ATE441664T1 - Verfahren zur produktion biologischer substanzen in enzymmangelmutanten von aspergillus niger - Google Patents

Verfahren zur produktion biologischer substanzen in enzymmangelmutanten von aspergillus niger

Info

Publication number
ATE441664T1
ATE441664T1 AT04758768T AT04758768T ATE441664T1 AT E441664 T1 ATE441664 T1 AT E441664T1 AT 04758768 T AT04758768 T AT 04758768T AT 04758768 T AT04758768 T AT 04758768T AT E441664 T1 ATE441664 T1 AT E441664T1
Authority
AT
Austria
Prior art keywords
aspergillus niger
biological substance
amylase
mutants
heterologous biological
Prior art date
Application number
AT04758768T
Other languages
English (en)
Inventor
Mariah Connelly
Howard Brody
Original Assignee
Novozymes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes Inc filed Critical Novozymes Inc
Application granted granted Critical
Publication of ATE441664T1 publication Critical patent/ATE441664T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/38—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/40—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
AT04758768T 2003-03-31 2004-03-31 Verfahren zur produktion biologischer substanzen in enzymmangelmutanten von aspergillus niger ATE441664T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45990203P 2003-03-31 2003-03-31
PCT/US2004/010126 WO2004090155A2 (en) 2003-03-31 2004-03-31 Methods for producing biological substances in enzyme-deficient mutants of aspergillus niger

Publications (1)

Publication Number Publication Date
ATE441664T1 true ATE441664T1 (de) 2009-09-15

Family

ID=33159708

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04758768T ATE441664T1 (de) 2003-03-31 2004-03-31 Verfahren zur produktion biologischer substanzen in enzymmangelmutanten von aspergillus niger

Country Status (8)

Country Link
US (3) US7303877B2 (de)
EP (1) EP1613761B1 (de)
JP (1) JP4638418B2 (de)
CN (2) CN101629204A (de)
AT (1) ATE441664T1 (de)
DE (1) DE602004022929D1 (de)
DK (1) DK1613761T3 (de)
WO (1) WO2004090155A2 (de)

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DK1954812T3 (da) 2005-11-29 2013-02-18 Dsm Ip Assets Bv DNA-bindingssted for en transskriptionsaktivator, der er anvendelig ved genekspression
PL2423315T3 (pl) 2006-06-29 2015-06-30 Dsm Ip Assets Bv Sposób osiągania lepszej ekspresji polipeptydu
EP2082046A2 (de) 2006-11-02 2009-07-29 DSMIP Assets B.V. Verbesserte produktion sezernierter proteine durch filamentöse pilze
AU2008214663B2 (en) 2007-02-15 2013-10-03 Dsm Ip Assets B.V. A recombinant host cell for the production of a compound of interest
CA2707847A1 (en) 2007-12-06 2009-06-11 Novozymes A/S Polypeptides having acetylxylan esterase activity and polynucleotides encoding same
DK2411511T3 (en) 2009-03-24 2018-11-26 Novozymes As POLYPEPTIDES WITH ACETYLXYLANESTERASE ACTIVITY AND POLYNUCLEOTIDES CODING THEM
CA2758404A1 (en) 2009-04-22 2010-10-28 Dsm Ip Assets B.V. Process for the production of a recombinant polypeptide of interest
EP2421965B1 (de) 2009-04-24 2016-05-25 DSM IP Assets B.V. Kohlenhydrat abbauendes polypeptid und verwendungen davon
MX350399B (es) * 2009-12-18 2017-09-06 Novozymes Inc Metodos para producir polipeptidos en mutantes de trichoderma deficientes en proteasa.
MX2012009282A (es) 2010-02-11 2012-09-07 Dsm Ip Assets Bv Polipeptido que tiene actividad de celobiohidrolasa y usos del mismo.
BR112012020802A2 (pt) 2010-02-11 2015-09-15 Dsm Ip Assets Bv célula hospedeira capaz de produzir enzimas úteis para degradação de material lignocelulósico
CN101906393B (zh) * 2010-06-28 2012-07-25 江南大学 一种谷氨酰胺转胺酶编码基因阻断吸水链霉菌及其应用
WO2012000886A1 (en) 2010-06-29 2012-01-05 Dsm Ip Assets B.V. Polypeptide having beta-glucosidase activity and uses thereof
EA201300057A1 (ru) 2010-06-29 2013-05-30 ДСМ АйПи АССЕТС Б.В. Полипептид, обладающий углеводдеградирующей активностью, и его применения
US9441214B2 (en) 2010-06-29 2016-09-13 Dsm Ip Assets B.V. Polypeptide having beta-glucosidase activity and uses thereof
EP2588600A1 (de) 2010-06-29 2013-05-08 DSM IP Assets B.V. Polypeptid mit acetylxylanesteraseaktivität und verwendungen davon
WO2012000887A1 (en) 2010-06-29 2012-01-05 Dsm Ip Assets B.V. Polypeptide having swollenin activity and uses thereof
WO2012000892A1 (en) 2010-06-29 2012-01-05 Dsm Ip Assets B.V. Polypeptide having or assisting in carbohydrate material degrading activity and uses thereof
AR083355A1 (es) 2010-10-06 2013-02-21 Bp Corp North America Inc Polipeptidos variantes cbh i
US20120276247A1 (en) * 2011-04-29 2012-11-01 Uwe Bornscheuer Lipase Variants
JP5846476B2 (ja) * 2011-07-08 2016-01-20 独立行政法人酒類総合研究所 微生物のコウジ酸生産性を向上させる方法
CN102296032B (zh) * 2011-08-31 2013-11-06 保龄宝生物股份有限公司 转葡糖苷酶及其制备和固定化方法
GB2508569A (en) * 2011-11-02 2014-06-04 Univ Putra Malaysia A method for producing a biopolymer
AU2013207165B2 (en) 2012-01-05 2018-10-04 Glykos Finland Oy Protease deficient filamentous fungal cells and methods of use thereof
WO2013174927A1 (en) 2012-05-23 2013-11-28 Novartis International Pharmaceutical Limited Production of fucosylated glycoproteins
US9598698B2 (en) 2012-08-17 2017-03-21 Novozymes A/S Methods for co-silencing expression of genes in filamentous fungal strains and uses thereof
EP3019602B1 (de) 2013-07-10 2018-09-05 Glykos Finland Oy Filamentöse pilzzellen mit mehrfacher proteasendefizienz und verfahren zur verwendung davon
DK3036324T3 (en) 2013-08-23 2019-04-01 Novozymes As Regulated PepC expression
CA2954974A1 (en) 2014-07-21 2016-01-28 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
WO2017182442A1 (en) * 2016-04-19 2017-10-26 Novozymes A/S Rlma-inactivated filamentous fungal host cell
CN108504615B (zh) * 2018-03-30 2020-12-29 江南大学 一种产酸性蛋白酶的重组菌及其应用
WO2020081789A1 (en) * 2018-10-17 2020-04-23 Perfect Day, Inc. Recombinant components and compositions for use in food products
CN114555777A (zh) * 2019-07-26 2022-05-27 诺维信公司 经修饰的丝状真菌宿主细胞
CN113265417A (zh) * 2020-02-14 2021-08-17 中国科学院天津工业生物技术研究所 有机酸产量提高的菌株及其构建方法和应用
EP4228424A1 (de) 2020-10-15 2023-08-23 DSM IP Assets B.V. Verfahren zur modulation gastrointestinaler metaboliten
WO2023225459A2 (en) 2022-05-14 2023-11-23 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections
CN114736880B (zh) * 2022-06-09 2022-09-27 中国农业科学院北京畜牧兽医研究所 酸稳定性提高葡萄糖氧化酶GoxM10的突变体D497N及其衍生突变体和应用
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Also Published As

Publication number Publication date
CN1798848A (zh) 2006-07-05
EP1613761A2 (de) 2006-01-11
JP4638418B2 (ja) 2011-02-23
US7303877B2 (en) 2007-12-04
EP1613761A4 (de) 2006-08-09
DE602004022929D1 (de) 2009-10-15
WO2004090155A3 (en) 2005-01-06
WO2004090155A2 (en) 2004-10-21
JP2006521826A (ja) 2006-09-28
CN101629204A (zh) 2010-01-20
EP1613761B1 (de) 2009-09-02
DK1613761T3 (da) 2009-12-14
US20100323448A1 (en) 2010-12-23
US20040191864A1 (en) 2004-09-30
US7771971B2 (en) 2010-08-10
CN100547078C (zh) 2009-10-07
US8445283B2 (en) 2013-05-21
US20080044858A1 (en) 2008-02-21

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