ATE520025T1 - Test für morbus-parkinson-therapeutika - Google Patents
Test für morbus-parkinson-therapeutikaInfo
- Publication number
- ATE520025T1 ATE520025T1 AT06848996T AT06848996T ATE520025T1 AT E520025 T1 ATE520025 T1 AT E520025T1 AT 06848996 T AT06848996 T AT 06848996T AT 06848996 T AT06848996 T AT 06848996T AT E520025 T1 ATE520025 T1 AT E520025T1
- Authority
- AT
- Austria
- Prior art keywords
- parkinson
- test
- parkin
- disease therapeutics
- disease
- Prior art date
Links
- 208000018737 Parkinson disease Diseases 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 108700007244 parkin Proteins 0.000 abstract 3
- 102000045222 parkin Human genes 0.000 abstract 3
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 abstract 1
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 238000000423 cell based assay Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000009465 prokaryotic expression Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74996405P | 2005-12-12 | 2005-12-12 | |
| PCT/US2006/047515 WO2007089334A2 (en) | 2005-12-12 | 2006-12-12 | Assay for parkinson's disease therapeutics and enzymatically active parkin preparations useful therein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE520025T1 true ATE520025T1 (de) | 2011-08-15 |
Family
ID=38179819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06848996T ATE520025T1 (de) | 2005-12-12 | 2006-12-12 | Test für morbus-parkinson-therapeutika |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20090317825A1 (de) |
| EP (1) | EP1969367B1 (de) |
| JP (1) | JP2009519040A (de) |
| AT (1) | ATE520025T1 (de) |
| CA (1) | CA2632657A1 (de) |
| WO (1) | WO2007089334A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8017348B1 (en) | 2005-12-12 | 2011-09-13 | Elan Pharma International Limited | Assay for Parkinson's Disease therapeutics |
| WO2007089334A2 (en) * | 2005-12-12 | 2007-08-09 | Elan Pharmaceuticals, Inc. | Assay for parkinson's disease therapeutics and enzymatically active parkin preparations useful therein |
| AR067182A1 (es) | 2007-06-29 | 2009-09-30 | Gilead Sciences Inc | Moduladores del receptor 7 tipo toll |
| US20090226946A1 (en) * | 2008-01-31 | 2009-09-10 | Elan Pharmaceuticals, Inc. | Thermal Denaturation Screening Assay to Identify Candidate Compounds for Prevention and Treatment of Parkinson's Disease |
| EP2318538A4 (de) * | 2008-07-25 | 2012-03-14 | Progenra Inc | Verfahren zur identifizierung von ubiquitin-ligase-modulatoren |
| ES2418459B1 (es) * | 2008-10-09 | 2014-08-12 | Universitat Autònoma De Barcelona | Relacionando agregación proteica con supervivencia de levadura |
| CN102272134B (zh) | 2008-12-09 | 2013-10-16 | 吉里德科学公司 | Toll样受体调节剂 |
| AU2010310813B2 (en) | 2009-10-22 | 2015-06-18 | Gilead Sciences, Inc. | Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections |
| JP6522732B2 (ja) | 2014-07-11 | 2019-05-29 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖを治療するためのトール様受容体の調節因子 |
| JP2017526730A (ja) | 2014-09-16 | 2017-09-14 | ギリアード サイエンシーズ， インコーポレイテッド | Ｔｏｌｌ様受容体モジュレーターの固体形態 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5925323A (ja) * | 1982-03-03 | 1984-02-09 | 鐘淵化学工業株式会社 | プテリン誘導体からなる脳内神経伝達物質の関わる疾病の治療剤 |
| US20050042607A1 (en) * | 2000-02-24 | 2005-02-24 | Yoshikuni Mizuno | Parkin protein as ubiquitin ligase |
| WO2002079459A2 (en) * | 2001-03-29 | 2002-10-10 | Nsgene A/S | Means for inhibiting proteolytical processing of parkin |
| JP2003018992A (ja) * | 2001-06-28 | 2003-01-21 | Inst Of Physical & Chemical Res | Ｐａｅｌ受容体、Ｐａｅｌ受容体発現細胞および動物、ならびにパーキンソン病治療薬のスクリーニング法 |
| US7070940B2 (en) * | 2002-07-18 | 2006-07-04 | Aventis Pharma S.A. | Method for determining the ability of a compound to modify the interaction between parkin and the p38 protein |
| US20060159681A1 (en) * | 2004-12-14 | 2006-07-20 | Functional Neuroscience Inc. | Compositions and methods to inhibit cell loss by using inhibitors of BAG |
| WO2007089334A2 (en) * | 2005-12-12 | 2007-08-09 | Elan Pharmaceuticals, Inc. | Assay for parkinson's disease therapeutics and enzymatically active parkin preparations useful therein |
-
2006
- 2006-12-12 WO PCT/US2006/047515 patent/WO2007089334A2/en active Application Filing
- 2006-12-12 EP EP06848996A patent/EP1969367B1/de active Active
- 2006-12-12 AT AT06848996T patent/ATE520025T1/de not_active IP Right Cessation
- 2006-12-12 CA CA002632657A patent/CA2632657A1/en not_active Abandoned
- 2006-12-12 JP JP2008545762A patent/JP2009519040A/ja active Pending
- 2006-12-12 US US12/096,890 patent/US20090317825A1/en not_active Abandoned
- 2006-12-12 US US11/638,242 patent/US20070212679A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2632657A1 (en) | 2007-08-09 |
| WO2007089334A2 (en) | 2007-08-09 |
| WO2007089334A3 (en) | 2008-01-10 |
| US20090317825A1 (en) | 2009-12-24 |
| JP2009519040A (ja) | 2009-05-14 |
| US20070212679A1 (en) | 2007-09-13 |
| EP1969367B1 (de) | 2011-08-10 |
| EP1969367A2 (de) | 2008-09-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |