DE60142226D1 - Pilz transkriptionsaktivator zur verwendung in verfahren zur herstellung von polypeptiden - Google Patents

Pilz transkriptionsaktivator zur verwendung in verfahren zur herstellung von polypeptiden

Info

Publication number
DE60142226D1
DE60142226D1 DE60142226T DE60142226T DE60142226D1 DE 60142226 D1 DE60142226 D1 DE 60142226D1 DE 60142226 T DE60142226 T DE 60142226T DE 60142226 T DE60142226 T DE 60142226T DE 60142226 D1 DE60142226 D1 DE 60142226D1
Authority
DE
Germany
Prior art keywords
polypeptides
mushroom
processes
preparation
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60142226T
Other languages
English (en)
Inventor
Carsten M Hjort
Van Den C Mjj Hondel
P J Punt
F H Schuren
Tove Christensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novozymes AS
Original Assignee
Novozymes AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes AS filed Critical Novozymes AS
Application granted granted Critical
Publication of DE60142226D1 publication Critical patent/DE60142226D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/385—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Penicillium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/38—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
DE60142226T 2000-03-14 2001-03-14 Pilz transkriptionsaktivator zur verwendung in verfahren zur herstellung von polypeptiden Expired - Lifetime DE60142226D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200000406 2000-03-14
PCT/DK2001/000169 WO2001068864A1 (en) 2000-03-14 2001-03-14 Fungal transcriptional activator useful in methods for producing polypeptides

Publications (1)

Publication Number Publication Date
DE60142226D1 true DE60142226D1 (de) 2010-07-08

Family

ID=8159325

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60142226T Expired - Lifetime DE60142226D1 (de) 2000-03-14 2001-03-14 Pilz transkriptionsaktivator zur verwendung in verfahren zur herstellung von polypeptiden

Country Status (8)

Country Link
EP (1) EP1266011B1 (de)
JP (1) JP2003526374A (de)
CN (2) CN1425068B (de)
AT (1) ATE469223T1 (de)
AU (1) AU2001242299A1 (de)
DE (1) DE60142226D1 (de)
DK (1) DK1266011T3 (de)
WO (1) WO2001068864A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE441664T1 (de) 2003-03-31 2009-09-15 Novozymes Inc Verfahren zur produktion biologischer substanzen in enzymmangelmutanten von aspergillus niger
WO2006040312A2 (en) * 2004-10-12 2006-04-20 Dsm Ip Assets B.V. Fungal transcriptional activators useful in methods for producing a polypeptide
CA2595056A1 (en) 2005-01-24 2006-07-27 Dsm Ip Assets B.V. Method for producing a compound of interest in a filamentous fungal cell
WO2006097464A1 (en) 2005-03-16 2006-09-21 Novozymes A/S Recombinant expression of defensins in filamentous fungi
ATE514770T1 (de) 2005-10-17 2011-07-15 Novozymes As Verwendung von pilzmutanten zur expression von antikörpern
US20090176219A1 (en) 2005-11-29 2009-07-09 Lucie Parenicova Dna binding site of a transcriptional activator useful in gene expression
EP2035561A1 (de) 2006-06-29 2009-03-18 DSMIP Assets B.V. Verfahren für verbesserte polypeptidexpression
US20100221783A1 (en) 2007-05-09 2010-09-02 Novozymes A/S Expression Cloning Method Suitable for Selecting Library Clones Producing a Polypeptide of Interest
CN101182352B (zh) * 2007-11-21 2010-06-09 中国科学院微生物研究所 一种转录激活因子及其编码基因与应用
WO2011009700A1 (en) 2009-07-22 2011-01-27 Dsm Ip Assets B.V. Improved host cell for the production of a compound of interest
CN101906393B (zh) * 2010-06-28 2012-07-25 江南大学 一种谷氨酰胺转胺酶编码基因阻断吸水链霉菌及其应用
CN103443268A (zh) 2011-01-20 2013-12-11 诺维信公司 植物过氧化物酶在丝状真菌中的表达
EP2527432A1 (de) 2011-05-23 2012-11-28 Novozymes A/S Bidirektionaler Cytosin-Deaminase-codierender Selektionsmarker
EP2527448A1 (de) 2011-05-23 2012-11-28 Novozymes A/S Gleichzeitige standortspezifische Integrationen von mehreren Genkopien in faserige Pilze
CA2861697C (en) 2012-01-05 2022-03-15 Novartis Ag Protease deficient filamentous fungal cells and methods of use thereof
US9695454B2 (en) 2012-05-23 2017-07-04 Glykos Finland Oy Production of fucosylated glycoproteins
DK2875119T3 (en) 2012-07-19 2018-04-03 Dsm Ip Assets Bv AGSE-DEFICIENT TRIALS
CA2916905A1 (en) 2013-07-10 2015-01-15 Novartis Ag Multiple proteases deficient filamentous fungal cells and methods of use thereof
AU2015293949B2 (en) 2014-07-21 2019-07-25 Teknologian Tutkimuskeskus Vtt Oy Production of glycoproteins with mammalian-like N-glycans in filamentous fungi
DK3242950T3 (da) 2015-01-06 2021-12-20 Dsm Ip Assets Bv Crispr-cas-system til en trådformet svampeværtscelle
JP6473339B2 (ja) * 2015-02-05 2019-02-20 本田技研工業株式会社 麹菌変異株及び形質転換体
AU2016221605B2 (en) * 2015-02-20 2019-12-05 Roal Oy Methods for controlling protease production
US20200063166A1 (en) 2017-03-13 2020-02-27 Dsm Ip Assets B.V. Zinc binuclear cluster transcriptional regulator-deficient strain
WO2018167153A1 (en) 2017-03-17 2018-09-20 Novozymes A/S Improved filamentous fungal host cell
EP3809852A1 (de) 2018-06-19 2021-04-28 DSM IP Assets B.V. Varianten lipolytischer enzyme
JP2023511858A (ja) 2020-01-14 2023-03-23 ザ プロテイン ブルワリー ビー．ヴイ． オボアルブミン及びその天然バリアントの発現
WO2023222614A1 (en) 2022-05-16 2023-11-23 Dsm Ip Assets B.V. Lipolytic enzyme variants
WO2023242273A1 (en) 2022-06-14 2023-12-21 Newmilkbuzz B.V. Expression of milk caseins in filamentous fungi

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4288627A (en) 1980-02-12 1981-09-08 Phillips Petroleum Company Oxidation of thiols employing cobalt molybdate/triethylamine catalyst
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
CA1333777C (en) 1988-07-01 1995-01-03 Randy M. Berka Aspartic proteinase deficient filamentous fungi
DE69333249T2 (de) 1992-04-15 2004-07-29 Novartis Ag Neue Schimmel-Protease
DK52293D0 (de) 1993-05-05 1993-05-05 Novo Nordisk As
DK76893D0 (de) 1993-06-28 1993-06-28 Novo Nordisk As
ES2165420T3 (es) 1994-06-03 2002-03-16 Novozymes Biotech Inc Lacasas myceliophthora purificadas y acidos nucleicos que las codifican.
JPH10501414A (ja) * 1994-06-17 1998-02-10 ノボ ノルディスク アクティーゼルスカブ ａｒｅＡ遺伝子が修飾された真菌及びアスペルギルス オリザエからのａｒｅＡ遺伝子
CN101659926A (zh) 1994-06-30 2010-03-03 诺沃奇梅兹有限公司 非毒性、非产毒性、非致病性镰孢属表达系统及所用启动子和终止子
WO1997012045A1 (en) 1995-09-27 1997-04-03 Chiron Corporation Method of making a protease deficient host
AU2152897A (en) 1996-03-27 1997-10-17 Novo Nordisk A/S Alkaline protease deficient filamentous fungi
DK0909273T3 (da) 1996-07-05 2006-03-13 Novozymes As Alpha-amylasetransskriptionsfaktor
JP4091119B2 (ja) 1996-09-19 2008-05-28 ノボザイムス アクティーゼルスカブ 新規な宿主細胞およびタンパク質生産方法
JP4563585B2 (ja) * 1998-10-05 2010-10-13 ノボザイムス アクティーゼルスカブ ポリペプチドの生成方法において有用な菌類転写活性化因子

Also Published As

Publication number Publication date
CN1425068B (zh) 2011-05-18
CN1425068A (zh) 2003-06-18
ATE469223T1 (de) 2010-06-15
CN102174535A (zh) 2011-09-07
CN102174535B (zh) 2014-04-09
DK1266011T3 (da) 2010-07-26
EP1266011A1 (de) 2002-12-18
AU2001242299A1 (en) 2001-09-24
JP2003526374A (ja) 2003-09-09
EP1266011B1 (de) 2010-05-26
WO2001068864A1 (en) 2001-09-20

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