MA29836B1 - Proteines de fusion avec l'albumine - Google Patents
Proteines de fusion avec l'albumineInfo
- Publication number
- MA29836B1 MA29836B1 MA30727A MA30727A MA29836B1 MA 29836 B1 MA29836 B1 MA 29836B1 MA 30727 A MA30727 A MA 30727A MA 30727 A MA30727 A MA 30727A MA 29836 B1 MA29836 B1 MA 29836B1
- Authority
- MA
- Morocco
- Prior art keywords
- fusion proteins
- albumin fusion
- albumin
- vectors
- host cells
- Prior art date
Links
- 102000009027 Albumins Human genes 0.000 title abstract 6
- 108010088751 Albumins Proteins 0.000 title abstract 6
- 102000037865 fusion proteins Human genes 0.000 title abstract 6
- 108020001507 fusion proteins Proteins 0.000 title abstract 6
- 102000039446 nucleic acids Human genes 0.000 abstract 4
- 108020004707 nucleic acids Proteins 0.000 abstract 4
- 150000007523 nucleic acids Chemical class 0.000 abstract 4
- 239000013598 vector Substances 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
La présente invention englobe des protéines de fusion d'albumine. Les molécules d'acides nucléiques codant pour les protéines de fusion d'albumine de l'invention sont également englobées par l'invention, de même que les vecteurs contenant ces acides nucléiques, les cellules hôtes transformées avec ces vecteurs d'acides nucléiques, et les procédés de fabrication des protéines de fusion d'albumine de l'invention et utilisant ces acides nucléiques, vecteurs, et/ou cellules hôtes. De plus, la présente invention comprend des compositions pharmaceutiques comprenant les protéines de fusion d'albumine et les procédés de traitement, de prévention, ou d'amélioration de maladies, troubles pathologies utilisant les protéines de fusion d'albumine de l'invention.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70752105P | 2005-08-12 | 2005-08-12 | |
US71238605P | 2005-08-31 | 2005-08-31 | |
US73272405P | 2005-11-03 | 2005-11-03 | |
US77691406P | 2006-02-28 | 2006-02-28 | |
US78136106P | 2006-03-13 | 2006-03-13 | |
US81018206P | 2006-06-02 | 2006-06-02 | |
US81368206P | 2006-06-15 | 2006-06-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA29836B1 true MA29836B1 (fr) | 2008-10-03 |
Family
ID=37758042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA30727A MA29836B1 (fr) | 2005-08-12 | 2008-03-07 | Proteines de fusion avec l'albumine |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1924596A4 (fr) |
JP (1) | JP2009504157A (fr) |
KR (1) | KR20080071119A (fr) |
AU (1) | AU2006280312A1 (fr) |
BR (1) | BRPI0614761A2 (fr) |
CA (1) | CA2618476A1 (fr) |
EC (1) | ECSP088262A (fr) |
IL (1) | IL189246A0 (fr) |
MA (1) | MA29836B1 (fr) |
MX (1) | MX2008001865A (fr) |
NO (1) | NO20081233L (fr) |
TN (1) | TNSN08064A1 (fr) |
WO (1) | WO2007021494A2 (fr) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
EP1276849A4 (fr) | 2000-04-12 | 2004-06-09 | Human Genome Sciences Inc | Proteines fusionnees a de l'albumine |
US20080194481A1 (en) | 2001-12-21 | 2008-08-14 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
EP2277889B1 (fr) | 2001-12-21 | 2014-07-09 | Human Genome Sciences, Inc. | Protéines chimériques d'albumine et interféron beta |
BRPI0507026A (pt) | 2004-02-09 | 2007-04-17 | Human Genome Sciences Inc | proteìnas de fusão de albumina |
EP1816201A1 (fr) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Facteur de coagulation VIIa modifié ayant une stabilité 'half-life' améliorée |
AU2007258609B2 (en) * | 2006-06-07 | 2013-01-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP2068905A4 (fr) * | 2006-09-14 | 2009-12-30 | Human Genome Sciences Inc | Protéines de fusion d'albumine |
US7884184B2 (en) | 2007-01-30 | 2011-02-08 | Epivax, Inc. | Regulatory T cell epitopes, compositions and uses thereof |
JP5685529B2 (ja) | 2008-06-13 | 2015-03-18 | プロイェクト、デ、ビオメディシナ、シーマ、ソシエダッド、リミターダProyecto De Biomedicina Cima, S.L. | 生物学的活性を有する化合物の投与のための複合体 |
EP2387420A2 (fr) | 2009-01-16 | 2011-11-23 | Teva Pharmaceutical Industries Limited | Nouvelles formulations stables de protéine de fusion d'albumine humaine recombinante et facteur humain de stimulation de colonie de granulocytes |
JP5936112B2 (ja) | 2009-02-11 | 2016-06-15 | アルブミディクス アクティーゼルスカブ | アルブミン変異体及び複合体 |
KR20100100254A (ko) * | 2009-03-05 | 2010-09-15 | (주)바이오큐어팜 | 인간 혈청 알부민-팀프-2 융합 단백질과 항암제를 포함하는암의 예방 또는 치료용 조성물 |
CN102741422B (zh) | 2009-08-24 | 2016-06-08 | 阿穆尼克斯运营公司 | 凝血因子ⅶ组合物及其制备和使用方法 |
CN105567699A (zh) * | 2009-10-30 | 2016-05-11 | 诺维信生物制药丹麦公司 | 白蛋白变体 |
CN106977608A (zh) | 2010-04-09 | 2017-07-25 | 阿尔布麦狄克斯公司 | 白蛋白衍生物和变体 |
US9238080B2 (en) | 2010-05-21 | 2016-01-19 | Merrimack Pharmaceuticals, Inc. | Bi-specific fusion proteins |
CN103402542B (zh) * | 2011-02-28 | 2017-05-03 | 独立行政法人国立循环器病研究中心 | 恶性肿瘤转移抑制用药物 |
US8822417B2 (en) | 2011-05-05 | 2014-09-02 | Novozymes Biopharma DIC A/S | Albumin variants |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
WO2012170969A2 (fr) | 2011-06-10 | 2012-12-13 | Biogen Idec Ma Inc. | Composés pro-coagulants et leurs procédés d'utilisation |
US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
US8853176B2 (en) | 2011-10-21 | 2014-10-07 | Abbvie Inc. | Methods for treating HCV |
GB2515942A (en) | 2011-10-21 | 2015-01-07 | Abbvie Inc | Combination treatment (e.g. with ABT-072 or ABT-333) of DAAs for use in treating HCV |
US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
WO2013075066A2 (fr) | 2011-11-18 | 2013-05-23 | Eleven Biotherapeutics, Inc. | Protéines ayant une demi-vie et d'autres propriétés améliorées |
BR112014017165B1 (pt) | 2012-01-12 | 2023-05-02 | Bioverativ Therapeutics Inc | Proteína quimérica compreendendo uma proteína de fator viii, composição farmacêutica, e seus usos |
JP6256882B2 (ja) | 2012-02-15 | 2018-01-10 | アムニクス オペレーティング インコーポレイテッド | 第viii因子組成物、ならびに組成物の作製方法および用途 |
JP6383666B2 (ja) | 2012-02-15 | 2018-08-29 | バイオベラティブ セラピューティクス インコーポレイテッド | 組換え第viii因子タンパク質 |
BR112014018679A2 (pt) | 2012-03-16 | 2017-07-04 | Novozymes Biopharma Dk As | variantes de albumina |
AU2013270683A1 (en) | 2012-06-08 | 2014-12-11 | Biogen Ma Inc. | Chimeric clotting factors |
JP2015521589A (ja) | 2012-06-08 | 2015-07-30 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | プロコアグラント化合物 |
CN103525695B (zh) * | 2012-07-04 | 2015-05-20 | 长沙中生众捷生物技术有限公司 | 便携式肾功能检测系统 |
SG10201913893XA (en) | 2012-07-11 | 2020-03-30 | Bioverativ Therapeutics Inc | Factor viii complex with xten and von willebrand factor protein, and uses thereof |
WO2014063108A1 (fr) | 2012-10-18 | 2014-04-24 | Biogen Idec Ma Inc. | Procédés d'utilisation d'une dose fixe d'un facteur de coagulation |
MX2015005363A (es) | 2012-11-08 | 2015-11-06 | Novozymes Biopharma Dk As | Variantes de albumina. |
EP3889173B1 (fr) | 2013-02-15 | 2023-07-05 | Bioverativ Therapeutics Inc. | Gène du facteur viii optimisé |
EP3318124A3 (fr) | 2013-02-16 | 2018-05-30 | Albumedix A/S | Modèle pharmacocinétique animal |
CA2899089C (fr) | 2013-03-15 | 2021-10-26 | Biogen Ma Inc. | Preparations contenant un polypeptide du facteur ix |
US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
EP3048899B1 (fr) | 2013-09-25 | 2021-09-08 | Bioverativ Therapeutics Inc. | Procédés d'inactivation de virus sur colonne |
EP3065769A4 (fr) | 2013-11-08 | 2017-05-31 | Biogen MA Inc. | Composé de fusion procoagulant |
RS63583B1 (sr) | 2014-01-10 | 2022-10-31 | Bioverativ Therapeutics Inc | Himerni proteini faktora viii i njihova upotreba |
US11008561B2 (en) | 2014-06-30 | 2021-05-18 | Bioverativ Therapeutics Inc. | Optimized factor IX gene |
NZ730563A (en) | 2014-10-14 | 2019-05-31 | Halozyme Inc | Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same |
MA40835A (fr) | 2014-10-23 | 2017-08-29 | Biogen Ma Inc | Anticorps anti-gpiib/iiia et leurs utilisations |
MA40861A (fr) | 2014-10-31 | 2017-09-05 | Biogen Ma Inc | Anticorps anti-glycoprotéines iib/iiia |
BR112018002150A2 (pt) | 2015-08-03 | 2018-09-18 | Bioverativ Therapeutics Inc | proteínas de fusão do fator ix e métodos de fabricação e uso das mesmas |
WO2017029407A1 (fr) | 2015-08-20 | 2017-02-23 | Albumedix A/S | Variants de l'albumine et leurs conjugués |
EP3355907B1 (fr) | 2015-10-02 | 2021-01-20 | Silver Creek Pharmaceuticals, Inc. | Protéines thérapeutiques bispécifiques pour la réparation de tissus |
CN105254766B (zh) * | 2015-10-26 | 2018-10-16 | 中国航天员科研训练中心 | 机械生长因子MGF E domain肽在调控记忆相关基因和miRNA表达中的应用 |
DK3411478T3 (da) | 2016-02-01 | 2022-09-12 | Bioverativ Therapeutics Inc | Optimerede faktor viii-gener |
WO2017189978A1 (fr) | 2016-04-28 | 2017-11-02 | Emory University | Compositions thérapeutiques à base de nucléotides et nucléosides contenant un alcyne et utilisations associées |
CN110337590A (zh) | 2016-11-04 | 2019-10-15 | 奥胡斯大学 | 以新生儿Fc受体过表达为特征的肿瘤的识别和治疗 |
IL266972B2 (en) | 2016-12-02 | 2024-04-01 | Bioverativ Therapeutics Inc | Methods for the treatment of hemophilic arthritis with the help of chimeric blood coagulation factors |
BR112019011198A2 (pt) | 2016-12-02 | 2019-12-17 | Bioverativ Therapeutics Inc | métodos de indução de tolerância imune a fatores de coagulação |
EP3562840A1 (fr) | 2016-12-16 | 2019-11-06 | Biogen MA Inc. | Facteur 11 de différenciation de croissance activé protéolytiquement stabilisé |
EA201991768A1 (ru) | 2017-01-31 | 2020-01-22 | Байоверетив Терапьютикс Инк. | Слитые белки на основе фактора ix и способы их получения и пути применения |
MA50141A (fr) * | 2017-04-20 | 2020-07-29 | Novo Nordisk As | Procédés de purification de protéines de fusion d'albumine |
CN111247251A (zh) | 2017-08-09 | 2020-06-05 | 比奥维拉迪维治疗股份有限公司 | 核酸分子及其用途 |
BR112020015228A2 (pt) | 2018-02-01 | 2020-12-29 | Bioverativ Therapeutics Inc. | Uso de vetores lentivirais que expressam fator viii |
EP3833766A1 (fr) | 2018-08-09 | 2021-06-16 | Bioverativ Therapeutics Inc. | Molécules d'acide nucléique et leurs utilisations pour une thérapie génique non virale |
US20200199626A1 (en) | 2018-12-06 | 2020-06-25 | Bioverativ Therapeutics Inc. | Use of lentiviral vectors expressing factor ix |
US20210113634A1 (en) | 2019-09-30 | 2021-04-22 | Bioverativ Therapeutics Inc. | Lentiviral vector formulations |
JPWO2022030580A1 (fr) * | 2020-08-06 | 2022-02-10 | ||
WO2024080306A1 (fr) * | 2022-10-11 | 2024-04-18 | Jcrファーマ株式会社 | Protéine de fusion d'albumine sérique et de protéine physiologiquement active |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2277889B1 (fr) * | 2001-12-21 | 2014-07-09 | Human Genome Sciences, Inc. | Protéines chimériques d'albumine et interféron beta |
CA2513213C (fr) * | 2003-01-22 | 2013-07-30 | Human Genome Sciences, Inc. | Proteines hybrides d'albumine |
BRPI0507026A (pt) * | 2004-02-09 | 2007-04-17 | Human Genome Sciences Inc | proteìnas de fusão de albumina |
US20060051859A1 (en) * | 2004-09-09 | 2006-03-09 | Yan Fu | Long acting human interferon analogs |
-
2006
- 2006-07-31 KR KR1020087006077A patent/KR20080071119A/ko not_active Application Discontinuation
- 2006-07-31 AU AU2006280312A patent/AU2006280312A1/en not_active Abandoned
- 2006-07-31 JP JP2008526056A patent/JP2009504157A/ja not_active Withdrawn
- 2006-07-31 EP EP06813242A patent/EP1924596A4/fr not_active Withdrawn
- 2006-07-31 BR BRPI0614761-5A patent/BRPI0614761A2/pt not_active IP Right Cessation
- 2006-07-31 CA CA002618476A patent/CA2618476A1/fr not_active Abandoned
- 2006-07-31 WO PCT/US2006/029391 patent/WO2007021494A2/fr active Application Filing
- 2006-07-31 MX MX2008001865A patent/MX2008001865A/es not_active Application Discontinuation
-
2008
- 2008-02-04 IL IL189246A patent/IL189246A0/en unknown
- 2008-02-11 TN TNP2008000064A patent/TNSN08064A1/en unknown
- 2008-03-07 MA MA30727A patent/MA29836B1/fr unknown
- 2008-03-10 NO NO20081233A patent/NO20081233L/no not_active Application Discontinuation
- 2008-03-12 EC EC2008008262A patent/ECSP088262A/es unknown
Also Published As
Publication number | Publication date |
---|---|
ECSP088262A (es) | 2008-05-30 |
MX2008001865A (es) | 2008-04-15 |
JP2009504157A (ja) | 2009-02-05 |
NO20081233L (no) | 2008-05-09 |
TNSN08064A1 (en) | 2009-07-14 |
KR20080071119A (ko) | 2008-08-01 |
CA2618476A1 (fr) | 2007-02-22 |
WO2007021494A3 (fr) | 2007-07-26 |
WO2007021494A2 (fr) | 2007-02-22 |
IL189246A0 (en) | 2008-08-07 |
EP1924596A2 (fr) | 2008-05-28 |
AU2006280312A1 (en) | 2007-02-22 |
EP1924596A4 (fr) | 2009-07-29 |
BRPI0614761A2 (pt) | 2009-05-19 |
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