para su uso en el tratamiento de enfermedad del corazón y el sistema circulatorio |
ES10184221.9T Expired - Lifetime ES2541604T3 (es) | 2003-06-27 | 2004-06-25 | Reparación y regeneración de tejido ocular usando células derivadas del cordón umbilical post parto |
ES04777231.4T Expired - Lifetime ES2597837T3 (es) | 2003-06-27 | 2004-06-25 | Células posparto derivadas de tejido de la placenta, y métodos de fabricación y utilización de los mismos |
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ES10183053.7T Expired - Lifetime ES2550267T3 (es) | 2003-06-27 | 2004-06-25 | Células derivadas de cordón umbilical post-parto para su uso en el tratamiento de enfermedad del corazón y el sistema circulatorio |
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