JP6167040B2 - Ｆｃドメイン中に突然変異を有する、安定したヘテロ二量体抗体の設計 - Google Patents

Ｆｃドメイン中に突然変異を有する、安定したヘテロ二量体抗体の設計 Download PDF

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JP6167040B2
JP6167040B2 JP2013536966A JP2013536966A JP6167040B2 JP 6167040 B2 JP6167040 B2 JP 6167040B2 JP 2013536966 A JP2013536966 A JP 2013536966A JP 2013536966 A JP2013536966 A JP 2013536966A JP 6167040 B2 JP6167040 B2 JP 6167040B2
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amino acid
domain polypeptide
polypeptide comprises
comprises amino
acid modifications
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JP2014504265A5 (https=
JP2014504265A (ja
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エスコバル カブレラ、エリック
エスコバル カブレラ、エリック
クロイデンシュタイン、トーマス スプレター フォン
クロイデンシュタイン、トーマス スプレター フォン
ビーマラオ ディキシット、スルジット
ビーマラオ ディキシット、スルジット
イレーネ ラリオ、ポーラ
イレーネ ラリオ、ポーラ
カイ ユエン プーン、デイヴィッド
カイ ユエン プーン、デイヴィッド
エドモンド パオロ ダンジェロ、イゴール
エドモンド パオロ ダンジェロ、イゴール
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ザイムワークス，インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2013536966A 2010-11-05 2011-11-04 Ｆｃドメイン中に突然変異を有する、安定したヘテロ二量体抗体の設計 Active JP6167040B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US41074610P 2010-11-05 2010-11-05
US61/410,746 2010-11-05
US201061425375P 2010-12-21 2010-12-21
US61/425,375 2010-12-21
US201161439341P 2011-02-03 2011-02-03
US61/439,341 2011-02-03
US201161475614P 2011-04-14 2011-04-14
US61/475,614 2011-04-14
US201161491846P 2011-05-31 2011-05-31
US61/491,846 2011-05-31
US201161497861P 2011-06-16 2011-06-16
US61/497,861 2011-06-16
PCT/CA2011/001238 WO2012058768A1 (en) 2010-11-05 2011-11-04 Stable heterodimeric antibody design with mutations in the fc domain

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JP2014504265A JP2014504265A (ja) 2014-02-20
JP2014504265A5 JP2014504265A5 (https=) 2014-12-25
JP6167040B2 true JP6167040B2 (ja) 2017-07-19

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US (4) US9562109B2 (https=)
EP (1) EP2635607B1 (https=)
JP (1) JP6167040B2 (https=)
KR (2) KR101973930B1 (https=)
CN (2) CN103429620B (https=)
AU (1) AU2011325833C1 (https=)
CA (1) CA2815266C (https=)
CY (1) CY1122409T1 (https=)
DK (1) DK2635607T3 (https=)
ES (1) ES2758994T3 (https=)
HR (1) HRP20192045T1 (https=)
HU (1) HUE047228T2 (https=)
MX (1) MX352929B (https=)
PL (1) PL2635607T3 (https=)
PT (1) PT2635607T (https=)
RS (1) RS59589B1 (https=)
RU (1) RU2604490C2 (https=)
WO (1) WO2012058768A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12415857B2 (en) 2021-06-25 2025-09-16 Chugai Seiyaku Kabushiki Kaisha Anti-CTLA-4 antibody and use thereof

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