HUP0301356A2 - Új, DPPIV-gyel rokon szerin proteáz gének - Google Patents
Új, DPPIV-gyel rokon szerin proteáz génekInfo
- Publication number
- HUP0301356A2 HUP0301356A2 HU0301356A HUP0301356A HUP0301356A2 HU P0301356 A2 HUP0301356 A2 HU P0301356A2 HU 0301356 A HU0301356 A HU 0301356A HU P0301356 A HUP0301356 A HU P0301356A HU P0301356 A2 HUP0301356 A2 HU P0301356A2
- Authority
- HU
- Hungary
- Prior art keywords
- proteins
- dppiv
- subject
- serine protease
- genes related
- Prior art date
Links
- 101000964562 Homo sapiens Zinc finger FYVE domain-containing protein 9 Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 239000003814 drug Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 238000012216 screening Methods 0.000 abstract 2
- 229940124597 therapeutic agent Drugs 0.000 abstract 2
- 101000684208 Homo sapiens Prolyl endopeptidase FAP Proteins 0.000 abstract 1
- 102100023832 Prolyl endopeptidase FAP Human genes 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
Abstract
A találmány tárgyát új fehérjék vagy polipeptidek képezik, amelyekszignifikáns szekvencia-homológiát mutatnak a DPPIV-gyel, valamint atalálmány tárgyát képezik az ezeket kódoló nukleinsavak, az olyansejtek, amiket úgy módosítottak az említett nukleinsavakkal, hogyexpresszálják ezeket a fehérjéket, az említett fehérjék elleniellenanyagok, szűrővizsgálati módszerek, amelyekkel új terápiáságenseket lehet felfedezni, amelyek gátolják ezeknek a fehérjéknek,vagy a rokon fehérjéknek az aktivitását, és a találmány tárgyátképezik az ilyen szűrővizsgálati módszerrel felfedezett terápiáságensek, és az új terápiás kezelések is. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24011700P | 2000-10-12 | 2000-10-12 | |
PCT/US2001/031874 WO2002031134A2 (en) | 2000-10-12 | 2001-10-12 | Novel serine protease genes related to dppiv |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0301356A2 true HUP0301356A2 (hu) | 2003-10-28 |
HUP0301356A3 HUP0301356A3 (en) | 2010-03-29 |
Family
ID=22905181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0301356A HUP0301356A3 (en) | 2000-10-12 | 2001-10-12 | Novel serine protease genes related to dppiv |
Country Status (18)
Country | Link |
---|---|
US (2) | US6844180B2 (hu) |
EP (1) | EP1346033A2 (hu) |
JP (1) | JP2004528812A (hu) |
KR (1) | KR100875221B1 (hu) |
CN (2) | CN101270362A (hu) |
AU (2) | AU1313802A (hu) |
CA (1) | CA2425001A1 (hu) |
CZ (1) | CZ20031301A3 (hu) |
HK (1) | HK1078104A1 (hu) |
HU (1) | HUP0301356A3 (hu) |
IL (2) | IL155245A0 (hu) |
MX (1) | MXPA03003191A (hu) |
NO (1) | NO329842B1 (hu) |
NZ (1) | NZ525443A (hu) |
PL (1) | PL366005A1 (hu) |
RU (1) | RU2305133C2 (hu) |
WO (1) | WO2002031134A2 (hu) |
ZA (1) | ZA200303306B (hu) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6979697B1 (en) * | 1998-08-21 | 2005-12-27 | Point Therapeutics, Inc. | Regulation of substrate activity |
JP4748908B2 (ja) * | 1999-09-10 | 2011-08-17 | ザ・ユニバーシティ・オブ・シドニー | ジペプチジルペプチダーゼ |
US20040047853A1 (en) * | 2000-06-09 | 2004-03-11 | Dahl Soren W | Purified proenzyme of dipeptidyl peptidase i (pro-dppi) |
AUPR107800A0 (en) * | 2000-10-27 | 2000-11-23 | University Of Sydney, The | Peptide and nucleic acid molecule ii |
GB0101760D0 (en) * | 2001-01-23 | 2001-03-07 | Glaxo Group Ltd | Novel protein |
AU2002249453A1 (en) * | 2001-04-24 | 2002-11-05 | Isis Innovation Ltd | Enzyme and snp marker for disease |
CN100341572C (zh) | 2001-05-11 | 2007-10-10 | 得克萨斯州立大学董事会 | 抗cd26单克隆抗体作为对与表达cd26的细胞相关疾病的治疗 |
DE10150203A1 (de) | 2001-10-12 | 2003-04-17 | Probiodrug Ag | Peptidylketone als Inhibitoren der DPIV |
US6709651B2 (en) | 2001-07-03 | 2004-03-23 | B.M.R.A. Corporation B.V. | Treatment of substance P-related disorders |
WO2003057916A2 (en) * | 2002-01-09 | 2003-07-17 | Riken | Cancer profiles |
EP1528931B1 (en) | 2002-08-09 | 2008-05-07 | Prosidion Ltd. | Dipeptidyl peptidase iv inhibitors for decreasing the rate of chronic weight gain |
US7687625B2 (en) | 2003-03-25 | 2010-03-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
EP1625122A1 (en) | 2003-05-14 | 2006-02-15 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
BRPI0413452A (pt) | 2003-08-13 | 2006-10-17 | Takeda Pharmaceutical | composto, composição farmacêutica, kit, artigo de fabricação, e, métodos de inibir dpp-iv, terapêutico e de tratar um estado de doença, cáncer, distúrbios autoimunes, uma condição einfecção por hiv |
US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7790734B2 (en) | 2003-09-08 | 2010-09-07 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
AU2004318013B8 (en) | 2004-03-15 | 2011-10-06 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2005106487A1 (en) * | 2004-04-28 | 2005-11-10 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with dipeptidyl-peptidase 9 (dpp9) |
WO2005106021A1 (en) * | 2004-04-28 | 2005-11-10 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with dipeptidyl-peptidase 8 (dpp8) |
WO2005118555A1 (en) | 2004-06-04 | 2005-12-15 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
US20060063719A1 (en) * | 2004-09-21 | 2006-03-23 | Point Therapeutics, Inc. | Methods for treating diabetes |
EP2805953B1 (en) * | 2004-12-21 | 2016-03-09 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US20070060529A1 (en) * | 2005-09-14 | 2007-03-15 | Christopher Ronald J | Administration of dipeptidyl peptidase inhibitors |
EP1942898B2 (en) | 2005-09-14 | 2014-05-14 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors for treating diabetes |
JP5122462B2 (ja) | 2005-09-16 | 2013-01-16 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼ阻害剤 |
WO2007047205A2 (en) * | 2005-10-11 | 2007-04-26 | Amano Enzyme Usa Co., Ltd. | Enzyme inhibitors of pai-1 |
WO2007054577A1 (en) | 2005-11-14 | 2007-05-18 | Probiodrug Ag | Cyclopropyl-fused pyrrolidine derivatives as dipeptidyl peptidase iv inhibitors |
WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
MX2008013130A (es) | 2006-04-12 | 2008-11-19 | Probiodrug Ag | Inhibidores de enzima. |
US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
CN101259119B (zh) * | 2007-03-08 | 2010-05-19 | 上海市计划生育科学研究所 | 一种丝氨酸蛋白酶抑制剂及其衍生物在生育调节中的应用 |
US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
US9593148B2 (en) * | 2012-11-02 | 2017-03-14 | Georg-August-Universitat Gottingen Stiftung Offentlichen Rechts | DPP8 and DPP9 peptide inhibitors |
US11427814B2 (en) | 2019-03-26 | 2022-08-30 | Encodia, Inc. | Modified cleavases, uses thereof and related kits |
KR102567902B1 (ko) * | 2019-03-26 | 2023-08-18 | 엔코디아, 인코포레이티드 | 변형된 클리바아제, 이의 용도 및 관련 키트 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6291662B1 (en) | 1984-12-05 | 2001-09-18 | Amgen Inc. | Recombinant methods for production of serine protease inhibitors and DNA sequences |
IL111785A0 (en) | 1993-12-03 | 1995-01-24 | Ferring Bv | Dp-iv inhibitors and pharmaceutical compositions containing them |
AU2501200A (en) | 1999-01-11 | 2000-08-01 | Incyte Pharmaceuticals, Inc. | Human peptidases |
JP2004507202A (ja) * | 1999-03-31 | 2004-03-11 | キュラジェン コーポレイション | ポリペプチドをコードするオープンリーディングフレームを含む核酸;「orfx」 |
JP4748908B2 (ja) | 1999-09-10 | 2011-08-17 | ザ・ユニバーシティ・オブ・シドニー | ジペプチジルペプチダーゼ |
CN1307128A (zh) | 2000-01-26 | 2001-08-08 | 上海博道基因技术有限公司 | 一种新的多肽——人二肽氨肽酶28和编码这种多肽的多核苷酸 |
WO2001098468A2 (en) * | 2000-06-16 | 2001-12-27 | Incyte Genomics, Inc. | Proteases |
-
2001
- 2001-10-12 IL IL15524501A patent/IL155245A0/xx unknown
- 2001-10-12 WO PCT/US2001/031874 patent/WO2002031134A2/en active IP Right Grant
- 2001-10-12 HU HU0301356A patent/HUP0301356A3/hu unknown
- 2001-10-12 EP EP01981501A patent/EP1346033A2/en not_active Ceased
- 2001-10-12 AU AU1313802A patent/AU1313802A/xx active Pending
- 2001-10-12 RU RU2003112700/13A patent/RU2305133C2/ru not_active IP Right Cessation
- 2001-10-12 CA CA002425001A patent/CA2425001A1/en not_active Abandoned
- 2001-10-12 CZ CZ20031301A patent/CZ20031301A3/cs unknown
- 2001-10-12 KR KR1020037005169A patent/KR100875221B1/ko not_active IP Right Cessation
- 2001-10-12 CN CNA2007101850111A patent/CN101270362A/zh active Pending
- 2001-10-12 CN CNB018173128A patent/CN100354417C/zh not_active Expired - Fee Related
- 2001-10-12 AU AU2002213138A patent/AU2002213138B2/en not_active Ceased
- 2001-10-12 US US09/976,674 patent/US6844180B2/en not_active Expired - Fee Related
- 2001-10-12 PL PL01366005A patent/PL366005A1/xx unknown
- 2001-10-12 NZ NZ525443A patent/NZ525443A/en unknown
- 2001-10-12 MX MXPA03003191A patent/MXPA03003191A/es active IP Right Grant
- 2001-10-12 JP JP2002534503A patent/JP2004528812A/ja active Pending
-
2003
- 2003-04-03 IL IL155245A patent/IL155245A/en not_active IP Right Cessation
- 2003-04-11 NO NO20031702A patent/NO329842B1/no not_active IP Right Cessation
- 2003-04-29 ZA ZA200303306A patent/ZA200303306B/en unknown
-
2004
- 2004-11-05 US US10/982,512 patent/US7157241B2/en not_active Expired - Fee Related
-
2005
- 2005-11-09 HK HK05109986A patent/HK1078104A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IL155245A0 (en) | 2003-11-23 |
HK1078104A1 (en) | 2006-03-03 |
CA2425001A1 (en) | 2002-04-18 |
US20050059081A1 (en) | 2005-03-17 |
MXPA03003191A (es) | 2004-12-03 |
US20020115843A1 (en) | 2002-08-22 |
WO2002031134A2 (en) | 2002-04-18 |
KR100875221B1 (ko) | 2008-12-19 |
CZ20031301A3 (cs) | 2003-10-15 |
US6844180B2 (en) | 2005-01-18 |
PL366005A1 (en) | 2005-01-24 |
WO2002031134A3 (en) | 2003-07-17 |
AU2002213138B2 (en) | 2006-07-20 |
NO20031702D0 (no) | 2003-04-11 |
CN101270362A (zh) | 2008-09-24 |
JP2004528812A (ja) | 2004-09-24 |
CN100354417C (zh) | 2007-12-12 |
HUP0301356A3 (en) | 2010-03-29 |
KR20030038815A (ko) | 2003-05-16 |
RU2305133C2 (ru) | 2007-08-27 |
NO20031702L (no) | 2003-05-15 |
CN1636061A (zh) | 2005-07-06 |
NZ525443A (en) | 2006-04-28 |
NO329842B1 (no) | 2011-01-10 |
ZA200303306B (en) | 2004-08-12 |
EP1346033A2 (en) | 2003-09-24 |
US7157241B2 (en) | 2007-01-02 |
IL155245A (en) | 2010-04-15 |
AU1313802A (en) | 2002-04-22 |
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