DK1613761T3 - Fremgangsmåder til fremstilling af biologiske stoffer i enzymdefekte mutanter af Aspergillus niger - Google Patents

Fremgangsmåder til fremstilling af biologiske stoffer i enzymdefekte mutanter af Aspergillus niger

Info

Publication number
DK1613761T3
DK1613761T3 DK04758768T DK04758768T DK1613761T3 DK 1613761 T3 DK1613761 T3 DK 1613761T3 DK 04758768 T DK04758768 T DK 04758768T DK 04758768 T DK04758768 T DK 04758768T DK 1613761 T3 DK1613761 T3 DK 1613761T3
Authority
DK
Denmark
Prior art keywords
aspergillus niger
methods
biological substance
enzyme
amylase
Prior art date
Application number
DK04758768T
Other languages
Danish (da)
English (en)
Inventor
Mariah Connelly
Howard Brody
Original Assignee
Novozymes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes Inc filed Critical Novozymes Inc
Application granted granted Critical
Publication of DK1613761T3 publication Critical patent/DK1613761T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/38—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/40—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
DK04758768T 2003-03-31 2004-03-31 Fremgangsmåder til fremstilling af biologiske stoffer i enzymdefekte mutanter af Aspergillus niger DK1613761T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45990203P 2003-03-31 2003-03-31
PCT/US2004/010126 WO2004090155A2 (en) 2003-03-31 2004-03-31 Methods for producing biological substances in enzyme-deficient mutants of aspergillus niger

Publications (1)

Publication Number Publication Date
DK1613761T3 true DK1613761T3 (da) 2009-12-14

Family

ID=33159708

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04758768T DK1613761T3 (da) 2003-03-31 2004-03-31 Fremgangsmåder til fremstilling af biologiske stoffer i enzymdefekte mutanter af Aspergillus niger

Country Status (8)

Country Link
US (3) US7303877B2 (de)
EP (1) EP1613761B1 (de)
JP (1) JP4638418B2 (de)
CN (2) CN100547078C (de)
AT (1) ATE441664T1 (de)
DE (1) DE602004022929D1 (de)
DK (1) DK1613761T3 (de)
WO (1) WO2004090155A2 (de)

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JP5250850B2 (ja) 2006-06-29 2013-07-31 ディーエスエム アイピー アセッツ ビー．ブイ． 改善されたポリペプチド発現を達成する方法
EP2082046A2 (de) 2006-11-02 2009-07-29 DSMIP Assets B.V. Verbesserte produktion sezernierter proteine durch filamentöse pilze
CN101784666A (zh) 2007-02-15 2010-07-21 帝斯曼知识产权资产管理有限公司 用于生产感兴趣的化合物的重组宿主细胞
DK2224822T3 (da) 2007-12-06 2014-08-25 Novozymes As Polypeptider med acetylxylanesterase-aktivitet og polynukleotider, der koder for disse
CN102365360A (zh) 2009-03-24 2012-02-29 诺维信公司 具有乙酰木聚糖酯酶活性的多肽和编码该多肽的多核苷酸
US20120041171A1 (en) 2009-04-22 2012-02-16 Dsm Ip Assets B.V. Process for the production of a recombinant polypeptide of interest
BRPI1015536A2 (pt) 2009-04-24 2019-07-02 Dsm Ip Assets Bv polipeptídeo de degradação de carboidratos e usos do mesmo
BR122018077153B1 (pt) * 2009-12-18 2020-10-27 Novozymes, Inc mutante de uma cepa de trichoderma reesei parental,e, métodos para produzir um polipeptídeo de interesse e para obter um mutante de uma cepa de trichoderma reesei parental
AU2011214324B2 (en) 2010-02-11 2014-11-20 Dsm Ip Assets B.V. Host cell capable of producing enzymes useful for degradation of lignocellulosic material
EA201201126A1 (ru) 2010-02-11 2013-05-30 ДСМ АйПи АССЕТС Б.В. Полипептид, обладающий активностью целлобиогидролазы, и его применение
CN101906393B (zh) * 2010-06-28 2012-07-25 江南大学 一种谷氨酰胺转胺酶编码基因阻断吸水链霉菌及其应用
PL2588494T3 (pl) 2010-06-29 2018-08-31 Dsm Ip Assets B.V. Polipeptyd mający aktywność beta-glukozydazy i jego zastosowania
CN102971338A (zh) 2010-06-29 2013-03-13 帝斯曼知识产权资产管理有限公司 具有β-葡糖苷酶活性的多肽及其用途
CA2803986C (en) 2010-06-29 2019-04-23 Dsm Ip Assets B.V. Polypeptide having or assisting in carbohydrate material degrading activity and uses thereof
CA2801824A1 (en) 2010-06-29 2012-01-05 Dsm Ip Assets B.V. Polypeptide having swollenin activity and uses thereof
CN103119156A (zh) 2010-06-29 2013-05-22 帝斯曼知识产权资产管理有限公司 具有降解碳水化合物活性的多肽及其用途
MX2012015144A (es) 2010-06-29 2013-03-05 Dsm Ip Assets Bv Polipeptido que tiene actividad de acetil-xilan-esterasa y usos del mismo.
US9096871B2 (en) 2010-10-06 2015-08-04 Bp Corporation North America Inc. Variant CBH I polypeptides with reduced product inhibition
US20120276247A1 (en) 2011-04-29 2012-11-01 Uwe Bornscheuer Lipase Variants
JP5846476B2 (ja) * 2011-07-08 2016-01-20 独立行政法人酒類総合研究所 微生物のコウジ酸生産性を向上させる方法
CN102296032B (zh) * 2011-08-31 2013-11-06 保龄宝生物股份有限公司 转葡糖苷酶及其制备和固定化方法
WO2013066149A1 (en) * 2011-11-02 2013-05-10 Universiti Putra Malaysia A method for producing a biopolymer
BR112014016587A2 (pt) 2012-01-05 2020-10-27 Novartis Ag células fúngicas filamentosas deficientes de protease e métodos de uso das mesmas
EP2852610B1 (de) 2012-05-23 2018-07-11 Glykos Finland Oy Herstellung von fucosylierten glykoproteinen
WO2014028833A1 (en) 2012-08-17 2014-02-20 Novozymes A/S Methods for co-silencing expression of genes in filamentous fungal strains and uses thereof
CA2916905A1 (en) 2013-07-10 2015-01-15 Novartis Ag Multiple proteases deficient filamentous fungal cells and methods of use thereof
WO2015025055A1 (en) * 2013-08-23 2015-02-26 Novozymes A/S Regulated pepc expression
SG11201700446XA (en) 2014-07-21 2017-02-27 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
US10550398B2 (en) 2016-04-19 2020-02-04 Novozymes A/S RlmA-inactivated filamentous fungal host cell
CN108504615B (zh) * 2018-03-30 2020-12-29 江南大学 一种产酸性蛋白酶的重组菌及其应用
CN113301812A (zh) * 2018-10-17 2021-08-24 完美日股份有限公司 用于食物产品的重组组分和组合物
US20220251581A1 (en) * 2019-07-26 2022-08-11 Novozymes A/S Modified filamentous fungal host cell
CN113265417A (zh) * 2020-02-14 2021-08-17 中国科学院天津工业生物技术研究所 有机酸产量提高的菌株及其构建方法和应用
EP4228424A1 (de) 2020-10-15 2023-08-23 DSM IP Assets B.V. Verfahren zur modulation gastrointestinaler metaboliten
WO2023225459A2 (en) 2022-05-14 2023-11-23 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections
CN114736880B (zh) * 2022-06-09 2022-09-27 中国农业科学院北京畜牧兽医研究所 酸稳定性提高葡萄糖氧化酶GoxM10的突变体D497N及其衍生突变体和应用
WO2023242273A1 (en) * 2022-06-14 2023-12-21 Newmilkbuzz B.V. Expression of milk caseins in filamentous fungi

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Also Published As

Publication number Publication date
JP4638418B2 (ja) 2011-02-23
CN1798848A (zh) 2006-07-05
WO2004090155A3 (en) 2005-01-06
US20100323448A1 (en) 2010-12-23
US8445283B2 (en) 2013-05-21
US20040191864A1 (en) 2004-09-30
US7771971B2 (en) 2010-08-10
EP1613761A2 (de) 2006-01-11
CN101629204A (zh) 2010-01-20
ATE441664T1 (de) 2009-09-15
JP2006521826A (ja) 2006-09-28
EP1613761A4 (de) 2006-08-09
WO2004090155A2 (en) 2004-10-21
US7303877B2 (en) 2007-12-04
CN100547078C (zh) 2009-10-07
US20080044858A1 (en) 2008-02-21
DE602004022929D1 (de) 2009-10-15
EP1613761B1 (de) 2009-09-02

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